JP2009506122A5 - - Google Patents
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- Publication number
- JP2009506122A5 JP2009506122A5 JP2008529207A JP2008529207A JP2009506122A5 JP 2009506122 A5 JP2009506122 A5 JP 2009506122A5 JP 2008529207 A JP2008529207 A JP 2008529207A JP 2008529207 A JP2008529207 A JP 2008529207A JP 2009506122 A5 JP2009506122 A5 JP 2009506122A5
- Authority
- JP
- Japan
- Prior art keywords
- agent
- activity
- oligodeoxynucleotide
- expression
- cxcl16
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003795 chemical substances by application Substances 0.000 claims 20
- 229940046166 oligodeoxynucleotide Drugs 0.000 claims 18
- 102100039396 C-X-C motif chemokine 16 Human genes 0.000 claims 9
- 101000889133 Homo sapiens C-X-C motif chemokine 16 Proteins 0.000 claims 9
- 239000000203 mixture Substances 0.000 claims 9
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 claims 8
- 230000028993 immune response Effects 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 102000036664 ADAM10 Human genes 0.000 claims 6
- 108091007504 ADAM10 Proteins 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 4
- 239000005557 antagonist Substances 0.000 claims 4
- 239000002213 purine nucleotide Substances 0.000 claims 3
- 150000003212 purines Chemical class 0.000 claims 3
- 239000002719 pyrimidine nucleotide Substances 0.000 claims 3
- 150000003230 pyrimidines Chemical class 0.000 claims 3
- SKJLITFHSZNZMQ-SGNDLWITSA-N benzyl N-[(5S)-5-[[(2R,3S)-3-[formyl(hydroxy)amino]-2-(2-methylpropyl)hexanoyl]amino]-6-oxo-6-(1,3-thiazol-2-ylamino)hexyl]carbamate Chemical compound C(=O)N([C@H]([C@H](C(=O)N[C@@H](CCCCNC(OCC1=CC=CC=C1)=O)C(NC=1SC=CN=1)=O)CC(C)C)CCC)O SKJLITFHSZNZMQ-SGNDLWITSA-N 0.000 claims 2
- 230000007423 decrease Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- PGHMRUGBZOYCAA-ADZNBVRBSA-N ionomycin Chemical compound O1[C@H](C[C@H](O)[C@H](C)[C@H](O)[C@H](C)/C=C/C[C@@H](C)C[C@@H](C)C(/O)=C/C(=O)[C@@H](C)C[C@@H](C)C[C@@H](CCC(O)=O)C)CC[C@@]1(C)[C@@H]1O[C@](C)([C@@H](C)O)CC1 PGHMRUGBZOYCAA-ADZNBVRBSA-N 0.000 claims 1
- PGHMRUGBZOYCAA-UHFFFAOYSA-N ionomycin Natural products O1C(CC(O)C(C)C(O)C(C)C=CCC(C)CC(C)C(O)=CC(=O)C(C)CC(C)CC(CCC(O)=O)C)CCC1(C)C1OC(C)(C(C)O)CC1 PGHMRUGBZOYCAA-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71354705P | 2005-08-31 | 2005-08-31 | |
| US60/713,547 | 2005-08-31 | ||
| PCT/US2006/033774 WO2007027718A1 (en) | 2005-08-31 | 2006-08-28 | Methods of altering an immune response induced by cpg oligodeoxynucleotides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009506122A JP2009506122A (ja) | 2009-02-12 |
| JP2009506122A5 true JP2009506122A5 (enExample) | 2009-08-13 |
| JP5481068B2 JP5481068B2 (ja) | 2014-04-23 |
Family
ID=37606913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529207A Active JP5481068B2 (ja) | 2005-08-31 | 2006-08-28 | ＣｐＧオリゴデオキシヌクレオチドによって誘発される免疫応答を変化させる方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7892569B2 (enExample) |
| EP (1) | EP1929014B1 (enExample) |
| JP (1) | JP5481068B2 (enExample) |
| AU (1) | AU2006284889B2 (enExample) |
| CA (1) | CA2620582C (enExample) |
