JP2009515851A5 - - Google Patents
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- JP2009515851A5 JP2009515851A5 JP2008539440A JP2008539440A JP2009515851A5 JP 2009515851 A5 JP2009515851 A5 JP 2009515851A5 JP 2008539440 A JP2008539440 A JP 2008539440A JP 2008539440 A JP2008539440 A JP 2008539440A JP 2009515851 A5 JP2009515851 A5 JP 2009515851A5
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- Japan
- Prior art keywords
- cancer
- carcinoma
- cell
- scc
- undifferentiated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 206010028980 Neoplasm Diseases 0.000 claims 51
- 210000004027 cell Anatomy 0.000 claims 45
- 201000009030 Carcinoma Diseases 0.000 claims 34
- 201000011510 cancer Diseases 0.000 claims 20
- 230000035772 mutation Effects 0.000 claims 20
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 20
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 20
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 13
- 201000002528 pancreatic cancer Diseases 0.000 claims 13
- 206010027476 Metastases Diseases 0.000 claims 11
- 208000002458 carcinoid tumor Diseases 0.000 claims 11
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 11
- 210000000981 epithelium Anatomy 0.000 claims 10
- 206010027406 Mesothelioma Diseases 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 9
- -1 3-chloro-4-fluorophenyl Chemical group 0.000 claims 8
- 206010039491 Sarcoma Diseases 0.000 claims 8
- 230000009401 metastasis Effects 0.000 claims 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 8
- 201000003076 Angiosarcoma Diseases 0.000 claims 6
- 206010003571 Astrocytoma Diseases 0.000 claims 6
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 6
- 208000003950 B-cell lymphoma Diseases 0.000 claims 6
- 241000219051 Fagopyrum Species 0.000 claims 6
- 235000009419 Fagopyrum esculentum Nutrition 0.000 claims 6
- 208000000527 Germinoma Diseases 0.000 claims 6
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 6
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 6
- 206010025323 Lymphomas Diseases 0.000 claims 6
- 201000003791 MALT lymphoma Diseases 0.000 claims 6
- 208000033766 Prolymphocytic Leukemia Diseases 0.000 claims 6
- 206010041067 Small cell lung cancer Diseases 0.000 claims 6
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 6
- 206010057644 Testis cancer Diseases 0.000 claims 6
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 6
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 6
- 230000003325 follicular Effects 0.000 claims 6
- 201000003115 germ cell cancer Diseases 0.000 claims 6
- 201000005202 lung cancer Diseases 0.000 claims 6
- 208000020816 lung neoplasm Diseases 0.000 claims 6
- 201000010225 mixed cell type cancer Diseases 0.000 claims 6
- 208000029638 mixed neoplasm Diseases 0.000 claims 6
- 201000005962 mycosis fungoides Diseases 0.000 claims 6
- 201000008968 osteosarcoma Diseases 0.000 claims 6
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 6
- 201000003120 testicular cancer Diseases 0.000 claims 6
- 201000002510 thyroid cancer Diseases 0.000 claims 6
- 206010006187 Breast cancer Diseases 0.000 claims 5
- 208000026310 Breast neoplasm Diseases 0.000 claims 5
- 208000003170 Bronchiolo-Alveolar Adenocarcinoma Diseases 0.000 claims 5
- 206010058354 Bronchioloalveolar carcinoma Diseases 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 5
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 5
- 208000000265 Lobular Carcinoma Diseases 0.000 claims 5
- 206010033128 Ovarian cancer Diseases 0.000 claims 5
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 5
- 206010060862 Prostate cancer Diseases 0.000 claims 5
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 5
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 5
- 201000003714 breast lobular carcinoma Diseases 0.000 claims 5
