JP2009526756A5 - - Google Patents
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- JP2009526756A5 JP2009526756A5 JP2008550490A JP2008550490A JP2009526756A5 JP 2009526756 A5 JP2009526756 A5 JP 2009526756A5 JP 2008550490 A JP2008550490 A JP 2008550490A JP 2008550490 A JP2008550490 A JP 2008550490A JP 2009526756 A5 JP2009526756 A5 JP 2009526756A5
- Authority
- JP
- Japan
- Prior art keywords
- antagonist
- osmrb
- composition
- treating
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005557 antagonist Substances 0.000 claims 16
- 239000000203 mixture Substances 0.000 claims 11
- 101150080012 OSMR gene Proteins 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 3
- 210000003594 spinal ganglia Anatomy 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101000586302 Homo sapiens Oncostatin-M-specific receptor subunit beta Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 102100030098 Oncostatin-M-specific receptor subunit beta Human genes 0.000 claims 1
- 208000003251 Pruritus Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000003042 antagnostic effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 210000000944 nerve tissue Anatomy 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75806606P | 2006-01-10 | 2006-01-10 | |
| US75797906P | 2006-01-10 | 2006-01-10 | |
| US77303106P | 2006-02-14 | 2006-02-14 | |
| US80555206P | 2006-06-22 | 2006-06-22 | |
| US80555006P | 2006-06-22 | 2006-06-22 | |
| US80555406P | 2006-06-22 | 2006-06-22 | |
| US82398706P | 2006-08-30 | 2006-08-30 | |
| US82398206P | 2006-08-30 | 2006-08-30 | |
| PCT/US2007/060337 WO2007133816A2 (en) | 2006-01-10 | 2007-01-10 | Methods of treating pain and inflammation in neuronal tissue using il-31ra and osmrb antagonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009526756A JP2009526756A (ja) | 2009-07-23 |
| JP2009526756A5 true JP2009526756A5 (enExample) | 2010-02-25 |
Family
ID=38694567
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550490A Pending JP2009526756A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１ｒａアンタゴニストおよびｏｓｍｒｂアンタゴニストを用いて神経組織における疼痛および炎症を治療する方法 |
| JP2008550488A Pending JP2009528264A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
| JP2012240592A Pending JP2013047259A (ja) | 2006-01-10 | 2012-10-31 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550488A Pending JP2009528264A (ja) | 2006-01-10 | 2007-01-10 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
| JP2012240592A Pending JP2013047259A (ja) | 2006-01-10 | 2012-10-31 | Ｉｌ−３１アンタゴニストを用いて神経組織における疼痛及び炎症を治療する方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (22) | US7514077B2 (enExample) |
| EP (4) | EP2001906A2 (enExample) |
| JP (3) | JP2009526756A (enExample) |
| KR (1) | KR101345586B1 (enExample) |
| AU (2) | AU2007254715B2 (enExample) |
| BR (1) | BRPI0706487A2 (enExample) |
| CA (2) | CA2636288C (enExample) |
| IL (4) | IL192130A0 (enExample) |
| MX (1) | MX2008008831A (enExample) |
| RU (1) | RU2565391C2 (enExample) |
| WO (2) | WO2007143231A2 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2325316B8 (en) | 1999-06-02 | 2017-04-19 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, NR10 |
| DE60025241T2 (de) | 1999-09-27 | 2007-01-11 | Chugai Seiyaku K.K. | HäMOPOIETINREZEPTOR-PROTEIN, NR12 |
| ATE401390T1 (de) * | 2002-01-18 | 2008-08-15 | Zymogenetics Inc | Zytokin (zcytor17-ligand) |
| CA2594490A1 (en) | 2005-02-14 | 2006-08-24 | Zymogenetics Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| EP1856150A2 (en) | 2005-02-14 | 2007-11-21 | ZymoGenetics, Inc. | Methods of treating diseases which are mediated by cutaneous lymphocyte antigen positive cells |
| US8101183B2 (en) | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| KR101446989B1 (ko) * | 2005-05-06 | 2014-10-15 | 지모제넥틱스, 인코포레이티드 | Ｉｌ-31 단클론성 항체 및 사용법 |
| US20130216542A1 (en) | 2005-05-06 | 2013-08-22 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| CA2636288C (en) * | 2006-01-10 | 2015-02-24 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31 antagonists |
