JP2017538659A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017538659A5 JP2017538659A5 JP2017512982A JP2017512982A JP2017538659A5 JP 2017538659 A5 JP2017538659 A5 JP 2017538659A5 JP 2017512982 A JP2017512982 A JP 2017512982A JP 2017512982 A JP2017512982 A JP 2017512982A JP 2017538659 A5 JP2017538659 A5 JP 2017538659A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- tumor
- group
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048773P | 2014-09-10 | 2014-09-10 | |
| US62/048,773 | 2014-09-10 | ||
| US201562146799P | 2015-04-13 | 2015-04-13 | |
| US62/146,799 | 2015-04-13 | ||
| PCT/US2015/049221 WO2016040505A1 (en) | 2014-09-10 | 2015-09-09 | Smyd inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013314A Division JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538659A JP2017538659A (ja) | 2017-12-28 |
| JP2017538659A5 true JP2017538659A5 (enExample) | 2018-10-18 |
Family
ID=55459528
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512982A Pending JP2017538659A (ja) | 2014-09-10 | 2015-09-09 | Smyd阻害剤 |
| JP2020013314A Pending JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
| JP2022118248A Pending JP2022163087A (ja) | 2014-09-10 | 2022-07-25 | Smyd阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013314A Pending JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
| JP2022118248A Pending JP2022163087A (ja) | 2014-09-10 | 2022-07-25 | Smyd阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10266526B2 (enExample) |
| EP (1) | EP3193600A4 (enExample) |
| JP (3) | JP2017538659A (enExample) |
| KR (2) | KR102496364B1 (enExample) |
| CN (2) | CN107072205B (enExample) |
| AU (1) | AU2015315174B2 (enExample) |
| BR (1) | BR112017004612A2 (enExample) |
| CA (1) | CA2960275A1 (enExample) |
| EA (1) | EA201790317A1 (enExample) |
| IL (2) | IL250891A0 (enExample) |
| MX (2) | MX2017002985A (enExample) |
| SG (2) | SG10201901192TA (enExample) |
| WO (1) | WO2016040505A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| WO2011133751A2 (en) | 2010-04-22 | 2011-10-27 | Vertex Pharmaceuticals Incorporated | Process of producing cycloalkylcarboxamido-indole compounds |
| SI3424534T1 (sl) | 2014-04-15 | 2021-08-31 | Vertex Pharmaceutical Incorporated | Farmacevtski sestavki za zdravljenje bolezni, ki jih povzroča regulator transmembranske prevodnosti pri cistični fibrozi |
| WO2016040515A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted piperidine compounds |
| US10428029B2 (en) | 2014-09-10 | 2019-10-01 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| JP2017527576A (ja) | 2014-09-10 | 2017-09-21 | エピザイム,インコーポレイティド | 置換シクロヘキシルアミン化合物 |
| WO2016040511A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| WO2018030550A1 (en) | 2016-08-09 | 2018-02-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds with an ror(gamma)t modulating activity |
| WO2018151678A1 (en) * | 2017-02-15 | 2018-08-23 | Agency For Science, Technology And Research | Compounds for treatment of cancer and epigenetics |
| IL269210B2 (en) * | 2017-03-10 | 2025-05-01 | Univ Rutgers | Indole derivatives as efflux pump inhibitors |
| JP2020524717A (ja) * | 2017-06-22 | 2020-08-20 | キュラデブ・ファーマ・リミテッドCuradev Pharma Limited | ヒトstingの小分子調節因子 |
| US11571423B2 (en) | 2017-06-22 | 2023-02-07 | Curadev Pharma Limited | Small molecule modulators of human sting |
| JP2020530844A (ja) | 2017-08-14 | 2020-10-29 | エピザイム,インコーポレイティド | Setd2を阻害することにより癌を処置する方法 |
