|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
NO812612L
(no)
|
1980-08-06 |
1982-02-08 |
Ferring Pharma Ltd |
Enzym-inhibitorer.
|
|
US4366241A
(en)
|
1980-08-07 |
1982-12-28 |
Syva Company |
Concentrating zone method in heterogeneous immunoassays
|
|
US4517288A
(en)
|
1981-01-23 |
1985-05-14 |
American Hospital Supply Corp. |
Solid phase system for ligand assay
|
|
US4475196A
(en)
|
1981-03-06 |
1984-10-02 |
Zor Clair G |
Instrument for locating faults in aircraft passenger reading light and attendant call control system
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
US4439196A
(en)
|
1982-03-18 |
1984-03-27 |
Merck & Co., Inc. |
Osmotic drug delivery system
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
US4870009A
(en)
|
1982-11-22 |
1989-09-26 |
The Salk Institute For Biological Studies |
Method of obtaining gene product through the generation of transgenic animals
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4486194A
(en)
|
1983-06-08 |
1984-12-04 |
James Ferrara |
Therapeutic device for administering medicaments through the skin
|
|
DE3572982D1
(en)
|
1984-03-06 |
1989-10-19 |
Takeda Chemical Industries Ltd |
Chemically modified lymphokine and production thereof
|
|
US5288641A
(en)
|
1984-06-04 |
1994-02-22 |
Arch Development Corporation |
Herpes Simplex virus as a vector
|
|
US4736866B1
(en)
|
1984-06-22 |
1988-04-12 |
|
Transgenic non-human mammals
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
US4699880A
(en)
|
1984-09-25 |
1987-10-13 |
Immunomedics, Inc. |
Method of producing monoclonal anti-idiotype antibody
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
|
US4676980A
(en)
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US5139941A
(en)
|
1985-10-31 |
1992-08-18 |
University Of Florida Research Foundation, Inc. |
AAV transduction vectors
|
|
DE3689123T2
(de)
|
1985-11-01 |
1994-03-03 |
Xoma Corp |
Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
|
|
CA1291031C
(en)
|
1985-12-23 |
1991-10-22 |
Nikolaas C.J. De Jaeger |
Method for the detection of specific binding agents and their correspondingbindable substances
|
|
WO1987005330A1
(en)
|
1986-03-07 |
1987-09-11 |
Michel Louis Eugene Bergh |
Method for enhancing glycoprotein stability
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
|
DE122007000007I2
(de)
|
1986-04-09 |
2010-12-30 |
Genzyme Corp |
Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
|
|
US4954617A
(en)
|
1986-07-07 |
1990-09-04 |
Trustees Of Dartmouth College |
Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes
|
|
US4902505A
(en)
|
1986-07-30 |
1990-02-20 |
Alkermes |
Chimeric peptides for neuropeptide delivery through the blood-brain barrier
|
|
US4881175A
(en)
|
1986-09-02 |
1989-11-14 |
Genex Corporation |
Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4987071A
(en)
|
1986-12-03 |
1991-01-22 |
University Patents, Inc. |
RNA ribozyme polymerases, dephosphorylases, restriction endoribonucleases and methods
|
|
US5116742A
(en)
|
1986-12-03 |
1992-05-26 |
University Patents, Inc. |
RNA ribozyme restriction endoribonucleases and methods
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・２・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
US5013653A
(en)
|
1987-03-20 |
1991-05-07 |
Creative Biomolecules, Inc. |
Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
|
|
US5132405A
(en)
|
1987-05-21 |
1992-07-21 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5091513A
(en)
|
1987-05-21 |
1992-02-25 |
Creative Biomolecules, Inc. |
Biosynthetic antibody binding sites
|
|
US5258498A
(en)
|
1987-05-21 |
1993-11-02 |
Creative Biomolecules, Inc. |
Polypeptide linkers for production of biosynthetic proteins
|
|
ATE243754T1
(de)
|
1987-05-21 |
2003-07-15 |
Micromet Ag |
Multifunktionelle proteine mit vorbestimmter zielsetzung
|
|
US4904582A
(en)
|
1987-06-11 |
1990-02-27 |
Synthetic Genetics |
Novel amphiphilic nucleic acid conjugates
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5677425A
(en)
|
1987-09-04 |
1997-10-14 |
Celltech Therapeutics Limited |
Recombinant antibody
|
|
US5476996A
(en)
|
1988-06-14 |
1995-12-19 |
Lidak Pharmaceuticals |
Human immune system in non-human animal
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
GB8823869D0
(en)
|
1988-10-12 |
1988-11-16 |
Medical Res Council |
Production of antibodies
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5116964A
(en)
|
1989-02-23 |
1992-05-26 |
Genentech, Inc. |
Hybrid immunoglobulins
|
|
US5328470A
(en)
|
1989-03-31 |
1994-07-12 |
The Regents Of The University Of Michigan |
Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
US5763266A
(en)
|
1989-06-15 |
1998-06-09 |
The Regents Of The University Of Michigan |
Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells
|
|
DE3923279A1
(de)
|
1989-07-14 |
1990-01-18 |
Will W Prof Dr Minuth |
Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren
|
|
EP0945515A3
(en)
|
1989-11-06 |
2002-08-21 |
Cell Genesys, Inc. |
Production of proteins using homologous recombination
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US5859205A
(en)
|
1989-12-21 |
1999-01-12 |
Celltech Limited |
Humanised antibodies
|
|
US5272071A
(en)
|
1989-12-22 |
1993-12-21 |
Applied Research Systems Ars Holding N.V. |
Method for the modification of the expression characteristics of an endogenous gene of a given cell line
|
|
US6153737A
(en)
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US6673986B1
(en)
|
1990-01-12 |
2004-01-06 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
US6075181A
(en)
|
1990-01-12 |
2000-06-13 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
US6150584A
(en)
|
1990-01-12 |
2000-11-21 |
Abgenix, Inc. |
Human antibodies derived from immunized xenomice
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US5283173A
(en)
|
1990-01-24 |
1994-02-01 |
The Research Foundation Of State University Of New York |
System to detect protein-protein interactions
|
|
US6641809B1
(en)
|
1990-03-26 |
2003-11-04 |
Bristol-Myers Squibb Company |
Method of regulating cellular processes mediated by B7 and CD28
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US6172197B1
(en)
|
1991-07-10 |
2001-01-09 |
Medical Research Council |
Methods for producing members of specific binding pairs
|
|
US5814318A
(en)
|
1990-08-29 |
1998-09-29 |
Genpharm International Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5661016A
(en)
|
1990-08-29 |
1997-08-26 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US5545806A
(en)
|
1990-08-29 |
1996-08-13 |
Genpharm International, Inc. |
Ransgenic non-human animals for producing heterologous antibodies
