JP2009507035A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009507035A5 JP2009507035A5 JP2008529356A JP2008529356A JP2009507035A5 JP 2009507035 A5 JP2009507035 A5 JP 2009507035A5 JP 2008529356 A JP2008529356 A JP 2008529356A JP 2008529356 A JP2008529356 A JP 2008529356A JP 2009507035 A5 JP2009507035 A5 JP 2009507035A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- composition
- disease
- independently selected
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- -1 carbonyl halide Chemical class 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000000542 sulfonic acid group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 150000007942 carboxylates Chemical class 0.000 claims 3
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 3
- 150000001735 carboxylic acids Chemical class 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000012634 optical imaging Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229910052711 selenium Inorganic materials 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 208000029534 Infectious Bone disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 230000030570 cellular localization Effects 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 208000016361 genetic disease Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000010189 intracellular transport Effects 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 claims 1
- 229940081066 picolinic acid Drugs 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71407405P | 2005-09-02 | 2005-09-02 | |
| US60/714,074 | 2005-09-02 | ||
| PCT/US2006/034406 WO2007028118A2 (en) | 2005-09-02 | 2006-09-01 | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012232544A Division JP2013014625A (ja) | 2005-09-02 | 2012-10-22 | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009507035A JP2009507035A (ja) | 2009-02-19 |
| JP2009507035A5 true JP2009507035A5 (https=) | 2009-12-24 |
| JP5416970B2 JP5416970B2 (ja) | 2014-02-12 |
Family
ID=37653212
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529356A Active JP5416970B2 (ja) | 2005-09-02 | 2006-09-01 | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
| JP2012232544A Withdrawn JP2013014625A (ja) | 2005-09-02 | 2012-10-22 | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012232544A Withdrawn JP2013014625A (ja) | 2005-09-02 | 2012-10-22 | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US8173819B2 (https=) |
| EP (1) | EP1934202B1 (https=) |
| JP (2) | JP5416970B2 (https=) |
| WO (1) | WO2007028118A2 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE536993T1 (de) | 2002-01-02 | 2011-12-15 | Visen Medical Inc | Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten |
| US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| CA2621137C (en) | 2005-09-02 | 2014-07-29 | Visen Medical, Inc. | Biocompatible n,n-disubstituted sulfonamide-containing fluorescent dye labels |
| US7947256B2 (en) * | 2005-09-02 | 2011-05-24 | Visen Medical, Inc. | Biocompatible fluorescent imaging agents |
| EP1934202B1 (en) | 2005-09-02 | 2019-01-09 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| WO2007136413A2 (en) | 2005-12-22 | 2007-11-29 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| US8221721B2 (en) | 2007-02-09 | 2012-07-17 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| US8815214B2 (en) | 2008-01-18 | 2014-08-26 | Visen Medical, Inc. | Fluorescent imaging agents |
| WO2010057944A1 (en) * | 2008-11-20 | 2010-05-27 | Ge Healthcare As | Dye conjugate imaging agents |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| JP2012524153A (ja) | 2009-04-17 | 2012-10-11 | ライコア インコーポレイテッド | 置換シアニン染料を用いた蛍光イメージング |
| JP2011046662A (ja) * | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| JP2011046663A (ja) * | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| GB201010878D0 (en) * | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| US9610367B2 (en) * | 2010-08-24 | 2017-04-04 | Canon Kabushiki Kaisha | Particle and contrast agent having the particle |
| US9777320B2 (en) | 2010-08-25 | 2017-10-03 | Pacific Biosciences Of California, Inc. | Molecular adaptors for dye conjugates |
