JP2009511590A5 - - Google Patents
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- Publication number
- JP2009511590A5 JP2009511590A5 JP2008535659A JP2008535659A JP2009511590A5 JP 2009511590 A5 JP2009511590 A5 JP 2009511590A5 JP 2008535659 A JP2008535659 A JP 2008535659A JP 2008535659 A JP2008535659 A JP 2008535659A JP 2009511590 A5 JP2009511590 A5 JP 2009511590A5
- Authority
- JP
- Japan
- Prior art keywords
- ergocalciferol
- cholecalciferol
- composition according
- total
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 31
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims 23
- 229960002061 ergocalciferol Drugs 0.000 claims 23
- 235000001892 vitamin D2 Nutrition 0.000 claims 23
- 239000011653 vitamin D2 Substances 0.000 claims 23
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 23
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 22
- 235000005282 vitamin D3 Nutrition 0.000 claims 22
- 239000011647 vitamin D3 Substances 0.000 claims 22
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 22
- 229940021056 vitamin d3 Drugs 0.000 claims 22
- 238000009472 formulation Methods 0.000 claims 5
- 210000002966 serum Anatomy 0.000 claims 3
- JWUBBDSIWDLEOM-XHQRYOPUSA-N (3e)-3-[(2e)-2-[1-(6-hydroxy-6-methylheptan-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol Chemical compound C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2\C1=C\C=C1/CC(O)CCC1=C JWUBBDSIWDLEOM-XHQRYOPUSA-N 0.000 claims 2
- 235000021318 Calcifediol Nutrition 0.000 claims 2
- 230000007812 deficiency Effects 0.000 claims 2
- 239000002702 enteric coating Substances 0.000 claims 2
- 238000009505 enteric coating Methods 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- KJKIIUAXZGLUND-ICCVIKJNSA-N 25-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C KJKIIUAXZGLUND-ICCVIKJNSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 230000002092 calcimimetic effect Effects 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 230000029087 digestion Effects 0.000 claims 1
- 210000003405 ileum Anatomy 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000011159 matrix material Substances 0.000 claims 1
- 239000008203 oral pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000002784 stomach Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72570905P | 2005-10-12 | 2005-10-12 | |
| US60/725,709 | 2005-10-12 | ||
| PCT/US2006/039787 WO2007047327A2 (en) | 2005-10-12 | 2006-10-12 | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511590A JP2009511590A (ja) | 2009-03-19 |
| JP2009511590A5 true JP2009511590A5 (https=) | 2010-02-18 |
| JP5303276B2 JP5303276B2 (ja) | 2013-10-02 |
Family
ID=37876888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008535659A Expired - Fee Related JP5303276B2 (ja) | 2005-10-12 | 2006-10-12 | ２５−ヒドロキシビタミンｄ不足および欠乏を治療するための方法および製品 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070122477A1 (https=) |
| EP (2) | EP3047847A1 (https=) |
| JP (1) | JP5303276B2 (https=) |
| CA (2) | CA2624897C (https=) |
| ES (1) | ES2567595T3 (https=) |
| WO (1) | WO2007047327A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3095447T1 (sl) | 2006-02-03 | 2022-02-28 | Opko Renal, Llc | Zdravljenje pomanjkanja vitamina D s 25-hidroksivitaminom D2 in 25-hidroksivitaminom D3 |
| HUE037309T2 (hu) | 2006-06-21 | 2018-08-28 | Opko Ireland Global Holdings Ltd | Terápia D-vitamin telítési szer alkalmazásával és D-vitamin hormon helyettesítõ szer |
| DK2148684T3 (da) * | 2007-04-25 | 2013-04-22 | Cytochroma Inc | Fremgangsmåde til behandling af vitamin D-insufficiens og -deficiens |
| PL2148661T3 (pl) | 2007-04-25 | 2013-07-31 | Cytochroma Inc | Doustne kompozycje o kontrolowanym uwalnianiu zawierające związek będący witaminą D i woskowy nośnik |
| US8592401B2 (en) | 2007-04-25 | 2013-11-26 | Proventiv Therapeutics, Llc | Methods and compounds for vitamin D therapy |
| PT3335712T (pt) | 2007-04-25 | 2025-10-23 | Opko Renal Llc | Método de tratamento e prevenção seguro e eficaz do hiperparatiroidismo secundário na doença renal crónica |