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| CL2007001665A1 (es) | 2006-06-08 | 2008-01-18 | Chugai Pharmaceutical Co Ltd | Anticuerpo o fragmento del mismo con actividad neutralizante de la proteina nr 10; agente que lo comprende; y su uso para prevenir o tratar una enfermedad inflamatoria. |
| RU2009111884A (ru) * | 2006-09-01 | 2010-10-10 | Займоджинетикс, Инк. (Us) | Последовательности вариабельных областей моноклональных антител против il-31 и способы использования |
| EP2061496A2 (en) * | 2007-01-10 | 2009-05-27 | Zymogenetics, Inc. | Methods of using il-31 to treat airway hyper-responsiveness and asthma |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| DK3059246T3 (en) * | 2007-09-26 | 2018-10-01 | Chugai Pharmaceutical Co Ltd | Modified constant region of an antibody |
| MY185647A (en) | 2007-12-05 | 2021-05-27 | Chugai Pharmaceutical Co Ltd | Therapeutic agent for pruritus |
| BRPI0821110B8 (pt) | 2007-12-05 | 2021-05-25 | Chugai Pharmaceutical Co Ltd | anticorpo de neutralização de anti-nr10/il31ra, composição farmacêutica compreendendo o referido anticorpo e uso do mesmo |
| LT2796466T (lt) | 2007-12-07 | 2018-02-26 | Zymogenetics, Inc. | Humanizuotų antikūnų molekulės, specifinės il-31 atžvilgiu |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| US20110229471A1 (en) | 2008-11-26 | 2011-09-22 | Cedars-Sinai Medical Center | Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease |
| EP2409991B1 (en) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
| JP5787446B2 (ja) | 2009-03-19 | 2015-09-30 | 中外製薬株式会社 | 抗体定常領域改変体 |
| EP2348128A1 (en) * | 2010-01-21 | 2011-07-27 | Sanofi | Methods and uses relating to the identification of compound involved in pain as well as methods of diagnosing algesia |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| US8790651B2 (en) | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| US20140179727A1 (en) | 2012-12-14 | 2014-06-26 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US8987289B2 (en) * | 2012-12-14 | 2015-03-24 | Trevi Therapeutics, Inc. | Methods for treating pruritus |
| US10039792B1 (en) | 2013-03-16 | 2018-08-07 | Brahm Holdings, Llc | Methods for the treatment of inflammation and pain using human birth tissue material composition |
| KR20240122922A (ko) * | 2013-03-27 | 2024-08-13 | 세다르스-신나이 메디칼 센터 | Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전 |
| CN110511279B (zh) | 2013-05-30 | 2024-03-29 | 基尼克萨制药有限公司 | 制瘤素m受体抗原结合蛋白 |
| EP4105236A1 (en) | 2013-07-19 | 2022-12-21 | Cedars-Sinai Medical Center | Anti-tl1a (tnfsf15) antibody for treatment of inflammatory bowel disease |
| WO2016120625A1 (en) * | 2015-01-29 | 2016-08-04 | Isis Innovation Limited | Biomarker |
| MA43918A (fr) | 2015-04-14 | 2018-12-05 | Chugai Pharmaceutical Co Ltd | Composition pharmaceutique pour la prã‰vention et/ou le traitement de la dermatite atopique contenant comme principe actif un antagoniste de l'il-31 |
| WO2017033951A1 (ja) * | 2015-08-24 | 2017-03-02 | 学校法人国際医療福祉大学 | 新規鎮痛剤 |
| CA3003616C (en) * | 2015-11-09 | 2020-07-28 | Ngm Biopharmaceuticals, Inc. | Methods for treatment of bile acid-related disorders |
| CN109462996A (zh) | 2016-03-17 | 2019-03-12 | 西达-赛奈医疗中心 | 通过rnaset2诊断炎性肠病的方法 |
| CN110545844A (zh) | 2017-02-21 | 2019-12-06 | 瑞美德生物医药科技有限公司 | 使用结合细胞毒性t淋巴细胞抗原-4(ctla-4)的抗体的癌症治疗 |
| CN110546549B (zh) | 2017-02-23 | 2022-06-07 | 奇跃公司 | 具有可变屈光力反射器的显示系统 |
| US10093731B2 (en) | 2017-02-24 | 2018-10-09 | Kindred Biosciences, Inc. | Anti-IL31 antibodies for veterinary use |
| WO2018190365A1 (ja) * | 2017-04-12 | 2018-10-18 | 国立大学法人九州大学 | 神経障害性疼痛マーカー及びその使用 |
| CA3093709C (en) | 2018-03-16 | 2024-03-26 | Zoetis Services Llc | Peptide vaccines against interleukin-31 |
| AU2019234220B2 (en) | 2018-03-16 | 2025-09-11 | Zoetis Services Llc | Interleukin-31 monoclonal antibodies for veterinary use |
