CA2629244C - Quinazoline derivatives for the treatment of cancer diseases - Google Patents
Quinazoline derivatives for the treatment of cancer diseases Download PDFInfo
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- CA2629244C CA2629244C CA2629244A CA2629244A CA2629244C CA 2629244 C CA2629244 C CA 2629244C CA 2629244 A CA2629244 A CA 2629244A CA 2629244 A CA2629244 A CA 2629244A CA 2629244 C CA2629244 C CA 2629244C
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Inorganic Chemistry (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2833706A CA2833706C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
| CA2833852A CA2833852C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05110656 | 2005-11-11 | ||
| EP05110656.5 | 2005-11-11 | ||
| PCT/EP2006/068313 WO2007054550A1 (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2833852A Division CA2833852C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
| CA2833706A Division CA2833706C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2629244A1 CA2629244A1 (en) | 2007-05-18 |
| CA2629244C true CA2629244C (en) | 2014-08-05 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
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| CA2629244A Active CA2629244C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
| CA2833706A Active CA2833706C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
| CA2833852A Active CA2833852C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2833706A Active CA2833706C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
| CA2833852A Active CA2833852C (en) | 2005-11-11 | 2006-11-09 | Quinazoline derivatives for the treatment of cancer diseases |
Country Status (5)
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| EP (2) | EP3173084B1 (enExample) |
| JP (2) | JP5688877B2 (enExample) |
| CA (3) | CA2629244C (enExample) |
| WO (1) | WO2007054550A1 (enExample) |
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| WO2000078735A1 (de) | 1999-06-21 | 2000-12-28 | Boehringer Ingelheim Pharma Kg | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
| US7019012B2 (en) * | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
| DE10221018A1 (de) * | 2002-05-11 | 2003-11-27 | Boehringer Ingelheim Pharma | Verwendung von Hemmern der EGFR-vermittelten Signaltransduktion zur Behandlung von gutartiger Prostatahyperplasie (BPH)/Prostatahypertrophie |
| US20050043233A1 (en) * | 2003-04-29 | 2005-02-24 | Boehringer Ingelheim International Gmbh | Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis |
| DE10349113A1 (de) * | 2003-10-17 | 2005-05-12 | Boehringer Ingelheim Pharma | Verfahren zur Herstellung von Aminocrotonylverbindungen |
| SI1948180T1 (sl) * | 2005-11-11 | 2013-06-28 | Boehringer Ingelheim International Gmbh | Kombinacijsko zdravljenje raka, ki obsega EGFR/HER2 inhibitorje |
| JP5688877B2 (ja) | 2005-11-11 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌疾患の治療用キナゾリン誘導体 |
| DK1981863T3 (da) * | 2006-01-26 | 2013-01-02 | Boehringer Ingelheim Int | Fremgangsmåde til fremstilling af aminocrotonylaminosubtituerede quinazolinderivater |
