ATE543796T1 - 24-sulfoximine vitamin d3 derivate - Google Patents
24-sulfoximine vitamin d3 derivateInfo
- Publication number
- ATE543796T1 ATE543796T1 AT03727105T AT03727105T ATE543796T1 AT E543796 T1 ATE543796 T1 AT E543796T1 AT 03727105 T AT03727105 T AT 03727105T AT 03727105 T AT03727105 T AT 03727105T AT E543796 T1 ATE543796 T1 AT E543796T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- derivatives
- sulfoximine
- vitamin
- sulfoximine vitamin
- Prior art date
Links
- 150000003704 vitamin D3 derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 abstract 1
- 102100027518 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Human genes 0.000 abstract 1
- 101000861278 Homo sapiens 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial Proteins 0.000 abstract 1
- 235000020964 calcitriol Nutrition 0.000 abstract 1
- 239000011612 calcitriol Substances 0.000 abstract 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000005555 sulfoximide group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Nutrition Science (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38790402P | 2002-06-13 | 2002-06-13 | |
| PCT/CA2003/000851 WO2003106411A1 (en) | 2002-06-13 | 2003-06-13 | 24-sulfoximine vitamin d3 compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE543796T1 true ATE543796T1 (de) | 2012-02-15 |
Family
ID=29736378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03727105T ATE543796T1 (de) | 2002-06-13 | 2003-06-13 | 24-sulfoximine vitamin d3 derivate |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US7101865B2 (de) |
| EP (1) | EP1511725B1 (de) |
| JP (1) | JP4490262B2 (de) |
| AT (1) | ATE543796T1 (de) |
| AU (1) | AU2003233735A1 (de) |
| CA (1) | CA2488334C (de) |
| ES (1) | ES2380748T3 (de) |
| WO (1) | WO2003106411A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006032299A1 (en) * | 2004-09-24 | 2006-03-30 | Susanna Miettinen | Use of inhibitors of 24-hydroxylase in the treatment of cancer |
| US20060078494A1 (en) * | 2004-09-24 | 2006-04-13 | Sapphire Therapeutics, Inc. | Use of inhibitors of 24-hydroxylase in the treatment of cancer |
| CA2624897C (en) * | 2005-10-12 | 2017-02-14 | Proventiv Therapeutics, Llc | Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency |
| EP1993559B1 (de) | 2006-02-03 | 2016-06-22 | OPKO Renal, LLC | Behandlug von vitamin-d-insuffizienz und -mangel mit 25-hydroxyvitamin d2 und 25-hydroxyvitamin d3 |
| ES2670029T3 (es) | 2006-06-21 | 2018-05-29 | Opko Ireland Global Holdings, Ltd. | Terapia usando agente de repleción de la vitamina D y agente de reemplazo de la hormona de la vitamina D |
| JP2010525080A (ja) | 2007-04-25 | 2010-07-22 | プロヴェンティヴ セラピュティックス リミテッド ライアビリティ カンパニー | 慢性腎臓病における続発性副甲状腺機能亢進症の安全かつ効果的な治療および予防方法 |
| CA2684778C (en) * | 2007-04-25 | 2017-09-05 | Cytochroma Inc. | Methods and compounds for vitamin d therapy |
| CA2683628C (en) * | 2007-04-25 | 2018-03-06 | Cytochroma Inc. | Method of treating vitamin d insufficiency and deficiency |
| HRP20231142T3 (hr) | 2007-04-25 | 2024-01-05 | Eirgen Pharma Ltd. | Kontrolirano oslobađanje 25-hidroksivitamina d |
| ES2954932T3 (es) | 2008-04-02 | 2023-11-27 | Eirgen Pharma Ltd | Métodos, composiciones, usos y kits útiles para la deficiencia de vitamina D y trastornos relacionados |
| JP5887672B2 (ja) * | 2010-01-13 | 2016-03-16 | シトクロマ インコーポレイテッド | ビタミンｄ関連化合物の１−デオキシ類似体 |
| WO2011123476A1 (en) | 2010-03-29 | 2011-10-06 | Cytochroma Inc. | Methods and compositions for reducing parathyroid levels |
