JP2017521371A5 - - Google Patents
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- JP2017521371A5 JP2017521371A5 JP2016569722A JP2016569722A JP2017521371A5 JP 2017521371 A5 JP2017521371 A5 JP 2017521371A5 JP 2016569722 A JP2016569722 A JP 2016569722A JP 2016569722 A JP2016569722 A JP 2016569722A JP 2017521371 A5 JP2017521371 A5 JP 2017521371A5
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- JP
- Japan
- Prior art keywords
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- moiety
- drug
- spacer
- enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229940079593 drug Drugs 0.000 claims 31
- 239000003814 drug Substances 0.000 claims 31
- 102000004190 Enzymes Human genes 0.000 claims 19
- 108090000790 Enzymes Proteins 0.000 claims 19
- 239000002105 nanoparticle Substances 0.000 claims 19
- 125000005647 linker group Chemical group 0.000 claims 18
- 125000006850 spacer group Chemical group 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 10
- 239000002202 Polyethylene glycol Substances 0.000 claims 9
- 229920001223 polyethylene glycol Polymers 0.000 claims 9
- 102000035195 Peptidases Human genes 0.000 claims 7
- 108091005804 Peptidases Proteins 0.000 claims 7
- 239000004365 Protease Substances 0.000 claims 7
- 235000001014 amino acid Nutrition 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 6
- 239000007850 fluorescent dye Substances 0.000 claims 6
- 230000008685 targeting Effects 0.000 claims 6
- ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 claims 4
- 108010016626 Dipeptides Proteins 0.000 claims 4
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 4
- 239000002067 L01XE06 - Dasatinib Substances 0.000 claims 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 229960002448 dasatinib Drugs 0.000 claims 4
- 229960002584 gefitinib Drugs 0.000 claims 4
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 230000002285 radioactive effect Effects 0.000 claims 4
- 229940124617 receptor tyrosine kinase inhibitor Drugs 0.000 claims 4
- 102000027426 receptor tyrosine kinases Human genes 0.000 claims 4
- 108091008598 receptor tyrosine kinases Proteins 0.000 claims 4
- 229920000620 organic polymer Polymers 0.000 claims 3
- ALBODLTZUXKBGZ-JUUVMNCLSA-N (2s)-2-amino-3-phenylpropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CC1=CC=CC=C1 ALBODLTZUXKBGZ-JUUVMNCLSA-N 0.000 claims 2
- CLUOUYPICNCYNF-IPIKRLCPSA-N (2s)-2-amino-5-(diaminomethylideneamino)pentanoic acid;(2s)-2-amino-3-phenylpropanoic acid Chemical compound OC(=O)[C@@H](N)CCCNC(N)=N.OC(=O)[C@@H](N)CC1=CC=CC=C1 CLUOUYPICNCYNF-IPIKRLCPSA-N 0.000 claims 2
- IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 claims 2
- 102000004225 Cathepsin B Human genes 0.000 claims 2
- 108090000712 Cathepsin B Proteins 0.000 claims 2
- 102000005927 Cysteine Proteases Human genes 0.000 claims 2
- 108010005843 Cysteine Proteases Proteins 0.000 claims 2
- 102000012479 Serine Proteases Human genes 0.000 claims 2
- 108010022999 Serine Proteases Proteins 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 238000003776 cleavage reaction Methods 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000007062 hydrolysis Effects 0.000 claims 2
- 238000006460 hydrolysis reaction Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- 230000007017 scission Effects 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- 210000004881 tumor cell Anatomy 0.000 claims 2
