ES2567595T3 - Métodos y artículos para tratar la insuficiencia y la deficiencia de 25-hidroxivitamina D - Google Patents
Métodos y artículos para tratar la insuficiencia y la deficiencia de 25-hidroxivitamina D Download PDFInfo
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- ES2567595T3 ES2567595T3 ES06836270.6T ES06836270T ES2567595T3 ES 2567595 T3 ES2567595 T3 ES 2567595T3 ES 06836270 T ES06836270 T ES 06836270T ES 2567595 T3 ES2567595 T3 ES 2567595T3
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- ergocalciferol
- cholecalciferol
- composition
- hydroxyvitamin
- vitamin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4875—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72570905P | 2005-10-12 | 2005-10-12 | |
| US725709P | 2005-10-12 | ||
| PCT/US2006/039787 WO2007047327A2 (en) | 2005-10-12 | 2006-10-12 | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2567595T3 true ES2567595T3 (es) | 2016-04-25 |
Family
ID=37876888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06836270.6T Active ES2567595T3 (es) | 2005-10-12 | 2006-10-12 | Métodos y artículos para tratar la insuficiencia y la deficiencia de 25-hidroxivitamina D |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20070122477A1 (https=) |
| EP (2) | EP1945185B1 (https=) |
| JP (1) | JP5303276B2 (https=) |
| CA (2) | CA2624897C (https=) |
| ES (1) | ES2567595T3 (https=) |
| WO (1) | WO2007047327A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2593047T3 (es) | 2006-02-03 | 2016-12-05 | Opko Renal, Llc | Tratamiento de la insuficiencia y deficiencia de vitamina D con 25-hidroxivitamina D2 y 25-hidroxivitamina D3 |
| ES2670029T3 (es) | 2006-06-21 | 2018-05-29 | Opko Ireland Global Holdings, Ltd. | Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D |
| US8592401B2 (en) | 2007-04-25 | 2013-11-26 | Proventiv Therapeutics, Llc | Methods and compounds for vitamin D therapy |
| KR20190028822A (ko) | 2007-04-25 | 2019-03-19 | 사이토크로마 인코포레이티드 | 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물 |
| HUE073014T2 (hu) * | 2007-04-25 | 2025-12-28 | Opko Renal Llc | Eljárás a másodlagos hyperparathyreoidismus biztonságos és hatékony kezelésére és megelõzésére krónikus vesebetegség esetén |
| US11752158B2 (en) * | 2007-04-25 | 2023-09-12 | Eirgen Pharma Ltd. | Method of treating vitamin D insufficiency and deficiency |
| PL2173356T5 (pl) * | 2007-08-07 | 2018-11-30 | Dsm Ip Assets B.V. | Stosowanie 25-hydroksywitaminy d3 do zwiększania masy mięśniowej u ssaków |
| KR20100126375A (ko) * | 2008-02-13 | 2010-12-01 | 디에스엠 아이피 어셋츠 비.브이. | 비타민 ｄ와 25-하이드록시비타민 ｄ3의 조합물 |
| JP5593550B2 (ja) * | 2008-02-13 | 2014-09-24 | ディーエスエム アイピー アセッツ ビー．ブイ． | ヒトの筋生理に影響を与えるための２５−ヒドロキシビタミンｄ３の使用 |
| MX2010008906A (es) * | 2008-02-13 | 2010-11-05 | Dsm Ip Assets Bv | Uso combinado de 25-hidroxi-vitamina d3 y vitamina d3 para mejorar la densidad mineral osea y para tratar osteoporosis. |
| US20100331286A1 (en) * | 2008-02-25 | 2010-12-30 | Ray Chow | Combination therapy for treatment of bone and mineral disorders for patients with impaired renal function |
| WO2009108297A2 (en) * | 2008-02-25 | 2009-09-03 | Nephrian, Inc. | Combination therapy for treatment of bone and mineral disorders for patients with impaired renal function |
| EP2281058B1 (en) | 2008-04-02 | 2016-06-29 | Opko Ireland Global Holdings, Ltd. | Methods, compositions, uses, and kits useful for vitamin d deficiency and related disorders |
| EP2310059B1 (en) * | 2008-05-29 | 2016-11-16 | Numat Biomedical S.L. | Pufa covered implants |
| WO2011123476A1 (en) | 2010-03-29 | 2011-10-06 | Cytochroma Inc. | Methods and compositions for reducing parathyroid levels |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CN104356038B (zh) * | 2014-10-15 | 2016-06-01 | 中国科学院上海药物研究所 | 维生素d2与d3的共晶及其制备方法和用途 |
| JP7032322B2 (ja) | 2016-03-28 | 2022-03-08 | オプコ アイルランド グローバル ホールディングス リミテッド | ビタミンｄ治療法 |
| CN117412739A (zh) * | 2021-03-17 | 2024-01-16 | 索米克生物技术有限公司 | 维生素d制剂 |