| WO2012065050A1 (en) | 2010-11-12 | 2012-05-18 | Wisconsin Alumni Research Foundation | 22-haloacetoxy-homopregnacalciferol analogs and their uses |
| KR101847947B1 (ko) | 2013-03-15 | 2018-05-28 | 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 | 안정화되고 변형된 비타민 ｄ 방출 제형 |
| US10220047B2 (en) | 2014-08-07 | 2019-03-05 | Opko Ireland Global Holdings, Ltd. | Adjunctive therapy with 25-hydroxyvitamin D and articles therefor |
| CN108883120A (zh) | 2016-03-28 | 2018-11-23 | 欧普科爱尔兰环球控股有限公司 | 维生素d治疗方法 |
| CN110396114B (zh) * | 2019-08-07 | 2021-08-27 | 成都理工大学 | 一种n-二芳基氧膦基亚砜亚胺的合成方法 |
| WO2025094144A1 (en) | 2023-11-02 | 2025-05-08 | Eirgen Pharma Ltd. | Controlling loss of kidney function |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4481198A (en) | 1984-02-13 | 1984-11-06 | Wisconsin Alumni Research Foundation | Vitamin D metabolism inhibitor |
| US4973584A (en) | 1989-03-09 | 1990-11-27 | Deluca Hector F | Novel 1α-hydroxyvitamin D2 epimer and derivatives |
| DE3908937A1 (de) | 1989-03-18 | 1990-09-20 | Hauni Werke Koerber & Co Kg | Verfahren zum herstellen von schnittabak |
| GB9007236D0 (en) | 1990-03-30 | 1990-05-30 | Leo Pharm Prod Ltd | Chemical compounds |
| JP2900607B2 (ja) * | 1992-02-28 | 1999-06-02 | 三菱自動車工業株式会社 | 吸排気可変機構付きエンジンの制御装置 |
| GB9223061D0 (en) | 1992-11-04 | 1992-12-16 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9226877D0 (en) | 1992-12-23 | 1993-02-17 | Leo Pharm Prod Ltd | Chemical compounds |
| JP3759639B2 (ja) * | 1994-04-11 | 2006-03-29 | 中外製薬株式会社 | ２２−チアビタミン▲ｄ３▼誘導体 |
| JP4012293B2 (ja) * | 1996-12-20 | 2007-11-21 | 中外製薬株式会社 | １６−エン−ビタミンｄ誘導体 |
| US6043386A (en) | 1998-06-03 | 2000-03-28 | John Hopkins University | Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3 |
| EP1180035B1 (de) | 1999-04-01 | 2006-11-02 | Johns Hopkins University | NICHT-CALCEMISCHE, TRANSKRIPTIONELL-AKTIVE, SCHWEFELHALTIGE ANALOGA VON 1-alpha, 25-DIHYDROXYVITAMIN D3 MIT ANTIPROLIFERATIVER WIRKUNG |
| US7074777B2 (en) * | 2000-04-19 | 2006-07-11 | Chugai Seiyaku Kabushiki Kaisha | Vitamin D derivatives |
| US7288407B2 (en) | 2002-05-02 | 2007-10-30 | Cytochroma, Inc. | Stable cytochrome P450 24 (CYP24) expressing cell line and methods and uses thereof |
-
2003
- 2003-06-13 AT AT03727105T patent/ATE543796T1/de active
- 2003-06-13 WO PCT/CA2003/000851 patent/WO2003106411A1/en not_active Ceased
- 2003-06-13 ES ES03727105T patent/ES2380748T3/es not_active Expired - Lifetime
- 2003-06-13 AU AU2003233735A patent/AU2003233735A1/en not_active Abandoned
- 2003-06-13 US US10/460,656 patent/US7101865B2/en not_active Expired - Lifetime
- 2003-06-13 JP JP2004513244A patent/JP4490262B2/ja not_active Expired - Fee Related
- 2003-06-13 EP EP03727105A patent/EP1511725B1/de not_active Expired - Lifetime
- 2003-06-13 CA CA2488334A patent/CA2488334C/en not_active Expired - Fee Related
-
2006
- 2006-05-30 US US11/442,148 patent/US7973024B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2488334A1 (en) | 2003-12-24 |
| EP1511725B1 (de) | 2012-02-01 |
| US7101865B2 (en) | 2006-09-05 |
| CA2488334C (en) | 2010-12-07 |
| ES2380748T3 (es) | 2012-05-18 |
| US20040038949A1 (en) | 2004-02-26 |
| AU2003233735A1 (en) | 2003-12-31 |
| EP1511725A1 (de) | 2005-03-09 |
| US20060217353A1 (en) | 2006-09-28 |
| AU2003233735A8 (en) | 2003-12-31 |
| US7973024B2 (en) | 2011-07-05 |
| JP2005529183A (ja) | 2005-09-29 |
| WO2003106411A1 (en) | 2003-12-24 |
| JP4490262B2 (ja) | 2010-06-23 |
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