CA2960277A1 - Substituted pyrrolidine carboxamide compounds - Google Patents

Info

Publication number

CA2960277A1

CA2960277A1 CA2960277A CA2960277A CA2960277A1 CA 2960277 A1 CA2960277 A1 CA 2960277A1 CA 2960277 A CA2960277 A CA 2960277A CA 2960277 A CA2960277 A CA 2960277A CA 2960277 A1 CA2960277 A1 CA 2960277A1

Authority

CA

Canada

Prior art keywords

cancer

cell

tumor

carcinoma

lymphoma

Prior art date

2014-09-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

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• CIPO
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• LCDCPQHFCOBUEF-UHFFFAOYSA-N pyrrolidine-1-carboxamide Chemical class NC(=O)N1CCCC1 LCDCPQHFCOBUEF-UHFFFAOYSA-N 0.000 title abstract description 5
• 150000001875 compounds Chemical class 0.000 claims abstract description 155
• 206010028980 Neoplasm Diseases 0.000 claims abstract description 74
• 150000003839 salts Chemical class 0.000 claims abstract description 56
• 108090000623 proteins and genes Proteins 0.000 claims abstract description 49
• 102000004169 proteins and genes Human genes 0.000 claims abstract description 46
• 201000011510 cancer Diseases 0.000 claims abstract description 45
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 44
• 239000012453 solvate Substances 0.000 claims abstract description 39
• 125000000217 alkyl group Chemical group 0.000 claims description 273
• -1 1-imidazolyl Chemical group 0.000 claims description 263
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 55
• 125000003282 alkyl amino group Chemical group 0.000 claims description 51
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 51
• 125000001072 heteroaryl group Chemical group 0.000 claims description 50
• 210000004027 cell Anatomy 0.000 claims description 45
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims description 42
• 229910052739 hydrogen Inorganic materials 0.000 claims description 41
• 239000001257 hydrogen Substances 0.000 claims description 40
• 125000003545 alkoxy group Chemical group 0.000 claims description 33
• 125000003118 aryl group Chemical group 0.000 claims description 32
• 125000006652 (C3-C12) cycloalkyl group Chemical group 0.000 claims description 31
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 29
• 238000000034 method Methods 0.000 claims description 29
• 125000004183 alkoxy alkyl group Chemical group 0.000 claims description 27
• 125000001424 substituent group Chemical group 0.000 claims description 27
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 26
• 229910052799 carbon Inorganic materials 0.000 claims description 24
• 125000005518 carboxamido group Chemical group 0.000 claims description 24
• 125000001188 haloalkyl group Chemical group 0.000 claims description 21
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 21
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 14
• 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims description 13
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