JP2017538659A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2017538659A5 JP2017538659A5 JP2017512982A JP2017512982A JP2017538659A5 JP 2017538659 A5 JP2017538659 A5 JP 2017538659A5 JP 2017512982 A JP2017512982 A JP 2017512982A JP 2017512982 A JP2017512982 A JP 2017512982A JP 2017538659 A5 JP2017538659 A5 JP 2017538659A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cancer
- tumor
- group
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462048773P | 2014-09-10 | 2014-09-10 | |
| US62/048,773 | 2014-09-10 | ||
| US201562146799P | 2015-04-13 | 2015-04-13 | |
| US62/146,799 | 2015-04-13 | ||
| PCT/US2015/049221 WO2016040505A1 (en) | 2014-09-10 | 2015-09-09 | Smyd inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013314A Division JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2017538659A JP2017538659A (ja) | 2017-12-28 |
| JP2017538659A5 true JP2017538659A5 (enExample) | 2018-10-18 |
Family
ID=55459528
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017512982A Pending JP2017538659A (ja) | 2014-09-10 | 2015-09-09 | Smyd阻害剤 |
| JP2020013314A Pending JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
| JP2022118248A Pending JP2022163087A (ja) | 2014-09-10 | 2022-07-25 | Smyd阻害剤 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020013314A Pending JP2020090520A (ja) | 2014-09-10 | 2020-01-30 | Smyd阻害剤 |
| JP2022118248A Pending JP2022163087A (ja) | 2014-09-10 | 2022-07-25 | Smyd阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10266526B2 (enExample) |
| EP (1) | EP3193600A4 (enExample) |
| JP (3) | JP2017538659A (enExample) |
| KR (2) | KR102496364B1 (enExample) |
| CN (2) | CN107072205B (enExample) |
| AU (1) | AU2015315174B2 (enExample) |
| BR (1) | BR112017004612A2 (enExample) |
| CA (1) | CA2960275A1 (enExample) |
| EA (1) | EA201790317A1 (enExample) |
| IL (2) | IL250891A0 (enExample) |
| MX (2) | MX2017002985A (enExample) |
| SG (2) | SG10201901192TA (enExample) |
| WO (1) | WO2016040505A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| PT3131582T (pt) | 2014-04-15 | 2018-10-08 | Vertex Pharma | Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística |
| MX2017002986A (es) | 2014-09-10 | 2017-10-24 | Epizyme Inc | Compuestos de piperidina sustituidos. |
| JP2017526706A (ja) | 2014-09-10 | 2017-09-14 | エピザイム,インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| JP2017528460A (ja) | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的smyd阻害剤としてのイソオキサゾールカルボキサミド |
| AU2015315171A1 (en) | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| WO2018030550A1 (en) | 2016-08-09 | 2018-02-15 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds with an ror(gamma)t modulating activity |
| WO2018151678A1 (en) * | 2017-02-15 | 2018-08-23 | Agency For Science, Technology And Research | Compounds for treatment of cancer and epigenetics |
| AU2018231120B2 (en) * | 2017-03-10 | 2022-06-23 | Rutgers, The State University Of New Jersey | Indole derivatives as efflux pump inhibitors |