|
|
US5625126A
(en)
|
1990-08-29 |
1997-04-29 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
WO1993012227A1
(en)
|
1991-12-17 |
1993-06-24 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5789650A
(en)
|
1990-08-29 |
1998-08-04 |
Genpharm International, Inc. |
Transgenic non-human animals for producing heterologous antibodies
|
|
US5877397A
(en)
|
1990-08-29 |
1999-03-02 |
Genpharm International Inc. |
Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
|
|
US6300129B1
(en)
|
1990-08-29 |
2001-10-09 |
Genpharm International |
Transgenic non-human animals for producing heterologous antibodies
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US6255458B1
(en)
|
1990-08-29 |
2001-07-03 |
Genpharm International |
High affinity human antibodies and human antibodies against digoxin
|
|
US5633425A
(en)
|
1990-08-29 |
1997-05-27 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5874299A
(en)
|
1990-08-29 |
1999-02-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5747469A
(en)
|
1991-03-06 |
1998-05-05 |
Board Of Regents, The University Of Texas System |
Methods and compositions comprising DNA damaging agents and p53
|
|
SG47766A1
(en)
|
1991-03-12 |
1998-04-17 |
Biogen Inc |
CD2-binding domain of lymphocyte function associated antigen 3
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
US5844095A
(en)
|
1991-06-27 |
1998-12-01 |
Bristol-Myers Squibb Company |
CTLA4 Ig fusion proteins
|
|
US5851795A
(en)
|
1991-06-27 |
1998-12-22 |
Bristol-Myers Squibb Company |
Soluble CTLA4 molecules and uses thereof
|
|
IL99120A0
(en)
|
1991-08-07 |
1992-07-15 |
Yeda Res & Dev |
Multimers of the soluble forms of tnf receptors,their preparation and pharmaceutical compositions containing them
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
WO1993008829A1
(en)
|
1991-11-04 |
1993-05-13 |
The Regents Of The University Of California |
Compositions that mediate killing of hiv-infected cells
|
|
US5932448A
(en)
|
1991-11-29 |
1999-08-03 |
Protein Design Labs., Inc. |
Bispecific antibody heterodimers
|
|
PT1024191E
(pt)
|
1991-12-02 |
2008-12-22 |
Medical Res Council |
Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos
|
|
US5776427A
(en)
|
1992-03-05 |
1998-07-07 |
Board Of Regents, The University Of Texas System |
Methods for targeting the vasculature of solid tumors
|
|
US5714350A
(en)
|
1992-03-09 |
1998-02-03 |
Protein Design Labs, Inc. |
Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region
|
|
CA2118508A1
(en)
|
1992-04-24 |
1993-11-11 |
Elizabeth S. Ward |
Recombinant production of immunoglobulin-like domains in prokaryotic cells
|
|
US6172208B1
(en)
|
1992-07-06 |
2001-01-09 |
Genzyme Corporation |
Oligonucleotides modified with conjugate groups
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
WO1994010300A1
(en)
|
1992-10-30 |
1994-05-11 |
The General Hospital Corporation |
Interaction trap system for isolating novel proteins
|
|
GB9223377D0
(en)
|
1992-11-04 |
1992-12-23 |
Medarex Inc |
Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes
|
|
GB9225453D0
(en)
|
1992-12-04 |
1993-01-27 |
Medical Res Council |
Binding proteins
|
|
GB9302660D0
(en)
|
1993-02-10 |
1993-03-24 |
Sihra Kirpal S |
A building system
|
|
AU6445894A
(en)
|
1993-03-19 |
1994-10-11 |
Duke University |
