ATE344039T1 - Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung - Google Patents

Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung

Info

Publication number
ATE344039T1
ATE344039T1 AT00921523T AT00921523T ATE344039T1 AT E344039 T1 ATE344039 T1 AT E344039T1 AT 00921523 T AT00921523 T AT 00921523T AT 00921523 T AT00921523 T AT 00921523T AT E344039 T1 ATE344039 T1 AT E344039T1
Authority
AT
Austria
Prior art keywords
dihydroxyvitamin
calcemic
alpha
sulfur containing
transcriptionally active
Prior art date
Application number
AT00921523T
Other languages
English (en)
Inventor
Gary H Posner
Jae Kyoo Lee
Qiang Wang
Kenneth R Crawford
Gyoonhee Han
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE344039T1 publication Critical patent/ATE344039T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Nutrition Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT00921523T 1999-04-01 2000-03-31 Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung ATE344039T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12732899P 1999-04-01 1999-04-01
US12847899P 1999-04-09 1999-04-09

Publications (1)

Publication Number Publication Date
ATE344039T1 true ATE344039T1 (de) 2006-11-15

Family

ID=26825543

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00921523T ATE344039T1 (de) 1999-04-01 2000-03-31 Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung

Country Status (13)

Country Link
US (1) US6380408B1 (de)
EP (2) EP1745787B1 (de)
JP (2) JP3630101B2 (de)
AT (1) ATE344039T1 (de)
CA (1) CA2366586C (de)
CY (1) CY1107548T1 (de)
DE (1) DE60031666T2 (de)
DK (1) DK1180035T3 (de)
ES (2) ES2614632T3 (de)
HK (1) HK1044293B (de)
MX (1) MXPA01009693A (de)
PT (1) PT1180035E (de)
WO (1) WO2000059513A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE428692T1 (de) * 2001-08-22 2009-05-15 Univ Johns Hopkins 24-schwefel-substituierte 1-alpha-25-dihydroxy- vitamin-d3-analogen
US6559138B1 (en) * 2001-09-21 2003-05-06 Syntex (U.S.A.) Llc 3-Desoxy-vitamin D3 analog esters
CA2488334C (en) * 2002-06-13 2010-12-07 Johns Hopkins University 24-sulfoximine vitamin d3 compounds
AU2003292920A1 (en) * 2002-12-18 2004-07-09 Cytochroma Inc. 25-so2-substituted analogs of 1alpha, 25-dihydroxyvitamin d3 (calcitriol)
US8188064B2 (en) 2003-11-25 2012-05-29 Wisconsin Alumni Research Foundation Vitamin D analogs for obesity prevention and treatment
WO2006074227A2 (en) * 2005-01-04 2006-07-13 Johns Hopkins University HIGHLY ANTIPROLIFERATIVE, LOW-CALCEMIC, ANALOGS OF THE HORMONE 1α, 25-DIHYDROXYVITAMIN D3 WITH CARBONYL SIDE CHAINS
BRPI0614894A2 (pt) * 2005-08-18 2016-08-30 Bioxell Spa método para produzir um composto, e, composto
CA2924200C (en) * 2005-10-12 2017-09-05 Proventiv Therapeutics, Llc Methods and articles for treating 25-hydroxyvitamin d insufficiency and deficiency
SI1993559T1 (sl) 2006-02-03 2017-01-31 Opko Renal, Llc Zdravljenje nezadostnosti in pomanjkanja vitamina D s 25-hidroksivitaminon D2 in 25-hidroksivitaminom D3
PT3357496T (pt) 2006-06-21 2020-05-12 Opko Ireland Global Holdings Ltd Terapia utilizando um agente de repleção de vitamina d e um agente de substituição hormonal de vitamina d
WO2008131267A2 (en) * 2007-04-18 2008-10-30 Johns Hopkins University Low calcemic, highly antiproliferative, analogs of calcitriol
KR20190141269A (ko) 2007-04-25 2019-12-23 사이토크로마 인코포레이티드 비타민 ｄ 화합물과 밀랍성 담체를 포함하는 경구 조절성 방출 조성물
CN101668532B (zh) * 2007-04-25 2014-08-20 赛特克罗公司 治疗维生素d不足和缺乏、继发性甲状旁腺功能亢进症和维生素d-响应疾病的组合物及其相应的制药用途
US8592401B2 (en) * 2007-04-25 2013-11-26 Proventiv Therapeutics, Llc Methods and compounds for vitamin D therapy
PL3225243T3 (pl) 2007-04-25 2025-12-22 Opko Renal, Llc Sposób bezpiecznego i skutecznego leczenia i zapobiegania wtórnej nadczynności przytarczyc w przewlekłej chorobie nerek
CN102046812A (zh) 2008-04-02 2011-05-04 赛特克罗公司 用于维生素d缺乏症和相关障碍的方法、组合物、用途和试剂盒
US9775903B2 (en) * 2010-01-13 2017-10-03 Johns Hopkins University 1-deoxy analogs of 1,25-dihydroxyvitamin D3 compounds
JP5770261B2 (ja) 2010-03-23 2015-08-26 ウイスコンシン アラムニ リサーチ ファンデーション （２０Ｓ）−２−メチレン−１９−ノル−２２−ジメチル−１α，２５−ジヒドロキシビタミンＤ３および（２０Ｒ）−２−メチレン−１９−ノル−２２−ジメチル−１α，２５−ヒドロキシビタミンＤ３
US8664206B2 (en) 2010-03-23 2014-03-04 Wisconsin Alumni Research Foundation Diastereomers of 2-methylene-19-nor-22-methyl-1α,25-dihydroxyvitamin D3
CA2797537C (en) 2010-03-29 2021-11-23 Cytochroma Inc. Use of 25-hydroxyvitamin d compound for reducing parathyroid levels
US8788551B2 (en) 2011-11-15 2014-07-22 Seagate Technology Llc Random number generation using switching regulators
US9201630B2 (en) 2012-02-10 2015-12-01 Seagate Technology Llc Random number generation using startup variances
KR101847947B1 (ko) 2013-03-15 2018-05-28 옵코 아이피 홀딩스 Ⅱ 인코포레이티드 안정화되고 변형된 비타민 ｄ 방출 제형
US10220047B2 (en) 2014-08-07 2019-03-05 Opko Ireland Global Holdings, Ltd. Adjunctive therapy with 25-hydroxyvitamin D and articles therefor
EP4596045A3 (de) 2016-03-28 2025-10-15 EirGen Pharma Ltd. Verfahren zur behandlung von vitamin d
WO2025094144A1 (en) 2023-11-02 2025-05-08 Eirgen Pharma Ltd. Controlling loss of kidney function

