JP2009526756A5 - - Google Patents
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- JP2009526756A5 JP2009526756A5 JP2008550490A JP2008550490A JP2009526756A5 JP 2009526756 A5 JP2009526756 A5 JP 2009526756A5 JP 2008550490 A JP2008550490 A JP 2008550490A JP 2008550490 A JP2008550490 A JP 2008550490A JP 2009526756 A5 JP2009526756 A5 JP 2009526756A5
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- osmrb
- composition
- treating
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005557 antagonist Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 11
- 101150080012 OSMR gene Proteins 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 3
- 210000003594 spinal ganglia Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101000586302 Homo sapiens Oncostatin-M-specific receptor subunit beta Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102100030098 Oncostatin-M-specific receptor subunit beta Human genes 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75806606P | 2006-01-10 | 2006-01-10 | |
| US75797906P | 2006-01-10 | 2006-01-10 | |
| US77303106P | 2006-02-14 | 2006-02-14 | |
| US80555206P | 2006-06-22 | 2006-06-22 | |
| US80555406P | 2006-06-22 | 2006-06-22 | |
| US80555006P | 2006-06-22 | 2006-06-22 | |
| US82398206P | 2006-08-30 | 2006-08-30 | |
| US82398706P | 2006-08-30 | 2006-08-30 | |
| PCT/US2007/060337 WO2007133816A2 (en) | 2006-01-10 | 2007-01-10 | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526756A JP2009526756A (ja) | 2009-07-23 |
| JP2009526756A5 true JP2009526756A5 (enExample) | 2010-02-25 |
Family
ID=38694567
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550488A Pending JP2009528264A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
| JP2008550490A Pending JP2009526756A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１ｒａアンタゴニストおよびｏｓｍｒｂアンタゴニストを用いて神経組織における疼痛および炎症を治療する方法 |
| JP2012240592A Pending JP2013047259A (ja) | 2006-01-10 | 2012-10-31 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550488A Pending JP2009528264A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012240592A Pending JP2013047259A (ja) | 2006-01-10 | 2012-10-31 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (22) | US7514077B2 (enExample) |
| EP (4) | EP2001906A2 (enExample) |
| JP (3) | JP2009528264A (enExample) |
| KR (1) | KR101345586B1 (enExample) |
| AU (2) | AU2007249713A1 (enExample) |
| BR (1) | BRPI0706487A2 (enExample) |
| CA (2) | CA2633439A1 (enExample) |
| IL (4) | IL192130A0 (enExample) |
| MX (1) | MX2008008831A (enExample) |
| RU (1) | RU2565391C2 (enExample) |
| WO (2) | WO2007133816A2 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1188830T3 (da) | 1999-06-02 | 2010-04-26 | Chugai Pharmaceutical Co Ltd | Nyt hæmopoietinreceptorprotein NR10 |
| EP1221482B1 (en) | 1999-09-27 | 2005-12-28 | Chugai Seiyaku Kabushiki Kaisha | Hemopoietin receptor protein, nr12 |
| RU2490276C2 (ru) | 2002-01-18 | 2013-08-20 | Займоджинетикс, Инк. | Новый лиганд рецептора цитокина zcytor17 |
| EP1858924A1 (en) | 2005-02-14 | 2007-11-28 | ZymoGenetics, Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| JP4927762B2 (ja) | 2005-02-14 | 2012-05-09 | ザイモジェネティクス， インコーポレイテッド | Ｉｌ−３１アンタゴニストに対するアトピー性皮膚炎の治療応答を予測する方法 |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| CN101198624B (zh) * | 2005-05-06 | 2012-10-10 | 津莫吉尼蒂克斯公司 | Il-31单克隆抗体及使用方法 |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| EP2001906A2 (en) | 2006-01-10 | 2008-12-17 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