Method of treatment of tumors with an antibody binding to tenascin
|
|
JPH08509612A
(ja)
|
1993-04-26 |
1996-10-15 |
ジェンファーム インターナショナル インコーポレイテッド |
異種抗体を産生することができるトランスジェニック非ヒト動物
|
|
ATE293686T1
(de)
|
1993-06-04 |
2005-05-15 |
Us Navy |
Verfahren zur selektiven stimulierung der t- zellproliferation.
|
|
AU691811B2
(en)
|
1993-06-16 |
1998-05-28 |
Celltech Therapeutics Limited |
Antibodies
|
|
CA2167091A1
(en)
*
|
1993-07-26 |
1995-02-02 |
Gordon J. Freeman |
B7-2: ctl a4/cd 28 counter receptor
|
|
ATE247128T1
(de)
|
1993-09-03 |
2003-08-15 |
Isis Pharmaceuticals Inc |
Aminoderivatisierte nukleoside und oligonukleoside
|
|
DE69534530T2
(de)
|
1994-08-12 |
2006-07-06 |
Immunomedics, Inc. |
Für b-zell-lymphom und leukämiezellen spezifische immunkonjugate und humane antikörper
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5801155A
(en)
|
1995-04-03 |
1998-09-01 |
Epoch Pharmaceuticals, Inc. |
Covalently linked oligonucleotide minor grove binder conjugates
|
|
US6121022A
(en)
|
1995-04-14 |
2000-09-19 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US5869046A
(en)
|
1995-04-14 |
1999-02-09 |
Genentech, Inc. |
Altered polypeptides with increased half-life
|
|
US6096532A
(en)
|
1995-06-07 |
2000-08-01 |
Aastrom Biosciences, Inc. |
Processor apparatus for use in a system for maintaining and growing biological cells
|
|
US5985653A
(en)
|
1995-06-07 |
1999-11-16 |
Aastrom Biosciences, Inc. |
Incubator apparatus for use in a system for maintaining and growing biological cells
|
|
US6410690B1
(en)
|
1995-06-07 |
2002-06-25 |
Medarex, Inc. |
Therapeutic compounds comprised of anti-Fc receptor antibodies
|
|
US5811097A
(en)
|
1995-07-25 |
1998-09-22 |
The Regents Of The University Of California |
Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
|
|
GB9517780D0
(en)
|
1995-08-31 |
1995-11-01 |
Roslin Inst Edinburgh |
Biological manipulation
|
|
GB9517779D0
(en)
|
1995-08-31 |
1995-11-01 |
Roslin Inst Edinburgh |
Biological manipulation
|
|
US5723125A
(en)
|
1995-12-28 |
1998-03-03 |
Tanox Biosystems, Inc. |
Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide
|
|
US6750334B1
(en)
|
1996-02-02 |
2004-06-15 |
Repligen Corporation |
CTLA4-immunoglobulin fusion proteins having modified effector functions and uses therefor
|
|
US6444806B1
(en)
|
1996-04-30 |
2002-09-03 |
Hisamitsu Pharmaceutical Co., Inc. |
Conjugates and methods of forming conjugates of oligonucleotides and carbohydrates
|
|
US5922845A
(en)
|
1996-07-11 |
1999-07-13 |
Medarex, Inc. |
Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies
|
|
US6653104B2
(en)
|
1996-10-17 |
2003-11-25 |
Immunomedics, Inc. |
Immunotoxins, comprising an internalizing antibody, directed against malignant and normal cells
|
|
ATE336240T1
(de)
|
1996-11-13 |
2006-09-15 |
Cold Spring Harbor Lab |
Therapeutische verwendung von stickstoffmonoxydinhibitoren
|
|
US6593372B2
(en)
|
1996-11-13 |
2003-07-15 |
Cold Spring Harbor Laboratory |
Therapeutic uses for nitric oxide inhibitors
|
|
US6277375B1
(en)
|
1997-03-03 |
2001-08-21 |
Board Of Regents, The University Of Texas System |
Immunoglobulin-like domains with increased half-lives
|
|
US20060084082A1
(en)
|
1997-03-07 |
2006-04-20 |
Human Genome Sciences, Inc. |
186 human secreted proteins
|
|
DE19742706B4
(de)
|
1997-09-26 |
2013-07-25 |
