JP2017528461A5 - - Google Patents
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- JP2017528461A5 JP2017528461A5 JP2017512983A JP2017512983A JP2017528461A5 JP 2017528461 A5 JP2017528461 A5 JP 2017528461A5 JP 2017512983 A JP2017512983 A JP 2017512983A JP 2017512983 A JP2017512983 A JP 2017512983A JP 2017528461 A5 JP2017528461 A5 JP 2017528461A5
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- INSSHDIMRIMVLZ-UHFFFAOYSA-N butan-2-ylcyclopropane Chemical compound CCC(C)C1CC1 INSSHDIMRIMVLZ-UHFFFAOYSA-N 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 210000004720 cerebrum Anatomy 0.000 claims 1
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
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- 239000003937 drug carrier Substances 0.000 claims 1
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- 208000029824 high grade glioma Diseases 0.000 claims 1
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- 201000000564 macroglobulinemia Diseases 0.000 claims 1
- 201000011614 malignant glioma Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 206010027191 meningioma Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 201000008026 nephroblastoma Diseases 0.000 claims 1
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- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical compound C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000016800 primary central nervous system lymphoma Diseases 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
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- SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 1
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| US62/146,804 | 2015-04-13 | ||
| PCT/US2015/049225 WO2016040508A1 (en) | 2014-09-10 | 2015-09-09 | Substituted pyrrolidine carboxamide compounds |
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| JP2017528461A JP2017528461A (ja) | 2017-09-28 |
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| JP2017526706A (ja) | 2014-09-10 | 2017-09-14 | エピザイム，インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| AU2015315171A1 (en) | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| MX2017002986A (es) | 2014-09-10 | 2017-10-24 | Epizyme Inc | Compuestos de piperidina sustituidos. |
| KR102496364B1 (ko) | 2014-09-10 | 2023-02-06 | 에피자임, 인코포레이티드 | Ｓｍｙｄ 억제제 |
| JP2017528460A (ja) | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド |
| CN111315735B (zh) | 2017-09-04 | 2024-03-08 | C4医药公司 | 二氢苯并咪唑酮 |
| EP4470618A3 (en) | 2019-03-06 | 2025-03-05 | C4 Therapeutics, Inc. | Heterocyclic compounds for medical treatment |
| GB201912674D0 (en) * | 2019-09-04 | 2019-10-16 | Mission Therapeutics Ltd | Novel compounds |
Family Cites Families (22)
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| GB1428493A (en) * | 1973-05-02 | 1976-03-17 | Science Union & Cie | Heterocyclic amides processes for their preparation and pharma ceutical compositions containing them |
| JPS52128368A (en) * | 1976-04-15 | 1977-10-27 | Yamanouchi Pharmaceut Co Ltd | Novel carboxylic acid amide derivatives and their preparation |
| GR66581B (enExample) * | 1978-02-21 | 1981-03-27 | Delalande Sa | |
| EP1013276A1 (en) * | 1998-12-23 | 2000-06-28 | Pfizer Inc. | Aminoazacycloalkanes as CCR5 modulators |
| DE10148290A1 (de) * | 2001-09-29 | 2003-04-17 | Bayer Cropscience Gmbh | Heterocyclische Amide, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung |
| ATE455104T1 (de) * | 2001-11-01 | 2010-01-15 | Icagen Inc | Pyrazolamide zur anwendung in der behandlung von schmerz |
| MXPA05009245A (es) * | 2003-03-11 | 2005-10-19 | Pfizer Prod Inc | Nuevos compuestos de pirazina como inhibidores del factor de crecimiento transformante (tgf). |
| DK1603917T3 (da) * | 2003-03-14 | 2011-02-28 | Medigene Ag | Immunmodulerende heterocycliske forbindelser |
| TW200526641A (en) * | 2003-12-26 | 2005-08-16 | Daiichi Seiyaku Co | Amidopyrazole derivatives |
| MXPA06011328A (es) * | 2004-04-02 | 2006-12-15 | Vertex Pharma | Azaindoles utiles como inhibidotes de roca y otras proteinas cinasas. |
| WO2006086609A2 (en) * | 2005-02-10 | 2006-08-17 | Axys Pharmaceuticals, Inc. | Inhibitors of tryptase |
| WO2006107923A1 (en) * | 2005-04-05 | 2006-10-12 | Boehringer Ingelheim International Gmbh | Substituted benzylimidazoles useful for the treatment of inflammatory diseases |
| CA2604356A1 (en) * | 2005-04-12 | 2006-10-19 | Solvay Pharmaceuticals Gmbh | Aminoalkyl-amidomethyl-substituted 2-(4-sulphonylamino)-3-hydroxy-3,4-dihydro-2h-chromen-6-yl derivatives and their use as potassium channel blockers |
| WO2007011760A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| JP5525261B2 (ja) * | 2006-10-24 | 2014-06-18 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｍｔｐ阻害性テトラヒドロ−ナフタレン−１−カルボン酸誘導体 |
| EP1975165A1 (de) * | 2007-03-27 | 2008-10-01 | Boehringer Ingelheim Pharma GmbH & Co. KG | Substituierte Pyrrolidinamide, deren Herstellung und deren Verwendung als Arzneimittel |
| KR20100020487A (ko) * | 2007-05-24 | 2010-02-22 | 와이어쓰 엘엘씨 | 히스타민-3 길항제로서 아자시클릴벤즈아미드 유도체 |
| WO2009014620A1 (en) * | 2007-07-20 | 2009-01-29 | Merck & Co., Inc. | Pyrazolo[1,5-a]pyrimidine derivatives |
| US20110306597A1 (en) * | 2008-06-18 | 2011-12-15 | James Michael Crawforth | Nicotinamide Derivatives |
| WO2010017046A1 (en) * | 2008-08-05 | 2010-02-11 | Merck & Co., Inc. | Pyrazolo[1,5-a]pyridines as mark inhibitors |
| JP2013028538A (ja) * | 2009-11-13 | 2013-02-07 | Dainippon Sumitomo Pharma Co Ltd | 新規アミド誘導体 |
| CA2892042C (en) * | 2012-11-29 | 2022-06-14 | Chemocentryx, Inc. | Cxcr7 antagonists |
-
2015
- 2015-09-09 US US15/510,583 patent/US20170247326A1/en not_active Abandoned
- 2015-09-09 CA CA2960277A patent/CA2960277A1/en not_active Abandoned
- 2015-09-09 AU AU2015315177A patent/AU2015315177A1/en not_active Abandoned
- 2015-09-09 WO PCT/US2015/049225 patent/WO2016040508A1/en not_active Ceased
- 2015-09-09 JP JP2017512983A patent/JP2017528461A/ja active Pending
- 2015-09-09 EP EP15839644.0A patent/EP3193609A4/en not_active Withdrawn
-
2019
- 2019-05-28 US US16/423,618 patent/US20200048195A1/en not_active Abandoned
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