| WO (1) | WO2007027718A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030026782A1 (en) * | 1995-02-07 | 2003-02-06 | Arthur M. Krieg | Immunomodulatory oligonucleotides |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| WO2000061151A2 (en) * | 1999-04-12 | 2000-10-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| US6977245B2 (en) | 1999-04-12 | 2005-12-20 | The United States Of America As Represented By The Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| AU2001227889A1 (en) * | 2000-01-14 | 2001-07-24 | The United States of America, represented by The Secretary, Department of Health & Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| AU2004275876B2 (en) * | 2003-09-25 | 2011-03-31 | Coley Pharmaceutical Gmbh | Nucleic acid-lipophilic conjugates |
| CA2745096C (en) | 2008-12-09 | 2013-11-05 | Coley Pharmaceutical Group, Inc. | Immunostimulatory oligonucleotides |
| US8552165B2 (en) * | 2008-12-09 | 2013-10-08 | Heather Davis | Immunostimulatory oligonucleotides |
| US20100233270A1 (en) | 2009-01-08 | 2010-09-16 | Northwestern University | Delivery of Oligonucleotide-Functionalized Nanoparticles |
| MX2011010050A (es) | 2009-03-25 | 2011-12-14 | Univ Texas | Composiciones para estimulación de resistencia inmune innata de mamiferos a patógenos. |
| EP2597084B1 (en) | 2010-07-08 | 2016-06-29 | Kaken Pharmaceutical Co., Ltd. | N-hydroxyformamide derivative and pharmaceutical containing same |
| CN103555726B (zh) * | 2013-10-14 | 2015-05-13 | 中国科学院海洋研究所 | 一种含有未甲基化CpG的DNA序列(CpG-DNA)及其应用 |
| US10434064B2 (en) | 2014-06-04 | 2019-10-08 | Exicure, Inc. | Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications |
| WO2016044839A2 (en) | 2014-09-19 | 2016-03-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating viral infections through stimulated innate immunity in combination with antiviral compounds |
| US11696954B2 (en) * | 2017-04-28 | 2023-07-11 | Exicure Operating Company | Synthesis of spherical nucleic acids using lipophilic moieties |
| EP3752194A4 (en) | 2018-02-13 | 2022-03-16 | Checkmate Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY |
| EP3775218A1 (en) | 2018-04-09 | 2021-02-17 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| WO2024137496A1 (en) | 2022-12-19 | 2024-06-27 | Six Therapeutics Inc. | Compositions and methods of using cpg oligonucleotides |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02138868A (ja) * | 1988-11-18 | 1990-05-28 | Eisai Co Ltd | 男性不妊症の診断試薬 |
| WO1999056755A1 (en) * | 1998-05-06 | 1999-11-11 | University Of Iowa Research Foundation | Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides |
| WO2000061151A2 (en) | 1999-04-12 | 2000-10-19 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Oligodeoxynucleotide and its use to induce an immune response |
| JP2003510290A (ja) | 1999-09-27 | 2003-03-18 | コーリー ファーマシューティカル グループ，インコーポレイテッド | 免疫刺激核酸誘導インターフェロンに関する方法 |
-
2006
- 2006-08-28 JP JP2008529207A patent/JP5481068B2/ja active Active
- 2006-08-28 WO PCT/US2006/033774 patent/WO2007027718A1/en not_active Ceased
- 2006-08-28 CA CA2620582A patent/CA2620582C/en not_active Expired - Fee Related
- 2006-08-28 AU AU2006284889A patent/AU2006284889B2/en not_active Ceased
- 2006-08-28 EP EP06813920.3A patent/EP1929014B1/en not_active Ceased
- 2006-08-28 US US12/065,085 patent/US7892569B2/en not_active Expired - Fee Related
-
2011
- 2011-01-12 US US13/005,488 patent/US8470342B2/en active Active
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