Pieris Proteolab Ag |
Lipocalinmuteine
|
|
WO1999026657A1
(en)
|
1997-11-25 |
1999-06-03 |
Musc Foundation For Research Development |
Inhibitors of nitric oxide synthase
|
|
US6982323B1
(en)
|
1997-12-23 |
2006-01-03 |
Alexion Pharmaceuticals, Inc. |
Chimeric proteins for diagnosis and treatment of diabetes
|
|
US6006758A
(en)
|
1998-02-03 |
1999-12-28 |
University Of Maryland |
Method and device for the detection and removal of head lice
|
|
US6194551B1
(en)
|
1998-04-02 |
2001-02-27 |
Genentech, Inc. |
Polypeptide variants
|
|
DK1071700T3
(da)
|
1998-04-20 |
2010-06-07 |
Glycart Biotechnology Ag |
Glykosylerings-modifikation af antistoffer til forbedring af antistofafhængig cellulær cytotoksicitet
|
|
US6300319B1
(en)
|
1998-06-16 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Targeted oligonucleotide conjugates
|
|
DK1100811T3
(da)
|
1998-07-28 |
2007-11-05 |
Univ California |
Nucleinsyrer, som koder for en G-protein-koblet receptor involveret i sensorisk transduktion
|
|
US6936697B2
(en)
|
1998-09-01 |
2005-08-30 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US20030096955A1
(en)
|
1998-09-01 |
2003-05-22 |
Genentech, Inc. |
Secreted and transmembrane polypeptides and nucleic acids encoding the same
|
|
US6335437B1
(en)
|
1998-09-07 |
2002-01-01 |
Isis Pharmaceuticals, Inc. |
Methods for the preparation of conjugated oligomers
|
|
JP2000184880A
(ja)
*
|
1998-10-14 |
2000-07-04 |
Kanegafuchi Chem Ind Co Ltd |
ガン細胞特異的傷害性ｔ細胞の増殖・活性化誘導方法及びそれに用いるデバイス
|
|
IL127127A0
(en)
|
1998-11-18 |
1999-09-22 |
Peptor Ltd |
Small functional units of antibody heavy chain variable regions
|
|
DK1133517T3
(da)
|
1998-11-24 |
2009-11-23 |
Bristol Myers Squibb Co |
Intranuklear målrettet transport af forbindelser ved hjælp af 70 kd varmeshock-protein
|
|
US6818418B1
(en)
|
1998-12-10 |
2004-11-16 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
US7115396B2
(en)
|
1998-12-10 |
2006-10-03 |
Compound Therapeutics, Inc. |
Protein scaffolds for antibody mimics and other binding proteins
|
|
PL209392B1
(pl)
|
1999-01-15 |
2011-08-31 |
Genentech Inc |
Przeciwciało, komórka gospodarza, sposób wytwarzania przeciwciała oraz zastosowanie przeciwciała
|
|
CA2704600C
(en)
|
1999-04-09 |
2016-10-25 |
Kyowa Kirin Co., Ltd. |
A method for producing antibodies with increased adcc activity
|
|
US6696686B1
(en)
|
1999-06-06 |
2004-02-24 |
Elgems Ltd. |
SPECT for breast cancer detection
|
|
CA2377513A1
(en)
|
1999-06-25 |
2001-01-04 |
Universitat Zurich |
Hetero-associating coiled-coil peptides
|
|
WO2001001137A1
(en)
|
1999-06-30 |
2001-01-04 |
Children's Medical Center Corporation |
Fusion protein and uses thereof
|
|
US7754855B1
(en)
|
1999-07-13 |
2010-07-13 |
Bolder Biotechnology, Inc. |
Immunoglobulin fusion proteins
|
|
PL354286A1
(en)
|
1999-08-23 |
2003-12-29 |
Dana-Farber Cancer Institutedana-Farber Cancer Institute |
Pd-1, a receptor for b7-4, and uses therefor
|
|
EP1212422B1
(en)
|
1999-08-24 |
2007-02-21 |
Medarex, Inc. |
Human ctla-4 antibodies and their uses
|
|
US6395437B1
(en)
|
1999-10-29 |
2002-05-28 |
Advanced Micro Devices, Inc. |
Junction profiling using a scanning voltage micrograph
|
|
GEP20094625B
(en)
|
2000-03-24 |
2009-03-10 |
Pharmacia Corp |
Amidino compound and salts thereof useful as nitric oxide synthase inhibitors
|
|
