JP2020508985A5 - - Google Patents

Download PDF

Info

Publication number
JP2020508985A5
JP2020508985A5 JP2019543376A JP2019543376A JP2020508985A5 JP 2020508985 A5 JP2020508985 A5 JP 2020508985A5 JP 2019543376 A JP2019543376 A JP 2019543376A JP 2019543376 A JP2019543376 A JP 2019543376A JP 2020508985 A5 JP2020508985 A5 JP 2020508985A5
Authority
JP
Japan
Prior art keywords
pharmaceutically acceptable
acceptable salt
dendrimer
formula
peg
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2019543376A
Other languages
English (en)
Japanese (ja)
Other versions
JP2020508985A (ja
JP7074761B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2018/054420 external-priority patent/WO2018154004A1/en
Publication of JP2020508985A publication Critical patent/JP2020508985A/ja
Publication of JP2020508985A5 publication Critical patent/JP2020508985A5/ja
Application granted granted Critical
Publication of JP7074761B2 publication Critical patent/JP7074761B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2019543376A 2017-02-22 2018-02-22 治療用デンドリマー Expired - Fee Related JP7074761B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762461983P 2017-02-22 2017-02-22
US62/461,983 2017-02-22
US201762488151P 2017-04-21 2017-04-21
US62/488,151 2017-04-21
US201762591823P 2017-11-29 2017-11-29
US62/591,823 2017-11-29
PCT/EP2018/054420 WO2018154004A1 (en) 2017-02-22 2018-02-22 Therapeutic dendrimers

Publications (3)

Publication Number Publication Date
JP2020508985A JP2020508985A (ja) 2020-03-26
JP2020508985A5 true JP2020508985A5 (https=) 2021-03-11
JP7074761B2 JP7074761B2 (ja) 2022-05-24

Family

ID=61386833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2019543376A Expired - Fee Related JP7074761B2 (ja) 2017-02-22 2018-02-22 治療用デンドリマー

Country Status (23)

Country Link
US (4) US10314920B2 (https=)
EP (1) EP3585441A1 (https=)
JP (1) JP7074761B2 (https=)
KR (2) KR20230093346A (https=)
CN (2) CN117582521A (https=)
AU (1) AU2018223149B2 (https=)
BR (1) BR112019016409A2 (https=)
CA (1) CA3053069A1 (https=)
CL (1) CL2019002240A1 (https=)
CO (1) CO2019009722A2 (https=)
CR (1) CR20190361A (https=)
DO (1) DOP2019000204A (https=)
EC (1) ECSP19056271A (https=)
IL (1) IL268648B (https=)
JO (1) JOP20190191B1 (https=)
MX (1) MX2019009442A (https=)
NI (1) NI201900088A (https=)
PE (1) PE20191660A1 (https=)
PH (1) PH12019501896A1 (https=)
SG (1) SG11201907334QA (https=)
TW (1) TWI773730B (https=)
UA (1) UA125655C2 (https=)
WO (1) WO2018154004A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180326081A1 (en) * 2011-06-06 2018-11-15 Starpharma Pty Ltd Macromolecules
TWI773730B (zh) * 2017-02-22 2022-08-11 瑞典商阿斯特捷利康公司 治療性樹枝狀聚合物
TWI856967B (zh) * 2018-08-17 2024-10-01 瑞典商阿斯特捷利康公司 樹枝狀體配製物
TWI831817B (zh) * 2018-08-17 2024-02-11 瑞典商阿斯特捷利康公司 治療癌症之方法
US12514853B2 (en) * 2018-11-20 2026-01-06 Starpharma Pty Ltd. Therapeutic dendrimer
US12127496B2 (en) 2019-05-07 2024-10-29 Syddansk Universitet Mechanism for dispensing biological material
US20220395525A1 (en) * 2019-09-26 2022-12-15 Starpharma Pty Ltd Therapeutic dendrimer
EP4069307A2 (en) * 2019-12-04 2022-10-12 Ashvattha Therapeutics, Inc. Dendrimer compositions and methods for drug delivery
TW202206106A (zh) * 2020-04-24 2022-02-16 大陸商上海森輝醫藥有限公司 一類載藥的大分子及其製備方法
IL297531A (en) 2020-04-24 2022-12-01 Ashvattha Therapeutics Inc Dendrimer preparations and methods for treating severe acute respiratory distress syndrome
US20230250077A1 (en) * 2020-07-10 2023-08-10 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Sulfonylbenzamide derivative and conjugate thereof, preparation method therefor and use thereof
EP4205767A4 (en) * 2020-08-25 2024-04-10 Shanghai Senhui Medicine Co., Ltd. ACTIVE INGREDIENT-LOADED MACROMOLECULE AND PRODUCTION PROCESS THEREOF
US20230263900A1 (en) * 2020-08-31 2023-08-24 Starpharma Pty Ltd. Dendrimer-drug conjugate