| US20110124608A1 (en) * | 2007-08-07 | 2011-05-26 | Thau Kiong Chung | Use of 25-hydroxy vitamin d3 to increase muscle mass in mammals |
| ES2599761T5 (en) * | 2008-02-13 | 2025-06-18 | Dsm Ip Assets Bv | Use of 25-hydroxy-vitamin d3 and vitamin d to affect human muscle physiology |
| US20110039809A1 (en) * | 2008-02-13 | 2011-02-17 | Neil Robert Buck | Combined use of 25-hydroxy-vitamin d3 and vitamin d3 for improving bone mineral density and for treating osteoporisis |
| CN106214683A (zh) * | 2008-02-13 | 2016-12-14 | 帝斯曼知识产权资产管理有限公司 | 维生素d和25‑羟基维生素d3的组合 |
| US20100331286A1 (en) * | 2008-02-25 | 2010-12-30 | Ray Chow | Combination therapy for treatment of bone and mineral disorders for patients with impaired renal function |
| WO2009108297A2 (en) * | 2008-02-25 | 2009-09-03 | Nephrian, Inc. | Combination therapy for treatment of bone and mineral disorders for patients with impaired renal function |
| CN102046812A (zh) * | 2008-04-02 | 2011-05-04 | 赛特克罗公司 | 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒 |
| LT2310059T (lt) * | 2008-05-29 | 2017-03-27 | Numat Biomedical S.L. | Pufa dengti implantai |
| PT2552484T (pt) | 2010-03-29 | 2020-04-03 | Opko Ireland Global Holdings Ltd | Métodos e composições para redução dos níveis de parafróides |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CN104356038B (zh) * | 2014-10-15 | 2016-06-01 | 中国科学院上海药物研究所 | 维生素d2与d3的共晶及其制备方法和用途 |
| MY198547A (en) | 2016-03-28 | 2023-09-04 | Opko Ireland Global Holdings Ltd | Methods of vitamin d treatment |
| CN117412739A (zh) * | 2021-03-17 | 2024-01-16 | 索米克生物技术有限公司 | 维生素d制剂 |
| EP4059490B1 (en) * | 2021-03-17 | 2024-06-05 | Solmic Biotech GmbH | Process for manufacturing vitamin d formulations |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3565924A (en) * | 1968-07-01 | 1971-02-23 | Wisconsin Alumni Res Found | 25-hydroxycholfcalciferol |
| US3880894A (en) * | 1974-05-24 | 1975-04-29 | Wisconsin Alumni Res Found | 1,25-Dihydroxyergocalciferol |
| US4004003A (en) * | 1974-08-28 | 1977-01-18 | The Upjohn Company | 25-Hydroxycalciferol compounds for treatment of steroid-induced osteoporosis |
| US4335120A (en) * | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
| US4230701A (en) * | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
| US4721613A (en) * | 1982-12-13 | 1988-01-26 | Alza Corporation | Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use |
| JPS59155309A (ja) * | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンｄ↓３類組成物 |
| US4684524A (en) * | 1984-03-19 | 1987-08-04 | Alza Corporation | Rate controlled dispenser for administering beneficial agent |
| US4555364A (en) * | 1984-11-01 | 1985-11-26 | Wisconsin Alumni Research Foundation | Method for preparing 1-hydroxyvitamin D compounds |
| US4695591A (en) * | 1985-03-29 | 1987-09-22 | Schering Corporation | Controlled release dosage forms comprising hydroxypropylmethylcellulose |
| US4668517A (en) * | 1985-04-04 | 1987-05-26 | Norwich Eaton Pharmaceuticals, Inc. | Furazolidone dosage form |
| DE3676235D1 (de) * | 1985-06-04 | 1991-01-31 | Teijin Ltd | Arzneizubereitung mit verzoegerter wirkstoffabgabe. |
| US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
| US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
| US5869473A (en) * | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| JP2893191B2 (ja) * | 1988-11-08 | 1999-05-17 | 武田薬品工業株式会社 | 放出制御性マトリックス剤 |
| US5026559A (en) * | 1989-04-03 | 1991-06-25 | Kinaform Technology, Inc. | Sustained-release pharmaceutical preparation |
| US6451341B1 (en) * | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
| JP2845342B2 (ja) * | 1990-04-28 | 1999-01-13 | 大正製薬株式会社 | ビタミンｄ▲下３▼誘導体含有固形製剤組成物 |
| TW212761B (https=) * | 1991-04-09 | 1993-09-11 | Takeda Pharm Industry Co Ltd | |
| US5693615A (en) * | 1991-06-05 | 1997-12-02 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
| US5160742A (en) * | 1991-12-31 | 1992-11-03 | Abbott Laboratories | System for delivering an active substance for sustained release |