JP2003531588A
(ja)
|
2000-04-11 |
2003-10-28 |
ジェネンテック・インコーポレーテッド |
多価抗体とその用途
|
|
US6545170B2
(en)
|
2000-04-13 |
2003-04-08 |
Pharmacia Corporation |
2-amino-5, 6 heptenoic acid derivatives useful as nitric oxide synthase inhibitors
|
|
EP1332209B1
(en)
|
2000-09-08 |
2009-11-11 |
Universität Zürich |
Collections of repeat proteins comprising repeat modules
|
|
US6559279B1
(en)
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
|
EP1373501A2
(en)
|
2000-10-06 |
2004-01-02 |
Novartis AG |
Targeting molecules for adenoviral vectors
|
|
CA2430013C
(en)
|
2000-11-30 |
2011-11-22 |
Medarex, Inc. |
Transgenic transchromosomal rodents for making human antibodies
|
|
US6562576B2
(en)
|
2001-01-04 |
2003-05-13 |
Myriad Genetics, Inc. |
Yeast two-hybrid system and use thereof
|
|
US20050063948A1
(en)
|
2001-03-08 |
2005-03-24 |
Dickerson Erin B. |
Methods for targeting interleukin-12 to malignant endothelium
|
|
AU2002338265A1
(en)
|
2001-03-28 |
2002-10-15 |
Incyte Genomics, Inc. |
Molecules for disease detection and treatment
|
|
ITTV20010035A1
(it)
|
2001-03-30 |
2002-09-30 |
Bettio Group Srl |
Zanzariera con dispositivo di aggancio e sgancio rapido della barra maniglia
|
|
WO2002092780A2
(en)
|
2001-05-17 |
2002-11-21 |
Diversa Corporation |
Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof
|
|
BRPI0209933B8
(pt)
|
2001-05-24 |
2021-05-25 |
Zymogenetics Inc |
proteína de fusão, e, molécula de ácido nucleico
|
|
US20030031671A1
(en)
|
2001-08-01 |
2003-02-13 |
Sydney Welt |
Methods of treating colon cancer utilizing tumor-specific antibodies
|
|
PT1419179E
(pt)
|
2001-08-10 |
2010-03-16 |
Univ Aberdeen |
Domínios de ligação de antigenes
|
|
US6797493B2
(en)
|
2001-10-01 |
2004-09-28 |
Lee-Hwei K. Sun |
Fc fusion proteins of human granulocyte colony-stimulating factor with increased biological activities
|
|
CA2463879C
(en)
|
2001-10-25 |
2012-12-04 |
Genentech, Inc. |
Glycoprotein compositions
|
|
AU2003217912A1
(en)
|
2002-03-01 |
2003-09-16 |
Xencor |
Antibody optimization
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
NZ553470A
(en)
|
2002-03-15 |
2008-10-31 |
Schering Corp |
Methods of modulating CD200 receptors
|
|
BR0309145A
(pt)
|
2002-04-09 |
2005-02-01 |
Kyowa Hakko Kogyo Kk |
Células das quais o genoma é modificado
|
|
AU2003281200A1
(en)
*
|
2002-07-03 |
2004-01-23 |
Tasuku Honjo |
Immunopotentiating compositions
|
|
GB2392158B
(en)
|
2002-08-21 |
2005-02-16 |
Proimmune Ltd |
Chimeric MHC protein and oligomer thereof
|
|
BRPI0315666B8
(pt)
|
2002-10-23 |
2021-05-25 |
Ludwig Inst For Cancer Res Ltd |
dna de a34 e a33 do tipo 3, proteínas, seus anticorpos e métodos de tratamento usando os mesmos
|
|
MXPA05005051A
(es)
|
2002-11-12 |
2006-03-10 |
Albert B Deisseroth |
Vacuna de vector adenoviral.
|
|
CN101899114A
(zh)
|
2002-12-23 |
2010-12-01 |
惠氏公司 |
抗pd-1抗体及其用途
|
|
US20090010920A1
(en)
|
2003-03-03 |
2009-01-08 |
Xencor, Inc. |
Fc Variants Having Decreased Affinity for FcyRIIb
|
|
CA2531238C
(en)
|
2003-07-04 |
2015-02-24 |
Affibody Ab |
Polypeptides having binding affinity for her2
|
|
WO2005019255A1
(en)
|
2003-08-25 |
2005-03-03 |
Pieris Proteolab Ag |
Muteins of tear lipocalin
|
|
US20060134105A1
(en)
|
2004-10-21 |
2006-06-22 |
Xencor, Inc. |
IgG immunoglobulin variants with optimized effector function
|
|