- 230000002124 endocrine Effects 0.000 claims 5
- 206010017758 gastric cancer Diseases 0.000 claims 5
- 208000014829 head and neck neoplasm Diseases 0.000 claims 5
- 238000011065 in-situ storage Methods 0.000 claims 5
- 230000002757 inflammatory effect Effects 0.000 claims 5
- 206010073096 invasive lobular breast carcinoma Diseases 0.000 claims 5
- 208000016992 lung adenocarcinoma in situ Diseases 0.000 claims 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 5
- 208000024191 minimally invasive lung adenocarcinoma Diseases 0.000 claims 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 5
- 208000014212 sarcomatoid carcinoma Diseases 0.000 claims 5
- 201000011549 stomach cancer Diseases 0.000 claims 5
- 208000010576 undifferentiated carcinoma Diseases 0.000 claims 5
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 4
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 4
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 claims 4
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 claims 4
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 claims 4
- 206010061424 Anal cancer Diseases 0.000 claims 3
- 208000007860 Anus Neoplasms Diseases 0.000 claims 3
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 3
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 3
- 206010004593 Bile duct cancer Diseases 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 3
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 3
- 208000010667 Carcinoma of liver and intrahepatic biliary tract Diseases 0.000 claims 3
- 206010008342 Cervix carcinoma Diseases 0.000 claims 3
- 208000005243 Chondrosarcoma Diseases 0.000 claims 3
- 208000006332 Choriocarcinoma Diseases 0.000 claims 3
- 206010073140 Clear cell sarcoma of soft tissue Diseases 0.000 claims 3
- 208000002699 Digestive System Neoplasms Diseases 0.000 claims 3
- 208000001976 Endocrine Gland Neoplasms Diseases 0.000 claims 3
- 206010014733 Endometrial cancer Diseases 0.000 claims 3
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 3
- 206010014967 Ependymoma Diseases 0.000 claims 3
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 3
- 208000006168 Ewing Sarcoma Diseases 0.000 claims 3
- 208000017259 Extragonadal germ cell tumor Diseases 0.000 claims 3
- 206010061850 Extranodal marginal zone B-cell lymphoma (MALT type) Diseases 0.000 claims 3
- 201000008808 Fibrosarcoma Diseases 0.000 claims 3
- 206010073069 Hepatic cancer Diseases 0.000 claims 3
- 208000017604 Hodgkin disease Diseases 0.000 claims 3
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 3
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 3
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 3
- 208000018142 Leiomyosarcoma Diseases 0.000 claims 3
- 201000004462 Leydig Cell Tumor Diseases 0.000 claims 3
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 3
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims 3
- 208000032271 Malignant tumor of penis Diseases 0.000 claims 3
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 3
- 208000007054 Medullary Carcinoma Diseases 0.000 claims 3
- 208000000172 Medulloblastoma Diseases 0.000 claims 3
- 206010029260 Neuroblastoma Diseases 0.000 claims 3
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 3
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 3
- 208000002471 Penile Neoplasms Diseases 0.000 claims 3
- 206010034299 Penile cancer Diseases 0.000 claims 3
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 3
- 208000007452 Plasmacytoma Diseases 0.000 claims 3
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 3
- 201000010208 Seminoma Diseases 0.000 claims 3
- 208000003274 Sertoli cell tumor Diseases 0.000 claims 3
- 208000009359 Sezary Syndrome Diseases 0.000 claims 3
- 208000021388 Sezary disease Diseases 0.000 claims 3
- 206010042971 T-cell lymphoma Diseases 0.000 claims 3
