JP2017528460A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017528460A5 JP2017528460A5 JP2017512975A JP2017512975A JP2017528460A5 JP 2017528460 A5 JP2017528460 A5 JP 2017528460A5 JP 2017512975 A JP2017512975 A JP 2017512975A JP 2017512975 A JP2017512975 A JP 2017512975A JP 2017528460 A5 JP2017528460 A5 JP 2017528460A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cell
- tumor
- lymphoma
- carcinoma
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 36
- 150000003839 salts Chemical class 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 201000011510 cancer Diseases 0.000 claims 9
- 206010018338 Glioma Diseases 0.000 claims 8
- 208000032612 Glial tumor Diseases 0.000 claims 7
- 206010025323 Lymphomas Diseases 0.000 claims 7
- 206010042971 T-cell lymphoma Diseases 0.000 claims 7
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 7
- 201000001441 melanoma Diseases 0.000 claims 7
- 206010044412 transitional cell carcinoma Diseases 0.000 claims 6
- 201000000053 blastoma Diseases 0.000 claims 5
- 201000008184 embryoma Diseases 0.000 claims 5
- 201000005962 mycosis fungoides Diseases 0.000 claims 5
- 208000024893 Acute lymphoblastic leukemia Diseases 0.000 claims 4
- 208000014697 Acute lymphocytic leukaemia Diseases 0.000 claims 4
- 208000003200 Adenoma Diseases 0.000 claims 4
- 206010001233 Adenoma benign Diseases 0.000 claims 4
- 206010003571 Astrocytoma Diseases 0.000 claims 4
- 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 claims 4
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 4
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 4
- 208000009565 Pharyngeal Neoplasms Diseases 0.000 claims 4
- 206010034811 Pharyngeal cancer Diseases 0.000 claims 4
- 208000007913 Pituitary Neoplasms Diseases 0.000 claims 4
- 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 claims 4
- 206010039491 Sarcoma Diseases 0.000 claims 4
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 4
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 4
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 4
- 206010017758 gastric cancer Diseases 0.000 claims 4
- 230000002710 gonadal effect Effects 0.000 claims 4
- 208000007538 neurilemmoma Diseases 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 201000009410 rhabdomyosarcoma Diseases 0.000 claims 4
- 206010039667 schwannoma Diseases 0.000 claims 4
- 206010041823 squamous cell carcinoma Diseases 0.000 claims 4
- 201000011549 stomach cancer Diseases 0.000 claims 4
- 201000002510 thyroid cancer Diseases 0.000 claims 4
- 208000021309 Germ cell tumor Diseases 0.000 claims 3
- 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 claims 3
- 208000009956 adenocarcinoma Diseases 0.000 claims 3
- 206010016629 fibroma Diseases 0.000 claims 3
- 208000032839 leukemia Diseases 0.000 claims 3
- 208000002008 AIDS-Related Lymphoma Diseases 0.000 claims 2
- 206010000871 Acute monocytic leukaemia Diseases 0.000 claims 2
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 2
- 208000001794 Adipose Tissue Neoplasms Diseases 0.000 claims 2
- 208000016683 Adult T-cell leukemia/lymphoma Diseases 0.000 claims 2
- 208000037540 Alveolar soft tissue sarcoma Diseases 0.000 claims 2
- 206010051810 Angiomyolipoma Diseases 0.000 claims 2
- 201000003076 Angiosarcoma Diseases 0.000 claims 2
- 201000008271 Atypical teratoid rhabdoid tumor Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 206010004146 Basal cell carcinoma Diseases 0.000 claims 2
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 206010005949 Bone cancer Diseases 0.000 claims 2
- 208000018084 Bone neoplasm Diseases 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 208000007690 Brenner tumor Diseases 0.000 claims 2
- 206010073258 Brenner tumour Diseases 0.000 claims 2
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 2