| US20200138827A1 (en) * | 2017-06-22 | 2020-05-07 | Curadev Pharma Limited | Small molecule modulators of human sting |
| AU2018288018C1 (en) | 2017-06-22 | 2022-10-20 | Curadev Pharma Limited | Small molecule modulators of human STING |
| CA3072746A1 (en) | 2017-08-14 | 2019-02-21 | Epizyme, Inc. | Methods of treating cancer by inhibiting setd2 |
| EP3837240A4 (en) * | 2018-08-14 | 2022-04-27 | Epizyme, Inc. | Substituted indoles and methods of use thereof |
| WO2020092394A1 (en) | 2018-10-30 | 2020-05-07 | Gilead Sciences, Inc. | Imidazopyridine derivatives as alpha4beta7 integrin inhibitors |
| DK3873884T3 (da) | 2018-10-30 | 2025-02-17 | Gilead Sciences Inc | 3-(quinolin-8-yl)-1,4-dihydropyrido[3,4-d]pyrimidin-2,4-dion-derivater som alpha4beta7-integrinhæmmere til behandling af inflammatoriske sygdomme |
| EP3873897B1 (en) | 2018-10-30 | 2024-08-14 | Gilead Sciences, Inc. | N-benzoyl-phenylalanine derivatives as alpha4beta7 integrin inhibitors for treating inflammatory diseases |
| PL3873605T3 (pl) | 2018-10-30 | 2025-03-03 | Gilead Sciences, Inc. | Związki hamujące integrynę alfa4beta7 |
| EP4010341A1 (en) * | 2019-08-08 | 2022-06-15 | Université de Strasbourg | Trkb positive allosteric modulators |
| US11578069B2 (en) | 2019-08-14 | 2023-02-14 | Gilead Sciences, Inc. | Compounds for inhibition of α4 β7 integrin |
| PH12022551379A1 (en) | 2019-12-06 | 2023-05-03 | Vertex Pharma | Substituted tetrahydrofurans as modulators of sodium channels |
| WO2021134004A1 (en) * | 2019-12-27 | 2021-07-01 | Schrodinger, Inc. | Cyclic compounds and methods of using same |
| US20230133671A1 (en) * | 2020-02-19 | 2023-05-04 | Epizyme, Inc. | Setd2 inhibitors and related methods and uses, including combination therapies |
| WO2021257544A1 (en) | 2020-06-16 | 2021-12-23 | Icahn School Of Medicine At Mount Sinai | Sox11 inhibitors for treating mantle cell lymphoma |
| EP4263535A1 (en) | 2020-12-17 | 2023-10-25 | Astrazeneca AB | N-(2-(4-cyanothiazolidin-3-yl)-2-oxoethyl)- quinoline-4-carboxamides |
| DK4347031T3 (da) | 2021-06-04 | 2025-12-01 | Vertex Pharma | N-(hydroxyalkyl-(hetero)aryl)-tetrahydrofuran-carboxamider som modulatorer af natriumkanaler |
| CN114246851B (zh) * | 2021-11-09 | 2024-01-26 | 澳门科技大学 | 一种组蛋白甲基转移酶smyd3小分子抑制剂的合成方法及用途 |
| CN114702552B (zh) * | 2022-03-11 | 2024-05-31 | 苏州思萃免疫技术研究所有限公司 | mTORC2抑制剂 |
| WO2023192665A2 (en) * | 2022-04-01 | 2023-10-05 | Praxis Precision Medicines, Inc. | T-type calcium channel modulators and methods of use thereof |
| GB2620976B (en) * | 2022-07-28 | 2024-07-24 | Jones Paul | Amido-amine hardener |
| CN120981228A (zh) * | 2022-11-17 | 2025-11-18 | 腾维治疗公司 | 化合物、组合物和方法 |
| CN120882411A (zh) * | 2022-11-17 | 2025-10-31 | 腾维治疗公司 | 化合物、组合物和方法 |
| WO2024158863A1 (en) * | 2023-01-25 | 2024-08-02 | The Rockefeller University | Sulfonamide-1h-pyrrole-2-carboxamide inhibitors of sars-cov-2 nsp14 methyltransferase and derivatives thereof |
| CN116327748B (zh) * | 2023-04-21 | 2024-09-17 | 武汉科技大学 | 联合用药物在制备抗肿瘤药物中的用途 |