| BR112021002633A2 (pt) * | 2018-08-14 | 2021-05-04 | Epizyme, Inc. | composto, composição farmacêutica, método para tratar um sujeito que precisa do mesmo, composto para uso, uso de um composto, kit, método para tratar um sujeito que tem mieloma múltiplo, método para identificar se um sujeito que tem mieloma múltiplo é um candidato para o tratamento com um composto, método para prever o resultado do tratamento em um sujeito que tem mieloma múltiplo e método que compreende administrar uma quantidade terapeuticamente eficaz de um composto |
| EP3873900B1 (en) | 2018-10-30 | 2025-01-08 | Gilead Sciences, Inc. | Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases |
| WO2020092383A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| PT3873884T (pt) | 2018-10-30 | 2025-02-25 | Gilead Sciences Inc | Derivados de 3-(quinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidina-2,4-diona como inibidores da integrina alfa4beta7 para o tratamento de doenças inflamatórias |
| PL3873605T3 (pl) | 2018-10-30 | 2025-03-03 | Gilead Sciences, Inc. | Związki hamujące integrynę alfa4beta7 |
| WO2021023858A1 (en) * | 2019-08-08 | 2021-02-11 | Université De Strasbourg | TrkB POSITIVE ALLOSTERIC MODULATORS |
| EP4013499A1 (en) | 2019-08-14 | 2022-06-22 | Gilead Sciences, Inc. | Compounds for inhibition of alpha 4 beta 7 integrin |
| DK4069691T3 (da) | 2019-12-06 | 2024-10-28 | Vertex Pharma | Substituerede tetrahydrofuraner som modulatorer af natriumkanaler |
| CA3161339A1 (en) * | 2019-12-27 | 2021-07-01 | Schrodinger, Inc. | Cyclic compounds and methods of using same |
| IL295654A (en) * | 2020-02-19 | 2022-10-01 | Epizyme Inc | Setd2 inhibitors and related methods and uses, including combination therapies |
| EP4164622A4 (en) | 2020-06-16 | 2024-09-11 | Icahn School of Medicine at Mount Sinai | SOX11 INHIBITORS FOR THE TREATMENT OF MANTLE CELL LYMPHOMA |
| KR20230122080A (ko) | 2020-12-17 | 2023-08-22 | 아스트라제네카 아베 | N-(2-(4-시아노티아졸리딘-3-일)-2-옥소에틸)-퀴놀린-4-카르복스아미드 |
| US11827627B2 (en) | 2021-06-04 | 2023-11-28 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
| CN114246851B (zh) * | 2021-11-09 | 2024-01-26 | 澳门科技大学 | 一种组蛋白甲基转移酶smyd3小分子抑制剂的合成方法及用途 |
| CN114702552B (zh) * | 2022-03-11 | 2024-05-31 | 苏州思萃免疫技术研究所有限公司 | mTORC2抑制剂 |
| WO2023192665A2 (en) * | 2022-04-01 | 2023-10-05 | Praxis Precision Medicines, Inc. | T-type calcium channel modulators and methods of use thereof |
| GB2620976B (en) * | 2022-07-28 | 2024-07-24 | Jones Paul | Amido-amine hardener |
| CN120882411A (zh) * | 2022-11-17 | 2025-10-31 | 腾维治疗公司 | 化合物、组合物和方法 |
| EP4618979A2 (en) * | 2022-11-17 | 2025-09-24 | Tenvie Therapeutics Inc. | Compounds, compositions, and methods |
| WO2024158863A1 (en) * | 2023-01-25 | 2024-08-02 | The Rockefeller University | Sulfonamide-1h-pyrrole-2-carboxamide inhibitors of sars-cov-2 nsp14 methyltransferase and derivatives thereof |
| CN116327748B (zh) * | 2023-04-21 | 2024-09-17 | 武汉科技大学 | 联合用药物在制备抗肿瘤药物中的用途 |
| WO2025165834A1 (en) * | 2024-01-31 | 2025-08-07 | Ensem Therapeutics, Inc. | Urea derivatives of tricyclic compounds, and compositions and methods thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09507846A (ja) * | 1993-12-30 | 1997-08-12 | スミスクライン・ビーチャム・コーポレイション | フェニルメチルヘキサンアミドおよびその使用 |
| WO1998022432A1 (en) * | 1996-11-18 | 1998-05-28 | Yamanouchi Pharmaceutical Co., Ltd. | Novel acylamino-substituted acylanilide derivatives or pharmaceutical composition comprising the same |
| WO2001021596A1 (en) * | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline derivatives and their use as pharmaceuticals |
| US6867299B2 (en) * | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
| TWI288745B (en) * | 2000-04-05 | 2007-10-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| KR20040101564A (ko) | 2000-07-19 | 2004-12-02 | 다케다 야쿠힌 고교 가부시키가이샤 | 1-치환-1,2,3-트리아졸 유도체, 그 중간체, 및 이들의제조 방법 |
| AUPR034000A0 (en) * | 2000-09-25 | 2000-10-19 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