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 3
- 208000026651 T-cell prolymphocytic leukemia Diseases 0.000 claims 3
- 206010043276 Teratoma Diseases 0.000 claims 3
- 208000033781 Thyroid carcinoma Diseases 0.000 claims 3
- 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 claims 3
- 206010046431 Urethral cancer Diseases 0.000 claims 3
- 206010046458 Urethral neoplasms Diseases 0.000 claims 3
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 3
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 3
- 206010047741 Vulval cancer Diseases 0.000 claims 3
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 3
- 208000008383 Wilms tumor Diseases 0.000 claims 3
- 208000012018 Yolk sac tumor Diseases 0.000 claims 3
- 201000011165 anus cancer Diseases 0.000 claims 3
- 201000007455 central nervous system cancer Diseases 0.000 claims 3
- 208000025997 central nervous system neoplasm Diseases 0.000 claims 3
- 210000003588 centroblast Anatomy 0.000 claims 3
- 201000010881 cervical cancer Diseases 0.000 claims 3
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 3
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 3
- 201000000292 clear cell sarcoma Diseases 0.000 claims 3
- 201000011523 endocrine gland cancer Diseases 0.000 claims 3
- 208000001991 endodermal sinus tumor Diseases 0.000 claims 3
- 230000003511 endothelial effect Effects 0.000 claims 3
- 208000010932 epithelial neoplasm Diseases 0.000 claims 3
- 201000004101 esophageal cancer Diseases 0.000 claims 3
- 230000001605 fetal effect Effects 0.000 claims 3
- 201000003444 follicular lymphoma Diseases 0.000 claims 3
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 claims 3
- 230000000762 glandular Effects 0.000 claims 3
- 230000002518 glial effect Effects 0.000 claims 3
- 208000005017 glioblastoma Diseases 0.000 claims 3
- 201000009277 hairy cell leukemia Diseases 0.000 claims 3
- 208000006359 hepatoblastoma Diseases 0.000 claims 3
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 3
- 230000002871 immunocytoma Effects 0.000 claims 3
- 208000022013 kidney Wilms tumor Diseases 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 206010024627 liposarcoma Diseases 0.000 claims 3
- 201000002250 liver carcinoma Diseases 0.000 claims 3
- 230000003211 malignant effect Effects 0.000 claims 3
- 201000000349 mediastinal cancer Diseases 0.000 claims 3
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 claims 3
- 201000001441 melanoma Diseases 0.000 claims 3
- 206010027191 meningioma Diseases 0.000 claims 3
- 210000003716 mesoderm Anatomy 0.000 claims 3
- 206010051747 multiple endocrine neoplasia Diseases 0.000 claims 3
- 201000000050 myeloid neoplasm Diseases 0.000 claims 3
- 208000001611 myxosarcoma Diseases 0.000 claims 3
- 208000018280 neoplasm of mediastinum Diseases 0.000 claims 3
- 201000008026 nephroblastoma Diseases 0.000 claims 3
- 208000007538 neurilemmoma Diseases 0.000 claims 3
- 208000028591 pheochromocytoma Diseases 0.000 claims 3
- 230000001817 pituitary effect Effects 0.000 claims 3
- 210000004180 plasmocyte Anatomy 0.000 claims 3
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 3
- 206010039667 schwannoma Diseases 0.000 claims 3
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 3
- 206010042863 synovial sarcoma Diseases 0.000 claims 3
- 208000008732 thymoma Diseases 0.000 claims 3
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims 3
- 201000005112 urinary bladder cancer Diseases 0.000 claims 3
- 210000002700 urine Anatomy 0.000 claims 3
- 206010046885 vaginal cancer Diseases 0.000 claims 3
- 208000013139 vaginal neoplasm Diseases 0.000 claims 3
- 230000002792 vascular Effects 0.000 claims 3
- 208000006542 von Hippel-Lindau disease Diseases 0.000 claims 3
- 201000005102 vulva cancer Diseases 0.000 claims 3
- 239000002253 acid Substances 0.000 claims 2