| WO2025165834A1 (en) * | 2024-01-31 | 2025-08-07 | Ensem Therapeutics, Inc. | Urea derivatives of tricyclic compounds, and compositions and methods thereof |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1441195A (en) * | 1993-12-30 | 1995-07-17 | Smithkline Beecham Corporation | Phenylmethyl hexanamides, and the use thereof |
| WO1998022432A1 (en) * | 1996-11-18 | 1998-05-28 | Yamanouchi Pharmaceutical Co., Ltd. | Novel acylamino-substituted acylanilide derivatives or pharmaceutical composition comprising the same |
| CZ20021009A3 (cs) * | 1999-09-21 | 2002-06-12 | Astrazeneca Ab | Deriváty chinazolinu, způsob jejich přípravy a jejich pouľití jako léčiv |
| US6867299B2 (en) * | 2000-02-24 | 2005-03-15 | Hoffmann-La Roche Inc. | Oxamide IMPDH inhibitors |
| TWI290136B (en) * | 2000-04-05 | 2007-11-21 | Daiichi Seiyaku Co | Ethylenediamine derivatives |
| CA2415961A1 (en) | 2000-07-19 | 2002-01-24 | Hirohiko Nishiyama | Production method of 1-substituted-1,2,3-triazole derivatives |
| AUPR034000A0 (en) * | 2000-09-25 | 2000-10-19 | Fujisawa Pharmaceutical Co., Ltd. | Aminoalcohol derivatives |
| AU2002338334B8 (en) * | 2001-04-03 | 2008-09-18 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists |
| EP1314733A1 (en) * | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
| GB0205176D0 (en) * | 2002-03-06 | 2002-04-17 | Astrazeneca Ab | Chemical compounds |
| JP2004175739A (ja) * | 2002-11-28 | 2004-06-24 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
| JP2004315395A (ja) * | 2003-04-14 | 2004-11-11 | Yamanouchi Pharmaceut Co Ltd | 新規な安息香酸誘導体又はその塩 |
| GB0317516D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as PDE4 inhibitors |
| CA2538759C (en) * | 2003-09-12 | 2015-11-03 | Elixir Pharmaceuticals, Inc. | Substituted heterocyclic compounds as sirtuin inhitibitors |
| JP2007518823A (ja) * | 2004-01-23 | 2007-07-12 | アムゲン インコーポレイテッド | キノリン、キナゾリン、ピリジン、及びピリミジン化合物と炎症、血管新生、及び癌に対する治療におけるそれら化合物の用途 |
| EP1718611A4 (en) * | 2004-02-13 | 2009-09-23 | Harvard College | 3-3-DI-SUBSTITUTED OXINDOLES AS INHIBITORS OF INITIATION OF TRANSLATION |
| JP2006089485A (ja) * | 2004-08-24 | 2006-04-06 | Santen Pharmaceut Co Ltd | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| CA2588607A1 (en) * | 2004-11-23 | 2006-06-01 | Ptc Therapeutics, Inc. | Carbazole, carboline and indole derivatives useful in the inhibition of vegf production |
| US20090253671A1 (en) * | 2005-03-04 | 2009-10-08 | Astrazeneca Ab | Tricyclic derivatives of azetidine and pyrrole with antibacterial activity |
| AU2006232620A1 (en) * | 2005-04-06 | 2006-10-12 | Astrazeneca Ab | Substituted heterocycles and their use as CHK1, PDK1 and PAK inhibitors |
| WO2007002220A2 (en) * | 2005-06-21 | 2007-01-04 | Bristol-Myers Squibb Company | Aminoacetamide acyl guanidines as beta-secretase inhibitors |
| TW200741009A (en) * | 2005-07-01 | 2007-11-01 | Oncotherapy Science Inc | Methods of modulating SMYD3 for treatment of cancer |
| PE20071092A1 (es) * | 2005-12-08 | 2007-12-10 | Aventis Pharma Inc | Composicion farmaceutica que comprende un antagonista de cb1 y un agente antisicotico |