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289872A (en) * 1979-04-06 1981-09-15 Allied Corporation Macromolecular highly branched homogeneous compound based on lysine units
US4410688A (en) * 1981-04-29 1983-10-18 Allied Corporation Macromolecular highly branched homogeneous compound
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
UY26942A1 (es) 2000-09-20 2002-04-26 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
WO2005049593A2 (en) 2003-11-13 2005-06-02 Abbott Laboratories N-acylsulfonamide apoptosis promoters
EP1888550B1 (en) 2005-05-12 2014-06-25 AbbVie Bahamas Ltd. Apoptosis promoters
AU2006308511B2 (en) * 2005-10-25 2013-06-13 Starpharma Pty Limited Macromolecular compounds having controlled stoichiometry
CN104524596B (zh) * 2006-01-20 2018-10-09 星药股份有限公司 经修饰的大分子
DK2052011T3 (da) * 2006-08-11 2020-12-07 Starpharma Pty Ltd Målrettet polylysin-dendrimer-terapeutisk stof
WO2008017122A1 (en) * 2006-08-11 2008-02-14 Starpharma Pty Ltd Polylysine dendrimer contrast agent
EP2094672B1 (en) 2006-11-15 2013-05-29 Genentech, Inc. Arylsulfonamide compounds
US9283302B2 (en) 2011-12-16 2016-03-15 Cormatrix Cardiovascular, Inc. Extracellular matrix encasement structures and methods
WO2009036035A1 (en) 2007-09-10 2009-03-19 Curis, Inc. Bcl-2 inhibitors
WO2009158668A1 (en) 2008-06-26 2009-12-30 Prolynx Llc Prodrugs and drug-macromolecule conjugates having controlled drug release rates
US8216549B2 (en) * 2008-07-25 2012-07-10 National Health Research Institutes Method for making a ligand-quantum dot conjugate
HUE029289T2 (en) 2008-12-05 2017-02-28 Abbvie Inc Sulfonamide derivatives as Bcl-2 selective apoptosis inducers for the treatment of cancer and immune diseases
NZ595708A (en) 2009-05-26 2014-03-28 Abbvie Bahamas Ltd Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
TWI540132B (zh) 2009-06-08 2016-07-01 亞培公司 Ｂｃｌ-２族群抑制劑之口服醫藥劑型
WO2011046842A1 (en) * 2009-10-12 2011-04-21 The Regents Of The University Of California Targeted nanoclusters and methods of their use
US8703907B2 (en) 2010-05-05 2014-04-22 Prolynx Llc Controlled drug release from dendrimers
EP2566334B1 (en) 2010-05-05 2018-04-18 Prolynx, LLC Controlled drug release from solid supports
EP2566335B1 (en) 2010-05-05 2016-06-29 Prolynx Llc Controlled release of active compounds from macromolecular conjugates
TWI535712B (zh) * 2010-08-06 2016-06-01 阿斯特捷利康公司 化合物
BR112013031556B1 (pt) * 2011-06-06 2022-03-29 Starpharma Pty Ltd Macromoléculas, uso das mesmas para tratar ou suprimir o crescimento de um câncer e composições farmacêuticas
WO2015035446A1 (en) * 2013-09-10 2015-03-19 Starpharma Pty Ltd Macromolecules of dendrimer-platinum conjugates
EP3152248B1 (en) * 2014-06-06 2019-10-09 Starpharma Pty Ltd Dendrimer-drug conjugates
TWI773730B (zh) * 2017-02-22 2022-08-11 瑞典商阿斯特捷利康公司 治療性樹枝狀聚合物
TWI856967B (zh) * 2018-08-17 2024-10-01 瑞典商阿斯特捷利康公司 樹枝狀體配製物
TWI831817B (zh) * 2018-08-17 2024-02-11 瑞典商阿斯特捷利康公司 治療癌症之方法

Similar Documents

Publication Publication Date Title
JP2020508985A5 (https=)
KR100559068B1 (ko) 캄프토테신 유도체, 이의 중합체성 복합체, 이들의 제조방법 및 이들을 함유하는 약제학적 조성물
RU2014134409A (ru) Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
JP2008536807A5 (https=)
US20200297693A1 (en) Glucose conjugates of triptolide, analogs and uses thereof
CA3025931A1 (en) Antibody drug conjugates having derivatives of amatoxin as the drug
TW201004647A (en) Novel dual targeting antitumoural conjugates
KR20210034011A (ko) 치료 덴드리머
US6376617B1 (en) Bioactive derivatives of camptothecin
RU2130941C1 (ru) Трехъядерные катионные комплексы платины, проявляющие противоопухолевую активность, способ их получения и фармацевтические композиции, содержащие эти комплексы
CA2396702A1 (en) N,o-amidomalonate platinum complexes
EP2737896B1 (en) Umirolimus micelle for the treating cancer
JP7506659B2 (ja) 癌を処置する方法に用いられるコンジュゲート
WO2014084378A1 (ja) 環状ｒｇｄ配列含有ペプチドを含む抗癌剤
WO2005079396A2 (en) O,o'-amidomalonate and n,o-amidomalonate platinum complexes
JP2008504235A5 (https=)
CA3126574C (en) Cd44 targeted multi-arm conjugate
TW201004631A (en) Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof
KR102138415B1 (ko) 신규 peg 유도체
CA2542007A1 (en) Protein tyrosine kinase inhibitors
JP6803589B2 (ja) 抗腫瘍剤
HRP20100301T1 (hr) Ciklopeptidni derivati sa anti-integrinskom aktivnošću
JP2021527123A (ja) 環状ペプチド化合物およびその使用方法
EP3747909B1 (en) Anticancer agent
JP4018854B2 (ja) 抗悪性腫瘍薬