| WO2012054784A1 (en) | 2010-10-20 | 2012-04-26 | Li-Cor, Inc. | Fluorescent imaging with substituted cyanine dyes |
| CN103687854A (zh) * | 2011-05-09 | 2014-03-26 | 文森医学公司 | 碳酸酐酶靶向剂及其使用方法 |
| CZ304094B6 (cs) * | 2011-12-01 | 2013-10-16 | Vysoká skola chemicko-technologická v Praze | Vyuzití polymethiniových solí jako mitochondriálních sond |
| US9375493B2 (en) | 2012-03-30 | 2016-06-28 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| EP2850086B1 (en) | 2012-05-18 | 2023-07-05 | Pacific Biosciences Of California, Inc. | Heteroarylcyanine dyes |
| US9315864B2 (en) | 2012-05-18 | 2016-04-19 | Pacific Biosciences Of California, Inc. | Heteroarylcyanine dyes with sulfonic acid substituents |
| CN104955484B (zh) | 2012-08-15 | 2019-01-15 | 文森医学公司 | 用于前列腺癌成像的前列腺特异性抗原药剂及其使用方法 |
| WO2014144702A2 (en) * | 2013-03-15 | 2014-09-18 | Visen Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| CA2901379C (en) | 2013-03-15 | 2023-05-16 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| JP7023604B2 (ja) | 2013-10-31 | 2022-02-22 | ベス・イスラエル・ディーコネス・メディカル・センター，インコーポレイテッド | 近赤外蛍光造影バイオイメージング剤及びその使用方法 |
| US11001562B2 (en) | 2013-10-31 | 2021-05-11 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent nerve contrast agents and methods of use thereof |
| CZ306320B6 (cs) * | 2014-04-01 | 2016-11-30 | Vysoká škola chemicko - technologická v Praze | Využití nových typů pentamethiniových solí s expandovanou chinoxalinovou jednotkou v protinádorové terapii |
| GB2567124A (en) * | 2017-05-08 | 2019-04-10 | Vysoka Akola Chemicko Tech V Praze | Imaging agents and methods |
| JP7032969B2 (ja) * | 2018-03-28 | 2022-03-09 | 日本化薬株式会社 | シアニン化合物 |
| US12440585B2 (en) | 2023-09-12 | 2025-10-14 | Curadel Surgical Innovations, Inc. | Zwitterionic metal chelators |
Family Cites Families (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3864644A (en) | 1971-03-22 | 1975-02-04 | Eastman Kodak Co | Dye lasers including rigidized carbocyanine dyes |
| DE2121014A1 (de) * | 1971-04-29 | 1972-11-02 | Agfa-Gevaert Ag, 5090 Leverkusen | Sensibilisierte elektrophotographische Schichten |
| US4011086A (en) | 1975-10-14 | 1977-03-08 | Eastman Kodak Company | Photographic emulsions and elements containing rigidized carbocyanine dyes |
| JPS6025781B2 (ja) | 1977-03-11 | 1985-06-20 | 富士ゼロックス株式会社 | 電子写真用感光材料 |
| US4370401A (en) * | 1979-12-07 | 1983-01-25 | Minnesota Mining And Manufacturing Company | Light sensitive, thermally developable imaging system |
| US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
| US5366603A (en) | 1984-03-29 | 1994-11-22 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting useing laser diodes |
| US5627027A (en) | 1986-04-18 | 1997-05-06 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5268486A (en) | 1986-04-18 | 1993-12-07 | Carnegie-Mellon Unversity | Method for labeling and detecting materials employing arylsulfonate cyanine dyes |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5569587A (en) | 1986-04-18 | 1996-10-29 | Carnegie Mellon University | Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes |
| DE3912046B4 (de) * | 1988-09-02 | 2004-03-25 | Carnegie Mellon University | Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt |
| US5073171A (en) | 1989-01-12 | 1991-12-17 | Eaton John W | Biocompatible materials comprising albumin-binding dyes |
| US4981977A (en) | 1989-06-09 | 1991-01-01 | Carnegie-Mellon University | Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups |
| JP2824917B2 (ja) * | 1989-08-30 | 1998-11-18 | 株式会社林原生物化学研究所 | 抗腫瘍剤 |
| US5831098A (en) | 1992-03-16 | 1998-11-03 | Minnesota Mining And Manufacturing Company | 2-methyl-4,4a-dihydro-3H-carbazolium salts and dyes derived therefrom |
| DE69332952T2 (de) | 1992-09-04 | 2004-02-19 | The General Hospital Corp., Boston | Diagnostische und therapeutische Einheiten enthaltende biokompatible Polymere |
| US5808044A (en) | 1993-01-22 | 1998-09-15 | Pharmacia Biotech Inc. | Indocarbocyanine and benzindocarbocyanine phosphoramidites |