| MX2021000908A (es) | 2018-07-23 | 2021-06-08 | Trevi Therapeutics Inc | Tratamiento de la tos cronica, la dificultad respiratoria y la disnea. |
| RU2707954C1 (ru) * | 2019-01-24 | 2019-12-02 | Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения Российской Федерации | Способ лечения онкологической боли |
| EP4062933A4 (en) | 2019-11-20 | 2023-12-13 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing preparation |
| MX2022008554A (es) | 2020-01-10 | 2022-08-10 | Trevi Therapeutics Inc | Metodos de administracion de nalbufina. |
| IL300694A (en) * | 2020-09-01 | 2023-04-01 | Chugai Pharmaceutical Co Ltd | A pharmaceutical preparation for the prevention and/or treatment of dialysis pruritus that includes an IL-31 antagonist as an active ingredient |
| TW202304510A (zh) * | 2021-04-07 | 2023-02-01 | 瑞士商葛德瑪控股公司 | 結節性癢疹之治療 |
| WO2025226834A1 (en) * | 2024-04-23 | 2025-10-30 | Attovia Therapeutics, Inc. | Il31-binding polypeptides and uses thereof |
| WO2026055142A1 (en) | 2024-09-03 | 2026-03-12 | Attovia Therapeutics, Inc. | Il13 and il31 bispecific polypeptides and uses thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US750795A (en) * | 1904-02-02 | Eugene j | ||
| US4054646A (en) * | 1973-07-30 | 1977-10-18 | General Electric | Method and apparatus for detection of antibodies and antigens |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| WO1988001649A1 (en) | 1986-09-02 | 1988-03-10 | Genex Corporation | Single polypeptide chain binding molecules |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| JPH07501451A (ja) | 1991-11-25 | 1995-02-16 | エンゾン・インコーポレイテッド | 多価抗原結合タンパク質 |
| US5492841A (en) * | 1994-02-18 | 1996-02-20 | E. I. Du Pont De Nemours And Company | Quaternary ammonium immunogenic conjugates and immunoassay reagents |
| US5783672A (en) | 1994-05-26 | 1998-07-21 | Immunex Corporation | Receptor for oncostatin M |
| US6074849A (en) | 1995-07-19 | 2000-06-13 | Genetics Institute, Inc. | Polynucleotides encoding human CTLA-8 related proteins |
| US5792850A (en) | 1996-05-23 | 1998-08-11 | Zymogenetics, Inc. | Hematopoietic cytokine receptor |
| EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| RU2175874C2 (ru) * | 1999-03-17 | 2001-11-20 | Борисов Виктор Александрович | Способ лечения нарушений функций центральной нервной системы и устройство для его осуществления |
| EP2325316B8 (en) | 1999-06-02 | 2017-04-19 | Chugai Seiyaku Kabushiki Kaisha | Novel hemopoietin receptor protein, NR10 |
| AU6531101A (en) | 2000-06-02 | 2001-12-17 | Genentech Inc | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| EP1309620A2 (en) | 2000-06-23 | 2003-05-14 | Genentech, Inc. | Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis |
| US20030096339A1 (en) * | 2000-06-26 | 2003-05-22 | Sprecher Cindy A. | Cytokine receptor zcytor17 |
| DK1325115T3 (en) * | 2000-06-26 | 2016-11-21 | Zymogenetics Inc | CYTOKINRECEPTOR ZCYTOR17 |
| JP2004514420A (ja) | 2000-07-20 | 2004-05-20 | ジェネンテック・インコーポレーテッド | 分泌及び膜貫通ポリペプチドとそれをコードする核酸 |
| CA2425169A1 (en) | 2000-10-06 | 2002-04-11 | Immunex Corporation | Hematopoietin receptors hpr1 and hpr2 |
| WO2002077230A1 (fr) | 2001-03-26 | 2002-10-03 | Chugai Seiyaku Kabushiki Kaisha | Variants d'epissage nr10 |
| ATE401390T1 (de) * | 2002-01-18 | 2008-08-15 | Zymogenetics Inc | Zytokin (zcytor17-ligand) |
| EP1576112B1 (en) | 2002-01-18 | 2012-02-29 | ZymoGenetics, Inc. | Cytokine receptor zcytor17 multimers |
| EP2110434A1 (en) | 2002-02-25 | 2009-10-21 | Genentech, Inc. | Type-1 cytokine receptor GLM-R |
| AU2006207945B2 (en) | 2005-01-28 | 2012-02-09 | Zymogenetics, Inc. | Homogeneous preparations of IL-31 |
| EP1856150A2 (en) | 2005-02-14 | 2007-11-21 | ZymoGenetics, Inc. | Methods of treating diseases which are mediated by cutaneous lymphocyte antigen positive cells |
| CA2594490A1 (en) | 2005-02-14 | 2006-08-24 | Zymogenetics Inc. | Methods of treating skin disorders using an il-31ra antagonist |
| KR101446989B1 (ko) * | 2005-05-06 | 2014-10-15 | 지모제넥틱스, 인코포레이티드 | Ｉｌ-31 단클론성 항체 및 사용법 |