| EP4059490B1 (en) * | 2021-03-17 | 2024-06-05 | Solmic Biotech GmbH | Process for manufacturing vitamin d formulations |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3565924A (en) * | 1968-07-01 | 1971-02-23 | Wisconsin Alumni Res Found | 25-hydroxycholfcalciferol |
| US3880894A (en) * | 1974-05-24 | 1975-04-29 | Wisconsin Alumni Res Found | 1,25-Dihydroxyergocalciferol |
| US4004003A (en) * | 1974-08-28 | 1977-01-18 | The Upjohn Company | 25-Hydroxycalciferol compounds for treatment of steroid-induced osteoporosis |
| US4335120A (en) * | 1979-03-21 | 1982-06-15 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
| US4230701A (en) * | 1979-03-21 | 1980-10-28 | Hoffmann-La Roche Inc. | Administration of biologically active vitamin D3 and vitamin D2 materials |
| US4721613A (en) * | 1982-12-13 | 1988-01-26 | Alza Corporation | Delivery system comprising means for shielding a multiplicity of reservoirs in selected environment of use |
| JPS59155309A (ja) * | 1983-02-22 | 1984-09-04 | Teijin Ltd | 活性型ビタミンｄ↓３類組成物 |
| US4684524A (en) * | 1984-03-19 | 1987-08-04 | Alza Corporation | Rate controlled dispenser for administering beneficial agent |
| US4555364A (en) * | 1984-11-01 | 1985-11-26 | Wisconsin Alumni Research Foundation | Method for preparing 1-hydroxyvitamin D compounds |
| US4695591A (en) * | 1985-03-29 | 1987-09-22 | Schering Corporation | Controlled release dosage forms comprising hydroxypropylmethylcellulose |
| US4668517A (en) * | 1985-04-04 | 1987-05-26 | Norwich Eaton Pharmaceuticals, Inc. | Furazolidone dosage form |
| DE3676235D1 (de) * | 1985-06-04 | 1991-01-31 | Teijin Ltd | Arzneizubereitung mit verzoegerter wirkstoffabgabe. |
| US5104864A (en) * | 1988-08-02 | 1992-04-14 | Bone Care International, Inc. | Method for treating and preventing loss of bone mass |
| US5602116A (en) * | 1988-08-02 | 1997-02-11 | Bone Care International, Inc. | Method for treating and preventing secondary hyperparathyroidism |
| US5869473A (en) * | 1988-08-02 | 1999-02-09 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| JP2893191B2 (ja) * | 1988-11-08 | 1999-05-17 | 武田薬品工業株式会社 | 放出制御性マトリックス剤 |
| US5026559A (en) * | 1989-04-03 | 1991-06-25 | Kinaform Technology, Inc. | Sustained-release pharmaceutical preparation |
| US6451341B1 (en) * | 1990-02-05 | 2002-09-17 | Thomas J. Slaga | Time release formulation of vitamins, minerals and other beneficial supplements |
| JP2845342B2 (ja) * | 1990-04-28 | 1999-01-13 | 大正製薬株式会社 | ビタミンｄ▲下３▼誘導体含有固形製剤組成物 |
| DE69214704T2 (de) * | 1991-04-09 | 1997-04-17 | Takeda Chemical Industries Ltd | Stabilisiertes Vitamin D Arzneimittel |
| US5693615A (en) * | 1991-06-05 | 1997-12-02 | The Procter & Gamble Company | Therapeutic compositions for osteoinduction |
| US5160742A (en) * | 1991-12-31 | 1992-11-03 | Abbott Laboratories | System for delivering an active substance for sustained release |
| JP3722832B2 (ja) * | 1992-06-22 | 2005-11-30 | ルーナー、コーポレーション | 経口用１α−ヒドロキシプレビタミンＤ |
| US5795882A (en) * | 1992-06-22 | 1998-08-18 | Bone Care International, Inc. | Method of treating prostatic diseases using delayed and/or sustained release vitamin D formulations |
| US5354743A (en) * | 1992-09-15 | 1994-10-11 | Thys Jacobs Susan | Method for the treatment of premenstrual syndrome with vitamin D |
| EP0660718B1 (en) * | 1992-09-15 | 1999-12-08 | THYS-JACOBS, Susan | Method of treating premenstrual syndrome symptomatology with vitamin d or vitamin d and calcium |
| US20020183288A1 (en) * | 1995-04-03 | 2002-12-05 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| US20040043971A1 (en) * | 1995-04-03 | 2004-03-04 | Bone Care International, Inc. | Method of treating and preventing hyperparathyroidism with active vitamin D analogs |
| US6376479B1 (en) * | 1995-04-03 | 2002-04-23 | Bone Care International, Inc. | Method for treating and preventing hyperparathyroidism |
| CA2269806C (en) * | 1996-10-28 | 2006-01-24 | Bernhard H. Van Lengerich | Embedding and encapsulation of controlled release particles |
| JP2001511811A (ja) * | 1997-02-13 | 2001-08-14 | ボーン ケア インターナショナル インコーポレイテッド | ビタミンｄ化合物の標的治療放出 |