| US5453505A (en) | 1994-06-30 | 1995-09-26 | Biometric Imaging, Inc. | N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels |
| US5605809A (en) | 1994-10-28 | 1997-02-25 | Oncoimmunin, Inc. | Compositions for the detection of proteases in biological samples and methods of use thereof |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| US6127134A (en) | 1995-04-20 | 2000-10-03 | Carnegie Mellon University | Difference gel electrophoresis using matched multiple dyes |
| US6008373A (en) | 1995-06-07 | 1999-12-28 | Carnegie Mellon University | Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer |
| IT1276833B1 (it) | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| US6004536A (en) | 1995-11-14 | 1999-12-21 | Molecular Probes, Inc. | Lipophilic cyanine dyes with enchanced aqueous solubilty |
| JP2000508709A (ja) | 1996-04-19 | 2000-07-11 | アマーシャム・ファルマシア・バイオテック・ユーケイ・リミテッド | スクアラート染料類および蛍光配列決定法におけるそれらの使用 |
| JPH1071766A (ja) | 1996-06-25 | 1998-03-17 | Fuji Photo Film Co Ltd | 情報記録媒体及び色素化合物 |
| JP3840301B2 (ja) * | 1996-07-18 | 2006-11-01 | 富士写真フイルム株式会社 | 情報記録媒体 |
| US6027709A (en) | 1997-01-10 | 2000-02-22 | Li-Cor Inc. | Fluorescent cyanine dyes |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US5877310A (en) | 1997-04-25 | 1999-03-02 | Carnegie Mellon University | Glycoconjugated fluorescent labeling reagents |
| US6133445A (en) | 1997-12-17 | 2000-10-17 | Carnegie Mellon University | Rigidized trimethine cyanine dyes |
| EP1042407B1 (en) | 1997-12-17 | 2001-09-12 | Carnegie-Mellon University | Rigidized trimethine cyanine dyes |
| AU3386399A (en) | 1998-04-08 | 1999-10-25 | Ewald A. Terpetschnig | Luminescent compounds |
| US6002003A (en) | 1998-04-14 | 1999-12-14 | Beckman Instruments, Inc. | Cyanine dye activating group with improved coupling selectivity |
| US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| ATE276754T1 (de) | 1998-07-21 | 2004-10-15 | Cytovia Inc | Neue fluoreszensfarbstoffe und ihre anwendung in fluoreszensnachweisverfahren ganzer zellen für kaspasen, peptidasen, proteasen und andere enzyme sowie deren verwendung |
| JP2000095758A (ja) | 1998-09-18 | 2000-04-04 | Schering Ag | 近赤外蛍光造影剤および蛍光造影方法 |
| ATE284433T1 (de) | 1999-07-02 | 2004-12-15 | Visen Medical Inc | Fluorescierende cyaninlabels mit einem sulphamidobrückenglied |
| EP1219626B1 (en) | 1999-09-20 | 2005-06-01 | Fuji Photo Film Co., Ltd. | Compounds for fluorescence labeling |
| JP2001323179A (ja) | 1999-10-06 | 2001-11-20 | Hayashibara Biochem Lab Inc | シアニン色素 |
| AU2002236683A1 (en) | 2000-10-27 | 2002-05-21 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| US6615063B1 (en) | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| EP1209205A1 (en) | 2000-11-28 | 2002-05-29 | Innosense S.r.l. | Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds |
| EP1221465A1 (en) * | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetric, monofunctionalised polymethine dyes labelling reagents |
| US20030044353A1 (en) | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| ATE536993T1 (de) | 2002-01-02 | 2011-12-15 | Visen Medical Inc | Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten |
| WO2003061711A2 (en) | 2002-01-16 | 2003-07-31 | Visen Medical, Inc. | Chromophore probes for optical imaging |
| WO2003079015A1 (en) | 2002-03-11 | 2003-09-25 | Visen Medical, Inc. | Optical imaging probes |
| EP1514093B1 (en) | 2002-06-04 | 2021-04-28 | Visen Medical, Inc. | Imaging volumes with arbitrary geometries in non-contact tomography |
| US7647091B2 (en) | 2003-02-05 | 2010-01-12 | The General Hospital Corporation | Method and system for free space optical tomography of diffuse media |
| WO2004108902A2 (en) | 2003-06-04 | 2004-12-16 | Visen Medical, Inc. | Biocompatible fluorescent silicon nanoparticles |
| EP1720945B1 (en) * | 2003-12-05 | 2016-03-16 | Life Technologies Corporation | Methine-substituted cyanine dye compounds |
| US20060099712A1 (en) | 2004-11-08 | 2006-05-11 | Eastman Kodak Company | Correlation of anti-cancer activity of dyes with redox potentials |