| SI2068880T1 (sl) | 2006-09-18 | 2012-08-31 | Boehringer Ingelheim Int | Postopek za zdravljenje raka, ki vsebuje mutacije EGFR |
| PE20100252A1 (es) * | 2008-06-06 | 2010-04-12 | Boehringer Ingelheim Int | Nuevas formulaciones farmaceuticas solidas que comprenden dimaleato de 4-[(3-cloro-4-fluorofenil) amino]-6-{[4-(n,n-dimetilamino)-1-oxo-2-buten-1-il] amino}-7-((s)-tetrahidrofuran-3-iloxi)-quinazolina |
| WO2010081817A1 (en) | 2009-01-14 | 2010-07-22 | Boehringer Ingelheim International Gmbh | Method for treating colorectal cancer |
| EP2429520A1 (en) | 2009-05-14 | 2012-03-21 | Boehringer Ingelheim International GmbH | New combination therapy in treatment of oncological and fibrotic diseases |
| JP5963672B2 (ja) | 2009-07-06 | 2016-08-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｂｉｂｗ２９９２、その塩及びこの活性成分を含む固体医薬製剤の乾燥方法 |
| EP2509592A1 (en) | 2009-12-07 | 2012-10-17 | Boehringer Ingelheim International GmbH | Bibw 2992 for use in the treatment of triple negative breast cancer |
| CN102146059A (zh) * | 2010-02-08 | 2011-08-10 | 上海艾力斯医药科技有限公司 | 喹唑啉衍生物、制备方法及其应用 |
| US20120107304A1 (en) * | 2010-04-27 | 2012-05-03 | Boehringer Ingelheim International Gmbh | Combination therapy in treatment of oncological and fibrotic diseases |
| DK2608792T3 (en) * | 2010-08-26 | 2018-01-15 | Boehringer Ingelheim Int | PROCEDURES FOR SUBMITTING AN EGFR INHIBITOR. |
| CN102382106A (zh) * | 2010-08-30 | 2012-03-21 | 黄振华 | 苯胺取代的喹唑啉衍生物 |
| CN102382065B (zh) * | 2010-08-30 | 2014-05-28 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| CN102452989B (zh) * | 2010-10-19 | 2014-10-22 | 山东轩竹医药科技有限公司 | 苯胺取代的喹唑啉衍生物 |
| KR20200003933A (ko) * | 2011-03-04 | 2020-01-10 | 뉴젠 세러퓨틱스 인코포레이티드 | 알킨 치환된 퀴나졸린 화합물 및 그것의 사용 방법 |
| CN102731485B (zh) * | 2011-04-02 | 2016-06-15 | 齐鲁制药有限公司 | 4-(取代苯氨基)喹唑啉衍生物及其制备方法、药物组合物和用途 |
| WO2012155339A1 (zh) * | 2011-05-17 | 2012-11-22 | 江苏康缘药业股份有限公司 | 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途 |
| US8828391B2 (en) | 2011-05-17 | 2014-09-09 | Boehringer Ingelheim International Gmbh | Method for EGFR directed combination treatment of non-small cell lung cancer |
| CN103748080B (zh) * | 2011-05-26 | 2016-09-28 | 山东轩竹医药科技有限公司 | 喹唑啉衍生物类酪氨酸激酶抑制剂及其制备方法与应用 |
| WO2013135176A1 (zh) * | 2012-03-16 | 2013-09-19 | 苏州迈泰生物技术有限公司 | 氨基喹唑啉衍生物及其在制备抗恶性肿瘤药物中的用途 |
| EP2739285B9 (en) * | 2011-08-02 | 2019-09-04 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Selective inhibition of malt1 protease by phenothiazine derivatives |
| SI2840080T1 (en) | 2012-04-17 | 2018-03-30 | Fujifilm Corporation | Nitrogen-containing heterocyclic compound or salt thereof |
| WO2014118197A1 (en) | 2013-02-01 | 2014-08-07 | Boehringer Ingelheim International Gmbh | Radiolabeled quinazoline derivatives |
| TWI609012B (zh) | 2013-04-28 | 2017-12-21 | 廣東東陽光藥業有限公司 | 氨基喹唑啉類衍生物及其鹽和使用方法 |
| WO2015007206A1 (zh) * | 2013-07-16 | 2015-01-22 | 杭州普晒医药科技有限公司 | 阿法替尼酸加成盐及其晶型、其制备方法及药物组合物 |
| PL3059227T3 (pl) | 2013-10-16 | 2019-11-29 | Fujifilm Corp | Sól heterocyklicznego związku zawierającego azot lub jej kryształ, kompozycja farmaceutyczna i inhibitor flt3 |
| US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
