JP2012510499A5 - - Google Patents
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- JP2012510499A5 JP2012510499A5 JP2011538991A JP2011538991A JP2012510499A5 JP 2012510499 A5 JP2012510499 A5 JP 2012510499A5 JP 2011538991 A JP2011538991 A JP 2011538991A JP 2011538991 A JP2011538991 A JP 2011538991A JP 2012510499 A5 JP2012510499 A5 JP 2012510499A5
- Authority
- JP
- Japan
- Prior art keywords
- vivo
- contrast agent
- synuclein
- imaging moiety
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 238000001727 in vivo Methods 0.000 claims 17
- 239000002872 contrast media Substances 0.000 claims 16
- 238000011503 in vivo imaging Methods 0.000 claims 12
- 102000003802 alpha-Synuclein Human genes 0.000 claims 8
- 108090000185 alpha-Synuclein Proteins 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 4
- 239000012453 solvate Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 208000018737 Parkinson disease Diseases 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 229910052760 oxygen Inorganic materials 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 230000002285 radioactive effect Effects 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 125000004103 aminoalkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 210000003403 autonomic nervous system Anatomy 0.000 claims 2
- 125000001188 haloalkyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 2
- 210000004558 lewy body Anatomy 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000004001 thioalkyl group Chemical group 0.000 claims 2
- 150000003573 thiols Chemical class 0.000 claims 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000005021 aminoalkenyl group Chemical group 0.000 claims 1
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 1
- 125000005014 aminoalkynyl group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 1
- 150000001768 cations Chemical group 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000005159 cyanoalkoxy group Chemical group 0.000 claims 1
- 125000004966 cyanoalkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 238000013399 early diagnosis Methods 0.000 claims 1
- 210000000105 enteric nervous system Anatomy 0.000 claims 1
- 125000000262 haloalkenyl group Chemical group 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000000232 haloalkynyl group Chemical group 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000005020 hydroxyalkenyl group Chemical group 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 125000005016 hydroxyalkynyl group Chemical group 0.000 claims 1
- 239000012216 imaging agent Substances 0.000 claims 1
- 210000002241 neurite Anatomy 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004971 nitroalkyl group Chemical group 0.000 claims 1
- 229910052755 nonmetal Inorganic materials 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
- 125000005309 thioalkoxy group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11906008P | 2008-12-02 | 2008-12-02 | |
| GB0821994.1 | 2008-12-02 | ||
| US61/119,060 | 2008-12-02 | ||
| GBGB0821994.1A GB0821994D0 (en) | 2008-12-02 | 2008-12-02 | In viva imaging method |
| PCT/EP2009/066120 WO2010063701A2 (en) | 2008-12-02 | 2009-12-01 | In vivo imaging method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012510499A JP2012510499A (ja) | 2012-05-10 |
| JP2012510499A5 true JP2012510499A5 (https=) | 2012-12-27 |
Family
ID=40262535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011538991A Withdrawn JP2012510499A (ja) | 2008-12-02 | 2009-12-01 | 生体内イメージング法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110236307A1 (https=) |
| EP (1) | EP2389200A2 (https=) |
| JP (1) | JP2012510499A (https=) |
| CN (1) | CN102300589A (https=) |
| GB (1) | GB0821994D0 (https=) |
| WO (1) | WO2010063701A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101297815B1 (ko) * | 2010-11-18 | 2013-09-03 | 충남대학교산학협력단 | 폴리감마글루탐산과 광학영상다이의 복합체를 함유하는 센티넬 림프노드 감지용 광학영상 프로브 |