EP1711196A4
(en)
|
2003-12-05 |
2011-09-14 |
Bristol Myers Squibb Co |
INHIBITORS OF TYPE-2 VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTORS
|
|
US20050256576A1
(en)
|
2004-05-13 |
2005-11-17 |
Moskowitz Nathan C |
Artificial expansile total lumbar and thoracic discs for posterior placement without supplemental instrumentation and its adaptation for anterior placement of artificial cervical, thoracic and lumbar discs
|
|
EP2194064A1
(en)
|
2004-05-13 |
2010-06-09 |
Eli Lilly & Company |
FGF-21 fusion proteins
|
|
PT1781682E
(pt)
|
2004-06-24 |
2013-05-14 |
Mayo Foundation |
B7-h5, um polipéptido coestimulante
|
|
WO2006050247A2
(en)
|
2004-10-29 |
2006-05-11 |
Neose Technologies, Inc. |
Remodeling and glycopegylation of fibroblast growth factor (fgf)
|
|
US7807619B2
(en)
|
2004-11-01 |
2010-10-05 |
The Regents Of The University Of California |
Compositions and methods for modification of biomolecules
|
|
US7700099B2
(en)
|
2005-02-14 |
2010-04-20 |
Merck & Co., Inc. |
Non-immunostimulatory antibody and compositions containing the same
|
|
US8236304B2
(en)
|
2005-04-25 |
2012-08-07 |
Trustees Of Dartmouth College |
Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate CD4+ and CD8+ T cell immunity
|
|
US8231872B2
(en)
|
2005-04-25 |
2012-07-31 |
The Trustees Of Dartmouth College |
Regulatory T cell mediator proteins and uses thereof
|
|
CA2611861C
(en)
*
|
2005-06-08 |
2017-11-28 |
The Brigham And Women's Hospital, Inc. |
Methods and compositions for the treatment of persistent infections
|
|
US20070009880A1
(en)
|
2005-07-11 |
2007-01-11 |
Toledo Luis H |
Methods And Solutions For Storing Donor Organs
|
|
US7531164B2
(en)
|
2005-10-21 |
2009-05-12 |
Duke University |
Preventing bacterial or viral infectivity and composition containing infection preventing additive
|
|
US7655778B2
(en)
|
2006-02-28 |
2010-02-02 |
Curonix Co., Ltd. |
SISP-1, a novel p53 target gene and use thereof
|
|
WO2008027236A2
(en)
|
2006-08-30 |
2008-03-06 |
Genentech, Inc. |
Multispecific antibodies
|
|
EP1958957A1
(en)
|
2007-02-16 |
2008-08-20 |
NascaCell Technologies AG |
Polypeptide comprising a knottin protein moiety
|
|
JP6157046B2
(ja)
|
2008-01-07 |
2017-07-05 |
アムジェン インコーポレイテッド |
静電的ステアリング（ｅｌｅｃｔｒｏｓｔａｔｉｃｓｔｅｅｒｉｎｇ）効果を用いた抗体Ｆｃヘテロ二量体分子を作製するための方法
|
|
CA2732574A1
(en)
|
2008-07-28 |
2010-02-04 |
Philip Tan |
Multi-specific binding proteins targeting b cell disorders
|
|
JP2012500855A
(ja)
|
2008-08-25 |
2012-01-12 |
アンプリミューン、インコーポレーテッド |
Ｐｄ−１アンタゴニストおよび感染性疾患を処置するための方法
|
|
CA2739454C
(en)
|
2008-10-03 |
2018-05-01 |
Emory University |
Methods for the treatment of graft-versus-host disease
|
|
US20100316639A1
(en)
|
2009-06-16 |
2010-12-16 |
Genentech, Inc. |
Biomarkers for igf-1r inhibitor therapy
|
|
ES2722300T3
(es)
|
2009-12-10 |
2019-08-09 |
Hoffmann La Roche |
Anticuerpos que se unen preferentemente al dominio extracelular 4 de CSF1R y su uso
|
|
WO2011090492A1
(en)
|
2010-01-19 |
2011-07-28 |
Immunomedics, Inc. |
Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r)
|
|
US20180237525A9
(en)
|
2010-03-26 |
2018-08-23 |
Randolph J. Noelle |
VISTA Agonist and Methods of Use
|
|
MX374075B
(es)
*
|
2010-03-26 |
2025-03-05 |
Dartmouth College |
Proteina mediadora de celula t regulatoria vista, agentes de enlace de vista y uso de los mismos.
