JP2017528460A5 - - Google Patents
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- JP2017528460A5 JP2017528460A5 JP2017512975A JP2017512975A JP2017528460A5 JP 2017528460 A5 JP2017528460 A5 JP 2017528460A5 JP 2017512975 A JP2017512975 A JP 2017512975A JP 2017512975 A JP2017512975 A JP 2017512975A JP 2017528460 A5 JP2017528460 A5 JP 2017528460A5
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- cancer
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- lymphoma
- carcinoma
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- 102000004169 proteins and genes Human genes 0.000 claims 1
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- 239000012453 solvate Substances 0.000 claims 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
- 229960000553 somatostatin Drugs 0.000 claims 1
- 208000013077 thyroid gland carcinoma Diseases 0.000 claims 1
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 claims 1
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| US201462048760P | 2014-09-10 | 2014-09-10 | |
| US62/048,760 | 2014-09-10 | ||
| PCT/US2015/049231 WO2016040511A1 (en) | 2014-09-10 | 2015-09-09 | Isoxazole carboxamides as irreversible smyd inhibitors |
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| JP2017528460A JP2017528460A (ja) | 2017-09-28 |
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| WO (1) | WO2016040511A1 (enExample) |
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| MX2017002985A (es) | 2014-09-10 | 2017-11-17 | Epizyme Inc | Inhibidores de smyd. |
| CA2960274A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| WO2016040502A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| JP2017528464A (ja) | 2014-09-10 | 2017-09-28 | エピザイム，インコーポレイティド | 置換ピペリジン化合物 |
| WO2016040511A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| CN114246851B (zh) * | 2021-11-09 | 2024-01-26 | 澳门科技大学 | 一种组蛋白甲基转移酶smyd3小分子抑制剂的合成方法及用途 |
| CN115998869B (zh) * | 2022-09-23 | 2025-08-05 | 华中科技大学同济医学院附属同济医院 | 组蛋白甲基转移酶smyd2在制备防治血管损伤后内膜新生导致再狭窄的药物中的应用 |
| IT202200021138A1 (it) * | 2022-10-13 | 2024-04-13 | Istituto Di Ricovero E Cura A Carattere Scient Saverio De Bellis | Formulati farmaceutici con attività inibente le metiltrasferasi istoniche per il trattamento di patologie neoplastiche |
| CN116211867A (zh) * | 2022-12-30 | 2023-06-06 | 复旦大学附属肿瘤医院 | Az505和恩杂鲁胺在制备治疗前列腺癌药物中的用途 |
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| EP1597256A1 (en) * | 2003-02-21 | 2005-11-23 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
| CN1528745A (zh) * | 2003-10-21 | 2004-09-15 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其制备方法 |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| US20090062286A1 (en) | 2007-05-04 | 2009-03-05 | Kenneth William Foreman | Crystal Structure of SMYD3 Protein |
| US20130072470A1 (en) * | 2011-09-21 | 2013-03-21 | Abbvie Inc. | Novel tricyclic compounds |
| MX2017002985A (es) | 2014-09-10 | 2017-11-17 | Epizyme Inc | Inhibidores de smyd. |
| CA2960274A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| US20170253601A1 (en) | 2014-09-10 | 2017-09-07 | Epizyme, Inc. | Substituted Pyrrolidine Compounds |
| WO2016040502A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| JP2017528461A (ja) | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 置換ピロリジンカルボキサミド化合物 |
| JP2017528464A (ja) * | 2014-09-10 | 2017-09-28 | エピザイム，インコーポレイティド | 置換ピペリジン化合物 |
| WO2016040511A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
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- 2015-09-09 AU AU2015315180A patent/AU2015315180A1/en not_active Abandoned
- 2015-09-09 JP JP2017512975A patent/JP2017528460A/ja active Pending
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2019
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