| US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| DK0600079T3 (da) * | 1992-06-22 | 2002-04-15 | Bone Care Int Inc | Oral 1alpha-hydroxyprævitamin D |
| EP0660718B1 (en) * | 1992-09-15 | 1999-12-08 | THYS-JACOBS, Susan | Method of treating premenstrual syndrome symptomatology with vitamin d or vitamin d and calcium |
| US5354743A (en) * | 1992-09-15 | 1994-10-11 | Thys Jacobs Susan | Method for the treatment of premenstrual syndrome with vitamin D |
| US6376479B1 (en) * | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| JP2002511777A (ja) * | 1996-10-28 | 2002-04-16 | ゼネラル ミルズ，インコーポレイテッド | 調放性粒子の埋包およびカプセル化 |
| JP2001511811A (ja) * | 1997-02-13 | 2001-08-14 | ボーン ケア インターナショナル インコーポレイテッド | ビタミンｄ化合物の標的治療放出 |
| FR2760639B1 (fr) * | 1997-03-14 | 2000-09-22 | Innothera Lab Sa | Association therapeutique mineralo-vitaminique sous forme de preparation unitaire liquide buvable |
| ITFI970184A1 (it) * | 1997-07-30 | 1999-01-30 | Menarini Farma Ind | Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico |
| US6245360B1 (en) * | 1998-06-26 | 2001-06-12 | John S. Markowitz | Nutritional supplement |
| US6139875A (en) * | 1998-09-29 | 2000-10-31 | Eastman Chemical Company | Aqueous enteric coating composition and low gastric permeability enteric coating |
| WO2000035419A2 (en) * | 1998-12-17 | 2000-06-22 | Alza Corporation | Conversion of liquid filled gelatin capsules into controlled release systems by multiple coatings |
| US6342249B1 (en) * | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
| US6432936B1 (en) * | 1999-01-20 | 2002-08-13 | Wisconsin Alumni Research Foundation | Crystalline 1α-hydroxyvitamin D2 and method of purification thereof |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| ATE344039T1 (de) * | 1999-04-01 | 2006-11-15 | Univ Johns Hopkins | Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung |
| AU5139600A (en) * | 1999-05-27 | 2000-12-18 | Drugtech Corporation | Nutritional formulations |
| US6051567A (en) * | 1999-08-02 | 2000-04-18 | Abbott Laboratories | Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol |
| US6274169B1 (en) * | 1999-08-02 | 2001-08-14 | Abbott Laboratories | Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol |
| EP1301479A2 (en) * | 2000-07-18 | 2003-04-16 | Bone Care International, Inc. | STABILIZED 1$g(a)-HYDROXY VITAMIN D |
| EP1297751A1 (de) * | 2001-10-01 | 2003-04-02 | Bogar AG | Oral zu verabreichende Zubereitung |
| JP4436674B2 (ja) * | 2001-10-12 | 2010-03-24 | ジョンズ ホプキンス ユニバーシティ | １α，２５−ジヒドロキシビタミンＤ３の低カルシウム血症性オキシム類似体 |
| US7056655B2 (en) * | 2001-11-02 | 2006-06-06 | Scantibodies Laboratory, Inc. | Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism |
| US20050070504A1 (en) * | 2001-12-21 | 2005-03-31 | The Procter & Gamble Co. | Risedronate compositions and their methods of use |
| ATE543796T1 (de) * | 2002-06-13 | 2012-02-15 | Univ Johns Hopkins | 24-sulfoximine vitamin d3 derivate |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| US20050124591A1 (en) * | 2003-07-29 | 2005-06-09 | Jin Tian | Use of vitamin Ds to treat kidney disease |
| US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
| US20050032741A1 (en) * | 2003-08-06 | 2005-02-10 | Balaji Venkataraman | Vitamin Compositions |
-
2006
- 2006-10-12 WO PCT/US2006/039787 patent/WO2007047327A2/en not_active Ceased
- 2006-10-12 JP JP2008535659A patent/JP5303276B2/ja not_active Expired - Fee Related
- 2006-10-12 EP EP15197974.7A patent/EP3047847A1/en not_active Withdrawn
- 2006-10-12 CA CA2624897A patent/CA2624897C/en not_active Expired - Fee Related
- 2006-10-12 EP EP06836270.6A patent/EP1945185B1/en not_active Not-in-force
- 2006-10-12 ES ES06836270.6T patent/ES2567595T3/es active Active
- 2006-10-12 CA CA2924200A patent/CA2924200C/en not_active Expired - Fee Related
- 2006-10-12 US US11/549,001 patent/US20070122477A1/en not_active Abandoned
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