| EP4793360A2 (en) * | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| ES2544888T3 (es) * | 2006-06-08 | 2015-09-04 | Chugai Seiyaku Kabushiki Kaisha | Prevención o remedio para enfermedades inflamatorias |
| EP2061811A2 (en) | 2006-09-01 | 2009-05-27 | ZymoGenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| AU2008204823A1 (en) | 2007-01-10 | 2008-07-17 | Zymogenetics, Inc | Methods of using IL-31 to treat airway hyper-responsiveness and asthma |
| ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| CA2708065C (en) * | 2007-12-05 | 2015-02-24 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for pruritus |
| TWI548418B (zh) | 2007-12-05 | 2016-09-11 | 中外製藥股份有限公司 | Anti-NR10 / IL-31RA antibody and its use |
| SI2796466T1 (en) | 2007-12-07 | 2018-01-31 | Zymogenetics, Inc. | Molecules of Humanized Specifics Specifiable for IL-31 |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| TWI544077B (zh) | 2009-03-19 | 2016-08-01 | 中外製藥股份有限公司 | Antibody constant region change body |
| JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2348128A1 (en) * | 2010-01-21 | 2011-07-27 | Sanofi | Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| US8790651B2 (en) * | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US8987289B2 (en) * | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US10039792B1 (en) | 2013-03-16 | 2018-08-07 | Brahm Holdings, Llc | Methods for the treatment of inflammation and pain using human birth tissue material composition |
| KR20240122922A (ko) | 2013-03-27 | 2024-08-13 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| HUE056580T2 (hu) | 2013-05-30 | 2022-02-28 | Kiniksa Pharmaceuticals Ltd | Onkosztatin-M-receptor antigénjét kötõ fehérjék |
| EP3022295A4 (en) | 2013-07-19 | 2017-03-01 | Cedars-Sinai Medical Center | Signature of tl1a (tnfsf15) signaling pathway |
| EP3250599B1 (en) * | 2015-01-29 | 2021-04-14 | Oxford University Innovation Limited | Biomarker |
| FI3284480T3 (fi) | 2015-04-14 | 2025-09-11 | Chugai Pharmaceutical Co Ltd | IL-31-antagonistia vaikuttavana ainesosana sisältävä farmaseuttinen koostumus atooppisen ihottuman ehkäisemiseksi ja/tai hoitamiseksi |
| WO2017033951A1 (ja) * | 2015-08-24 | 2017-03-02 | 学校法人国際医療福祉大学 | 新規鎮痛剤 |
| JP6728352B2 (ja) * | 2015-11-09 | 2020-07-22 | エヌジーエム バイオファーマシューティカルス，インコーポレーテッド | 胆汁酸に関係した障害の治療方法 |
| CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
| US11319372B2 (en) | 2017-02-21 | 2022-05-03 | Remd Biotherapeutics, Inc. | Cancer treatment using antibodies that bind cytotoxic T-lymphocyte antigen-4 (CTLA-4) |
| EP3586187B1 (en) | 2017-02-23 | 2024-01-03 | Magic Leap, Inc. | Display system with variable power reflector |
| US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
| JP7067800B2 (ja) * | 2017-04-12 | 2022-05-16 | 国立大学法人九州大学 | 神経障害性疼痛マーカー及びその使用 |
| CA3093709C (en) | 2018-03-16 | 2024-03-26 | Zoetis Services Llc | Peptide vaccines against interleukin-31 |
| JP7449234B2 (ja) | 2018-03-16 | 2024-03-13 | ゾエティス・サービシーズ・エルエルシー | 獣医学使用のためのインターロイキン３１モノクローナル抗体 |
| CN118512451A (zh) | 2018-07-23 | 2024-08-20 | 特雷维治疗股份有限公司 | 慢性咳嗽、呼吸急促和呼吸困难的治疗 |
| RU2707954C1 (ru) * | 2019-01-24 | 2019-12-02 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения онкологической боли |
| JP7671275B2 (ja) | 2019-08-29 | 2025-05-01 | エランコ・ユーエス・インコーポレイテッド | 動物用の抗ｉｌ３１抗体 |
| WO2021100794A1 (ja) | 2019-11-20 | 2021-05-27 | 中外製薬株式会社 | 抗体含有製剤 |
| IL294601A (en) | 2020-01-10 | 2022-09-01 | Trevi Therapeutics Inc | Methods of administration of nalbuphine |
