JP2017528461A - 置換ピロリジンカルボキサミド化合物 - Google Patents

置換ピロリジンカルボキサミド化合物 Download PDF

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Publication number
JP2017528461A
JP2017528461A JP2017512983A JP2017512983A JP2017528461A JP 2017528461 A JP2017528461 A JP 2017528461A JP 2017512983 A JP2017512983 A JP 2017512983A JP 2017512983 A JP2017512983 A JP 2017512983A JP 2017528461 A JP2017528461 A JP 2017528461A
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cancer
tumor
cell
lymphoma
alkyl
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JP2017528461A5 (enExample
Inventor
アレーネ クルーナン フォリー，メーガン
アレーネ クルーナン フォリー，メーガン
ウェイン クンツ，ケヴィン
ウェイン クンツ，ケヴィン
ヘレン ミッチェル，ローナ
ヘレン ミッチェル，ローナ
ジョン ムンチョフ，マイケル
ジョン ムンチョフ，マイケル
マーティン ハーヴィー，ダレン
マーティン ハーヴィー，ダレン
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エピザイム インコーポレイテッド
エピザイム インコーポレイテッド
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Publication of JP2017528461A publication Critical patent/JP2017528461A/ja
Publication of JP2017528461A5 publication Critical patent/JP2017528461A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2017512983A 2014-09-10 2015-09-09 置換ピロリジンカルボキサミド化合物 Pending JP2017528461A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462048763P 2014-09-10 2014-09-10
US62/048,763 2014-09-10
US201562146804P 2015-04-13 2015-04-13
US62/146,804 2015-04-13
PCT/US2015/049225 WO2016040508A1 (en) 2014-09-10 2015-09-09 Substituted pyrrolidine carboxamide compounds

Publications (2)

Publication Number Publication Date
JP2017528461A true JP2017528461A (ja) 2017-09-28
JP2017528461A5 JP2017528461A5 (enExample) 2018-10-18

Family

ID=55459531

Family Applications (1)

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JP2017512983A Pending JP2017528461A (ja) 2014-09-10 2015-09-09 置換ピロリジンカルボキサミド化合物

Country Status (6)

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US (2) US20170247326A1 (enExample)
EP (1) EP3193609A4 (enExample)
JP (1) JP2017528461A (enExample)
AU (1) AU2015315177A1 (enExample)
CA (1) CA2960277A1 (enExample)
WO (1) WO2016040508A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022546717A (ja) * 2019-09-04 2022-11-07 ミッション セラピューティクス リミティド Ｕｓｐ３０阻害剤としての活性を有する置換シアノピロリジン類

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017526706A (ja) 2014-09-10 2017-09-14 エピザイム，インコーポレイティド イソオキサゾールカルボキサミド化合物
AU2015315171A1 (en) 2014-09-10 2017-03-16 Epizyme, Inc. Substituted cyclohexylamine compounds
MX2017002986A (es) 2014-09-10 2017-10-24 Epizyme Inc Compuestos de piperidina sustituidos.
KR102496364B1 (ko) 2014-09-10 2023-02-06 에피자임, 인코포레이티드 Ｓｍｙｄ 억제제
JP2017528460A (ja) 2014-09-10 2017-09-28 エピザイム インコーポレイテッド 不可逆的ｓｍｙｄ阻害剤としてのイソオキサゾールカルボキサミド
CN111315735B (zh) 2017-09-04 2024-03-08 C4医药公司 二氢苯并咪唑酮
EP4470618A3 (en) 2019-03-06 2025-03-05 C4 Therapeutics, Inc. Heterocyclic compounds for medical treatment

Citations (20)

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JPS5018472A (enExample) * 1973-05-02 1975-02-26
JPS52128368A (en) * 1976-04-15 1977-10-27 Yamanouchi Pharmaceut Co Ltd Novel carboxylic acid amide derivatives and their preparation
JP2000212159A (ja) * 1998-12-23 2000-08-02 Pfizer Inc Ｃｃｒ５モジュレ―タ―
WO2003037274A2 (en) * 2001-11-01 2003-05-08 Icagen, Inc. Pyrazole-amides and-sulfonamides
JP2005504105A (ja) * 2001-09-29 2005-02-10 バイエル クロップサイエンス ゲーエムベーハー 農薬としてのヘテロシクリルニコチンアミド及び類似のピリミジン誘導体
WO2005063737A1 (ja) * 2003-12-26 2005-07-14 Daiichi Pharmaceutical Co., Ltd. アミドピラゾール誘導体
WO2006086609A2 (en) * 2005-02-10 2006-08-17 Axys Pharmaceuticals, Inc. Inhibitors of tryptase
JP2006519833A (ja) * 2003-03-11 2006-08-31 ファイザー・プロダクツ・インク トランスフォーミング成長因子（ｔｇｆ）阻害剤としてのピラジン化合物
JP2006520372A (ja) * 2003-03-14 2006-09-07 アヴィデックス リミテッド 免疫調節複素環化合物
WO2007011760A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
JP2007531740A (ja) * 2004-04-02 2007-11-08 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｒｏｃｋの阻害剤として有用なアザインドールおよび他のプロテインキナーゼ
JP2008536842A (ja) * 2005-04-12 2008-09-11 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング アミノアルキル−アミドメチル置換２−スルホニルアミノ）−３−ヒドロキシ−３，４−ジヒドロ−２ｈ−クロメン−６−イル誘導体およびそのカリウムチャンネル遮断薬としての使用
WO2008147945A1 (en) * 2007-05-24 2008-12-04 Wyeth Azacyclylbenzamide derivatives as histamine-3 antagonists
WO2010017046A1 (en) * 2008-08-05 2010-02-11 Merck & Co., Inc. Pyrazolo[1,5-a]pyridines as mark inhibitors
JP2010507616A (ja) * 2006-10-24 2010-03-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｍｔｐ阻害性テトラヒドロ−ナフタレン−１−カルボン酸誘導体
JP2010522713A (ja) * 2007-03-27 2010-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピロリジンアミド、それの製造方法、及び、それの薬剤としての使用
JP2010534206A (ja) * 2007-07-20 2010-11-04 メルク・シャープ・エンド・ドーム・コーポレイション ピラゾロ［１，５−ａ］ピリミジン誘導体
JP2011524894A (ja) * 2008-06-18 2011-09-08 ファイザー・リミテッド ニコチンアミド誘導体
JP2013028538A (ja) * 2009-11-13 2013-02-07 Dainippon Sumitomo Pharma Co Ltd 新規アミド誘導体
US20140154179A1 (en) * 2012-11-29 2014-06-05 Chemocentryx, Inc. Cxcr7 antagonists