- 201000010983 breast ductal carcinoma Diseases 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 208000037828 epithelial carcinoma Diseases 0.000 claims 2
- 230000037431 insertion Effects 0.000 claims 2
- 238000003780 insertion Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 210000004877 mucosa Anatomy 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- VZKYTQVHJVJYLY-JBBWGLPISA-N (Z)-but-2-enedioic acid 7-[(3S)-oxolan-3-yl]oxyquinazoline Chemical compound OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C1OCC[C@@H]1OC1=CC=C(C=NC=N2)C2=C1 VZKYTQVHJVJYLY-JBBWGLPISA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05110656 | 2005-11-11 | ||
| EP05110656.5 | 2005-11-11 | ||
| PCT/EP2006/068313 WO2007054550A1 (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013006405A Division JP5695680B2 (ja) | 2005-11-11 | 2013-01-17 | 癌疾患の治療用キナゾリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515851A JP2009515851A (ja) | 2009-04-16 |
| JP2009515851A5 true JP2009515851A5 (enExample) | 2010-01-07 |
| JP5688877B2 JP5688877B2 (ja) | 2015-03-25 |
Family
ID=37700909
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539440A Active JP5688877B2 (ja) | 2005-11-11 | 2006-11-09 | 癌疾患の治療用キナゾリン誘導体 |
| JP2013006405A Active JP5695680B2 (ja) | 2005-11-11 | 2013-01-17 | 癌疾患の治療用キナゾリン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013006405A Active JP5695680B2 (ja) | 2005-11-11 | 2013-01-17 | 癌疾患の治療用キナゾリン誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (5) | US8404697B2 (enExample) |
| EP (2) | EP3173084B1 (enExample) |
| JP (2) | JP5688877B2 (enExample) |
| CA (3) | CA2629244C (enExample) |
| WO (1) | WO2007054550A1 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000078735A1 (de) | 1999-06-21 | 2000-12-28 | Boehringer Ingelheim Pharma Kg | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| US7019012B2 (en) * | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| DE10349113A1 (de) * | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| SI1948180T1 (sl) * | 2005-11-11 | 2013-06-28 | Boehringer Ingelheim International Gmbh | Kombinacijsko zdravljenje raka, ki obsega EGFR/HER2 inhibitorje |
| JP5688877B2 (ja) | 2005-11-11 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌疾患の治療用キナゾリン誘導体 |
| DK1981863T3 (da) * | 2006-01-26 | 2013-01-02 | Boehringer Ingelheim Int | Fremgangsmåde til fremstilling af aminocrotonylaminosubtituerede quinazolinderivater |
| SI2068880T1 (sl) | 2006-09-18 | 2012-08-31 | Boehringer Ingelheim Int | Postopek za zdravljenje raka, ki vsebuje mutacije EGFR |
| PE20100252A1 (es) * | 2008-06-06 | 2010-04-12 | Boehringer Ingelheim Int | Nuevas formulaciones farmaceuticas solidas que comprenden dimaleato de 4-[(3-cloro-4-fluorofenil) amino]-6-{[4-(n,n-dimetilamino)-1-oxo-2-buten-1-il] amino}-7-((s)-tetrahidrofuran-3-iloxi)-quinazolina |
| WO2010081817A1 (en) | 2009-01-14 | 2010-07-22 | Boehringer Ingelheim International Gmbh | Method for treating colorectal cancer |
| EP2429520A1 (en) | 2009-05-14 | 2012-03-21 | Boehringer Ingelheim International GmbH | New combination therapy in treatment of oncological and fibrotic diseases |
| JP5963672B2 (ja) | 2009-07-06 | 2016-08-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｉｂｗ２９９２、その塩及びこの活性成分を含む固体医薬製剤の乾燥方法 |
| EP2509592A1 (en) | 2009-12-07 | 2012-10-17 | Boehringer Ingelheim International GmbH | Bibw 2992 for use in the treatment of triple negative breast cancer |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| US20120107304A1 (en) * | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| DK2608792T3 (en) * | 2010-08-26 | 2018-01-15 | Boehringer Ingelheim Int | PROCEDURES FOR SUBMITTING AN EGFR INHIBITOR. |