| CA3189847A1 (en) * | 2020-09-01 | 2022-03-10 | Naoki Fukazawa | Pharmaceutical composition for prevention and/or treatment of dialysis pruritus containing il-31 antagonist as active ingredient |
| WO2025226834A1 (en) * | 2024-04-23 | 2025-10-30 | Attovia Therapeutics, Inc. | Il31-binding polypeptides and uses thereof |
| WO2026055142A1 (en) | 2024-09-03 | 2026-03-12 | Attovia Therapeutics, Inc. | Il13 and il31 bispecific polypeptides and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US750795A (en) * | 1904-02-02 | Eugene j | ||
| US4054646A (en) | 1973-07-30 | 1977-10-18 | General Electric | Method and apparatus for detection of antibodies and antigens |
| EP0281604B1 (en) | 1986-09-02 | 1993-03-31 | Enzon Labs Inc. | Single polypeptide chain binding molecules |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| EP1690935A3 (en) | 1990-01-12 | 2008-07-30 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
| US5492841A (en) | 1994-02-18 | 1996-02-20 | E. I. Du Pont De Nemours And Company | Quaternary ammonium immunogenic conjugates and immunoassay reagents |
| US5783672A (en) | 1994-05-26 | 1998-07-21 | Immunex Corporation | Receptor for oncostatin M |
| US6074849A (en) * | 1995-07-19 | 2000-06-13 | Genetics Institute, Inc. | Polynucleotides encoding human CTLA-8 related proteins |
| US5792850A (en) * | 1996-05-23 | 1998-08-11 | Zymogenetics, Inc. | Hematopoietic cytokine receptor |
| WO2002008288A2 (en) | 2000-07-20 | 2002-01-31 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1972194A1 (en) | 1996-12-03 | 2008-09-24 | Amgen Fremont Inc. | Transgenic mammals having human ig loci including plural vh and vk regions and antibodies produced therefrom |
| RU2175874C2 (ru) * | 1999-03-17 | 2001-11-20 | Борисов Виктор Александрович | Способ лечения нарушений функций центральной нервной системы и устройство для его осуществления |
| DK1188830T3 (da) | 1999-06-02 | 2010-04-26 | Chugai Pharmaceutical Co Ltd | Nyt hæmopoietinreceptorprotein NR10 |
| AU6531101A (en) | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP2075253A1 (en) | 2000-06-23 | 2009-07-01 | Genentech, Inc. | Compositions and methds for the diagnosis and treatment of disorders involving angiogensis |
| US20030096339A1 (en) | 2000-06-26 | 2003-05-22 | Sprecher Cindy A. | Cytokine receptor zcytor17 |
| EP1325115B1 (en) | 2000-06-26 | 2016-07-27 | ZymoGenetics, Inc. | Cytokine receptor zcytor17 |
| US20030059871A1 (en) | 2000-10-06 | 2003-03-27 | Cosman David J. | Hematopoietin receptors HPR1 and HPR2 |
| WO2002077230A1 (fr) | 2001-03-26 | 2002-10-03 | Chugai Seiyaku Kabushiki Kaisha | Variants d'epissage nr10 |
| RU2490276C2 (ru) * | 2002-01-18 | 2013-08-20 | Займоджинетикс, Инк. | Новый лиганд рецептора цитокина zcytor17 |
| WO2004003140A2 (en) | 2002-01-18 | 2004-01-08 | Zymogenetics, Inc. | Cytokine receptor zcytor17 multimers |
| US7303896B2 (en) | 2002-02-25 | 2007-12-04 | Genentech, Inc. | Nucleic acid encoding novel type-1 cytokine receptor GLM-R |
| ES2579758T3 (es) | 2005-01-28 | 2016-08-16 | Zymogenetics, Inc. | Preparaciones homogéneas de IL-31 |
| EP1858924A1 (en) | 2005-02-14 | 2007-11-28 | ZymoGenetics, Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| JP4927762B2 (ja) | 2005-02-14 | 2012-05-09 | ザイモジェネティクス， インコーポレイテッド | Ｉｌ−３１アンタゴニストに対するアトピー性皮膚炎の治療応答を予測する方法 |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| CN101198624B (zh) | 2005-05-06 | 2012-10-10 | 津莫吉尼蒂克斯公司 | Il-31单克隆抗体及使用方法 |
| EP2001906A2 (en) | 2006-01-10 | 2008-12-17 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