| US7259157B2 (en) * | 2001-04-03 | 2007-08-21 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists |
| EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| GB0205176D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| JP2004175739A (ja) * | 2002-11-28 | 2004-06-24 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| JP2004315395A (ja) * | 2003-04-14 | 2004-11-11 | Yamanouchi Pharmaceut Co Ltd | 新規な安息香酸誘導体又はその塩 |
| GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
| CA2538759C (en) * | 2003-09-12 | 2015-11-03 | Elixir Pharmaceuticals, Inc. | Substituted heterocyclic compounds as sirtuin inhitibitors |
| AU2005207946A1 (en) * | 2004-01-23 | 2005-08-11 | Amgen Inc. | Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer |
| CA2555812A1 (en) * | 2004-02-13 | 2005-09-01 | President And Fellows Of Harvard College | 3-3-di-substituted-oxindoles as inhibitors of translation initiation |
| JP2006089485A (ja) * | 2004-08-24 | 2006-04-06 | Santen Pharmaceut Co Ltd | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| CA2588384A1 (en) * | 2004-11-23 | 2006-06-22 | Ptc Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control |
| EP1861396A1 (en) * | 2005-03-04 | 2007-12-05 | AstraZeneca AB | Tricyclic derivatives of azetidine and pyrrole with antibacterial activity |
| RU2007140734A (ru) * | 2005-04-06 | 2009-05-20 | Астразенека Аб (Se) | Замещенные гетероциклы и их применение в качестве ингибиторов chki, pdki и pak |
| US7273882B2 (en) * | 2005-06-21 | 2007-09-25 | Bristol-Myers Squibb Company | Aminoacetamide acyl guanidines as β-secretase inhibitors |
| TW200741009A (en) * | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| DOP2006000273A (es) * | 2005-12-08 | 2007-10-15 | Aventis Pharma Inc | Uso de un antagonista de cb1 para tratar efectos secundarios y sintomas negativos de la esquizofrenia |
| GB0525083D0 (en) * | 2005-12-09 | 2006-01-18 | Astrazeneca Ab | Pyrimidine derivatives |
| US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| EP2043634A2 (en) * | 2006-07-12 | 2009-04-08 | Merck & Co., Inc. | Substituted pyrazoles as ghrelin receptor antagonists |
| WO2008016666A2 (en) * | 2006-08-02 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
| EP2121626A1 (en) * | 2006-12-15 | 2009-11-25 | Pfizer Products Inc. | Benzimidazole derivatives |
| WO2008075172A2 (en) * | 2006-12-19 | 2008-06-26 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| PE20091576A1 (es) * | 2008-02-19 | 2009-11-05 | Sanofi Aventis | DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 |
| WO2009143039A2 (en) * | 2008-05-19 | 2009-11-26 | Schering Corporation | Heterocyclic compounds as factor ixa inhibitors |
| TW201010997A (en) * | 2008-06-18 | 2010-03-16 | Pfizer Ltd | Nicotinamide derivatives |
| US9265734B2 (en) * | 2008-09-03 | 2016-02-23 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| CN103209982B (zh) * | 2010-10-14 | 2016-03-16 | Jw制药公司 | 反转模拟物的化合物、其制造方法及其用途 |
| EP2648736A4 (en) * | 2010-12-08 | 2015-04-29 | Lycera Corp | CYCLOALKYL GUANIDINE F1F0 ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF |
| WO2012135697A2 (en) * | 2011-03-30 | 2012-10-04 | H. Lee Moffitt Cancer Center & Research Institute Inc. | Novel rho kinase inhibitors and methods of use |
| EP2532661A1 (en) * | 2011-06-10 | 2012-12-12 | Syngenta Participations AG | Novel insecticides |
| WO2012171860A1 (en) * | 2011-06-17 | 2012-12-20 | Basilea Pharmaceutica Ag | Tricyclic antibiotics |
| US9145412B2 (en) * | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| CN103877078B (zh) * | 2012-12-20 | 2017-03-15 | 上海交通大学医学院 | Senp2小分子抑制剂及其应用 |
