AU2015315180A1 - Isoxazole carboxamides as irreversible SMYD inhibitors - Google Patents
Isoxazole carboxamides as irreversible SMYD inhibitors Download PDFInfo
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- AU2015315180A1 AU2015315180A1 AU2015315180A AU2015315180A AU2015315180A1 AU 2015315180 A1 AU2015315180 A1 AU 2015315180A1 AU 2015315180 A AU2015315180 A AU 2015315180A AU 2015315180 A AU2015315180 A AU 2015315180A AU 2015315180 A1 AU2015315180 A1 AU 2015315180A1
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- ZNJHFNUEQDVFCJ-UHFFFAOYSA-M sodium;2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid;hydroxide Chemical compound [OH-].[Na+].OCCN1CCN(CCS(O)(=O)=O)CC1 ZNJHFNUEQDVFCJ-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048760P | 2014-09-10 | 2014-09-10 | |
| US62/048,760 | 2014-09-10 | ||
| PCT/US2015/049231 WO2016040511A1 (en) | 2014-09-10 | 2015-09-09 | Isoxazole carboxamides as irreversible smyd inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AU2015315180A1 true AU2015315180A1 (en) | 2017-03-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| AU2015315180A Abandoned AU2015315180A1 (en) | 2014-09-10 | 2015-09-09 | Isoxazole carboxamides as irreversible SMYD inhibitors |
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| Country | Link |
|---|---|
| US (2) | US10179773B2 (enExample) |
| EP (1) | EP3193606B1 (enExample) |
| JP (1) | JP2017528460A (enExample) |
| AU (1) | AU2015315180A1 (enExample) |
| CA (1) | CA2960279A1 (enExample) |
| WO (1) | WO2016040511A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015315167A1 (en) | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| CN107072207A (zh) | 2014-09-10 | 2017-08-18 | Epizyme股份有限公司 | 经取代的哌啶化合物 |
| JP2017528460A (ja) * | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド |
| EP3193600A4 (en) | 2014-09-10 | 2018-05-23 | Epizyme, Inc. | Smyd inhibitors |
| CA2960271A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| CN114246851B (zh) * | 2021-11-09 | 2024-01-26 | 澳门科技大学 | 一种组蛋白甲基转移酶smyd3小分子抑制剂的合成方法及用途 |
| CN115998869B (zh) * | 2022-09-23 | 2025-08-05 | 华中科技大学同济医学院附属同济医院 | 组蛋白甲基转移酶smyd2在制备防治血管损伤后内膜新生导致再狭窄的药物中的应用 |
| IT202200021138A1 (it) * | 2022-10-13 | 2024-04-13 | Istituto Di Ricovero E Cura A Carattere Scient Saverio De Bellis | Formulati farmaceutici con attività inibente le metiltrasferasi istoniche per il trattamento di patologie neoplastiche |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004074283A1 (en) * | 2003-02-21 | 2004-09-02 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
| CN1528745A (zh) * | 2003-10-21 | 2004-09-15 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其制备方法 |
| AR052559A1 (es) | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| WO2008137834A2 (en) | 2007-05-04 | 2008-11-13 | Osi Pharmaceuticals, Inc. | Crystal structure of smyd3 protein |
| WO2013043826A1 (en) * | 2011-09-21 | 2013-03-28 | Abbvie Inc. | Tricyclic compounds useful as protein kinase inhibitors |
| AU2015315167A1 (en) * | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| CN107072207A (zh) | 2014-09-10 | 2017-08-18 | Epizyme股份有限公司 | 经取代的哌啶化合物 |
| WO2016040504A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted pyrrolidine compounds |
| AU2015315177A1 (en) | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted pyrrolidine carboxamide compounds |
| JP2017528460A (ja) * | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド |
| EP3193600A4 (en) | 2014-09-10 | 2018-05-23 | Epizyme, Inc. | Smyd inhibitors |
| CA2960271A1 (en) * | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
-
2015
- 2015-09-09 JP JP2017512975A patent/JP2017528460A/ja active Pending
- 2015-09-09 WO PCT/US2015/049231 patent/WO2016040511A1/en not_active Ceased
- 2015-09-09 EP EP15840663.7A patent/EP3193606B1/en active Active
- 2015-09-09 AU AU2015315180A patent/AU2015315180A1/en not_active Abandoned
- 2015-09-09 CA CA2960279A patent/CA2960279A1/en not_active Abandoned
- 2015-09-09 US US15/510,589 patent/US10179773B2/en active Active
-
2019
- 2019-01-11 US US16/245,986 patent/US10669243B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016040511A1 (en) | 2016-03-17 |
| US20180230110A1 (en) | 2018-08-16 |
| US10179773B2 (en) | 2019-01-15 |
| US10669243B2 (en) | 2020-06-02 |
| CA2960279A1 (en) | 2016-03-17 |
| US20190241529A1 (en) | 2019-08-08 |
| JP2017528460A (ja) | 2017-09-28 |
| EP3193606B1 (en) | 2020-06-24 |
| EP3193606A1 (en) | 2017-07-26 |
| EP3193606A4 (en) | 2018-04-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK5 | Application lapsed section 142(2)(e) - patent request and compl. specification not accepted |