- QVDFJBYGHPQTNP-UHFFFAOYSA-N C=CS(=O)(=O)NC1CCC(CC1)NC(=O)C1=NOC(=C1)C1CC1 Chemical compound C=CS(=O)(=O)NC1CCC(CC1)NC(=O)C1=NOC(=C1)C1CC1 QVDFJBYGHPQTNP-UHFFFAOYSA-N 0.000 claims 2
- 201000009030 Carcinoma Diseases 0.000 claims 2
- 208000009458 Carcinoma in Situ Diseases 0.000 claims 2
- 201000000274 Carcinosarcoma Diseases 0.000 claims 2
- 208000007389 Cementoma Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- 201000005262 Chondroma Diseases 0.000 claims 2
- 201000009047 Chordoma Diseases 0.000 claims 2
- 208000006332 Choriocarcinoma Diseases 0.000 claims 2
- 208000004378 Choroid plexus papilloma Diseases 0.000 claims 2
- 206010009253 Clear cell sarcoma of the kidney Diseases 0.000 claims 2
- 206010009944 Colon cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000009798 Craniopharyngioma Diseases 0.000 claims 2
- 208000008334 Dermatofibrosarcoma Diseases 0.000 claims 2
- 201000009051 Embryonal Carcinoma Diseases 0.000 claims 2
- 208000033832 Eosinophilic Acute Leukemia Diseases 0.000 claims 2
- 208000031637 Erythroblastic Acute Leukemia Diseases 0.000 claims 2
- 208000036566 Erythroleukaemia Diseases 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 206010061850 Extranodal marginal zone B-cell lymphoma (MALT type) Diseases 0.000 claims 2
- 201000008808 Fibrosarcoma Diseases 0.000 claims 2
- 208000022072 Gallbladder Neoplasms Diseases 0.000 claims 2
- 206010017993 Gastrointestinal neoplasms Diseases 0.000 claims 2
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 2
- 102000051325 Glucagon Human genes 0.000 claims 2
- 108060003199 Glucagon Proteins 0.000 claims 2
- 208000005234 Granulosa Cell Tumor Diseases 0.000 claims 2
- 208000001258 Hemangiosarcoma Diseases 0.000 claims 2
- 208000002250 Hematologic Neoplasms Diseases 0.000 claims 2
- 208000017604 Hodgkin disease Diseases 0.000 claims 2
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 2
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 2
- 208000005016 Intestinal Neoplasms Diseases 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 2
- 206010023825 Laryngeal cancer Diseases 0.000 claims 2
- 201000004462 Leydig Cell Tumor Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025219 Lymphangioma Diseases 0.000 claims 2
- 206010025312 Lymphoma AIDS related Diseases 0.000 claims 2
- 201000003791 MALT lymphoma Diseases 0.000 claims 2
- 208000006644 Malignant Fibrous Histiocytoma Diseases 0.000 claims 2
- 206010064281 Malignant atrophic papulosis Diseases 0.000 claims 2
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 2
- 208000009018 Medullary thyroid cancer Diseases 0.000 claims 2
- 208000000172 Medulloblastoma Diseases 0.000 claims 2
- 208000035490 Megakaryoblastic Acute Leukemia Diseases 0.000 claims 2
- 208000002030 Merkel cell carcinoma Diseases 0.000 claims 2
- 206010027406 Mesothelioma Diseases 0.000 claims 2
- 208000035489 Monocytic Acute Leukemia Diseases 0.000 claims 2
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 208000007727 Muscle Tissue Neoplasms Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 206010073137 Myxoid liposarcoma Diseases 0.000 claims 2
- 208000002454 Nasopharyngeal Carcinoma Diseases 0.000 claims 2
- 206010061306 Nasopharyngeal cancer Diseases 0.000 claims 2
- 206010028811 Natural killer-cell leukaemia Diseases 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 206010029266 Neuroendocrine carcinoma of the skin Diseases 0.000 claims 2
- 201000004404 Neurofibroma Diseases 0.000 claims 2
- 208000005890 Neuroma Diseases 0.000 claims 2
- 206010029488 Nodular melanoma Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010061872 Non-renal cell carcinoma of kidney Diseases 0.000 claims 2
- 208000007871 Odontogenic Tumors Diseases 0.000 claims 2
- 206010048757 Oncocytoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 208000002063 Oxyphilic Adenoma Diseases 0.000 claims 2