| WO2006063246A1 (en) | 2004-12-08 | 2006-06-15 | The General Hospital Corporation | System and method for normalized fluorescence or bioluminescence imaging |
| US20060239916A1 (en) | 2005-01-07 | 2006-10-26 | Kai Licha | Use of cyanine dyes for the diagnosis of proliferative diseases |
| EP1934202B1 (en) | 2005-09-02 | 2019-01-09 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| US7947256B2 (en) | 2005-09-02 | 2011-05-24 | Visen Medical, Inc. | Biocompatible fluorescent imaging agents |
| CA2621137C (en) | 2005-09-02 | 2014-07-29 | Visen Medical, Inc. | Biocompatible n,n-disubstituted sulfonamide-containing fluorescent dye labels |
| EP1926425B1 (en) | 2005-09-13 | 2015-08-19 | Philips Intellectual Property & Standards GmbH | Multiple contrast agent injection for imaging |
| WO2007136413A2 (en) | 2005-12-22 | 2007-11-29 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| US20100189657A1 (en) | 2006-03-20 | 2010-07-29 | The General Hospital Corporation | Intramolecularly quenched fluorochrome conjugates and methods of use |
| US8221721B2 (en) | 2007-02-09 | 2012-07-17 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| US8314406B2 (en) | 2007-04-06 | 2012-11-20 | The General Hospital Corporation | Systems and methods for optical imaging using early arriving photons |
| US8815214B2 (en) | 2008-01-18 | 2014-08-26 | Visen Medical, Inc. | Fluorescent imaging agents |
| CN102026671B (zh) | 2008-03-14 | 2014-09-03 | Visen医药公司 | 整联蛋白靶向试剂及使用其的体内和体外成像方法 |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
-
2006
- 2006-09-01 EP EP06802888.5A patent/EP1934202B1/en active Active
- 2006-09-01 JP JP2008529356A patent/JP5416970B2/ja active Active
- 2006-09-01 US US12/065,391 patent/US8173819B2/en active Active
- 2006-09-01 WO PCT/US2006/034406 patent/WO2007028118A2/en not_active Ceased
-
2012
- 2012-04-18 US US13/450,003 patent/US8455651B2/en active Active
- 2012-10-22 JP JP2012232544A patent/JP2013014625A/ja not_active Withdrawn
-
2013
- 2013-03-14 US US13/828,648 patent/US8771646B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009507035A5 (https=) | ||
| Usama et al. | On the mechanisms of uptake of tumor-seeking cyanine dyes | |
| JP2009507108A5 (https=) | ||
| JP2010518236A5 (https=) | ||
| Teunissen et al. | Investigating supramolecular systems using Förster resonance energy transfer | |
| AU2022203395A1 (en) | Fluorescent compound comprising a fluorophore conjugated to a pH -triggered polypeptide | |
| AU2018258581A1 (en) | RAF-degrading conjugate compounds | |
| ES2702541T3 (es) | Pamoato de donepezilo, método de preparación y su uso | |
| JP2016521254A5 (https=) | ||
| Plunkett et al. | In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing | |
| JP2007500192A (ja) | 高度放射性プローブを組合わせたポリマーソーム | |
| Luo et al. | Near-infrared persistent luminescence nanoprobe for early detection of atherosclerotic plaque | |
| JP2015532641A5 (https=) | ||
| JP2010195764A (ja) | 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤 | |
| CN102770460A (zh) | 新吲哚菁化合物、其合成法及其精制法、使用该吲哚菁化合物的诊断用组合物、使用该诊断用组合物的生物体内动态测定装置以及循环可视化装置 | |
| CN112313267A (zh) | 可生物降解聚合物 | |
| Nam et al. | A Pressure‐Sensitive, repositionable bioadhesive for instant, atraumatic surgical application on internal organs | |
| CN112955130A (zh) | 包含取代茚满的固体分散体和药物组合物及其制备和使用方法 | |
| Xu et al. | Utilization of aggregation‐induced emission materials in urinary system diseases | |
| Tavakoli et al. | Aggregation-induced emission fluorescent gels: Current trends and future perspectives | |
| Chen et al. | Targeted cyclo [8] pyrrole-Based NIR-II photoacoustic tomography probe for suppression of orthotopic pancreatic tumor growth and intra-abdominal metastases | |
| Oh et al. | Thoracoscopic color and fluorescence imaging system for sentinel lymph node mapping in porcine lung using indocyanine green-neomannosyl human serum albumin: intraoperative image-guided sentinel nodes navigation | |
| KR20230058122A (ko) | 종양 조영 화합물, 이의 제조 방법 및 종양 진단 이미징에서의 응용 | |
| US20190275175A1 (en) | Carbon Nanotubes for Imaging and Drug Delivery | |
| JP2009137950A (ja) | 光音響造影剤 |