|
|
US20150231215A1
(en)
|
2012-06-22 |
2015-08-20 |
Randolph J. Noelle |
VISTA Antagonist and Methods of Use
|
|
US10745467B2
(en)
|
2010-03-26 |
2020-08-18 |
The Trustees Of Dartmouth College |
VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders
|
|
EP2371369A1
(en)
|
2010-04-01 |
2011-10-05 |
Institut Gustave Roussy (IGR) |
EGFR inhibitor and antiviral agent for simultaneous, separate or sequential use in the treatment and/or prevention and/or palliation of cancer
|
|
US20110243943A1
(en)
|
2010-04-02 |
2011-10-06 |
Athena Discovery, Inc. |
Treatment using relaxin-fusion proteins with extended in vivo half-lives
|
|
ES2813415T3
(es)
|
2011-08-10 |
2021-03-23 |
Lankenau Inst Medical Res |
Métodos y composiciones para el tratamiento de enfermedades autoinmunes e inflamatorias
|
|
EP3202419A1
(en)
|
2012-06-06 |
2017-08-09 |
OncoMed Pharmaceuticals, Inc. |
Pvrig binding agents that modulate the hippo pathway and uses thereof
|
|
JP6285923B2
(ja)
|
2012-06-22 |
2018-02-28 |
トラスティーズ・オブ・ダートマス・カレッジ |
新規ＶＩＳＴＡ−Ｉｇコンストラクト及び自己免疫、アレルギー性及び炎症性障害の処置のためのＶＩＳＴＡ−Ｉｇの使用
|
|
US9890215B2
(en)
*
|
2012-06-22 |
2018-02-13 |
King's College London |
Vista modulators for diagnosis and treatment of cancer
|
|
US9381244B2
(en)
|
2012-09-07 |
2016-07-05 |
King's College London |
VISTA modulators for diagnosis and treatment of cancer
|
|
BR112015029395A2
(pt)
*
|
2013-05-24 |
2017-09-19 |
Medimmune Llc |
Anticorpos anti-b7-h5 e seus usos
|
|
SG11201509982UA
(enExample)
|
2013-06-06 |
2016-04-28 |
Igenica Biotherapeutics Inc |
|
|
WO2015097536A2
(en)
|
2013-12-24 |
2015-07-02 |
Janssen Pharmaceutical Nv |
Anti-vista antibodies and fragments
|
|
US11014987B2
(en)
|
2013-12-24 |
2021-05-25 |
Janssen Pharmaceutics Nv |
Anti-vista antibodies and fragments, uses thereof, and methods of identifying same
|
|
EP3094346B1
(en)
|
2014-01-14 |
2019-12-11 |
The Trustees Of Dartmouth College |
Vista antagonist and methods of use
|
|
SG11201608303QA
(en)
|
2014-04-04 |
2016-11-29 |
Del Mar Pharmaceuticals |
Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer
|
|
US11123426B2
(en)
|
2014-06-11 |
2021-09-21 |
The Trustees Of Dartmouth College |
Use of vista agonists and antagonists to suppress or enhance humoral immunity
|
|
CA2969730A1
(en)
|
2014-12-05 |
2016-06-09 |
Immunext, Inc. |
Identification of vsig8 as the putative vista receptor and its use thereof to produce vista/vsig8 modulators
|
|
CA2990360C
(en)
|
2015-06-24 |
2024-02-13 |
Janssen Pharmaceutica Nv |
Anti-vista antibodies and fragments
|
|
WO2017137830A1
(en)
|
2016-02-12 |
2017-08-17 |
Janssen Pharmaceutica Nv |
Anti-vista (b7h5) antibodies
|
|
WO2017181109A1
(en)
|
2016-04-15 |
2017-10-19 |
Michael Molloy |
Anti-human vista antibodies and use thereof
|
|
KR20230119259A
(ko)
|
2016-04-15 |
2023-08-16 |
이뮤넥스트, 인크. |
항-인간 vista 항체 및 이의 용도
|
|
WO2018027042A1
(en)
|
2016-08-03 |
2018-02-08 |
Bio-Techne Corporation |
Identification of vsig3/vista as a novel immune checkpoint and use thereof for immunotherapy
|