| CN102382106A (zh) * | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| CN102382065B (zh) * | 2010-08-30 | 2014-05-28 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| CN102452989B (zh) * | 2010-10-19 | 2014-10-22 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| KR20200003933A (ko) * | 2011-03-04 | 2020-01-10 | 뉴젠 세러퓨틱스 인코포레이티드 | 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 |
| CN102731485B (zh) * | 2011-04-02 | 2016-06-15 | 齐鲁制药有限公司 | 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途 |
| WO2012155339A1 (zh) * | 2011-05-17 | 2012-11-22 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| CN103748080B (zh) * | 2011-05-26 | 2016-09-28 | 山东轩竹医药科技有限公司 | 喹唑啉衍生物类酪氨酸激酶抑制剂及其制备方法与应用 |
| WO2013135176A1 (zh) * | 2012-03-16 | 2013-09-19 | 苏州迈泰生物技术有限公司 | 氨基喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
| EP2739285B9 (en) * | 2011-08-02 | 2019-09-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Selective inhibition of malt1 protease by phenothiazine derivatives |
| SI2840080T1 (en) | 2012-04-17 | 2018-03-30 | Fujifilm Corporation | Nitrogen-containing heterocyclic compound or salt thereof |
| WO2014118197A1 (en) | 2013-02-01 | 2014-08-07 | Boehringer Ingelheim International Gmbh | Radiolabeled quinazoline derivatives |
| TWI609012B (zh) | 2013-04-28 | 2017-12-21 | 廣東東陽光藥業有限公司 | 氨基喹唑啉類衍生物及其鹽和使用方法 |
| WO2015007206A1 (zh) * | 2013-07-16 | 2015-01-22 | 杭州普晒医药科技有限公司 | 阿法替尼酸加成盐及其晶型、其制备方法及药物组合物 |
| PL3059227T3 (pl) | 2013-10-16 | 2019-11-29 | Fujifilm Corp | Sól heterocyklicznego związku zawierającego azot lub jej kryształ, kompozycja farmaceutyczna i inhibitor flt3 |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| WO2015154064A2 (en) * | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| RU2727195C2 (ru) | 2014-08-22 | 2020-07-21 | Фуджифилм Корпорэйшн | Фармацевтическая композиция для лечения злокачественной опухоли, положительной по мутации flt3, ингибитор мутантного flt3 и их применение |
| CN105777655B (zh) * | 2014-12-25 | 2018-02-02 | 深圳海王医药科技研究院有限公司 | 萘普替尼对甲苯磺酸盐的α晶型及制备方法和含有其的药物组合物 |
| CN105777656B (zh) * | 2014-12-25 | 2018-02-02 | 深圳海王医药科技研究院有限公司 | 萘普替尼对甲苯磺酸盐的β晶型及制备方法和含有其的药物组合物 |
| CN105801568B (zh) | 2015-01-15 | 2019-07-30 | 杭州普晒医药科技有限公司 | 阿法替尼一马来酸盐晶型及其制备方法和药物组合物 |
| JP6412471B2 (ja) | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| EP3359526A4 (en) | 2015-10-05 | 2019-04-03 | The Trustees of Columbia University in the City of New York | ACTIVATORS OF AUTOPHAGIC RIVER AND PHOSPHOLIPASE D AND PURIFICATION OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES |
| CN107721985A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107721986A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107721987A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN109265449B (zh) * | 2018-11-07 | 2021-11-23 | 沈阳工业大学 | Egfr和her2双靶点酪氨酸激酶抑制剂及制备方法和用途 |
| TWI820414B (zh) * | 2020-04-17 | 2023-11-01 | 大陸商北京賽特明強醫藥科技有限公司 | 喹唑啉類化合物、製備方法及其應用 |
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-
2006
- 2006-11-09 JP JP2008539440A patent/JP5688877B2/ja active Active
- 2006-11-09 WO PCT/EP2006/068313 patent/WO2007054550A1/en not_active Ceased
- 2006-11-09 CA CA2629244A patent/CA2629244C/en active Active
- 2006-11-09 US US12/093,321 patent/US8404697B2/en active Active
- 2006-11-09 EP EP16201715.6A patent/EP3173084B1/en active Active
- 2006-11-09 EP EP06819379A patent/EP1948179A1/en not_active Ceased
- 2006-11-09 CA CA2833706A patent/CA2833706C/en active Active
- 2006-11-09 CA CA2833852A patent/CA2833852C/en active Active
-
2013
- 2013-01-17 JP JP2013006405A patent/JP5695680B2/ja active Active
- 2013-02-14 US US13/766,914 patent/US9089571B2/en active Active
-
2015
- 2015-06-15 US US14/739,299 patent/US9539258B2/en active Active
-
2016
- 2016-10-31 US US15/338,632 patent/US20170112835A1/en not_active Abandoned
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2017
- 2017-12-19 US US15/846,356 patent/US20180360834A1/en not_active Abandoned
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