JP2009500431A5 - - Google Patents

Info

Publication number

JP2009500431A5

JP2009500431A5 JP2008520685A JP2008520685A JP2009500431A5 JP 2009500431 A5 JP2009500431 A5 JP 2009500431A5 JP 2008520685 A JP2008520685 A JP 2008520685A JP 2008520685 A JP2008520685 A JP 2008520685A JP 2009500431 A5 JP2009500431 A5 JP 2009500431A5

Authority

JP

Japan

Prior art keywords

complex

pharmaceutically acceptable

composition according

angiopep

amino acid

Prior art date

2006-07-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 150000003839 salts Chemical class 0.000 claims 11
• 125000003275 alpha amino acid group Chemical group 0.000 claims 10
• 206010028980 Neoplasm Diseases 0.000 claims 9
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 8
• 239000002246 antineoplastic agent Substances 0.000 claims 8
• 229940041181 antineoplastic drug Drugs 0.000 claims 8
• 201000011510 cancer Diseases 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 7
• 102000004196 processed proteins & peptides Human genes 0.000 claims 7
• 229920001184 polypeptide Polymers 0.000 claims 6
• 235000001014 amino acid Nutrition 0.000 claims 5
• 235000018102 proteins Nutrition 0.000 claims 5
• 102000004169 proteins and genes Human genes 0.000 claims 5
• 108090000623 proteins and genes Proteins 0.000 claims 5
• 108010064942 Angiopep-2 Proteins 0.000 claims 4
• 229930012538 Paclitaxel Natural products 0.000 claims 4
• 229960004679 doxorubicin Drugs 0.000 claims 4
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 claims 4
• 229960005420 etoposide Drugs 0.000 claims 4
• 229960001592 paclitaxel Drugs 0.000 claims 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 4
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• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 2
• 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 2
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 claims 2
• 229960004630 chlorambucil Drugs 0.000 claims 2
• 229960004397 cyclophosphamide Drugs 0.000 claims 2
• 229940079593 drug Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 150000002148 esters Chemical class 0.000 claims 2
• 239000012634 fragment Substances 0.000 claims 2
• 208000020816 lung neoplasm Diseases 0.000 claims 2
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• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 2
• 229960001924 melphalan Drugs 0.000 claims 2
• -1 polyoxyethylene Polymers 0.000 claims 2
• 150000004579 taxol derivatives Chemical class 0.000 claims 2
• 229940063683 taxotere Drugs 0.000 claims 2
• 229960003048 vinblastine Drugs 0.000 claims 2
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 claims 2
• 229960004528 vincristine Drugs 0.000 claims 2
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 2
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 2
• 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
• 208000032612 Glial tumor Diseases 0.000 claims 1
• 206010018338 Glioma Diseases 0.000 claims 1
• 206010019695 Hepatic neoplasm Diseases 0.000 claims 1
• 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
• 229930195725 Mannitol Natural products 0.000 claims 1
• 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 claims 1
• 206010027476 Metastases Diseases 0.000 claims 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
• 235000018417 cysteine Nutrition 0.000 claims 1
• 235000014113 dietary fatty acids Nutrition 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 208000024519 eye neoplasm Diseases 0.000 claims 1
• 239000000194 fatty acid Substances 0.000 claims 1
• 229930195729 fatty acid Natural products 0.000 claims 1
• 150000004665 fatty acids Chemical class 0.000 claims 1
• 208000005017 glioblastoma Diseases 0.000 claims 1
• 208000014018 liver neoplasm Diseases 0.000 claims 1
• 239000000594 mannitol Substances 0.000 claims 1
• 235000010355 mannitol Nutrition 0.000 claims 1
• 201000001441 melanoma Diseases 0.000 claims 1
• 230000009401 metastasis Effects 0.000 claims 1
• 230000001394 metastastic effect Effects 0.000 claims 1
• 208000037819 metastatic cancer Diseases 0.000 claims 1
• 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
• 206010061289 metastatic neoplasm Diseases 0.000 claims 1
• 210000000056 organ Anatomy 0.000 claims 1
• 208000030266 primary brain neoplasm Diseases 0.000 claims 1
• 229940126586 small molecule drug Drugs 0.000 claims 1
• 230000002485 urinary effect Effects 0.000 claims 1