| WO2016040511A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Isoxazole carboxamides as irreversible smyd inhibitors |
| US10428029B2 (en) | 2014-09-10 | 2019-10-01 | Epizyme, Inc. | Isoxazole carboxamide compounds |
| US20170253601A1 (en) | 2014-09-10 | 2017-09-07 | Epizyme, Inc. | Substituted Pyrrolidine Compounds |
| WO2016040508A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted pyrrolidine carboxamide compounds |
| WO2016040515A1 (en) | 2014-09-10 | 2016-03-17 | Epizyme, Inc. | Substituted piperidine compounds |
| JP2017527576A (ja) | 2014-09-10 | 2017-09-21 | エピザイム,インコーポレイティド | 置換シクロヘキシルアミン化合物 |
-
2015
- 2015-09-09 KR KR1020177009602A patent/KR102496364B1/ko active Active
- 2015-09-09 BR BR112017004612-1A patent/BR112017004612A2/pt not_active Application Discontinuation
- 2015-09-09 SG SG10201901192TA patent/SG10201901192TA/en unknown
- 2015-09-09 JP JP2017512982A patent/JP2017538659A/ja active Pending
- 2015-09-09 CA CA2960275A patent/CA2960275A1/en active Pending
- 2015-09-09 WO PCT/US2015/049221 patent/WO2016040505A1/en not_active Ceased
- 2015-09-09 KR KR1020237003762A patent/KR20230026515A/ko not_active Ceased
- 2015-09-09 MX MX2017002985A patent/MX2017002985A/es unknown
- 2015-09-09 EP EP15840789.0A patent/EP3193600A4/en not_active Withdrawn
- 2015-09-09 EA EA201790317A patent/EA201790317A1/ru unknown
- 2015-09-09 CN CN201580060859.4A patent/CN107072205B/zh not_active Expired - Fee Related
- 2015-09-09 AU AU2015315174A patent/AU2015315174B2/en not_active Ceased
- 2015-09-09 US US15/510,586 patent/US10266526B2/en active Active
- 2015-09-09 CN CN202210734932.3A patent/CN115028619A/zh active Pending
- 2015-09-09 SG SG11201701598PA patent/SG11201701598PA/en unknown
-
2017
- 2017-03-02 IL IL250891A patent/IL250891A0/en unknown
- 2017-03-07 MX MX2023006257A patent/MX2023006257A/es unknown
-
2019
- 2019-02-06 US US16/269,338 patent/US20190322660A1/en not_active Abandoned
-
2020
- 2020-01-30 JP JP2020013314A patent/JP2020090520A/ja active Pending
- 2020-05-01 US US16/864,891 patent/US20210198252A1/en not_active Abandoned
-
2021
- 2021-10-10 IL IL287113A patent/IL287113A/en unknown
- 2021-11-22 US US17/532,422 patent/US20230101819A1/en not_active Abandoned
-
2022
- 2022-07-25 JP JP2022118248A patent/JP2022163087A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017538659A5 (enExample) | ||
| JP2020090520A5 (enExample) | ||
| JP2017528461A5 (enExample) | ||
| JP2017511801A5 (enExample) | ||
| CA2807620C (en) | Pharmaceutically active compounds as axl inhibitors | |
| JP2017528464A5 (enExample) | ||
| US9546156B2 (en) | N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors | |
| AU2017221802B2 (en) | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain | |
| US9790210B2 (en) | N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | |
| US9981959B2 (en) | Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | |
| AU2015330506B2 (en) | EGFR inhibitor, and preparation and application thereof | |
| RU2632908C2 (ru) | Гетероциклическое производное и фармацевтическое средство | |
| US9969694B2 (en) | N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | |
| US9809578B2 (en) | Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors | |
| JP2017527577A5 (enExample) | ||
| JP2020503299A5 (enExample) | ||
| CN112601747B (zh) | 作为malt1抑制剂的吡唑衍生物 | |
| JP2011510995A5 (enExample) | ||
| JP2017538659A (ja) | Smyd阻害剤 | |
| WO2014078408A1 (en) | Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors | |
| MXPA05007990A (es) | Compuestos de tienopirimidina y uso de los mismos. | |
| JP2017528460A5 (enExample) | ||
| CN104098551A (zh) | 作为欧若拉激酶抑制剂的取代喹唑啉类衍生物 | |
| JP2017527577A (ja) | 置換ピロリジン化合物 | |
| JP2017527576A5 (enExample) |