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462004738P | 2014-05-29 | 2014-05-29 | |
| US62/004,738 | 2014-05-29 | ||
| US201462094923P | 2014-12-19 | 2014-12-19 | |
| US62/094,923 | 2014-12-19 | ||
| PCT/US2015/032565 WO2015183882A1 (en) | 2014-05-29 | 2015-05-27 | Nanoparticle drug conjugates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017521371A JP2017521371A (ja) | 2017-08-03 |
| JP2017521371A5 true JP2017521371A5 (https=) | 2019-01-10 |
| JP6573633B2 JP6573633B2 (ja) | 2019-09-11 |
Family
ID=53284649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016569722A Active JP6573633B2 (ja) | 2014-05-29 | 2015-05-27 | ナノ粒子薬物コンジュゲート |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US10111963B2 (https=) |
| EP (2) | EP3148591B1 (https=) |
| JP (1) | JP6573633B2 (https=) |
| KR (2) | KR102051038B1 (https=) |
| CN (2) | CN113082225A (https=) |
| AU (1) | AU2015267200B2 (https=) |
| BR (1) | BR112016027624A8 (https=) |
| CA (2) | CA2947895C (https=) |
| DK (1) | DK3148591T3 (https=) |
| ES (1) | ES2788865T3 (https=) |
| PL (1) | PL3148591T3 (https=) |
| RU (1) | RU2016144055A (https=) |
| WO (1) | WO2015183882A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US12161734B2 (en) | 2009-07-02 | 2024-12-10 | Sloan-Kettering Institute For Cancer Research | Multimodal silica-based nanoparticles |
| WO2011003109A1 (en) | 2009-07-02 | 2011-01-06 | Sloan-Kettering Institute For Cancer Research | Fluorescent silica-based nanoparticles |
| EP2968621B1 (en) | 2013-03-15 | 2022-08-10 | Memorial Sloan-Kettering Cancer Center | Multimodal silica-based nanoparticles |
| JP6681334B2 (ja) | 2013-12-31 | 2020-04-15 | メモリアル スローン ケタリング キャンサー センター | リアルタイムの蛍光源のマルチチャネル撮像のためのシステム、方法、および装置 |
| CN113082225A (zh) | 2014-05-29 | 2021-07-09 | 纪念斯隆-凯特琳癌症中心 | 纳米粒子药物结合物 |
| JP6751715B2 (ja) | 2014-12-15 | 2020-09-09 | メモリアル スローン ケタリング キャンサー センター | 神経結合選択性が増強された環状ペプチド、当該環状ペプチドと結合したナノ粒子、およびリアルタイムｉｎ ｖｉｖｏ神経組織撮像ための当該環状ペプチドの使用 |
| JP6974178B2 (ja) | 2015-05-29 | 2021-12-01 | メモリアル スローン ケタリング キャンサー センター | フェロトーシスを介して栄養欠乏がん細胞の細胞死を誘導するための極小ナノ粒子を使用する処置方法 |
| CN109069666B (zh) * | 2016-04-29 | 2023-04-04 | 纪念斯隆凯特琳癌症中心 | 使靶向颗粒穿透、分布和响应于恶性脑肿瘤中的组合物和方法 |
| BR112019000143A2 (pt) | 2016-07-07 | 2019-04-16 | Memorial Sloan Kettering Cancer Center | sistemas de imagem e métodos para radiogenomia de câncer conduzido por partícula, baseado no conhecimento e preditivo |
| CA3064253A1 (en) * | 2017-05-25 | 2018-11-29 | Memorial Sloan Kettering Cancer Center | Ultrasmall nanoparticles labeled with zirconium-89 and methods thereof |
| WO2018237253A1 (en) | 2017-06-23 | 2018-12-27 | Memorial Sloan Kettering Cancer Center | Method of imaging in vivo tissues using nanoparticles comprising a reference dye and a sensor dye. |
| RU2679075C1 (ru) * | 2017-11-09 | 2019-02-05 | Федеральное бюджетное учреждение науки "Государственный научный центр вирусологии и биотехнологии "Вектор" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека (ФБУН ГНЦ ВБ "Вектор" Роспотребнадзора) | Конъюгат люминесцентных наночастиц диоксида кремния с рекомбинантными однодоменными нано - моноантителами C7b ламы, способными специфически взаимодействовать с рекомбинантным белком HER2/neu - аналогом природного рецептора эпидермального фактора роста EGFR/ERBB клеток человека |
| US20200383943A1 (en) | 2017-12-04 | 2020-12-10 | Memorial Sloan Kettering Cancer Center | Methods of cancer treatment via regulated ferroptosis |
