ATE344039T1 - Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung - Google Patents

Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung

Info

Publication number
ATE344039T1
ATE344039T1 AT00921523T AT00921523T ATE344039T1 AT E344039 T1 ATE344039 T1 AT E344039T1 AT 00921523 T AT00921523 T AT 00921523T AT 00921523 T AT00921523 T AT 00921523T AT E344039 T1 ATE344039 T1 AT E344039T1
Authority
AT
Austria
Prior art keywords
dihydroxyvitamin
calcemic
alpha
sulfur containing
transcriptionally active
Prior art date
Application number
AT00921523T
Other languages
English (en)
Inventor
Gary H Posner
Jae Kyoo Lee
Qiang Wang
Kenneth R Crawford
Gyoonhee Han
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE344039T1 publication Critical patent/ATE344039T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT00921523T 1999-04-01 2000-03-31 Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung ATE344039T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12732899P 1999-04-01 1999-04-01
US12847899P 1999-04-09 1999-04-09

Publications (1)

Publication Number Publication Date
ATE344039T1 true ATE344039T1 (de) 2006-11-15

Family

ID=26825543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00921523T ATE344039T1 (de) 1999-04-01 2000-03-31 Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung

Country Status (13)

Country Link
US (1) US6380408B1 (de)
EP (2) EP1745787B1 (de)
JP (2) JP3630101B2 (de)
AT (1) ATE344039T1 (de)
CA (1) CA2366586C (de)
CY (1) CY1107548T1 (de)
DE (1) DE60031666T2 (de)
DK (1) DK1180035T3 (de)
ES (2) ES2274785T3 (de)
HK (1) HK1044293B (de)
MX (1) MXPA01009693A (de)
PT (1) PT1180035E (de)
WO (1) WO2000059513A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60231987D1 (de) * 2001-08-22 2009-05-28 Univ Johns Hopkins 24-schwefel-substituierte 1-alpha-25-dihydroxy-vitamin-d3-analogen
US6559138B1 (en) * 2001-09-21 2003-05-06 Syntex (U.S.A.) Llc 3-Desoxy-vitamin D3 analog esters
JP4490262B2 (ja) * 2002-06-13 2010-06-23 ジョンズ ホプキンス ユニバーシティ ２４−スルホキシイミンビタミンｄ３化合物
AU2003292920A1 (en) * 2002-12-18 2004-07-09 Cytochroma Inc. 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
EP1689412A4 (de) * 2003-11-25 2009-03-11 Wisconsin Alumni Res Found Vitamin-d-analoga zur prävention und behandlung von adipositas
WO2006074227A2 (en) * 2005-01-04 2006-07-13 Johns Hopkins University HIGHLY ANTIPROLIFERATIVE, LOW-CALCEMIC, ANALOGS OF THE HORMONE 1α, 25-DIHYDROXYVITAMIN D3 WITH CARBONYL SIDE CHAINS
CA2619311A1 (en) * 2005-08-18 2007-02-22 Bioxell S.P.A. Synthesis of 1.alpha.-fluoro-25-hydroxy-16-23e-diene-26,27-bishomo-20-epi-cholecalciferol
CA2924200C (en) * 2005-10-12 2017-09-05 Proventiv Therapeutics, Llc Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency
CA2882048C (en) 2006-02-03 2020-03-24 Proventiv Therapeutics, Llc Treating vitamin d insufficiency and deficiency with 25-hydroxyvitamin d2 and 25-hydroxyvitamin d3
ES2497494T3 (es) 2006-06-21 2014-09-23 Opko Renal, Llc Método de tratamiento y prevención del hiperparatiroidismo secundario
EP2144872A2 (de) * 2007-04-18 2010-01-20 Johns Hopkins University Gering kalzämische und hoch antiproliferative calcitriol-analoga
KR20190028822A (ko) 2007-04-25 2019-03-19 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
WO2009047644A2 (en) * 2007-04-25 2009-04-16 Cytochroma Inc. Method of treating vitamin d insufficiency and deficiency
WO2008134523A1 (en) 2007-04-25 2008-11-06 Proventiv Therapeutics, Llc Method of safely and effectively treating and preventing secondary hyperparathyroidism in chronic kidney disease
WO2008134518A2 (en) * 2007-04-25 2008-11-06 Cytochroma Inc. Methods and compounds for vitamin d therapy
US8962239B2 (en) 2008-04-02 2015-02-24 Opko Renal, Llc Methods useful for vitamin D deficiency and related disorders
US9775903B2 (en) * 2010-01-13 2017-10-03 Johns Hopkins University 1-deoxy analogs of 1,25-dihydroxyvitamin D3 compounds
US8664206B2 (en) 2010-03-23 2014-03-04 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
CA2794006C (en) 2010-03-23 2017-11-28 Wisconsin Alumni Research Foundation (20s)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-dihydroxyvitamin d3 and (20r)-2-methylene-19-nor-22-dimethyl-1.alpha.,25-hydroxyvitamin d3
PT2552484T (pt) 2010-03-29 2020-04-03 Opko Ireland Global Holdings Ltd Métodos e composições para redução dos níveis de parafróides
US8788551B2 (en) 2011-11-15 2014-07-22 Seagate Technology Llc Random number generation using switching regulators
US9201630B2 (en) 2012-02-10 2015-12-01 Seagate Technology Llc Random number generation using startup variances
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
EP3193925A2 (de) 2014-08-07 2017-07-26 OPKO Ireland Global Holdings, Ltd. Adjunktive therapie mit 25-hydroxyvitamin d
IL290855B1 (en) 2016-03-28 2024-02-01 Eirgen Pharma Ltd Treatment methods using vitamin D