| US8101183B2 (en) * | 2005-05-06 | 2012-01-24 | Zymogentics, Inc. | Variable region sequences of IL-31 monoclonal antibodies |
| CA2636288C (en) | 2006-01-10 | 2015-02-24 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31 antagonists |
| RU2009111884A (ru) * | 2006-09-01 | 2010-10-10 | Займоджинетикс, Инк. (Us) | Последовательности вариабельных областей моноклональных антител против il-31 и способы использования |
| EP2061496A2 (en) * | 2007-01-10 | 2009-05-27 | Zymogenetics, Inc. | Methods of using il-31 to treat airway hyper-responsiveness and asthma |
| LT2796466T (lt) * | 2007-12-07 | 2018-02-26 | Zymogenetics, Inc. | Humanizuotų antikūnų molekulės, specifinės il-31 atžvilgiu |
-
2007
- 2007-01-10 CA CA2636288A patent/CA2636288C/en active Active
- 2007-01-10 BR BRPI0706487-0A patent/BRPI0706487A2/pt not_active Application Discontinuation
- 2007-01-10 EP EP07777559A patent/EP2001906A2/en not_active Withdrawn
- 2007-01-10 EP EP14161547.6A patent/EP2749571A3/en not_active Withdrawn
- 2007-01-10 US US11/621,829 patent/US7514077B2/en active Active
- 2007-01-10 EP EP07811781A patent/EP1991581A2/en not_active Withdrawn
- 2007-01-10 AU AU2007254715A patent/AU2007254715B2/en not_active Ceased
- 2007-01-10 WO PCT/US2007/060330 patent/WO2007143231A2/en not_active Ceased
- 2007-01-10 JP JP2008550490A patent/JP2009526756A/ja active Pending
- 2007-01-10 KR KR1020087019496A patent/KR101345586B1/ko not_active Expired - Fee Related
- 2007-01-10 US US11/621,840 patent/US7638126B2/en active Active
- 2007-01-10 JP JP2008550488A patent/JP2009528264A/ja active Pending
- 2007-01-10 MX MX2008008831A patent/MX2008008831A/es active IP Right Grant
- 2007-01-10 AU AU2007249713A patent/AU2007249713A1/en not_active Abandoned
- 2007-01-10 EP EP13154292.0A patent/EP2594585A1/en not_active Withdrawn
- 2007-01-10 CA CA002633439A patent/CA2633439A1/en not_active Withdrawn
- 2007-01-10 WO PCT/US2007/060337 patent/WO2007133816A2/en not_active Ceased
- 2007-01-10 RU RU2011137369/15A patent/RU2565391C2/ru active
-
2008
- 2008-06-12 IL IL192130A patent/IL192130A0/en unknown
- 2008-06-19 IL IL192296A patent/IL192296A0/en unknown
-
2009
- 2009-02-27 US US12/395,095 patent/US7939068B2/en active Active
- 2009-10-28 US US12/607,831 patent/US7943132B2/en active Active
-
2011
- 2011-03-30 US US13/075,412 patent/US8105590B2/en active Active
- 2011-03-30 US US13/075,845 patent/US8105591B2/en active Active
- 2011-12-20 US US13/331,145 patent/US8377438B2/en active Active
- 2011-12-21 US US13/332,758 patent/US8409571B2/en active Active
-
2012
- 2012-05-09 IL IL219678A patent/IL219678A0/en unknown
- 2012-05-09 IL IL219677A patent/IL219677A0/en unknown
- 2012-10-31 JP JP2012240592A patent/JP2013047259A/ja active Pending
-
2013
- 2013-01-23 US US13/747,899 patent/US8637015B2/en active Active
- 2013-03-07 US US13/788,454 patent/US8685395B2/en active Active
- 2013-12-19 US US14/134,278 patent/US8968732B2/en active Active
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2014
- 2014-02-07 US US14/175,117 patent/US8974783B2/en active Active
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2015
- 2015-01-23 US US14/603,406 patent/US9334321B2/en active Active
- 2015-01-27 US US14/606,063 patent/US9334322B2/en active Active
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2016
- 2016-04-15 US US15/099,647 patent/US9631022B2/en active Active
- 2016-04-15 US US15/099,639 patent/US9631021B2/en active Active
-
2017
- 2017-03-15 US US15/459,901 patent/US9834602B2/en active Active
- 2017-03-16 US US15/461,090 patent/US9828431B2/en active Active
- 2017-10-31 US US15/799,445 patent/US20180044426A1/en not_active Abandoned
- 2017-11-01 US US15/800,980 patent/US20180066050A1/en not_active Abandoned
-
2018
- 2018-12-20 US US16/227,266 patent/US20190119372A1/en not_active Abandoned
- 2018-12-20 US US16/227,307 patent/US20190112369A1/en not_active Abandoned
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