| WO2015154064A2 (en) * | 2014-04-04 | 2015-10-08 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
| RU2727195C2 (ru) | 2014-08-22 | 2020-07-21 | Фуджифилм Корпорэйшн | Фармацевтическая композиция для лечения злокачественной опухоли, положительной по мутации flt3, ингибитор мутантного flt3 и их применение |
| CN105777655B (zh) * | 2014-12-25 | 2018-02-02 | 深圳海王医药科技研究院有限公司 | 萘普替尼对甲苯磺酸盐的α晶型及制备方法和含有其的药物组合物 |
| CN105777656B (zh) * | 2014-12-25 | 2018-02-02 | 深圳海王医药科技研究院有限公司 | 萘普替尼对甲苯磺酸盐的β晶型及制备方法和含有其的药物组合物 |
| CN105801568B (zh) | 2015-01-15 | 2019-07-30 | 杭州普晒医药科技有限公司 | 阿法替尼一马来酸盐晶型及其制备方法和药物组合物 |
| JP6412471B2 (ja) | 2015-07-15 | 2018-10-24 | 富士フイルム株式会社 | 含窒素複素環化合物の製造方法およびその中間体 |
| EP3359526A4 (en) | 2015-10-05 | 2019-04-03 | The Trustees of Columbia University in the City of New York | ACTIVATORS OF AUTOPHAGIC RIVER AND PHOSPHOLIPASE D AND PURIFICATION OF PROTEIN AGGREGATES INCLUDING TAU AND TREATMENT OF PROTEINOPATHIES |
| CN107721985A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107721986A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN107721987A (zh) * | 2016-08-12 | 2018-02-23 | 山东轩竹医药科技有限公司 | 喹唑啉类酪氨酸激酶抑制剂的晶型 |
| CN109265449B (zh) * | 2018-11-07 | 2021-11-23 | 沈阳工业大学 | Egfr和her2双靶点酪氨酸激酶抑制剂及制备方法和用途 |
| TWI820414B (zh) * | 2020-04-17 | 2023-11-01 | 大陸商北京賽特明強醫藥科技有限公司 | 喹唑啉類化合物、製備方法及其應用 |
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-
2006
- 2006-11-09 JP JP2008539440A patent/JP5688877B2/ja active Active
- 2006-11-09 WO PCT/EP2006/068313 patent/WO2007054550A1/en not_active Ceased
- 2006-11-09 CA CA2629244A patent/CA2629244C/en active Active
- 2006-11-09 US US12/093,321 patent/US8404697B2/en active Active
- 2006-11-09 EP EP16201715.6A patent/EP3173084B1/en active Active
- 2006-11-09 EP EP06819379A patent/EP1948179A1/en not_active Ceased
- 2006-11-09 CA CA2833706A patent/CA2833706C/en active Active
- 2006-11-09 CA CA2833852A patent/CA2833852C/en active Active
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2013
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- 2013-02-14 US US13/766,914 patent/US9089571B2/en active Active
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2015
- 2015-06-15 US US14/739,299 patent/US9539258B2/en active Active
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2016
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| US20150272954A1 (en) | 2015-10-01 |
| US9539258B2 (en) | 2017-01-10 |
| US20130178487A1 (en) | 2013-07-11 |
| US8404697B2 (en) | 2013-03-26 |
| WO2007054550A1 (en) | 2007-05-18 |
| CA2833852C (en) | 2014-10-21 |
| JP5688877B2 (ja) | 2015-03-25 |
| US20170112835A1 (en) | 2017-04-27 |
| US20180360834A1 (en) | 2018-12-20 |
| CA2629244A1 (en) | 2007-05-18 |
| JP5695680B2 (ja) | 2015-04-08 |
| CA2833852A1 (en) | 2007-05-18 |
| CA2833706A1 (en) | 2007-05-18 |
| EP3173084B1 (en) | 2019-10-23 |
| CA2833706C (en) | 2014-10-21 |
| US20090306044A1 (en) | 2009-12-10 |
| US9089571B2 (en) | 2015-07-28 |
| JP2009515851A (ja) | 2009-04-16 |
| EP1948179A1 (en) | 2008-07-30 |
| JP2013064024A (ja) | 2013-04-11 |
| EP3173084A1 (en) | 2017-05-31 |
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