|
US4179337A
(en)
*
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
NZ210501A
(en)
*
|
1983-12-13 |
1991-08-27 |
Kirin Amgen Inc |
Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
|
|
KR850004274A
(ko)
*
|
1983-12-13 |
1985-07-11 |
원본미기재 |
에리트로포이에틴의 제조방법
|
|
US4703008A
(en)
|
1983-12-13 |
1987-10-27 |
Kiren-Amgen, Inc. |
DNA sequences encoding erythropoietin
|
|
US4677195A
(en)
*
|
1985-01-11 |
1987-06-30 |
Genetics Institute, Inc. |
Method for the purification of erythropoietin and erythropoietin compositions
|
|
AU610083B2
(en)
|
1986-08-18 |
1991-05-16 |
Clinical Technologies Associates, Inc. |
Delivery systems for pharmacological agents
|
|
US5006333A
(en)
*
|
1987-08-03 |
1991-04-09 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5080891A
(en)
*
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
WO1990008822A1
(en)
|
1989-02-03 |
1990-08-09 |
Genetics Institute, Inc. |
Erythropoietin receptor
|
|
US5166322A
(en)
|
1989-04-21 |
1992-11-24 |
Genetics Institute |
Cysteine added variants of interleukin-3 and chemical modifications thereof
|
|
DK0400472T3
(da)
|
1989-05-27 |
1996-05-13 |
Sumitomo Pharma |
Fremgangsmåde til fremstilling af polyethylenglycolderivater og modificeret protein
|
|
US5143854A
(en)
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
|
US5424186A
(en)
|
1989-06-07 |
1995-06-13 |
Affymax Technologies N.V. |
Very large scale immobilized polymer synthesis
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5723286A
(en)
|
1990-06-20 |
1998-03-03 |
Affymax Technologies N.V. |
Peptide library and screening systems
|
|
US5292654A
(en)
*
|
1990-12-13 |
1994-03-08 |
Whitehead Institute For Biomedical Research |
Mutant EPO receptor and uses therefor
|
|
ATE240740T1
(de)
|
1991-03-15 |
2003-06-15 |
Amgen Inc |
Pegylation von polypeptiden
|
|
JP3507486B2
(ja)
|
1991-03-15 |
2004-03-15 |
アムジエン・インコーポレーテツド |
顆粒球コロニー刺激因子の肺内投与
|
|
JPH06506217A
(ja)
|
1991-03-18 |
1994-07-14 |
エンゾン，インコーポレーテッド |
ポリペプチドまたはグリコポリペプチドとポリマーとのヒドラジン含有結合体
|
|
US5770358A
(en)
|
1991-09-18 |
1998-06-23 |
Affymax Technologies N.V. |
Tagged synthetic oligomer libraries
|
|
US5614184A
(en)
*
|
1992-07-28 |
1997-03-25 |
New England Deaconess Hospital |
Recombinant human erythropoietin mutants and therapeutic methods employing them
|
|
US6153407A
(en)
*
|
1992-07-28 |
2000-11-28 |
Beth Israel Deaconess Medical Center |
Erythropoietin DNA having modified 5' and 3' sequences and its use to prepare EPO therapeutics
|
|
US5888511A
(en)
*
|
1993-02-26 |
1999-03-30 |
Advanced Biotherapy Concepts, Inc. |
Treatment of autoimmune diseases, including AIDS
|
|
US5919455A
(en)
*
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
US5773569A
(en)
*
|
1993-11-19 |
1998-06-30 |
Affymax Technologies N.V. |
Compounds and peptides that bind to the erythropoietin receptor
|
|
US5830851A
(en)
*
|
1993-11-19 |
1998-11-03 |
Affymax Technologies N.V. |
Methods of administering peptides that bind to the erythropoietin receptor
|
|
US5580853A
(en)
*
|
1994-03-22 |
1996-12-03 |
New England Deaconess Hospital |
Modified polypeptides with increased biological activity
|
|
US5747446A
(en)
*
|
1994-03-22 |
1998-05-05 |
Beth Israel Deaconess Medical Center |
Modified polypeptides with increased biological activity
|
|
US5919758A
(en)
*
|
1994-03-22 |
1999-07-06 |
Beth Israel Deaconess Medical Center |
Modified polypeptides with altered biological activity
|
|
US5451569A
(en)
|
1994-04-19 |
1995-09-19 |
Hong Kong University Of Science And Technology R & D Corporation Limited |
Pulmonary drug delivery system
|
|
US5677280A
(en)
*
|
1995-06-07 |
1997-10-14 |
Glaxo Group Limited |
Peptides and compounds that bind to the IL-5 receptor
|
|
