JP2010518236A5 - - Google Patents
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- JP2010518236A5 JP2010518236A5 JP2009549253A JP2009549253A JP2010518236A5 JP 2010518236 A5 JP2010518236 A5 JP 2010518236A5 JP 2009549253 A JP2009549253 A JP 2009549253A JP 2009549253 A JP2009549253 A JP 2009549253A JP 2010518236 A5 JP2010518236 A5 JP 2010518236A5
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- 150000001875 compounds Chemical class 0.000 claims description 63
- 239000007850 fluorescent dye Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- -1 N- hydroxy sulfosuccinimide ester Chemical class 0.000 claims description 15
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000000523 sample Substances 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 238000012634 optical imaging Methods 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000005647 linker group Chemical group 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- HFHFGHLXUCOHLN-UHFFFAOYSA-N 2-fluorophenol Chemical class OC1=CC=CC=C1F HFHFGHLXUCOHLN-UHFFFAOYSA-N 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 2
- 208000020084 Bone disease Diseases 0.000 claims description 2
- 208000035473 Communicable disease Diseases 0.000 claims description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 150000001540 azides Chemical class 0.000 claims description 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 150000007942 carboxylates Chemical class 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims description 2
- 238000002659 cell therapy Methods 0.000 claims description 2
- 238000002591 computed tomography Methods 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 208000016097 disease of metabolism Diseases 0.000 claims description 2
- 208000030533 eye disease Diseases 0.000 claims description 2
- 208000016361 genetic disease Diseases 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 208000026278 immune system disease Diseases 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000008300 phosphoramidites Chemical class 0.000 claims description 2
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims description 2
- NAYYNDKKHOIIOD-UHFFFAOYSA-N phthalamide Chemical compound NC(=O)C1=CC=CC=C1C(N)=O NAYYNDKKHOIIOD-UHFFFAOYSA-N 0.000 claims description 2
- 125000003367 polycyclic group Chemical group 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 208000017520 skin disease Diseases 0.000 claims description 2
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 238000003325 tomography Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 2
- 230000007762 localization of cell Effects 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88906607P | 2007-02-09 | 2007-02-09 | |
| US60/889,066 | 2007-02-09 | ||
| PCT/US2008/053399 WO2008100817A2 (en) | 2007-02-09 | 2008-02-08 | Polycyclo dyes and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014071365A Division JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518236A JP2010518236A (ja) | 2010-05-27 |
| JP2010518236A5 true JP2010518236A5 (https=) | 2012-03-22 |
| JP5643514B2 JP5643514B2 (ja) | 2014-12-17 |
Family
ID=39690741
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549253A Active JP5643514B2 (ja) | 2007-02-09 | 2008-02-08 | ポリシクロ染料およびその使用 |
| JP2014071365A Withdrawn JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014071365A Withdrawn JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8221721B2 (https=) |
| EP (1) | EP2118206B9 (https=) |
| JP (2) | JP5643514B2 (https=) |
| DK (1) | DK2118206T3 (https=) |
| ES (1) | ES2670852T3 (https=) |
| WO (1) | WO2008100817A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002038190A2 (en) * | 2000-10-27 | 2002-05-16 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| US7947256B2 (en) * | 2005-09-02 | 2011-05-24 | Visen Medical, Inc. | Biocompatible fluorescent imaging agents |