| EP3160978B1 (en) * | 2014-06-25 | 2020-07-29 | NuCana plc | Gemcitabine prodrugs |
| BR112018068066B1 (pt) | 2016-03-11 | 2023-11-28 | Ac Immune Sa | Compostos bicíclicos e seu uso, composição diagnóstica e farmacêutica, misturas, métodos de coleção de dados para diagnóstico, para determinar uma predisposição a, para monitorar transtorno residual e para prever a capacidade de resposta de um paciente sofrendo de transtorno ou anormalidade associado com agregados de alfa-sinucleína, métodos para determinar a quantidade de agregados de alfa-sinucleína e para preparar um composto, kit teste e kit para preparar uma preparação radio farmacêutica |
| JP7227157B2 (ja) | 2016-12-29 | 2023-02-21 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| EP3562306B1 (en) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzyme inhibitor compounds |
| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| US11844846B2 (en) | 2018-05-16 | 2023-12-19 | Emory University | Styrylbenzothiazole derivatives and uses in imaging methods |
| WO2019234243A1 (en) | 2018-06-08 | 2019-12-12 | Ac Immune Sa | Novel compounds for diagnosis |
| US20200085979A1 (en) | 2018-09-11 | 2020-03-19 | Stanley Satz | Precision medicine theranostics and diagnostics a combination thereof |
| JP2022516969A (ja) | 2019-01-08 | 2022-03-03 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| KR20230008183A (ko) | 2020-05-07 | 2023-01-13 | 에이씨 이뮨 에스에이 | 진단을 위한 신규한 화합물 |
| CN118215667A (zh) | 2021-11-10 | 2024-06-18 | Ac免疫有限公司 | 用于诊断的4h-咪唑并[1,5-b]吡唑衍生物 |
| AU2022387830A1 (en) | 2021-11-10 | 2024-05-23 | Ac Immune Sa | Dihydropyrrolo[3,4c]-pyrazole derivatives and their use in diagnosis |
| EP4430044A1 (en) | 2021-11-10 | 2024-09-18 | AC Immune SA | Dihydropyrrolo[3,4-c]pyrazole derivatives and their use in diagnosis |
| JP2026500311A (ja) | 2022-12-16 | 2026-01-06 | エーシー・イミューン・エス・アー | 診断のための新規化合物 |
| CN120344535A (zh) | 2022-12-16 | 2025-07-18 | Ac免疫有限公司 | 用于诊断的新化合物 |
| WO2024240186A1 (zh) | 2023-05-22 | 2024-11-28 | 深圳博芮健制药有限公司 | 含硫稠环化合物、含其的药物组合物、其制备方法及其应用 |
| WO2025037013A1 (en) | 2023-08-16 | 2025-02-20 | Ac Immune Sa | Diagnostic compounds that bind to alpha-synuclein |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010047032A1 (en) * | 1999-12-30 | 2001-11-29 | Castillo Gerardo M. | Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases |
| US6379650B1 (en) * | 2001-03-19 | 2002-04-30 | Wesley Scott Ashton | Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging |
| US7521481B2 (en) * | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| US8329142B2 (en) * | 2003-05-29 | 2012-12-11 | Pettegrew Jay W | Compounds, compositions and methods for medical imaging of Parkinson's disease |
| WO2007011834A2 (en) * | 2005-07-15 | 2007-01-25 | The Regents Of The University Of California | Compounds and method for the diagnosis and treatment of amyloid associated diseases |
| CN101351458A (zh) * | 2005-12-01 | 2009-01-21 | 匹兹堡大学 | 作为促淀粉样变蛋白成像剂的同位素标记的苯并噻唑化合物 |
| CA2662863A1 (en) * | 2006-09-06 | 2008-03-13 | The Board Of Regents Of The University Of Texas System | Methods and compositions for the detection of protein folding disorders |
| SI2074145T1 (sl) * | 2006-10-02 | 2017-12-29 | Ac Immune S.A. | Humanizirano protitelo proti amiloid beta |
| EP2171478A4 (en) * | 2007-03-30 | 2013-01-30 | Univ California | IN VIVO IMAGING METHOD FOR SULPHOTRANSFERASES |
-
2008
- 2008-12-02 GB GBGB0821994.1A patent/GB0821994D0/en not_active Ceased
-
2009
- 2009-12-01 JP JP2011538991A patent/JP2012510499A/ja not_active Withdrawn
- 2009-12-01 EP EP09768015A patent/EP2389200A2/en not_active Withdrawn
- 2009-12-01 WO PCT/EP2009/066120 patent/WO2010063701A2/en not_active Ceased
- 2009-12-01 US US13/132,109 patent/US20110236307A1/en not_active Abandoned
- 2009-12-01 CN CN2009801562662A patent/CN102300589A/zh active Pending
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