| FR2760639B1 (fr) * | 1997-03-14 | 2000-09-22 | Innothera Lab Sa | Association therapeutique mineralo-vitaminique sous forme de preparation unitaire liquide buvable |
| ITFI970184A1 (it) * | 1997-07-30 | 1999-01-30 | Menarini Farma Ind | Composizioni farmaceutiche contenenti vitamina d e calcio,loro preparazione ed uso terapeutico |
| US6245360B1 (en) * | 1998-06-26 | 2001-06-12 | John S. Markowitz | Nutritional supplement |
| US6139875A (en) * | 1998-09-29 | 2000-10-31 | Eastman Chemical Company | Aqueous enteric coating composition and low gastric permeability enteric coating |
| PT1140012E (pt) * | 1998-12-17 | 2004-05-31 | Alza Corp | Conversao de capsulas de gelatina cheias com liquido em sistemas de libertacao controlada por camadas multiplas |
| US6342249B1 (en) * | 1998-12-23 | 2002-01-29 | Alza Corporation | Controlled release liquid active agent formulation dosage forms |
| US6432936B1 (en) * | 1999-01-20 | 2002-08-13 | Wisconsin Alumni Research Foundation | Crystalline 1α-hydroxyvitamin D2 and method of purification thereof |
| US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
| EP1745787B1 (en) * | 1999-04-01 | 2016-11-09 | Johns Hopkins University | NON-CALCEMIC, ANTIPROLIFERATIVE, TRANSCRIPTIONALLY ACTIVE SULFUR-CONTAINING ANALOGS OF 1-alpha 25-DIHYDROXY VITAMIN D3 |
| WO2000072831A1 (en) * | 1999-05-27 | 2000-12-07 | Drugtech Corporation | Nutritional formulations |
| US6274169B1 (en) * | 1999-08-02 | 2001-08-14 | Abbott Laboratories | Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol |
| US6051567A (en) * | 1999-08-02 | 2000-04-18 | Abbott Laboratories | Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol |
| AU7895601A (en) * | 2000-07-18 | 2002-01-30 | Bone Care Int Inc | Stabilized 1alpha-hydroxy vitamin d |
| EP1297751A1 (de) * | 2001-10-01 | 2003-04-02 | Bogar AG | Oral zu verabreichende Zubereitung |
| ES2283593T3 (es) * | 2001-10-12 | 2007-11-01 | Johns Hopkins University | Analogos de oxima poco calcemicos de 1alfa,25-dihidroxi vitamina d3. |
| US7056655B2 (en) * | 2001-11-02 | 2006-06-06 | Scantibodies Laboratory, Inc. | Methods for monitoring and guiding therapeutic suppression of parathyroid hormone in renal patients having secondary hyperparathyroidism |
| US20050070504A1 (en) * | 2001-12-21 | 2005-03-31 | The Procter & Gamble Co. | Risedronate compositions and their methods of use |
| US7101865B2 (en) * | 2002-06-13 | 2006-09-05 | Cytochroma Inc. | 24-sulfoximine vitamin D3 compounds |
| US20050101576A1 (en) * | 2003-11-06 | 2005-05-12 | Novacea, Inc. | Methods of using vitamin D compounds in the treatment of myelodysplastic syndromes |
| US20050148557A1 (en) * | 2003-07-29 | 2005-07-07 | Jin Tian | Use of Vitamin Ds to treat kidney disease |
| US20050124591A1 (en) * | 2003-07-29 | 2005-06-09 | Jin Tian | Use of vitamin Ds to treat kidney disease |
| US20050032741A1 (en) * | 2003-08-06 | 2005-02-10 | Balaji Venkataraman | Vitamin Compositions |
-
2006
- 2006-10-12 CA CA2624897A patent/CA2624897C/en not_active Expired - Fee Related
- 2006-10-12 ES ES06836270.6T patent/ES2567595T3/es active Active
- 2006-10-12 JP JP2008535659A patent/JP5303276B2/ja not_active Expired - Fee Related
- 2006-10-12 EP EP06836270.6A patent/EP1945185B1/en not_active Not-in-force
- 2006-10-12 CA CA2924200A patent/CA2924200C/en not_active Expired - Fee Related
- 2006-10-12 US US11/549,001 patent/US20070122477A1/en not_active Abandoned
- 2006-10-12 WO PCT/US2006/039787 patent/WO2007047327A2/en not_active Ceased
- 2006-10-12 EP EP15197974.7A patent/EP3047847A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US20070122477A1 (en) | 2007-05-31 |
| CA2924200C (en) | 2017-09-05 |
| CA2624897C (en) | 2017-02-14 |
| EP1945185B1 (en) | 2016-02-03 |
| EP1945185A2 (en) | 2008-07-23 |
| JP2009511590A (ja) | 2009-03-19 |
| WO2007047327A3 (en) | 2007-12-21 |
| WO2007047327A2 (en) | 2007-04-26 |
| CA2624897A1 (en) | 2007-04-26 |
| JP5303276B2 (ja) | 2013-10-02 |
| EP3047847A1 (en) | 2016-07-27 |
| CA2924200A1 (en) | 2007-04-26 |
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