CA2960279A1 - Isoxazole carboxamides as irreversible smyd inhibitors - Google Patents
Isoxazole carboxamides as irreversible smyd inhibitors Download PDFInfo
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- CA2960279A1 CA2960279A1 CA2960279A CA2960279A CA2960279A1 CA 2960279 A1 CA2960279 A1 CA 2960279A1 CA 2960279 A CA2960279 A CA 2960279A CA 2960279 A CA2960279 A CA 2960279A CA 2960279 A1 CA2960279 A1 CA 2960279A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048760P | 2014-09-10 | 2014-09-10 | |
| US62/048,760 | 2014-09-10 | ||
| PCT/US2015/049231 WO2016040511A1 (en) | 2014-09-10 | 2015-09-09 | Isoxazole carboxamides as irreversible smyd inhibitors |
Publications (1)
| Publication Number | Publication Date |
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| CA2960279A1 true CA2960279A1 (en) | 2016-03-17 |
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| JP (1) | JP2017528460A (enExample) |
| AU (1) | AU2015315180A1 (enExample) |
| CA (1) | CA2960279A1 (enExample) |
| WO (1) | WO2016040511A1 (enExample) |
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| JP2017526706A (ja) | 2014-09-10 | 2017-09-14 | エピザイム，インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| AU2015315171A1 (en) | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| MX2017002986A (es) | 2014-09-10 | 2017-10-24 | Epizyme Inc | Compuestos de piperidina sustituidos. |
| KR102496364B1 (ko) | 2014-09-10 | 2023-02-06 | 에피자임, 인코포레이티드 | Ｓｍｙｄ 억제제 |
| JP2017528460A (ja) * | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド |
| CN114246851B (zh) * | 2021-11-09 | 2024-01-26 | 澳门科技大学 | 一种组蛋白甲基转移酶smyd3小分子抑制剂的合成方法及用途 |
| CN115998869B (zh) * | 2022-09-23 | 2025-08-05 | 华中科技大学同济医学院附属同济医院 | 组蛋白甲基转移酶smyd2在制备防治血管损伤后内膜新生导致再狭窄的药物中的应用 |
| IT202200021138A1 (it) * | 2022-10-13 | 2024-04-13 | Istituto Di Ricovero E Cura A Carattere Scient Saverio De Bellis | Formulati farmaceutici con attività inibente le metiltrasferasi istoniche per il trattamento di patologie neoplastiche |
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| EP1597256A1 (en) * | 2003-02-21 | 2005-11-23 | Pfizer Inc. | N-heterocyclyl-substituted amino-thiazole derivatives as protein kinase inhibitors |
| CN1528745A (zh) * | 2003-10-21 | 2004-09-15 | 山东大学 | 吡咯烷类基质金属蛋白酶抑制剂及其制备方法 |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| WO2008137834A2 (en) * | 2007-05-04 | 2008-11-13 | Osi Pharmaceuticals, Inc. | Crystal structure of smyd3 protein |
| WO2013043826A1 (en) * | 2011-09-21 | 2013-03-28 | Abbvie Inc. | Tricyclic compounds useful as protein kinase inhibitors |
| JP2017526706A (ja) * | 2014-09-10 | 2017-09-14 | エピザイム，インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| AU2015315171A1 (en) * | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| MX2017002986A (es) * | 2014-09-10 | 2017-10-24 | Epizyme Inc | Compuestos de piperidina sustituidos. |
| KR102496364B1 (ko) | 2014-09-10 | 2023-02-06 | 에피자임, 인코포레이티드 | Ｓｍｙｄ 억제제 |
| JP2017528460A (ja) * | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド |
| US20170247326A1 (en) | 2014-09-10 | 2017-08-31 | Epizyme, Inc. | Substituted Pyrrolidine Carboxamide Compounds |
| US20170253601A1 (en) | 2014-09-10 | 2017-09-07 | Epizyme, Inc. | Substituted Pyrrolidine Compounds |
-
2015
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- 2015-09-09 WO PCT/US2015/049231 patent/WO2016040511A1/en not_active Ceased
- 2015-09-09 CA CA2960279A patent/CA2960279A1/en not_active Abandoned
- 2015-09-09 US US15/510,589 patent/US10179773B2/en active Active
- 2015-09-09 EP EP15840663.7A patent/EP3193606B1/en active Active
- 2015-09-09 AU AU2015315180A patent/AU2015315180A1/en not_active Abandoned
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2019
- 2019-01-11 US US16/245,986 patent/US10669243B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10179773B2 (en) | 2019-01-15 |
| EP3193606B1 (en) | 2020-06-24 |
| WO2016040511A1 (en) | 2016-03-17 |
| EP3193606A1 (en) | 2017-07-26 |
| US20180230110A1 (en) | 2018-08-16 |
| US20190241529A1 (en) | 2019-08-08 |
| JP2017528460A (ja) | 2017-09-28 |
| EP3193606A4 (en) | 2018-04-11 |
| AU2015315180A1 (en) | 2017-03-16 |
| US10669243B2 (en) | 2020-06-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |
Effective date: 20211201 |
|
| FZDE | Discontinued |
Effective date: 20211201 |