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JPS5119752A (en) 1974-08-07 1976-02-17 Masayuki Ishikawa 1 arufua* 2 arufuaa jihidorokishikorekarushifuerooruno seiho
US4224231A (en) 1979-09-04 1980-09-23 Wisconsin Alumni Research Foundation Derivatives of 25-hydroxycholecalciferol
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
JPH0667898B2 (ja) * 1989-02-15 1994-08-31 大同ほくさん株式会社 ２２，２３―セコビタミンｄ若しくはその活性型またはそれらの誘導体の製造方法
US5401732A (en) 1989-02-23 1995-03-28 Leo Pharmaceutical Products Ltd. A/S Kemiske Fabrik Produkionsaktiese Skab Vitamin D analogues
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5401731A (en) 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
GB8915770D0 (en) 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
US5260290A (en) 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9015774D0 (en) 1990-07-18 1990-09-05 Leo Pharm Prod Ltd Novel treatment
US5274142A (en) 1992-03-12 1993-12-28 The Johns Hopkins University Vitamin D3 analogues
US5830885A (en) 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
US5403832A (en) 1992-03-12 1995-04-04 The Johns Hopkins University Vitamin D3 analogues
GB9226877D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
US6043386A (en) 1998-06-03 2000-03-28 John Hopkins University Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3

Also Published As

Publication number Publication date
EP1745787A3 (de) 2007-02-07
DE60031666D1 (de) 2006-12-14
HK1044293A1 (en) 2002-10-18
JP2002541112A (ja) 2002-12-03
JP3796508B2 (ja) 2006-07-12
DK1180035T3 (da) 2007-03-05
EP1745787B1 (de) 2016-11-09
DE60031666T2 (de) 2007-08-30
WO2000059513A1 (en) 2000-10-12
ES2274785T3 (es) 2007-06-01
PT1180035E (pt) 2007-02-28
CY1107548T1 (el) 2013-03-13
EP1745787A2 (de) 2007-01-24
JP3630101B2 (ja) 2005-03-16
CA2366586C (en) 2004-06-22
JP2005023087A (ja) 2005-01-27
ES2614632T3 (es) 2017-06-01
MXPA01009693A (es) 2002-03-14
EP1180035A1 (de) 2002-02-20
US6380408B1 (en) 2002-04-30
EP1180035A4 (de) 2003-07-30
EP1180035B1 (de) 2006-11-02
CA2366586A1 (en) 2000-10-12
WO2000059513A8 (en) 2001-02-15
HK1044293B (zh) 2007-06-08

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