- 201000010630 Pancoast tumor Diseases 0.000 claims 2
- 208000015330 Pancoast tumour Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010033701 Papillary thyroid cancer Diseases 0.000 claims 2
- 208000037064 Papilloma of choroid plexus Diseases 0.000 claims 2
- 206010061332 Paraganglion neoplasm Diseases 0.000 claims 2
- 206010050487 Pinealoblastoma Diseases 0.000 claims 2
- 208000007641 Pinealoma Diseases 0.000 claims 2
- 201000005746 Pituitary adenoma Diseases 0.000 claims 2
- 206010061538 Pituitary tumour benign Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 208000007452 Plasmacytoma Diseases 0.000 claims 2
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 claims 2
- 208000033826 Promyelocytic Acute Leukemia Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000034541 Rare lymphatic malformation Diseases 0.000 claims 2
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 2
- 208000033889 Renal medullary carcinoma Diseases 0.000 claims 2
- 201000000582 Retinoblastoma Diseases 0.000 claims 2
- 208000025316 Richter syndrome Diseases 0.000 claims 2
- 208000006938 Schwannomatosis Diseases 0.000 claims 2
- 201000010208 Seminoma Diseases 0.000 claims 2
- 208000003274 Sertoli cell tumor Diseases 0.000 claims 2
- 208000009359 Sezary Syndrome Diseases 0.000 claims 2
- 208000021388 Sezary disease Diseases 0.000 claims 2
- 208000003252 Signet Ring Cell Carcinoma Diseases 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 206010041067 Small cell lung cancer Diseases 0.000 claims 2
- 208000021712 Soft tissue sarcoma Diseases 0.000 claims 2
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 2
- 208000024313 Testicular Neoplasms Diseases 0.000 claims 2
- 208000015778 Undifferentiated pleomorphic sarcoma Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 208000008385 Urogenital Neoplasms Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 208000002495 Uterine Neoplasms Diseases 0.000 claims 2
- 201000005969 Uveal melanoma Diseases 0.000 claims 2
- 208000014070 Vestibular schwannoma Diseases 0.000 claims 2
- 206010047741 Vulval cancer Diseases 0.000 claims 2
- 208000004354 Vulvar Neoplasms Diseases 0.000 claims 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 2
- 208000000260 Warts Diseases 0.000 claims 2
- 208000012018 Yolk sac tumor Diseases 0.000 claims 2
- 208000006336 acinar cell carcinoma Diseases 0.000 claims 2
- 208000004064 acoustic neuroma Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 208000021841 acute erythroid leukemia Diseases 0.000 claims 2
- 208000013593 acute megakaryoblastic leukemia Diseases 0.000 claims 2
- 208000020700 acute megakaryocytic leukemia Diseases 0.000 claims 2
- 208000002517 adenoid cystic carcinoma Diseases 0.000 claims 2
- 208000020990 adrenal cortex carcinoma Diseases 0.000 claims 2
- 201000005188 adrenal gland cancer Diseases 0.000 claims 2
- 208000024447 adrenal gland neoplasm Diseases 0.000 claims 2
- 208000007128 adrenocortical carcinoma Diseases 0.000 claims 2
- 201000006966 adult T-cell leukemia Diseases 0.000 claims 2
- 208000015230 aggressive NK-cell leukemia Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 206010065867 alveolar rhabdomyosarcoma Diseases 0.000 claims 2
- 201000009076 bladder urachal carcinoma Diseases 0.000 claims 2
- 201000011143 bone giant cell tumor Diseases 0.000 claims 2
- 210000000845 cartilage Anatomy 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 208000006990 cholangiocarcinoma Diseases 0.000 claims 2
- 208000030748 clear cell sarcoma of kidney Diseases 0.000 claims 2
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 2
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 2
- 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 claims 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 2
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 2