| CN101296927A (zh) | 2005-09-02 | 2008-10-29 | Visen医药公司 | 生物相容的含n,n-二取代磺酰胺的荧光染料标记 |
| JP5416970B2 (ja) | 2005-09-02 | 2014-02-12 | ビセン メディカル， インコーポレイテッド | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
| WO2007136413A2 (en) | 2005-12-22 | 2007-11-29 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| US8221721B2 (en) | 2007-02-09 | 2012-07-17 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| ES2658852T3 (es) | 2008-01-18 | 2018-03-12 | Visen Medical, Inc. | Agentes de imaginología fluorescentes |
| US9023611B2 (en) * | 2009-02-06 | 2015-05-05 | Beth Israel Deaconess Medical Center | Charged-balanced imaging agents |
| AU2012253502C1 (en) * | 2011-05-09 | 2017-12-14 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| US9375493B2 (en) | 2012-03-30 | 2016-06-28 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| JP6370785B2 (ja) | 2012-08-15 | 2018-08-08 | ビセン メディカル， インコーポレイテッド | 前立腺がんイメージングのための前立腺特異的抗原薬剤およびその使用方法 |
| US20140051973A1 (en) * | 2012-08-15 | 2014-02-20 | Aspect Imaging Ltd | Mri imaging system for generating a rendered image |
| IL221489A0 (en) * | 2012-08-15 | 2012-12-31 | Aspect Imaging Ltd | Imaging system for generating a rendered image |
| US20140051975A1 (en) * | 2012-08-15 | 2014-02-20 | Aspect Imaging Ltd. | Multiple heterogeneous imaging systems for clinical and preclinical diagnosis |
| CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
| JP6606487B2 (ja) | 2013-03-15 | 2019-11-13 | ビセン メディカル， インコーポレイテッド | ｉｎｖｉｔｒｏおよびｉｎｖｉｖｏイメージングおよび検出のための置換シラキサンテニウム赤色〜近赤外蛍光色素 |
| EP3165153A1 (en) * | 2015-11-05 | 2017-05-10 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | System for fluorescence aided surgery |
| US11549017B2 (en) | 2017-09-29 | 2023-01-10 | Perkinelmer Health Sciences, Inc. | NIR to SWIR fluorescent compounds for imaging and detection |
| US10633542B2 (en) | 2018-03-21 | 2020-04-28 | Ecole polytechnique fédérale de Lausanne (EPFL) | Azacyanine dyes and use thereof |
| JP2021520424A (ja) * | 2018-03-21 | 2021-08-19 | エコール・ポリテクニーク・フェデラル・ドゥ・ローザンヌ（ウペエフエル）Ｅｃｏｌｅ Ｐｏｌｙｔｅｃｈｎｉｑｕｅ Ｆｅｄｅｒａｌｅ ｄｅ Ｌａｕｓａｎｎｅ （ＥＰＦＬ） | アザシアニン色素及びその使用 |
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| IT1276833B1 (it) * | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
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| US7947256B2 (en) * | 2005-09-02 | 2011-05-24 | Visen Medical, Inc. | Biocompatible fluorescent imaging agents |
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| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| US20090037114A1 (en) * | 2007-07-30 | 2009-02-05 | Chengbin Peng | 4d+ prestack seismic data structure, and methods and apparatus for processing 4d+ prestack seismic data |
| ES2658852T3 (es) * | 2008-01-18 | 2018-03-12 | Visen Medical, Inc. | Agentes de imaginología fluorescentes |
| CN102026671B (zh) * | 2008-03-14 | 2014-09-03 | Visen医药公司 | 整联蛋白靶向试剂及使用其的体内和体外成像方法 |
| US8864821B2 (en) * | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
-
2008
- 2008-02-08 US US12/028,209 patent/US8221721B2/en not_active Expired - Fee Related
- 2008-02-08 DK DK08729371.8T patent/DK2118206T3/en active
- 2008-02-08 EP EP08729371.8A patent/EP2118206B9/en active Active
- 2008-02-08 ES ES08729371.8T patent/ES2670852T3/es active Active
- 2008-02-08 WO PCT/US2008/053399 patent/WO2008100817A2/en not_active Ceased
- 2008-02-08 JP JP2009549253A patent/JP5643514B2/ja active Active
-
2012
- 2012-07-13 US US13/548,451 patent/US9365721B2/en active Active
-
2014
- 2014-03-31 JP JP2014071365A patent/JP2014167119A/ja not_active Withdrawn
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