| GB0525083D0 (en) * | 2005-12-09 | 2006-01-18 | Astrazeneca Ab | Pyrimidine derivatives |
| US7838542B2 (en) * | 2006-06-29 | 2010-11-23 | Kinex Pharmaceuticals, Llc | Bicyclic compositions and methods for modulating a kinase cascade |
| EP2043634A2 (en) * | 2006-07-12 | 2009-04-08 | Merck & Co., Inc. | Substituted pyrazoles as ghrelin receptor antagonists |
| WO2008016666A2 (en) * | 2006-08-02 | 2008-02-07 | Cytokinetics, Incorporated | Certain chemical entities, compositions, and methods |
| JP2010513263A (ja) * | 2006-12-15 | 2010-04-30 | ファイザー・プロダクツ・インク | ベンズイミダゾール誘導体 |
| CA2672373C (en) * | 2006-12-19 | 2011-08-30 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| PE20091576A1 (es) * | 2008-02-19 | 2009-11-05 | Sanofi Aventis | DERIVADOS DE 3-(AMIDO O SULFAMIDO)-4-(4-AZINIL SUSTITUIDO)BENZAMIDA COMO INHIBIDORES DEL RECEPTOR DE QUIMIOQUINAS CxCR3 |
| WO2009143039A2 (en) * | 2008-05-19 | 2009-11-26 | Schering Corporation | Heterocyclic compounds as factor ixa inhibitors |
| TW201010997A (en) | 2008-06-18 | 2010-03-16 | Pfizer Ltd | Nicotinamide derivatives |
| ES2620027T3 (es) * | 2008-09-03 | 2017-06-27 | Biomarin Pharmaceutical Inc. | Composiciones que incluyen derivados del ácido 6-aminohexanoico como inhibidores de HDAC |
| WO2012050393A2 (ko) * | 2010-10-14 | 2012-04-19 | 제이더블유중외제약 주식회사 | 리버스-턴 유사체의 신규한 화합물 및 그 제조방법과 용도 |
| CA2820035A1 (en) * | 2010-12-08 | 2012-06-14 | Lycera Corporation | Cycloalkyl guanidine f1f0-atpase inhibitors and therapeutic uses thereof |
| WO2012135697A2 (en) * | 2011-03-30 | 2012-10-04 | H. Lee Moffitt Cancer Center & Research Institute Inc. | Novel rho kinase inhibitors and methods of use |
| EP2532661A1 (en) * | 2011-06-10 | 2012-12-12 | Syngenta Participations AG | Novel insecticides |
| CN103635474B (zh) * | 2011-06-17 | 2016-04-27 | 巴斯利尔药物股份公司 | 三环抗生素 |
| US9145412B2 (en) * | 2012-11-02 | 2015-09-29 | Acetylon Pharmaceuticals, Inc. | Selective HDAC1 and HDAC2 inhibitors |
| CN103877078B (zh) * | 2012-12-20 | 2017-03-15 | 上海交通大学医学院 | Senp2小分子抑制剂及其应用 |
| JP2017526706A (ja) | 2014-09-10 | 2017-09-14 | エピザイム,インコーポレイティド | イソオキサゾールカルボキサミド化合物 |
| US20170247326A1 (en) | 2014-09-10 | 2017-08-31 | Epizyme, Inc. | Substituted Pyrrolidine Carboxamide Compounds |
| AU2015315171A1 (en) | 2014-09-10 | 2017-03-16 | Epizyme, Inc. | Substituted cyclohexylamine compounds |
| MX2017002986A (es) | 2014-09-10 | 2017-10-24 | Epizyme Inc | Compuestos de piperidina sustituidos. |
| JP2017528460A (ja) | 2014-09-10 | 2017-09-28 | エピザイム インコーポレイテッド | 不可逆的smyd阻害剤としてのイソオキサゾールカルボキサミド |
| US20170253601A1 (en) | 2014-09-10 | 2017-09-07 | Epizyme, Inc. | Substituted Pyrrolidine Compounds |
-
2015
- 2015-09-09 KR KR1020177009602A patent/KR102496364B1/ko active Active
- 2015-09-09 MX MX2017002985A patent/MX2017002985A/es unknown
- 2015-09-09 CA CA2960275A patent/CA2960275A1/en active Pending
- 2015-09-09 BR BR112017004612-1A patent/BR112017004612A2/pt not_active Application Discontinuation
- 2015-09-09 EA EA201790317A patent/EA201790317A1/ru unknown
