JP2009507108A5 - - Google Patents
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- Publication number
- JP2009507108A5 JP2009507108A5 JP2008529317A JP2008529317A JP2009507108A5 JP 2009507108 A5 JP2009507108 A5 JP 2009507108A5 JP 2008529317 A JP2008529317 A JP 2008529317A JP 2008529317 A JP2008529317 A JP 2008529317A JP 2009507108 A5 JP2009507108 A5 JP 2009507108A5
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- JP
- Japan
- Prior art keywords
- group
- unsubstituted
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- membered
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229910052760 oxygen Inorganic materials 0.000 claims 20
- 229910052717 sulfur Inorganic materials 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 18
- 229910052736 halogen Inorganic materials 0.000 claims 15
- 150000002367 halogens Chemical class 0.000 claims 15
- 125000000524 functional group Chemical group 0.000 claims 13
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 230000000269 nucleophilic effect Effects 0.000 claims 11
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 9
- 125000002877 alkyl aryl group Chemical group 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 8
- 125000002837 carbocyclic group Chemical group 0.000 claims 7
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000001931 aliphatic group Chemical group 0.000 claims 6
- 150000001408 amides Chemical class 0.000 claims 5
- 150000001412 amines Chemical class 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 5
- 150000007942 carboxylates Chemical class 0.000 claims 5
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 5
- 150000001735 carboxylic acids Chemical class 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 229940124530 sulfonamide Drugs 0.000 claims 5
- 150000003456 sulfonamides Chemical class 0.000 claims 5
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 5
- 125000000542 sulfonic acid group Chemical group 0.000 claims 5
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 4
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- 125000004122 cyclic group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000012038 nucleophile Substances 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052711 selenium Inorganic materials 0.000 claims 4
- 125000004104 aryloxy group Chemical group 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- 150000003460 sulfonic acids Chemical class 0.000 claims 3
- -1 Q is absent Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- 238000012634 optical imaging Methods 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- HFHFGHLXUCOHLN-UHFFFAOYSA-N 2-fluorophenol Chemical class OC1=CC=CC=C1F HFHFGHLXUCOHLN-UHFFFAOYSA-N 0.000 claims 1
- 125000001963 4 membered heterocyclic group Chemical group 0.000 claims 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 229940126062 Compound A Drugs 0.000 claims 1
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 208000029534 Infectious Bone disease Diseases 0.000 claims 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000003610 charcoal Substances 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 238000011156 evaluation Methods 0.000 claims 1
- 208000016361 genetic disease Diseases 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 230000004807 localization Effects 0.000 claims 1
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 150000008300 phosphoramidites Chemical class 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical group [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 230000032258 transport Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71363205P | 2005-09-02 | 2005-09-02 | |
| US60/713,632 | 2005-09-02 | ||
| PCT/US2006/034260 WO2007028037A1 (en) | 2005-09-02 | 2006-09-01 | Biocompatible n, n-disubstituted sulfonamide-containing fluorescent dye labels |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012183467A Division JP2012224646A (ja) | 2005-09-02 | 2012-08-22 | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009507108A JP2009507108A (ja) | 2009-02-19 |
| JP2009507108A5 true JP2009507108A5 (https=) | 2009-10-22 |
| JP5106397B2 JP5106397B2 (ja) | 2012-12-26 |
Family
ID=37649605
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529317A Active JP5106397B2 (ja) | 2005-09-02 | 2006-09-01 | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