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GR66581B (enExample) * 1978-02-21 1981-03-27 Delalande Sa
WO2006107923A1 (en) * 2005-04-05 2006-10-12 Boehringer Ingelheim International Gmbh Substituted benzylimidazoles useful for the treatment of inflammatory diseases

Patent Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5018472A (enExample) * 1973-05-02 1975-02-26
JPS52128368A (en) * 1976-04-15 1977-10-27 Yamanouchi Pharmaceut Co Ltd Novel carboxylic acid amide derivatives and their preparation
JP2000212159A (ja) * 1998-12-23 2000-08-02 Pfizer Inc Ｃｃｒ５モジュレ―タ―
JP2005504105A (ja) * 2001-09-29 2005-02-10 バイエル クロップサイエンス ゲーエムベーハー 農薬としてのヘテロシクリルニコチンアミド及び類似のピリミジン誘導体
WO2003037274A2 (en) * 2001-11-01 2003-05-08 Icagen, Inc. Pyrazole-amides and-sulfonamides
JP2006519833A (ja) * 2003-03-11 2006-08-31 ファイザー・プロダクツ・インク トランスフォーミング成長因子（ｔｇｆ）阻害剤としてのピラジン化合物
JP2006520372A (ja) * 2003-03-14 2006-09-07 アヴィデックス リミテッド 免疫調節複素環化合物
WO2005063737A1 (ja) * 2003-12-26 2005-07-14 Daiichi Pharmaceutical Co., Ltd. アミドピラゾール誘導体
JP2007531740A (ja) * 2004-04-02 2007-11-08 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｒｏｃｋの阻害剤として有用なアザインドールおよび他のプロテインキナーゼ
WO2006086609A2 (en) * 2005-02-10 2006-08-17 Axys Pharmaceuticals, Inc. Inhibitors of tryptase
JP2008536842A (ja) * 2005-04-12 2008-09-11 ゾルファイ ファーマスーティカルズ ゲゼルシャフト ミット ベシュレンクテル ハフツング アミノアルキル−アミドメチル置換２−スルホニルアミノ）−３−ヒドロキシ−３，４−ジヒドロ−２ｈ−クロメン−６−イル誘導体およびそのカリウムチャンネル遮断薬としての使用
WO2007011760A2 (en) * 2005-07-15 2007-01-25 Kalypsys, Inc. Inhibitors of mitotic kinesin
JP2010507616A (ja) * 2006-10-24 2010-03-11 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｍｔｐ阻害性テトラヒドロ−ナフタレン−１−カルボン酸誘導体
JP2010522713A (ja) * 2007-03-27 2010-07-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 置換ピロリジンアミド、それの製造方法、及び、それの薬剤としての使用
WO2008147945A1 (en) * 2007-05-24 2008-12-04 Wyeth Azacyclylbenzamide derivatives as histamine-3 antagonists
JP2010534206A (ja) * 2007-07-20 2010-11-04 メルク・シャープ・エンド・ドーム・コーポレイション ピラゾロ［１，５−ａ］ピリミジン誘導体
JP2011524894A (ja) * 2008-06-18 2011-09-08 ファイザー・リミテッド ニコチンアミド誘導体
WO2010017046A1 (en) * 2008-08-05 2010-02-11 Merck & Co., Inc. Pyrazolo[1,5-a]pyridines as mark inhibitors
JP2013028538A (ja) * 2009-11-13 2013-02-07 Dainippon Sumitomo Pharma Co Ltd 新規アミド誘導体
US20140154179A1 (en) * 2012-11-29 2014-06-05 Chemocentryx, Inc. Cxcr7 antagonists

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022546717A (ja) * 2019-09-04 2022-11-07 ミッション セラピューティクス リミティド Ｕｓｐ３０阻害剤としての活性を有する置換シアノピロリジン類

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Publication number Publication date
US20200048195A1 (en) 2020-02-13
AU2015315177A1 (en) 2017-03-16
US20170247326A1 (en) 2017-08-31
WO2016040508A1 (en) 2016-03-17
CA2960277A1 (en) 2016-03-17
EP3193609A1 (en) 2017-07-26
EP3193609A4 (en) 2018-02-28

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