JP2017538659A5 - - Google Patents

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Publication number
JP2017538659A5
JP2017538659A5 JP2017512982A JP2017512982A JP2017538659A5 JP 2017538659 A5 JP2017538659 A5 JP 2017538659A5 JP 2017512982 A JP2017512982 A JP 2017512982A JP 2017512982 A JP2017512982 A JP 2017512982A JP 2017538659 A5 JP2017538659 A5 JP 2017538659A5
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JP
Japan
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alkyl
cancer
tumor
group
cell
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Pending
Application number
JP2017512982A
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English (en)
Japanese (ja)
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JP2017538659A (ja
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Priority claimed from PCT/US2015/049221 external-priority patent/WO2016040505A1/en
Publication of JP2017538659A publication Critical patent/JP2017538659A/ja
Publication of JP2017538659A5 publication Critical patent/JP2017538659A5/ja
Pending legal-status Critical Current

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JP2017512982A 2014-09-10 2015-09-09 Smyd阻害剤 Pending JP2017538659A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462048773P 2014-09-10 2014-09-10
US62/048,773 2014-09-10
US201562146799P 2015-04-13 2015-04-13
US62/146,799 2015-04-13
PCT/US2015/049221 WO2016040505A1 (en) 2014-09-10 2015-09-09 Smyd inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2020013314A Division JP2020090520A (ja) 2014-09-10 2020-01-30 Smyd阻害剤

Publications (2)

Publication Number Publication Date
JP2017538659A JP2017538659A (ja) 2017-12-28
JP2017538659A5 true JP2017538659A5 (enExample) 2018-10-18

Family

ID=55459528

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2017512982A Pending JP2017538659A (ja) 2014-09-10 2015-09-09 Smyd阻害剤
JP2020013314A Pending JP2020090520A (ja) 2014-09-10 2020-01-30 Smyd阻害剤
JP2022118248A Pending JP2022163087A (ja) 2014-09-10 2022-07-25 Smyd阻害剤

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2020013314A Pending JP2020090520A (ja) 2014-09-10 2020-01-30 Smyd阻害剤
JP2022118248A Pending JP2022163087A (ja) 2014-09-10 2022-07-25 Smyd阻害剤

Country Status (13)