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5119752A (en) 1974-08-07 1976-02-17 Masayuki Ishikawa 1 arufua* 2 arufuaa jihidorokishikorekarushifuerooruno seiho
US4224231A (en) 1979-09-04 1980-09-23 Wisconsin Alumni Research Foundation Derivatives of 25-hydroxycholecalciferol
US4927815A (en) * 1988-04-29 1990-05-22 Wisconsin Alumni Research Foundation Compounds effective in inducing cell differentiation and process for preparing same
JPH0667898B2 (ja) * 1989-02-15 1994-08-31 大同ほくさん株式会社 ２２，２３―セコビタミンｄ若しくはその活性型またはそれらの誘導体の製造方法
US5401732A (en) 1989-02-23 1995-03-28 Leo Pharmaceutical Products Ltd. A/S Kemiske Fabrik Produkionsaktiese Skab Vitamin D analogues
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5401731A (en) 1989-06-29 1995-03-28 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Productionsaktieselskab) Vitamin D analogues
GB8915770D0 (en) 1989-07-10 1989-08-31 Leo Pharm Prod Ltd Chemical compounds
US5260290A (en) 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
GB9007236D0 (en) * 1990-03-30 1990-05-30 Leo Pharm Prod Ltd Chemical compounds
GB9015774D0 (en) 1990-07-18 1990-09-05 Leo Pharm Prod Ltd Novel treatment
US5830885A (en) 1992-03-12 1998-11-03 The Johns Hopkins University Antiproliferative vitamin D3 hybrids
US5274142A (en) 1992-03-12 1993-12-28 The Johns Hopkins University Vitamin D3 analogues
US5403832A (en) 1992-03-12 1995-04-04 The Johns Hopkins University Vitamin D3 analogues
GB9226877D0 (en) 1992-12-23 1993-02-17 Leo Pharm Prod Ltd Chemical compounds
US6043386A (en) 1998-06-03 2000-03-28 John Hopkins University Non-calcemic, antiproliferative, transcriptionally active 24-fluorinated hybrid analogs of 1α,-25-dihydroxy vitamin D3