| CA3115355A1 (en) | 2018-10-16 | 2020-04-23 | Silicycle Inc. | Tunable process for silica capsules/spheres preparation and their use |
| GB201904336D0 (en) * | 2019-03-28 | 2019-05-15 | Sisaf Ltd | A delivery system |
| WO2022076523A1 (en) * | 2020-10-06 | 2022-04-14 | Washington University | Methods and compositions for imaging and treating cancer |
| CN112168977A (zh) * | 2020-10-27 | 2021-01-05 | 西南大学 | 转铁蛋白修饰的二氧化硅荷载白藜芦醇及制备方法和应用 |
| WO2022093800A2 (en) | 2020-10-27 | 2022-05-05 | Elucida Oncology, Inc. | Carrier particle-drug conjugates, self-immolative linkers, and uses thereof |
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| WO2011003109A1 (en) | 2009-07-02 | 2011-01-06 | Sloan-Kettering Institute For Cancer Research | Fluorescent silica-based nanoparticles |
| CN102791294A (zh) * | 2009-12-16 | 2012-11-21 | 布里格姆妇女医院股份有限公司 | 用于多种药物递送的粒子 |
| DK2528625T3 (da) * | 2010-04-15 | 2013-10-14 | Spirogen Sarl | Pyrrolobenzodiazepiner og konjugater deraf |
| CN104703625B (zh) * | 2012-06-22 | 2017-08-29 | 康奈尔大学 | 介孔氧化物纳米颗粒以及制备和使用其的方法 |
| WO2014011973A2 (en) | 2012-07-13 | 2014-01-16 | The Trustees Of Columbia University In The City Of New York | Quinazolinone-based oncogenic-ras-selective lethal compounds and their use |
| CN112587671A (zh) * | 2012-07-18 | 2021-04-02 | 博笛生物科技有限公司 | 癌症的靶向免疫治疗 |
| EP2968621B1 (en) | 2013-03-15 | 2022-08-10 | Memorial Sloan-Kettering Cancer Center | Multimodal silica-based nanoparticles |
| CN113082225A (zh) | 2014-05-29 | 2021-07-09 | 纪念斯隆-凯特琳癌症中心 | 纳米粒子药物结合物 |
| JP6974178B2 (ja) | 2015-05-29 | 2021-12-01 | メモリアル スローン ケタリング キャンサー センター | フェロトーシスを介して栄養欠乏がん細胞の細胞死を誘導するための極小ナノ粒子を使用する処置方法 |
| WO2018237253A1 (en) | 2017-06-23 | 2018-12-27 | Memorial Sloan Kettering Cancer Center | Method of imaging in vivo tissues using nanoparticles comprising a reference dye and a sensor dye. |
-
2015
- 2015-05-27 CN CN202110399761.9A patent/CN113082225A/zh active Pending
- 2015-05-27 CN CN201580029280.1A patent/CN106659797B/zh active Active
- 2015-05-27 DK DK15727248.5T patent/DK3148591T3/da active
- 2015-05-27 KR KR1020167035356A patent/KR102051038B1/ko active Active
- 2015-05-27 BR BR112016027624A patent/BR112016027624A8/pt not_active Application Discontinuation
- 2015-05-27 PL PL15727248T patent/PL3148591T3/pl unknown
- 2015-05-27 RU RU2016144055A patent/RU2016144055A/ru not_active Application Discontinuation
- 2015-05-27 US US14/722,307 patent/US10111963B2/en active Active
- 2015-05-27 ES ES15727248T patent/ES2788865T3/es active Active
- 2015-05-27 JP JP2016569722A patent/JP6573633B2/ja active Active
- 2015-05-27 CA CA2947895A patent/CA2947895C/en active Active
- 2015-05-27 CA CA3201974A patent/CA3201974C/en active Active
- 2015-05-27 KR KR1020197034930A patent/KR102231672B1/ko active Active
- 2015-05-27 WO PCT/US2015/032565 patent/WO2015183882A1/en not_active Ceased
- 2015-05-27 AU AU2015267200A patent/AU2015267200B2/en active Active
- 2015-05-27 EP EP15727248.5A patent/EP3148591B1/en active Active
- 2015-05-27 EP EP20152240.6A patent/EP3693026A1/en active Pending
-
2018
- 2018-09-21 US US16/137,709 patent/US10485881B2/en active Active
-
2019
- 2019-10-15 US US16/653,490 patent/US20200289668A1/en not_active Abandoned
-
2024
- 2024-10-10 US US18/911,705 patent/US20250269054A1/en active Pending
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