CN102300589A - 用于帕金森氏病症的体内成像方法 - Google Patents

用于帕金森氏病症的体内成像方法 Download PDF

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Publication number
CN102300589A
CN102300589A CN2009801562662A CN200980156266A CN102300589A CN 102300589 A CN102300589 A CN 102300589A CN 2009801562662 A CN2009801562662 A CN 2009801562662A CN 200980156266 A CN200980156266 A CN 200980156266A CN 102300589 A CN102300589 A CN 102300589A
Authority
CN
China
Prior art keywords
vivo imaging
imaging agent
synuclein
group
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801562662A
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English (en)
Chinese (zh)
Inventor
P·A·琼斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GE Healthcare Ltd
Original Assignee
GE Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN102300589A publication Critical patent/CN102300589A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1018—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against material from animals or humans

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN2009801562662A 2008-12-02 2009-12-01 用于帕金森氏病症的体内成像方法 Pending CN102300589A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11906008P 2008-12-02 2008-12-02
GB0821994.1 2008-12-02
US61/119060 2008-12-02
GBGB0821994.1A GB0821994D0 (en) 2008-12-02 2008-12-02 In viva imaging method
PCT/EP2009/066120 WO2010063701A2 (en) 2008-12-02 2009-12-01 In vivo imaging method

Publications (1)

Publication Number Publication Date
CN102300589A true CN102300589A (zh) 2011-12-28

Family

ID=40262535

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801562662A Pending CN102300589A (zh) 2008-12-02 2009-12-01 用于帕金森氏病症的体内成像方法

Country Status (6)

Country Link
US (1) US20110236307A1 (https=)
EP (1) EP2389200A2 (https=)
JP (1) JP2012510499A (https=)
CN (1) CN102300589A (https=)
GB (1) GB0821994D0 (https=)
WO (1) WO2010063701A2 (https=)

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CN112105393A (zh) * 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途

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KR101297815B1 (ko) * 2010-11-18 2013-09-03 충남대학교산학협력단 폴리감마글루탐산과 광학영상다이의 복합체를 함유하는 센티넬 림프노드 감지용 광학영상 프로브
HRP20230584T1 (hr) * 2014-06-25 2023-09-15 NuCana plc Prolijekovi gemcitabina
NZ746901A (en) 2016-03-11 2023-06-30 Ac Immune Sa Bicyclic compounds for diagnosis and therapy
EP3562306B1 (en) 2016-12-29 2025-02-26 Ji Xing Pharmaceuticals Hong Kong Limited Metalloenzyme inhibitor compounds
FI3562487T3 (fi) 2016-12-29 2023-12-14 Ji Xing Pharmaceuticals Hong Kong Ltd Metalloentsyymi-inhibiittoriyhdisteitä
MX2021011775A (es) 2017-04-26 2023-01-10 Basilea Pharm Int Ag Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos.
IL279219B2 (en) 2018-06-08 2024-08-01 Ac Immune Sa Novel compounds for diagnosis
US20200085979A1 (en) 2018-09-11 2020-03-19 Stanley Satz Precision medicine theranostics and diagnostics a combination thereof
CA3126224A1 (en) 2019-01-08 2020-07-16 Corxel Pharmaceuticals Hong Kong Limited Metalloenzyme inhibitor compounds
EP4146653A1 (en) 2020-05-07 2023-03-15 AC Immune SA Novel compounds for diagnosis
EP4430044A1 (en) 2021-11-10 2024-09-18 AC Immune SA Dihydropyrrolo[3,4-c]pyrazole derivatives and their use in diagnosis
JP2024544539A (ja) 2021-11-10 2024-12-03 エーシー・イミューン・エス・アー 診断のための４ｈ－イミダゾ［１，５－ｂ］ピラゾール誘導体
WO2023083998A1 (en) 2021-11-10 2023-05-19 Ac Immune Sa Dihydropyrrolo[3,4c]-pyrazole derivatives and their use in diagnosis
EP4634191A1 (en) 2022-12-16 2025-10-22 AC Immune SA Novel compounds for diagnosis
EP4634190A1 (en) 2022-12-16 2025-10-22 AC Immune SA Novel compounds for diagnosis
CN121100114A (zh) 2023-05-22 2025-12-09 深圳博芮健制药有限公司 含硫稠环化合物、含其的药物组合物、其制备方法及其应用
WO2025037013A1 (en) 2023-08-16 2025-02-20 Ac Immune Sa Diagnostic compounds that bind to alpha-synuclein

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US20010047032A1 (en) * 1999-12-30 2001-11-29 Castillo Gerardo M. Polyhydroxylated aromatic compounds for the treatment of amyloidosis and alpha-synuclein fibril diseases
US6379650B1 (en) * 2001-03-19 2002-04-30 Wesley Scott Ashton Technetium 99m-N2S2-congo red complexes utilizing diamide dithiolate ligand systems for radioimaging
US7521481B2 (en) * 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
US8329142B2 (en) * 2003-05-29 2012-12-11 Pettegrew Jay W Compounds, compositions and methods for medical imaging of Parkinson's disease
US7666886B2 (en) * 2005-07-15 2010-02-23 The Regents Of The University Of California Compounds and methods for the diagnosis and treatment of amyloid associated diseases
CN101351458A (zh) * 2005-12-01 2009-01-21 匹兹堡大学 作为促淀粉样变蛋白成像剂的同位素标记的苯并噻唑化合物
WO2008030973A2 (en) * 2006-09-06 2008-03-13 The Board Of Regents Of The University Of Texas System Methods and compositions for the detection of protein folding disorders
KR20150002879A (ko) * 2006-10-02 2015-01-07 에이씨 이뮨 에스.에이. 아밀로이드 베타에 대해 인간화된 항체
WO2008121407A1 (en) * 2007-03-30 2008-10-09 The Regents Of The University Of California In vivo imaging of sulfotransferases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A. JOHANSSON: "[11C]-PIB imaging in patients with Parkinson’s disease: Preliminary results", 《PARKINSONISM AND RELATED DISORDERS》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105393A (zh) * 2018-05-16 2020-12-18 爱默蕾大学 苯乙烯基苯并噻唑衍生物及在成像中的用途
US11844846B2 (en) 2018-05-16 2023-12-19 Emory University Styrylbenzothiazole derivatives and uses in imaging methods

Also Published As

Publication number Publication date
GB0821994D0 (en) 2009-01-07
US20110236307A1 (en) 2011-09-29
JP2012510499A (ja) 2012-05-10
EP2389200A2 (en) 2011-11-30
WO2010063701A2 (en) 2010-06-10
WO2010063701A3 (en) 2010-08-05

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Application publication date: 20111228