JP2009521911A5 - - Google Patents

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JP2009521911A5
JP2009521911A5 JP2008547880A JP2008547880A JP2009521911A5 JP 2009521911 A5 JP2009521911 A5 JP 2009521911A5 JP 2008547880 A JP2008547880 A JP 2008547880A JP 2008547880 A JP2008547880 A JP 2008547880A JP 2009521911 A5 JP2009521911 A5 JP 2009521911A5
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variant
asp
protein
ser259asp
substitution
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JP2008547880A
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JP5175214B2 (ja
JP2009521911A (ja
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Priority claimed from PCT/EP2006/012301 external-priority patent/WO2007076933A1/en
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JP2008547880A 2005-12-30 2006-12-20 改良された安定性を有するインターロイキン−１２ｐ４０変種 Active JP5175214B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75538205P 2005-12-30 2005-12-30
US60/755,382 2005-12-30
PCT/EP2006/012301 WO2007076933A1 (en) 2005-12-30 2006-12-20 Interleukin-12p40 variants with improved stability

Publications (3)

Publication Number Publication Date
JP2009521911A JP2009521911A (ja) 2009-06-11
JP2009521911A5 true JP2009521911A5 (https=) 2010-02-18
JP5175214B2 JP5175214B2 (ja) 2013-04-03

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JP2008547880A Active JP5175214B2 (ja) 2005-12-30 2006-12-20 改良された安定性を有するインターロイキン−１２ｐ４０変種

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US (3) US7872107B2 (https=)
EP (1) EP1966238B1 (https=)
JP (1) JP5175214B2 (https=)
KR (1) KR101343682B1 (https=)
CN (1) CN101351475B (https=)
AT (1) ATE555125T1 (https=)
AU (1) AU2006332138B2 (https=)
BR (1) BRPI0620648B1 (https=)
CA (1) CA2635618C (https=)
CY (1) CY1112884T1 (https=)
DK (1) DK1966238T3 (https=)
EA (1) EA015338B1 (https=)
ES (1) ES2384055T3 (https=)
PL (1) PL1966238T3 (https=)
PT (1) PT1966238E (https=)
SI (1) SI1966238T1 (https=)
WO (1) WO2007076933A1 (https=)
ZA (1) ZA200806611B (https=)

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CN111630062A (zh) 2017-11-28 2020-09-04 中外制药株式会社 具有可调节的配体结合活性的配体结合分子
EP3861016A2 (en) * 2018-10-03 2021-08-11 Xencor, Inc. Il-12 heterodimeric fc-fusion proteins
CN110264184B (zh) * 2019-06-28 2021-07-23 Oppo（重庆）智能科技有限公司 支付控制方法及相关产品
CN115916233A (zh) * 2019-10-03 2023-04-04 Xencor股份有限公司 靶向IL-12异源二聚体Fc融合蛋白
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WO2022155263A2 (en) * 2021-01-12 2022-07-21 Askgene Pharma Inc. Chimeric molecules comprising il-12 agonist polypeptide
JP2024527582A (ja) * 2021-07-19 2024-07-25 中外製薬株式会社 融合ポリペプチドを用いるプロテアーゼ媒介性の標的特異的サイトカイン送達
WO2023043978A2 (en) * 2021-09-17 2023-03-23 Bicara Therapeutics Inc. Caix targeting il-12 fusion proteins and methods of use thereof
JP2024539139A (ja) 2021-10-20 2024-10-28 シンセカイン インコーポレイテッド ヘテロ二量体ｆｃサイトカインおよびその使用
JP2024540938A (ja) * 2021-10-20 2024-11-06 シンセカイン インコーポレイテッド ヒトＩＬ－１２ｐ４０バリアントおよびその使用
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WO2023242769A1 (en) * 2022-06-17 2023-12-21 Pfizer Inc. Il-12 variants, anti-pd1 antibodies, fusion proteins, and uses thereof
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BRPI0620648B1 (pt) 2005-12-30 2022-12-20 Merck Patent Gesellschaft Mit Beschrãnkter Haftung Variante de il-12 p40, proteínas il-12, il-23 e de fusão, composição farmacêutica e uso da mesma

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