Country Link
US (4) US10266526B2 (enExample)
EP (1) EP3193600A4 (enExample)
JP (3) JP2017538659A (enExample)
KR (2) KR102496364B1 (enExample)
CN (2) CN107072205B (enExample)
AU (1) AU2015315174B2 (enExample)
BR (1) BR112017004612A2 (enExample)
CA (1) CA2960275A1 (enExample)
EA (1) EA201790317A1 (enExample)
IL (2) IL250891A0 (enExample)
MX (2) MX2017002985A (enExample)
SG (2) SG10201901192TA (enExample)
WO (1) WO2016040505A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
WO2011133751A2 (en) 2010-04-22 2011-10-27 Vertex Pharmaceuticals Incorporated Process of producing cycloalkylcarboxamido-indole compounds
SI3424534T1 (sl) 2014-04-15 2021-08-31 Vertex Pharmaceutical Incorporated Farmacevtski sestavki za zdravljenje bolezni, ki jih povzroča regulator transmembranske prevodnosti pri cistični fibrozi
WO2016040515A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Substituted piperidine compounds
US10428029B2 (en) 2014-09-10 2019-10-01 Epizyme, Inc. Isoxazole carboxamide compounds
JP2017527576A (ja) 2014-09-10 2017-09-21 エピザイム,インコーポレイティド 置換シクロヘキシルアミン化合物
WO2016040511A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Isoxazole carboxamides as irreversible smyd inhibitors
WO2018030550A1 (en) 2016-08-09 2018-02-15 Takeda Pharmaceutical Company Limited Heterocyclic compounds with an ror(gamma)t modulating activity
WO2018151678A1 (en) * 2017-02-15 2018-08-23 Agency For Science, Technology And Research Compounds for treatment of cancer and epigenetics
IL269210B2 (en) * 2017-03-10 2025-05-01 Univ Rutgers Indole derivatives as efflux pump inhibitors
JP2020524717A (ja) * 2017-06-22 2020-08-20 キュラデブ・ファーマ・リミテッドCuradev Pharma Limited ヒトstingの小分子調節因子
US11571423B2 (en) 2017-06-22 2023-02-07 Curadev Pharma Limited Small molecule modulators of human sting
JP2020530844A (ja) 2017-08-14 2020-10-29 エピザイム,インコーポレイティド Setd2を阻害することにより癌を処置する方法
BR112021002633A2 (pt) * 2018-08-14 2021-05-04 Epizyme, Inc. composto, composição farmacêutica, método para tratar um sujeito que precisa do mesmo, composto para uso, uso de um composto, kit, método para tratar um sujeito que tem mieloma múltiplo, método para identificar se um sujeito que tem mieloma múltiplo é um candidato para o tratamento com um composto, método para prever o resultado do tratamento em um sujeito que tem mieloma múltiplo e método que compreende administrar uma quantidade terapeuticamente eficaz de um composto
EP3873900B1 (en) 2018-10-30 2025-01-08 Gilead Sciences, Inc. Imidazo[1,2-a]pyridine derivatives as alpha4beta7 integrin inhibitors for the treatment of inflammatory diseases
WO2020092383A1 (en) 2018-10-30 2020-05-07 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
PT3873884T (pt) 2018-10-30 2025-02-25 Gilead Sciences Inc Derivados de 3-(quinolin-8-il)-1,4-dihidropirido[3,4-d]pirimidina-2,4-diona como inibidores da integrina alfa4beta7 para o tratamento de doenças inflamatórias
PL3873605T3 (pl) 2018-10-30 2025-03-03 Gilead Sciences, Inc. Związki hamujące integrynę alfa4beta7
WO2021023858A1 (en) * 2019-08-08 2021-02-11 Université De Strasbourg TrkB POSITIVE ALLOSTERIC MODULATORS
EP4013499A1 (en) 2019-08-14 2022-06-22 Gilead Sciences, Inc. Compounds for inhibition of alpha 4 beta 7 integrin
DK4069691T3 (da) 2019-12-06 2024-10-28 Vertex Pharma Substituerede tetrahydrofuraner som modulatorer af natriumkanaler
CA3161339A1 (en) * 2019-12-27 2021-07-01 Schrodinger, Inc. Cyclic compounds and methods of using same
IL295654A (en) * 2020-02-19 2022-10-01 Epizyme Inc Setd2 inhibitors and related methods and uses, including combination therapies
EP4164622A4 (en) 2020-06-16 2024-09-11 Icahn School of Medicine at Mount Sinai SOX11 INHIBITORS FOR THE TREATMENT OF MANTLE CELL LYMPHOMA
KR20230122080A (ko) 2020-12-17 2023-08-22 아스트라제네카 아베 N-(2-(4-시아노티아졸리딘-3-일)-2-옥소에틸)-퀴놀린-4-카르복스아미드
US11827627B2 (en) 2021-06-04 2023-11-28 Vertex Pharmaceuticals Incorporated N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels
CN114246851B (zh) * 2021-11-09 2024-01-26 澳门科技大学 一种组蛋白甲基转移酶smyd3小分子抑制剂的合成方法及用途
CN114702552B (zh) * 2022-03-11 2024-05-31 苏州思萃免疫技术研究所有限公司 mTORC2抑制剂
WO2023192665A2 (en) * 2022-04-01 2023-10-05 Praxis Precision Medicines, Inc. T-type calcium channel modulators and methods of use thereof
GB2620976B (en) * 2022-07-28 2024-07-24 Jones Paul Amido-amine hardener
CN120882411A (zh) * 2022-11-17 2025-10-31 腾维治疗公司 化合物、组合物和方法
EP4618979A2 (en) * 2022-11-17 2025-09-24 Tenvie Therapeutics Inc. Compounds, compositions, and methods
WO2024158863A1 (en) * 2023-01-25 2024-08-02 The Rockefeller University Sulfonamide-1h-pyrrole-2-carboxamide inhibitors of sars-cov-2 nsp14 methyltransferase and derivatives thereof
CN116327748B (zh) * 2023-04-21 2024-09-17 武汉科技大学 联合用药物在制备抗肿瘤药物中的用途
WO2025165834A1 (en) * 2024-01-31 2025-08-07 Ensem Therapeutics, Inc. Urea derivatives of tricyclic compounds, and compositions and methods thereof