- 2015-09-09 WO PCT/US2015/049221 patent/WO2016040505A1/en not_active Ceased
- 2015-09-09 CN CN201580060859.4A patent/CN107072205B/zh not_active Expired - Fee Related
- 2015-09-09 SG SG10201901192TA patent/SG10201901192TA/en unknown
- 2015-09-09 US US15/510,586 patent/US10266526B2/en active Active
- 2015-09-09 CN CN202210734932.3A patent/CN115028619A/zh active Pending
- 2015-09-09 JP JP2017512982A patent/JP2017538659A/ja active Pending
- 2015-09-09 AU AU2015315174A patent/AU2015315174B2/en not_active Ceased
- 2015-09-09 EP EP15840789.0A patent/EP3193600A4/en not_active Withdrawn
- 2015-09-09 KR KR1020237003762A patent/KR20230026515A/ko not_active Ceased
- 2015-09-09 SG SG11201701598PA patent/SG11201701598PA/en unknown
-
2017
- 2017-03-02 IL IL250891A patent/IL250891A0/en unknown
- 2017-03-07 MX MX2023006257A patent/MX2023006257A/es unknown
-
2019
- 2019-02-06 US US16/269,338 patent/US20190322660A1/en not_active Abandoned
-
2020
- 2020-01-30 JP JP2020013314A patent/JP2020090520A/ja active Pending
- 2020-05-01 US US16/864,891 patent/US20210198252A1/en not_active Abandoned
-
2021
- 2021-10-10 IL IL287113A patent/IL287113A/en unknown
- 2021-11-22 US US17/532,422 patent/US20230101819A1/en not_active Abandoned
-
2022
- 2022-07-25 JP JP2022118248A patent/JP2022163087A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2017538659A5 (enExample) | ||
| JP2020090520A5 (enExample) | ||
| JP2017528461A5 (enExample) | ||
| JP2017511801A5 (enExample) | ||
| CA2807620C (en) | Pharmaceutically active compounds as axl inhibitors | |
| JP2017528464A5 (enExample) | ||
| US9546156B2 (en) | N-bicyclic aryl,N'-pyrazolyl urea, thiourea, guanidine cyanoguanidine compounds as TrkA kinase inhibitors | |
| AU2017221802B2 (en) | Bicyclic urea, thiourea, guanidine and cyanoguanidine compounds useful for the treatment of pain | |
| US9790210B2 (en) | N-(monocyclic aryl),N'-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | |
| AU2015330506B2 (en) | EGFR inhibitor, and preparation and application thereof | |
| RU2632908C2 (ru) | Гетероциклическое производное и фармацевтическое средство | |
| US9969694B2 (en) | N-(arylalkyl)-N′-pyrazolyl-urea, thiourea, guanidine and cyanoguanidine compounds as TrkA kinase inhibitors | |
| US9809578B2 (en) | Pyrazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trkA kinase inhibitors | |
| JP2017527577A5 (enExample) | ||
| JP2020503299A5 (enExample) | ||
| CN112601747B (zh) | 作为malt1抑制剂的吡唑衍生物 | |
| JP2011510995A5 (enExample) | ||
| JP2017538659A (ja) | Smyd阻害剤 | |
| US20160280702A1 (en) | Thiazolyl and oxazolyl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors | |
| WO2014078408A1 (en) | Bicyclic heteroaryl urea, thiourea, guanidine and cyanoguanidine compounds as trka kinase inhibitors | |
| JP2019519595A (ja) | 新規のイミダゾピリジン誘導体、その製造方法及びこれを有効成分として含有する癌の予防又は治療用医薬組成物 | |
| MXPA05007990A (es) | Compuestos de tienopirimidina y uso de los mismos. | |
| JP2017528460A5 (enExample) | ||
| JP2017526706A5 (enExample) | ||
| JP2017527577A (ja) | 置換ピロリジン化合物 |