| JP2012183467A Withdrawn JP2012224646A (ja) | 2005-09-02 | 2012-08-22 | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012183467A Withdrawn JP2012224646A (ja) | 2005-09-02 | 2012-08-22 | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9574085B2 (https=) |
| EP (1) | EP1934211B1 (https=) |
| JP (2) | JP5106397B2 (https=) |
| CN (2) | CN101296927A (https=) |
| AU (1) | AU2006284565B2 (https=) |
| CA (1) | CA2621137C (https=) |
| DK (1) | DK1934211T3 (https=) |
| ES (1) | ES2618361T3 (https=) |
| WO (1) | WO2007028037A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE536993T1 (de) | 2002-01-02 | 2011-12-15 | Visen Medical Inc | Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten |
| CN101296927A (zh) | 2005-09-02 | 2008-10-29 | Visen医药公司 | 生物相容的含n,n-二取代磺酰胺的荧光染料标记 |
| JP5416970B2 (ja) | 2005-09-02 | 2014-02-12 | ビセン メディカル， インコーポレイテッド | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
| WO2007136413A2 (en) | 2005-12-22 | 2007-11-29 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| US8221721B2 (en) * | 2007-02-09 | 2012-07-17 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| ES2658852T3 (es) * | 2008-01-18 | 2018-03-12 | Visen Medical, Inc. | Agentes de imaginología fluorescentes |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| TW201036941A (en) * | 2009-03-30 | 2010-10-16 | Sumitomo Chemical Co | Method for producing sulfonamide compound |
| AU2012253502C1 (en) | 2011-05-09 | 2017-12-14 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| US9375493B2 (en) | 2012-03-30 | 2016-06-28 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| JP6370785B2 (ja) * | 2012-08-15 | 2018-08-08 | ビセン メディカル， インコーポレイテッド | 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法 |
| US9636425B2 (en) * | 2012-09-18 | 2017-05-02 | Focal Point Technologies, Llc | Method of dry dye delivery for staining the eye |
| BR112015022763A8 (pt) | 2013-03-14 | 2019-11-26 | Profusa Inc | sensor para detectar um analito |
| JP6606487B2 (ja) | 2013-03-15 | 2019-11-13 | ビセン メディカル， インコーポレイテッド | ｉｎｖｉｔｒｏおよびｉｎｖｉｖｏイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素 |
| CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
| EP3795999A1 (en) | 2014-07-15 | 2021-03-24 | Valitacell Limited | A method of determining the abundance of a target molecule in a sample |
| WO2018119204A1 (en) | 2016-12-21 | 2018-06-28 | Profusa, Inc. | Polymerizable near-ir dyes |
| EP3348560A1 (en) | 2017-01-16 | 2018-07-18 | Spago Nanomedical AB | Chemical compounds for coating of nanostructures |
| AU2019293250A1 (en) | 2018-06-27 | 2021-01-07 | Profusa, Inc. | Near-IR glucose sensors |
| CN116947823B (zh) * | 2023-07-25 | 2025-02-07 | 李哲 | 一种具有长余辉发光性质的有机小分子及其生物应用 |
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| CN101296927A (zh) | 2005-09-02 | 2008-10-29 | Visen医药公司 | 生物相容的含n,n-二取代磺酰胺的荧光染料标记 |
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| CN102026671B (zh) * | 2008-03-14 | 2014-09-03 | Visen医药公司 | 整联蛋白靶向试剂及使用其的体内和体外成像方法 |
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| AU2012253502C1 (en) | 2011-05-09 | 2017-12-14 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| JP6370785B2 (ja) | 2012-08-15 | 2018-08-08 | ビセン メディカル， インコーポレイテッド | 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法 |
| JP6606487B2 (ja) | 2013-03-15 | 2019-11-13 | ビセン メディカル， インコーポレイテッド | ｉｎｖｉｔｒｏおよびｉｎｖｉｖｏイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素 |
| CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
-
2006
- 2006-09-01 CN CNA2006800403608A patent/CN101296927A/zh active Pending
- 2006-09-01 JP JP2008529317A patent/JP5106397B2/ja active Active
- 2006-09-01 EP EP06802829.9A patent/EP1934211B1/en active Active
- 2006-09-01 CN CN201510093931.5A patent/CN104788433A/zh active Pending
- 2006-09-01 DK DK06802829.9T patent/DK1934211T3/en active
- 2006-09-01 AU AU2006284565A patent/AU2006284565B2/en active Active
- 2006-09-01 US US12/065,387 patent/US9574085B2/en active Active
- 2006-09-01 WO PCT/US2006/034260 patent/WO2007028037A1/en not_active Ceased
- 2006-09-01 ES ES06802829.9T patent/ES2618361T3/es active Active
- 2006-09-01 CA CA2621137A patent/CA2621137C/en active Active
-
2012
- 2012-08-22 JP JP2012183467A patent/JP2012224646A/ja not_active Withdrawn
-
2017
- 2017-02-15 US US15/433,688 patent/US10442930B2/en active Active
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