US5683983A
(en)
*
|
1995-06-07 |
1997-11-04 |
Glaxo Group Limited |
Peptides and compounds that bind to the IL-5 receptor
|
|
US6083913A
(en)
|
1995-06-07 |
2000-07-04 |
Glaxo Wellcome Inc. |
Peptides and compounds that bind to a thrombopoietin receptor
|
|
US5668110A
(en)
*
|
1995-06-07 |
1997-09-16 |
Affymax Technologies N.V. |
Peptides and compounds that bind to the IL-5 receptor
|
|
CA2223833C
(en)
|
1995-06-07 |
2010-12-21 |
Nicholas C. Wrighton |
Compounds and peptides that bind to the erythropoietin receptor
|
|
AU6046696A
(en)
|
1995-06-07 |
1996-12-30 |
Glaxo Group Limited |
Peptides and compounds that bind to a receptor
|
|
US6251864B1
(en)
*
|
1995-06-07 |
2001-06-26 |
Glaxo Group Limited |
Peptides and compounds that bind to a receptor
|
|
US5869451A
(en)
*
|
1995-06-07 |
1999-02-09 |
Glaxo Group Limited |
Peptides and compounds that bind to a receptor
|
|
US5767078A
(en)
*
|
1995-06-07 |
1998-06-16 |
Johnson; Dana L. |
Agonist peptide dimers
|
|
US5654276A
(en)
*
|
1995-06-07 |
1997-08-05 |
Affymax Technologies N.V. |
Peptides and compounds that bind to the IL-5 receptor
|
|
US5672662A
(en)
*
|
1995-07-07 |
1997-09-30 |
Shearwater Polymers, Inc. |
Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
|
|
US6346390B1
(en)
|
1996-03-08 |
2002-02-12 |
Receptron, Inc. |
Receptor derived peptides involved in modulation of response to ligand binding
|
|
US6103879A
(en)
*
|
1996-06-21 |
2000-08-15 |
Axys Pharmaceuticals, Inc. |
Bivalent molecules that form an activating complex with an erythropoietin receptor
|
|
EP0964702B1
(en)
*
|
1996-08-02 |
2006-10-04 |
Ortho-McNeil Pharmaceutical, Inc. |
Polypeptides having a single covalently bound n-terminal water-soluble polymer
|
|
US5932546A
(en)
*
|
1996-10-04 |
1999-08-03 |
Glaxo Wellcome Inc. |
Peptides and compounds that bind to the thrombopoietin receptor
|
|
PL333023A1
(en)
*
|
1996-10-25 |
1999-11-08 |
Searle & Co |
Chimerical antagonists of haeomogenic multifunctional receptors
|
|
US6221608B1
(en)
*
|
1997-01-22 |
2001-04-24 |
Ortho Pharmaceutical Corporation |
Methods for identifying erythropoietin receptor binding protein
|
|
JP4304757B2
(ja)
|
1998-04-24 |
2009-07-29 |
株式会社デンソー |
Ａｂｓアクチュエータ
|
|
RU2246318C2
(ru)
|
1998-08-06 |
2005-02-20 |
Маунтэн Вью Фармасьютикэлз, Инк. |
Конъюгаты peg-уриказы и их использование
|
|
ATE498409T1
(de)
*
|
1998-08-06 |
2011-03-15 |
Mountain View Pharmaceuticals |
Peg-uricase konjugate und verwendung davon
|
|
US6783965B1
(en)
*
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
|
EP1008355A1
(en)
|
1998-12-08 |
2000-06-14 |
Debio Recherche Pharmaceutique S.A. |
Method for identifying or analyzing polymer linkage sites on macromolecules using amino acid report binding
|
|
EP1107998B1
(en)
|
1998-08-28 |
2004-02-04 |
Gryphon Sciences |
Method for the preparation of polyamide chains of precise length, their conjugates with proteins
|
|
US6660843B1
(en)
|
1998-10-23 |
2003-12-09 |
Amgen Inc. |
Modified peptides as therapeutic agents
|
|
MEP42108A
(en)
|
1998-10-23 |
2011-02-10 |
Kiren Amgen Inc |
Dimeric thrombopoietin peptide mimetics binding to mp1 receptor and having thrombopoietic activity
|
|
JP2002529502A
(ja)
*
|
1998-11-17 |
2002-09-10 |
スミスクライン・ビーチャム・コーポレイション |
血小板減少症の治療法
|
|
CZ299516B6
(cs)
*
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
|
JO2291B1
(en)
*
|
1999-07-02 |
2005-09-12 |
اف . هوفمان لاروش ايه جي |
Erythropoietin derivatives
|
|
AUPQ873300A0
(en)
*
|
2000-07-12 |
2000-08-03 |
Medvet Science Pty. Ltd. |
A binding motif of a receptor (2)
|
|
WO2001021180A1
(en)
*
|
1999-09-24 |
2001-03-29 |
Smithkline Beecham Corporation |
Thrombopoietin mimetics
|
|
AU7445900A
(en)
*
|
1999-09-27 |