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09507846A (ja) * 1993-12-30 1997-08-12 スミスクライン・ビーチャム・コーポレイション フェニルメチルヘキサンアミドおよびその使用
WO1998022432A1 (en) * 1996-11-18 1998-05-28 Yamanouchi Pharmaceutical Co., Ltd. Novel acylamino-substituted acylanilide derivatives or pharmaceutical composition comprising the same
WO2001021596A1 (en) * 1999-09-21 2001-03-29 Astrazeneca Ab Quinazoline derivatives and their use as pharmaceuticals
US6867299B2 (en) * 2000-02-24 2005-03-15 Hoffmann-La Roche Inc. Oxamide IMPDH inhibitors
TWI288745B (en) * 2000-04-05 2007-10-21 Daiichi Seiyaku Co Ethylenediamine derivatives
KR20040101564A (ko) 2000-07-19 2004-12-02 다케다 야쿠힌 고교 가부시키가이샤 1-치환-1,2,3-트리아졸 유도체, 그 중간체, 및 이들의제조 방법
AUPR034000A0 (en) * 2000-09-25 2000-10-19 Fujisawa Pharmaceutical Co., Ltd. Aminoalcohol derivatives
US7259157B2 (en) * 2001-04-03 2007-08-21 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists
EP1314733A1 (en) * 2001-11-22 2003-05-28 Aventis Pharma Deutschland GmbH Indole-2-carboxamides as factor Xa inhibitors
GB0205176D0 (en) * 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
JP2004175739A (ja) * 2002-11-28 2004-06-24 Tanabe Seiyaku Co Ltd 医薬組成物
JP2004315395A (ja) * 2003-04-14 2004-11-11 Yamanouchi Pharmaceut Co Ltd 新規な安息香酸誘導体又はその塩
GB0317516D0 (en) * 2003-07-25 2003-08-27 Pfizer Ltd Nicotinamide derivatives useful as PDE4 inhibitors
CA2538759C (en) * 2003-09-12 2015-11-03 Elixir Pharmaceuticals, Inc. Substituted heterocyclic compounds as sirtuin inhitibitors
AU2005207946A1 (en) * 2004-01-23 2005-08-11 Amgen Inc. Quinoline quinazoline pyridine and pyrimidine counds and their use in the treatment of inflammation angiogenesis and cancer
CA2555812A1 (en) * 2004-02-13 2005-09-01 President And Fellows Of Harvard College 3-3-di-substituted-oxindoles as inhibitors of translation initiation
JP2006089485A (ja) * 2004-08-24 2006-04-06 Santen Pharmaceut Co Ltd ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体
CA2588384A1 (en) * 2004-11-23 2006-06-22 Ptc Therapeutics, Inc. Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control
EP1861396A1 (en) * 2005-03-04 2007-12-05 AstraZeneca AB Tricyclic derivatives of azetidine and pyrrole with antibacterial activity
RU2007140734A (ru) * 2005-04-06 2009-05-20 Астразенека Аб (Se) Замещенные гетероциклы и их применение в качестве ингибиторов chki, pdki и pak
US7273882B2 (en) * 2005-06-21 2007-09-25 Bristol-Myers Squibb Company Aminoacetamide acyl guanidines as β-secretase inhibitors
TW200741009A (en) * 2005-07-01 2007-11-01 Oncotherapy Science Inc Methods of modulating SMYD3 for treatment of cancer
DOP2006000273A (es) * 2005-12-08 2007-10-15 Aventis Pharma Inc Uso de un antagonista de cb1 para tratar efectos secundarios y sintomas negativos de la esquizofrenia
GB0525083D0 (en) * 2005-12-09 2006-01-18 Astrazeneca Ab Pyrimidine derivatives
US7838542B2 (en) * 2006-06-29 2010-11-23 Kinex Pharmaceuticals, Llc Bicyclic compositions and methods for modulating a kinase cascade
EP2043634A2 (en) * 2006-07-12 2009-04-08 Merck & Co., Inc. Substituted pyrazoles as ghrelin receptor antagonists
WO2008016666A2 (en) * 2006-08-02 2008-02-07 Cytokinetics, Incorporated Certain chemical entities, compositions, and methods
EP2121626A1 (en) * 2006-12-15 2009-11-25 Pfizer Products Inc. Benzimidazole derivatives
WO2008075172A2 (en) * 2006-12-19 2008-06-26 Pfizer Products Inc. Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases
PE20091576A1 (es) * 2008-02-19 2009-11-05 Sanofi Aventis DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3
WO2009143039A2 (en) * 2008-05-19 2009-11-26 Schering Corporation Heterocyclic compounds as factor ixa inhibitors
TW201010997A (en) * 2008-06-18 2010-03-16 Pfizer Ltd Nicotinamide derivatives
US9265734B2 (en) * 2008-09-03 2016-02-23 Biomarin Pharmaceutical Inc. Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors
CN103209982B (zh) * 2010-10-14 2016-03-16 Jw制药公司 反转模拟物的化合物、其制造方法及其用途
EP2648736A4 (en) * 2010-12-08 2015-04-29 Lycera Corp CYCLOALKYL GUANIDINE F1F0 ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF
WO2012135697A2 (en) * 2011-03-30 2012-10-04 H. Lee Moffitt Cancer Center & Research Institute Inc. Novel rho kinase inhibitors and methods of use
EP2532661A1 (en) * 2011-06-10 2012-12-12 Syngenta Participations AG Novel insecticides
WO2012171860A1 (en) * 2011-06-17 2012-12-20 Basilea Pharmaceutica Ag Tricyclic antibiotics
US9145412B2 (en) * 2012-11-02 2015-09-29 Acetylon Pharmaceuticals, Inc. Selective HDAC1 and HDAC2 inhibitors
CN103877078B (zh) * 2012-12-20 2017-03-15 上海交通大学医学院 Senp2小分子抑制剂及其应用
WO2016040511A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Isoxazole carboxamides as irreversible smyd inhibitors
US10428029B2 (en) 2014-09-10 2019-10-01 Epizyme, Inc. Isoxazole carboxamide compounds
US20170253601A1 (en) 2014-09-10 2017-09-07 Epizyme, Inc. Substituted Pyrrolidine Compounds
WO2016040508A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Substituted pyrrolidine carboxamide compounds
WO2016040515A1 (en) 2014-09-10 2016-03-17 Epizyme, Inc. Substituted piperidine compounds
JP2017527576A (ja) 2014-09-10 2017-09-21 エピザイム,インコーポレイティド 置換シクロヘキシルアミン化合物

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