JP2017528461A5 - - Google Patents
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- JP2017528461A5 JP2017528461A5 JP2017512983A JP2017512983A JP2017528461A5 JP 2017528461 A5 JP2017528461 A5 JP 2017528461A5 JP 2017512983 A JP2017512983 A JP 2017512983A JP 2017512983 A JP2017512983 A JP 2017512983A JP 2017528461 A5 JP2017528461 A5 JP 2017528461A5
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
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| US62/146,804 | 2015-04-13 | ||
| PCT/US2015/049225 WO2016040508A1 (en) | 2014-09-10 | 2015-09-09 | Substituted pyrrolidine carboxamide compounds |
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| BR112017004589A2 (pt) | 2014-09-10 | 2018-01-23 | Epizyme Inc | composto, composição farmacêutica, método para tratar um paciente, uso de um composto, kit, e método para tratar um distúrbio mediado por proteína smyd |
| AU2015315174B2 (en) | 2014-09-10 | 2019-12-12 | Epizyme, Inc. | Smyd inhibitors |
| WO2016040511A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| EP3190891B1 (en) | 2014-09-10 | 2020-01-15 | Epizyme, Inc. | Isoxazolecarboxamide substituted by a cyclohexylamine as smyd protein inhibitors |
| CA2960274A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| WO2019043217A1 (en) | 2017-09-04 | 2019-03-07 | F. Hoffmann-La Roche Ag | DIHYDROBENZIMIDAZOLONES |
| ES2995214T3 (en) | 2019-03-06 | 2025-02-07 | C4 Therapeutics Inc | Heterocyclic compounds for medical treatment |
| GB201912674D0 (en) * | 2019-09-04 | 2019-10-16 | Mission Therapeutics Ltd | Novel compounds |
Family Cites Families (22)
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| GB1428493A (en) * | 1973-05-02 | 1976-03-17 | Science Union & Cie | Heterocyclic amides processes for their preparation and pharma ceutical compositions containing them |
| JPS52128368A (en) * | 1976-04-15 | 1977-10-27 | Yamanouchi Pharmaceut Co Ltd | Novel carboxylic acid amide derivatives and their preparation |
| GR66581B (enExample) * | 1978-02-21 | 1981-03-27 | Delalande Sa | |
| EP1013276A1 (en) * | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalkanes as CCR5 modulators |
| DE10148290A1 (de) * | 2001-09-29 | 2003-04-17 | Bayer Cropscience Gmbh | Heterocyclische Amide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung |
| AU2002363250A1 (en) * | 2001-11-01 | 2003-05-12 | Icagen, Inc. | Pyrazole-amides and-sulfonamides |
| DE602004015429D1 (de) * | 2003-03-11 | 2008-09-11 | Pfizer Prod Inc | Pyrazinverbindungen als inhibitoren des transforming growth factor (tgf) |
| EP1603917B1 (en) * | 2003-03-14 | 2010-11-24 | MediGene Ltd. | Immunomodulating heterocyclic compounds |
| TW200526641A (en) * | 2003-12-26 | 2005-08-16 | Daiichi Seiyaku Co | Amidopyrazole derivatives |
| US7514448B2 (en) * | 2004-04-02 | 2009-04-07 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
| WO2006086609A2 (en) * | 2005-02-10 | 2006-08-17 | Axys Pharmaceuticals, Inc. | Inhibitors of tryptase |
| WO2006107923A1 (en) * | 2005-04-05 | 2006-10-12 | Boehringer Ingelheim International Gmbh | Substituted benzylimidazoles useful for the treatment of inflammatory diseases |
| CN101160301B (zh) * | 2005-04-12 | 2012-03-28 | 索尔瓦药物有限公司 | 氨基烷基-酰胺基甲基-取代的2-(4-磺酰基氨基)-3-羟基-3,4-二氢-2h-色烯-6-基衍生物以及它们作为钾通道阻断剂的用途 |
| WO2007011760A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| EA017376B1 (ru) * | 2006-10-24 | 2012-12-28 | Янссен Фармацевтика Нв | Производные тетрагидронафталин-1-карбоновой кислоты, ингибирующие мтр |
| EP1975165A1 (de) * | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| AR066721A1 (es) * | 2007-05-24 | 2009-09-09 | Wyeth Corp | Derivados de benzo[d]imidazol-1-il, composicion farmaceutica, proceso de preparacion y uso. |
| AU2008279759A1 (en) * | 2007-07-20 | 2009-01-29 | Merck & Co., Inc. | Pyrazolo[1,5-a]pyrimidine derivatives |
| EP2307378A1 (en) * | 2008-06-18 | 2011-04-13 | Pfizer Limited | Nicotinamide derivatives |
| WO2010017046A1 (en) * | 2008-08-05 | 2010-02-11 | Merck & Co., Inc. | Pyrazolo[1,5-a]pyridines as mark inhibitors |
| JP2013028538A (ja) * | 2009-11-13 | 2013-02-07 | Dainippon Sumitomo Pharma Co Ltd | 新規アミド誘導体 |
| AU2013352304C1 (en) * | 2012-11-29 | 2018-03-22 | Chemocentryx, Inc. | CXCR7 antagonists |
-
2015
- 2015-09-09 EP EP15839644.0A patent/EP3193609A4/en not_active Withdrawn
- 2015-09-09 US US15/510,583 patent/US20170247326A1/en not_active Abandoned
- 2015-09-09 WO PCT/US2015/049225 patent/WO2016040508A1/en not_active Ceased
- 2015-09-09 CA CA2960277A patent/CA2960277A1/en not_active Abandoned
- 2015-09-09 JP JP2017512983A patent/JP2017528461A/ja active Pending
- 2015-09-09 AU AU2015315177A patent/AU2015315177A1/en not_active Abandoned
-
2019
- 2019-05-28 US US16/423,618 patent/US20200048195A1/en not_active Abandoned
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