| EP2061811A2 (en) | 2006-09-01 | 2009-05-27 | ZymoGenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| AU2008204823A1 (en) | 2007-01-10 | 2008-07-17 | Zymogenetics, Inc | Methods of using IL-31 to treat airway hyper-responsiveness and asthma |
| SI2796466T1 (en) | 2007-12-07 | 2018-01-31 | Zymogenetics, Inc. | Molecules of Humanized Specifics Specifiable for IL-31 |
-
2007
- 2007-01-10 EP EP07777559A patent/EP2001906A2/en not_active Withdrawn
- 2007-01-10 EP EP14161547.6A patent/EP2749571A3/en not_active Withdrawn
- 2007-01-10 KR KR1020087019496A patent/KR101345586B1/ko not_active Expired - Fee Related
- 2007-01-10 CA CA002633439A patent/CA2633439A1/en not_active Withdrawn
- 2007-01-10 BR BRPI0706487-0A patent/BRPI0706487A2/pt not_active Application Discontinuation
- 2007-01-10 AU AU2007249713A patent/AU2007249713A1/en not_active Abandoned
- 2007-01-10 WO PCT/US2007/060337 patent/WO2007133816A2/en not_active Ceased
- 2007-01-10 RU RU2011137369/15A patent/RU2565391C2/ru active
- 2007-01-10 US US11/621,829 patent/US7514077B2/en active Active
- 2007-01-10 JP JP2008550488A patent/JP2009528264A/ja active Pending
- 2007-01-10 JP JP2008550490A patent/JP2009526756A/ja active Pending
- 2007-01-10 CA CA2636288A patent/CA2636288C/en active Active
- 2007-01-10 EP EP13154292.0A patent/EP2594585A1/en not_active Withdrawn
- 2007-01-10 MX MX2008008831A patent/MX2008008831A/es active IP Right Grant
- 2007-01-10 AU AU2007254715A patent/AU2007254715B2/en not_active Ceased
- 2007-01-10 WO PCT/US2007/060330 patent/WO2007143231A2/en not_active Ceased
- 2007-01-10 EP EP07811781A patent/EP1991581A2/en not_active Withdrawn
- 2007-01-10 US US11/621,840 patent/US7638126B2/en active Active
-
2008
- 2008-06-12 IL IL192130A patent/IL192130A0/en unknown
- 2008-06-19 IL IL192296A patent/IL192296A0/en unknown
-
2009
- 2009-02-27 US US12/395,095 patent/US7939068B2/en active Active
- 2009-10-28 US US12/607,831 patent/US7943132B2/en active Active
-
2011
- 2011-03-30 US US13/075,845 patent/US8105591B2/en active Active
- 2011-03-30 US US13/075,412 patent/US8105590B2/en active Active
- 2011-12-20 US US13/331,145 patent/US8377438B2/en active Active
- 2011-12-21 US US13/332,758 patent/US8409571B2/en active Active
-
2012
- 2012-05-09 IL IL219678A patent/IL219678A0/en unknown
- 2012-05-09 IL IL219677A patent/IL219677A0/en unknown
- 2012-10-31 JP JP2012240592A patent/JP2013047259A/ja active Pending
-
2013
- 2013-01-23 US US13/747,899 patent/US8637015B2/en active Active
- 2013-03-07 US US13/788,454 patent/US8685395B2/en active Active
- 2013-12-19 US US14/134,278 patent/US8968732B2/en active Active
-
2014
- 2014-02-07 US US14/175,117 patent/US8974783B2/en active Active
-
2015
- 2015-01-23 US US14/603,406 patent/US9334321B2/en active Active
- 2015-01-27 US US14/606,063 patent/US9334322B2/en active Active
-
2016
- 2016-04-15 US US15/099,647 patent/US9631022B2/en active Active
- 2016-04-15 US US15/099,639 patent/US9631021B2/en active Active
-
2017
- 2017-03-15 US US15/459,901 patent/US9834602B2/en active Active
- 2017-03-16 US US15/461,090 patent/US9828431B2/en active Active
- 2017-10-31 US US15/799,445 patent/US20180044426A1/en not_active Abandoned
- 2017-11-01 US US15/800,980 patent/US20180066050A1/en not_active Abandoned
-
2018
- 2018-12-20 US US16/227,307 patent/US20190112369A1/en not_active Abandoned
- 2018-12-20 US US16/227,266 patent/US20190119372A1/en not_active Abandoned
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