- 230000002124 endocrine Effects 0.000 claims 2
- 208000001991 endodermal sinus tumor Diseases 0.000 claims 2
- 208000037902 enteropathy Diseases 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 208000024519 eye neoplasm Diseases 0.000 claims 2
- 210000003754 fetus Anatomy 0.000 claims 2
- 201000003444 follicular lymphoma Diseases 0.000 claims 2
- 201000010175 gallbladder cancer Diseases 0.000 claims 2
- 201000008822 gestational choriocarcinoma Diseases 0.000 claims 2
- 208000005017 glioblastoma Diseases 0.000 claims 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 2
- 229960004666 glucagon Drugs 0.000 claims 2
- 201000009277 hairy cell leukemia Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 201000002222 hemangioblastoma Diseases 0.000 claims 2
- 201000005787 hematologic cancer Diseases 0.000 claims 2
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 claims 2
- 208000006359 hepatoblastoma Diseases 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 201000004933 in situ carcinoma Diseases 0.000 claims 2
- 201000002313 intestinal cancer Diseases 0.000 claims 2
- 208000028774 intestinal disease Diseases 0.000 claims 2
- 206010073096 invasive lobular breast carcinoma Diseases 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000020319 kidney medullary carcinoma Diseases 0.000 claims 2
- 206010023841 laryngeal neoplasm Diseases 0.000 claims 2
- 231100000518 lethal Toxicity 0.000 claims 2
- 230000001665 lethal effect Effects 0.000 claims 2
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 2
- 206010024627 liposarcoma Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000012804 lymphangiosarcoma Diseases 0.000 claims 2
- 230000003211 malignant effect Effects 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 208000015179 malignant superior sulcus neoplasm Diseases 0.000 claims 2
- 201000001117 malignant triton tumor Diseases 0.000 claims 2
- 201000007924 marginal zone B-cell lymphoma Diseases 0.000 claims 2
- 208000021937 marginal zone lymphoma Diseases 0.000 claims 2
- 208000000516 mast-cell leukemia Diseases 0.000 claims 2
- 208000029586 mediastinal germ cell tumor Diseases 0.000 claims 2
- 208000030163 medullary breast carcinoma Diseases 0.000 claims 2
- 208000023356 medullary thyroid gland carcinoma Diseases 0.000 claims 2
- 230000001394 metastastic effect Effects 0.000 claims 2
- 206010061289 metastatic neoplasm Diseases 0.000 claims 2
- 201000010225 mixed cell type cancer Diseases 0.000 claims 2
- 208000029638 mixed neoplasm Diseases 0.000 claims 2
- 208000022669 mucinous neoplasm Diseases 0.000 claims 2
- 201000009368 muscle benign neoplasm Diseases 0.000 claims 2
- 208000009091 myxoma Diseases 0.000 claims 2
- 208000001611 myxosarcoma Diseases 0.000 claims 2
- 208000014761 nasopharyngeal type undifferentiated carcinoma Diseases 0.000 claims 2
- 201000011216 nasopharynx carcinoma Diseases 0.000 claims 2
- 208000025189 neoplasm of testis Diseases 0.000 claims 2
- 230000009826 neoplastic cell growth Effects 0.000 claims 2
- 201000009494 neurilemmomatosis Diseases 0.000 claims 2
- 208000027831 neuroepithelial neoplasm Diseases 0.000 claims 2
- 201000000032 nodular malignant melanoma Diseases 0.000 claims 2
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 2
- 201000008106 ocular cancer Diseases 0.000 claims 2
- 208000027825 odontogenic neoplasm Diseases 0.000 claims 2
- 208000027500 optic nerve neoplasm Diseases 0.000 claims 2
- 201000008968 osteosarcoma Diseases 0.000 claims 2
- 230000002611 ovarian Effects 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 208000007312 paraganglioma Diseases 0.000 claims 2
- 230000002093 peripheral effect Effects 0.000 claims 2
- 201000003113 pineoblastoma Diseases 0.000 claims 2
- 230000001817 pituitary effect Effects 0.000 claims 2
- 208000021310 pituitary gland adenoma Diseases 0.000 claims 2