Also Published As

Publication number Publication date
CY1107548T1 (el) 2013-03-13
DE60031666T2 (de) 2007-08-30
WO2000059513A1 (en) 2000-10-12
ES2614632T3 (es) 2017-06-01
PT1180035E (pt) 2007-02-28
HK1044293B (en) 2007-06-08
WO2000059513A8 (en) 2001-02-15
HK1044293A1 (en) 2002-10-18
MXPA01009693A (es) 2002-03-14
EP1180035A4 (de) 2003-07-30
DK1180035T3 (da) 2007-03-05
DE60031666D1 (de) 2006-12-14
ES2274785T3 (es) 2007-06-01
EP1745787B1 (de) 2016-11-09
EP1745787A2 (de) 2007-01-24
JP2005023087A (ja) 2005-01-27
EP1180035A1 (de) 2002-02-20
JP3630101B2 (ja) 2005-03-16
JP2002541112A (ja) 2002-12-03
EP1180035B1 (de) 2006-11-02
CA2366586C (en) 2004-06-22
CA2366586A1 (en) 2000-10-12
EP1745787A3 (de) 2007-02-07
US6380408B1 (en) 2002-04-30
JP3796508B2 (ja) 2006-07-12

Similar Documents

Publication Publication Date Title
ATE344039T1 (de) Nicht-calcemische, transkriptionell-aktive, schwefelhaltige analoga von 1-alpha, 25- dihydroxyvitamin d3 mit antiproliferativer wirkung
AR020848A1 (es) Metodos y composiciones para la prevencion y el tratamiento de anemia
DE60016670D1 (de) Kosmetisches Mittel enthaltend mindestens einen Hydroxystilben und Ascorbinsäure
ATE33503T1 (de) Pharmazeutische und tiermedizinische praeparate von interleukin-2, in dem cystein-125 ausgetauscht worden ist (muteine), sowie deren herstellung.
PT2455083E (pt) Composição farmacêutica para aplicação dérmica compreendendo calcipotriol e betametasona para o tratamento da psoríase
ATE77077T1 (de) Metoprololsuccinat und dieses enthaltende pharmazeutische zusammensetzung.
MX9304710A (es) Composicion farmaceutica y/o cosmetica y su uso.
DE69032679D1 (de) Threo (2R, 3S)-3-amino-2-hydroxypentansäure und threo (2R,3S)-3-(p-methoxy-benzyloxycarbonyl/FMOC) amino-2-hydroxy-pentansäure
ATE203669T1 (de) Verwendung von r-(+)alpha-liponsäure, r(-)- dihydroliponsäure und metabolite zur behandlung von diabetes mellitus sowie seiner folgeerkrankungen
ATE218336T1 (de) Verwendung von 3-benzoylphenylessigsäuren, deren estern oder amiden zur behandlung von glc1a glaukom
NL163713B (nl) Samenstel van gebitsprothese en ten minste een samenwerkend implantaat.
DE69312232D1 (de) Bpc-peptide, ihre herstellung und verwendung
DK1511740T3 (da) Vitamin-D-receptor-modulatorer af phenyl-thiophen-typen
DK1565422T3 (da) Vitamin-D-receptor-modulatorer
NO882453D0 (no) T-pa-analog.
NZ224914A (en) Tissue plasminogen activator analog
ATE239700T1 (de) 24,24-difluorierte analogen von 1-alpha,25- dihydroxy vitamin d3
EP0212912A3 (de) Calcitonin-Analoga mit C-terminalen D-Aminosäurensubstituenten
DK0415902T3 (da) Oxy- eller thiosubstituerede fedtsyreanaloger til anvendelse ved behandling af retrovirale infektioner
ATE216254T1 (de) Pharmazeutische zusammensetzungen enthaltend cyclosporin und einen träger mit mindestens einer ester-alpha-glycerophosphorsäure
ES2038729T3 (es) Producto insecticida.
DK261283D0 (da) Antimikrobielle disulfidprolaegemidler
IT1283684B1 (it) Calzatura con struttura di sostegno e irrigidimento e procedimento per realizzare tale calzatura
GB2000783A (en) Physiologically active enkephalin analogues
ATE81002T1 (de) Fixe arzneimittelkombination mit verzoegerter freisetzung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1180035

Country of ref document: EP