2001-04-30 |
Chugai Seiyaku Kabushiki Kaisha |
Novel hemopoietin receptor protein, nr12
|
|
US6703480B1
(en)
|
1999-11-24 |
2004-03-09 |
Palani Balu |
Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use
|
|
US6858630B2
(en)
*
|
1999-12-06 |
2005-02-22 |
Smithkline Beecham Corporation |
Naphthimidazole derivatives and their use as thrombopoietin mimetics
|
|
AU8149901A
(en)
*
|
2000-03-21 |
2001-10-03 |
Wisconsin Alummi Res Foundatio |
Methods and reagents for regulation of cellular responses in biological systems
|
|
US6777387B2
(en)
*
|
2000-03-31 |
2004-08-17 |
Enzon Pharmaceuticals, Inc. |
Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
|
|
ME00673B
(me)
*
|
2000-05-15 |
2011-12-20 |
Hoffmann La Roche |
Nova farmaceutska smjesa
|
|
CN1318084C
(zh)
|
2000-05-26 |
2007-05-30 |
奥索-麦克尼尔药品公司 |
神经保护肽
|
|
CA2417550A1
(en)
*
|
2000-08-02 |
2002-02-07 |
Ortho-Mcneil Pharmaceutical, Inc. |
Improved anti-viral and anti-tumor chemotherapy by administration of erythropoeitin
|
|
KR20030057529A
(ko)
*
|
2000-09-08 |
2003-07-04 |
그리폰 테라퓨틱스, 인코포레이티드 |
합성 적혈구생성 자극 단백질
|
|
AU2002233230B2
(en)
*
|
2000-12-20 |
2007-02-01 |
F. Hoffmann-La Roche Ag |
Erythropoietin conjugates
|
|
US6531121B2
(en)
*
|
2000-12-29 |
2003-03-11 |
The Kenneth S. Warren Institute, Inc. |
Protection and enhancement of erythropoietin-responsive cells, tissues and organs
|
|
US7767643B2
(en)
*
|
2000-12-29 |
2010-08-03 |
The Kenneth S. Warren Institute, Inc. |
Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
|
|
ATE378342T1
(de)
|
2001-02-20 |
2007-11-15 |
Enzon Inc |
Terminal verzweigte, polymere linker und diese enthaltende polymere konjugate
|
|
FR2823220B1
(fr)
*
|
2001-04-04 |
2003-12-12 |
Genodyssee |
Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
|
|
US20020169128A1
(en)
*
|
2001-04-09 |
2002-11-14 |
Geroge Sigounas |
Erythropoietin ameliorates chemotherapy-induced toxicity in vivo
|
|
CA2450985A1
(en)
|
2001-06-28 |
2003-01-09 |
Mountain View Pharmaceuticals, Inc. |
Polymer stabilized proteinases
|
|
US6784154B2
(en)
*
|
2001-11-01 |
2004-08-31 |
University Of Utah Research Foundation |
Method of use of erythropoietin to treat ischemic acute renal failure
|
|
US7087229B2
(en)
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7122189B2
(en)
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US20050176627A1
(en)
*
|
2002-09-09 |
2005-08-11 |
Anthony Cerami |
Long acting erythropoietins that maintain tissue protective activity of endogenous erythropoietin
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US8129330B2
(en)
*
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US7396913B2
(en)
*
|
2002-10-14 |
2008-07-08 |
Abbott Laboratories |
Erythropoietin receptor binding antibodies
|
|
WO2004043457A1
(en)
*
|
2002-11-06 |
2004-05-27 |
Schering Corporation |
Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
|
|
GEP20084487B
(en)
*
|
2002-12-26 |
2008-09-25 |
Mountain View Pharmaceuticals |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof
|
|
JP5207590B2
(ja)
|
2002-12-26 |
2013-06-12 |
マウンテン ビュー ファーマシューティカルズ，インコーポレイテッド |
増強された生物学的能力を有するインターフェロン−βのポリマー結合体
|
|
AU2004238868B2
(en)
|
2003-05-12 |
2010-01-21 |
Affymax, Inc. |
Peptides that bind to the erythropoietin receptor
|
|
US7919118B2
(en)
|
2003-05-12 |
2011-04-05 |
Affymax, Inc. |
Spacer moiety for poly (ethylene glycol) modified peptide based compounds
|
|
CN1820024B
(zh)
|
2003-05-12 |
2011-06-22 |
阿费麦克斯公司 |
新的聚(乙二醇)修饰的化合物及其用途
|
|
ATE428727T1
(de)
|
2003-05-12 |
2009-05-15 |
Affymax Inc |
Neue, an den erythropoietinrezeptor bindende peptide
|
|
US7550433B2
(en)
*
|
2005-06-03 |
2009-06-23 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|