- 208000010916 pituitary tumor Diseases 0.000 claims 2
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 206010038038 rectal cancer Diseases 0.000 claims 2
- 201000001275 rectum cancer Diseases 0.000 claims 2
- 201000007416 salivary gland adenoid cystic carcinoma Diseases 0.000 claims 2
- 201000008123 signet ring cell adenocarcinoma Diseases 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 201000010153 skin papilloma Diseases 0.000 claims 2
- 208000000649 small cell carcinoma Diseases 0.000 claims 2
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 2
- 201000002314 small intestine cancer Diseases 0.000 claims 2
- 206010062113 splenic marginal zone lymphoma Diseases 0.000 claims 2
- 210000004243 sweat Anatomy 0.000 claims 2
- 206010042863 synovial sarcoma Diseases 0.000 claims 2
- 201000003120 testicular cancer Diseases 0.000 claims 2
- 208000030045 thyroid gland papillary carcinoma Diseases 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 201000007363 trachea carcinoma Diseases 0.000 claims 2
- 208000025443 tumor of adipose tissue Diseases 0.000 claims 2
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- 206010046766 uterine cancer Diseases 0.000 claims 2
- 206010046885 vaginal cancer Diseases 0.000 claims 2
- 208000013139 vaginal neoplasm Diseases 0.000 claims 2
- 230000000007 visual effect Effects 0.000 claims 2
- 201000005102 vulva cancer Diseases 0.000 claims 2
- -1 5-cyclopropyl-N- (1- (vinylsulfonyl) pyrrolidin-3-yl) isoxazole Chemical compound 0.000 claims 1
- 241000321096 Adenoides Species 0.000 claims 1
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 1
- 208000032568 B-cell prolymphocytic leukaemia Diseases 0.000 claims 1
- 206010004593 Bile duct cancer Diseases 0.000 claims 1
- 206010005969 Bone giant cell tumour Diseases 0.000 claims 1
- WZFISHKVFZBXFE-UHFFFAOYSA-N C(C=C)(=O)N1CCC(CC1)NC(=O)C1=NOC(=C1)C1CC1 Chemical compound C(C=C)(=O)N1CCC(CC1)NC(=O)C1=NOC(=C1)C1CC1 WZFISHKVFZBXFE-UHFFFAOYSA-N 0.000 claims 1
- NGAZAJGIKLHYLD-UHFFFAOYSA-N C1(CC1)C1=CC(=NO1)C(=O)NC1CCN(CC1)S(=O)(=O)C=C Chemical compound C1(CC1)C1=CC(=NO1)C(=O)NC1CCN(CC1)S(=O)(=O)C=C NGAZAJGIKLHYLD-UHFFFAOYSA-N 0.000 claims 1
- KCDNATPKRYRFRZ-UHFFFAOYSA-N C1(CC1)C1=CC(=NO1)C(=O)NC1CN(C1)S(=O)(=O)C=C Chemical compound C1(CC1)C1=CC(=NO1)C(=O)NC1CN(C1)S(=O)(=O)C=C KCDNATPKRYRFRZ-UHFFFAOYSA-N 0.000 claims 1
- WCXOHKPYBYVLEG-NUHJPDEHSA-N C1(CC1)C1=CC(=NO1)C(=O)NC1C[C@@H](N(CC1)S(=O)(=O)C=C)C Chemical compound C1(CC1)C1=CC(=NO1)C(=O)NC1C[C@@H](N(CC1)S(=O)(=O)C=C)C WCXOHKPYBYVLEG-NUHJPDEHSA-N 0.000 claims 1
- WCXOHKPYBYVLEG-RWANSRKNSA-N C1(CC1)C1=CC(=NO1)C(=O)NC1C[C@H](N(CC1)S(=O)(=O)C=C)C Chemical compound C1(CC1)C1=CC(=NO1)C(=O)NC1C[C@H](N(CC1)S(=O)(=O)C=C)C WCXOHKPYBYVLEG-RWANSRKNSA-N 0.000 claims 1
- YWQNUEWPEZGQPH-UHFFFAOYSA-N C=CC(=O)NC1CCC(CC1)NC(=O)C1=NOC(=C1)C1CC1 Chemical compound C=CC(=O)NC1CCC(CC1)NC(=O)C1=NOC(=C1)C1CC1 YWQNUEWPEZGQPH-UHFFFAOYSA-N 0.000 claims 1
- 206010007953 Central nervous system lymphoma Diseases 0.000 claims 1
- OENTXAYVUCLRJQ-UHFFFAOYSA-N ClCC(=O)N1CCC(CC1)NC(=O)C1=NOC(=C1)C1CC1 Chemical compound ClCC(=O)N1CCC(CC1)NC(=O)C1=NOC(=C1)C1CC1 OENTXAYVUCLRJQ-UHFFFAOYSA-N 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 206010016935 Follicular thyroid cancer Diseases 0.000 claims 1
- 208000003098 Ganglion Cysts Diseases 0.000 claims 1
- 208000000527 Germinoma Diseases 0.000 claims 1
- 208000002966 Giant Cell Tumor of Bone Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 201000010133 Oligodendroglioma Diseases 0.000 claims 1
- 208000035416 Prolymphocytic B-Cell Leukemia Diseases 0.000 claims 1
- 102000005157 Somatostatin Human genes 0.000 claims 1
- 108010056088 Somatostatin Proteins 0.000 claims 1
- 206010041329 Somatostatinoma Diseases 0.000 claims 1
- 208000005400 Synovial Cyst Diseases 0.000 claims 1
- 208000033781 Thyroid carcinoma Diseases 0.000 claims 1
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims 1
- 208000008383 Wilms tumor Diseases 0.000 claims 1
- 206010000583 acral lentiginous melanoma Diseases 0.000 claims 1
- 210000002534 adenoid Anatomy 0.000 claims 1
- 201000008395 adenosquamous carcinoma Diseases 0.000 claims 1
- 230000002707 ameloblastic effect Effects 0.000 claims 1
- 206010002449 angioimmunoblastic T-cell lymphoma Diseases 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 208000026900 bile duct neoplasm Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 210000004720 cerebrum Anatomy 0.000 claims 1
- 210000003298 dental enamel Anatomy 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000014616 embryonal neoplasm Diseases 0.000 claims 1
- 210000000981 epithelium Anatomy 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 230000003352 fibrogenic effect Effects 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 230000003325 follicular Effects 0.000 claims 1
- 230000002538 fungal effect Effects 0.000 claims 1
- 201000003115 germ cell cancer Diseases 0.000 claims 1
- 210000004907 gland Anatomy 0.000 claims 1
- 230000001401 hemangioblastic effect Effects 0.000 claims 1
- 208000029824 high grade glioma Diseases 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 210000002751 lymph Anatomy 0.000 claims 1
- 201000000564 macroglobulinemia Diseases 0.000 claims 1
- 201000011614 malignant glioma Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
- 210000005036 nerve Anatomy 0.000 claims 1
- 210000004248 oligodendroglia Anatomy 0.000 claims 1
- 210000001328 optic nerve Anatomy 0.000 claims 1
- 201000011130 optic nerve sheath meningioma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000016800 primary central nervous system lymphoma Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
- 229960000553 somatostatin Drugs 0.000 claims 1
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims 1
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 claims 1
- 208000013706 tumor of meninges Diseases 0.000 claims 1
- 208000023747 urothelial carcinoma Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048760P | 2014-09-10 | 2014-09-10 | |
| US62/048,760 | 2014-09-10 | ||
| PCT/US2015/049231 WO2016040511A1 (en) | 2014-09-10 | 2015-09-09 | Isoxazole carboxamides as irreversible smyd inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017528460A JP2017528460A (ja) | 2017-09-28 |
| JP2017528460A5 true JP2017528460A5 (enExample) | 2018-10-25 |
Family
ID=55459533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512975A Pending JP2017528460A (ja) | 2014-09-10 | 2015-09-09 | 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10179773B2 (enExample) |
| EP (1) | EP3193606B1 (enExample) |
| JP (1) | JP2017528460A (enExample) |
| AU (1) | AU2015315180A1 (enExample) |
| CA (1) | CA2960279A1 (enExample) |
| WO (1) | WO2016040511A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112017004589A2 (pt) | 2014-09-10 | 2018-01-23 | Epizyme Inc | composto, composição farmacêutica, método para tratar um paciente, uso de um composto, kit, e método para tratar um distúrbio mediado por proteína smyd |
| AU2015315174B2 (en) | 2014-09-10 | 2019-12-12 | Epizyme, Inc. | Smyd inhibitors |
| WO2016040511A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| EP3190891B1 (en) | 2014-09-10 | 2020-01-15 | Epizyme, Inc. | Isoxazolecarboxamide substituted by a cyclohexylamine as smyd protein inhibitors |
| CA2960274A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| CN114246851B (zh) * | 2021-11-09 | 2024-01-26 | 澳门科技大学 | 一种组蛋白甲基转移酶smyd3小分子抑制剂的合成方法及用途 |
| CN115998869B (zh) * | 2022-09-23 | 2025-08-05 | 华中科技大学同济医学院附属同济医院 | 组蛋白甲基转移酶smyd2在制备防治血管损伤后内膜新生导致再狭窄的药物中的应用 |
| IT202200021138A1 (it) * | 2022-10-13 | 2024-04-13 | Istituto Di Ricovero E Cura A Carattere Scient Saverio De Bellis | Formulati farmaceutici con attività inibente le metiltrasferasi istoniche per il trattamento di patologie neoplastiche |
| CN116211867A (zh) * | 2022-12-30 | 2023-06-06 | 复旦大学附属肿瘤医院 | Az505和恩杂鲁胺在制备治疗前列腺癌药物中的用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006518368A (ja) * | 2003-02-21 | 2006-08-10 | ファイザー・インク | プロテインキナーゼ阻害剤としてのｎ−ヘテロシクリル置換アミノチアゾール誘導体 |
| CN1528745A (zh) * | 2003-10-21 | 2004-09-15 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其制备方法 |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| WO2008137834A2 (en) | 2007-05-04 | 2008-11-13 | Osi Pharmaceuticals, Inc. | Crystal structure of smyd3 protein |
| WO2013043826A1 (en) * | 2011-09-21 | 2013-03-28 | Abbvie Inc. | Tricyclic compounds useful as protein kinase inhibitors |
| EP3193609A4 (en) | 2014-09-10 | 2018-02-28 | Epizyme, Inc. | Substituted pyrrolidine carboxamide compounds |
| BR112017004589A2 (pt) | 2014-09-10 | 2018-01-23 | Epizyme Inc | composto, composição farmacêutica, método para tratar um paciente, uso de um composto, kit, e método para tratar um distúrbio mediado por proteína smyd |
| AU2015315174B2 (en) | 2014-09-10 | 2019-12-12 | Epizyme, Inc. | Smyd inhibitors |
| JP2017527577A (ja) | 2014-09-10 | 2017-09-21 | エピザイム，インコーポレイティド | 置換ピロリジン化合物 |
| WO2016040511A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| EP3190891B1 (en) | 2014-09-10 | 2020-01-15 | Epizyme, Inc. | Isoxazolecarboxamide substituted by a cyclohexylamine as smyd protein inhibitors |
| CA2960274A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamide compounds |
-
2015
- 2015-09-09 WO PCT/US2015/049231 patent/WO2016040511A1/en not_active Ceased
- 2015-09-09 CA CA2960279A patent/CA2960279A1/en not_active Abandoned
- 2015-09-09 JP JP2017512975A patent/JP2017528460A/ja active Pending
- 2015-09-09 US US15/510,589 patent/US10179773B2/en active Active
- 2015-09-09 AU AU2015315180A patent/AU2015315180A1/en not_active Abandoned
- 2015-09-09 EP EP15840663.7A patent/EP3193606B1/en active Active
-
2019
- 2019-01-11 US US16/245,986 patent/US10669243B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2018138735A (ru) | Деструкторы белка mdm2 | |
| JP2016514695A5 (enExample) | ||
| JP2017528464A5 (enExample) | ||
| JP2017538659A5 (enExample) | ||
| JP2017526706A5 (enExample) | ||
| JP2017527577A5 (enExample) | ||
| JP2019514950A5 (enExample) | ||
| CY1121661T1 (el) | Παραγωγα πυριδονης ως αναστολεις της αναδιαταγμενης κατα τη διαμολυνση (ret) κινασης | |
| JP2017527576A5 (enExample) | ||
| Kamdje et al. | Signaling pathways in breast cancer: therapeutic targeting of the microenvironment | |
| DOP2017000067A (es) | Nuevos compuestos como inhibidores de reorganizado durante la transfección (ret) | |
| Bellaye et al. | Heat shock proteins in fibrosis and wound healing: good or evil? | |
| JP2017528461A5 (enExample) | ||
| JP2009515851A5 (enExample) | ||
| IL272697B1 (en) | A polymorphic form of tg02 | |
| Park et al. | Olmutinib (BI 1482694; HM61713), an EGFR mutant-specific inhibitor, in T790M+ NSCLC: efficacy and safety at the RP2D | |
| JP2015533796A5 (enExample) | ||
| Sharma et al. | ErbBs in lung cancer | |
| NZ595602A (en) | Anti-cancer drugs, and uses relating for malignant melanoma and other cancers | |
| JP2019507143A5 (enExample) | ||
| RU2016118008A (ru) | Применение ингибиторов бромодомена свр/ер300 для иммунотерапии рака | |
| EA201492004A1 (ru) | Органические композиции для лечения kras-ассоциированных заболеваний | |
| EA200901538A1 (ru) | Замещенные пирролопиридины и пиразолопиридины в качестве модуляторов киназ | |
| FI4053128T3 (fi) | 5-(2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)-3-(1h-pyratsol-1-yyli)pyratsolo[1,5-a]pyrimidiinijohdannaisia ja niihin liittyviä yhdisteitä trk-kinaasinhibiittoreina syövän hoitoon | |
| JP2024506612A5 (enExample) |