JP2008542282A5 - - Google Patents
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- Publication number
- JP2008542282A5 JP2008542282A5 JP2008513675A JP2008513675A JP2008542282A5 JP 2008542282 A5 JP2008542282 A5 JP 2008542282A5 JP 2008513675 A JP2008513675 A JP 2008513675A JP 2008513675 A JP2008513675 A JP 2008513675A JP 2008542282 A5 JP2008542282 A5 JP 2008542282A5
- Authority
- JP
- Japan
- Prior art keywords
- alanine
- free
- pharmaceutical composition
- edible
- supplement according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims 42
- 229940000635 beta-alanine Drugs 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 18
- 239000013589 supplement Substances 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 13
- 238000013268 sustained release Methods 0.000 claims 7
- 239000012730 sustained-release form Substances 0.000 claims 7
- 238000009472 formulation Methods 0.000 claims 6
- 244000269722 Thea sinensis Species 0.000 claims 4
- 235000013305 food Nutrition 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 3
- 108010087806 Carnosine Proteins 0.000 claims 2
- 240000007311 Commiphora myrrha Species 0.000 claims 2
- 235000006965 Commiphora myrrha Nutrition 0.000 claims 2
- 235000011201 Ginkgo Nutrition 0.000 claims 2
- 244000194101 Ginkgo biloba Species 0.000 claims 2
- 235000008100 Ginkgo biloba Nutrition 0.000 claims 2
- 235000007265 Myrrhis odorata Nutrition 0.000 claims 2
- 244000131316 Panax pseudoginseng Species 0.000 claims 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims 2
- 235000003140 Panax quinquefolius Nutrition 0.000 claims 2
- 235000001014 amino acid Nutrition 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000003963 antioxidant agent Substances 0.000 claims 2
- 239000008122 artificial sweetener Substances 0.000 claims 2
- 235000021311 artificial sweeteners Nutrition 0.000 claims 2
- 229940038481 bee pollen Drugs 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 235000014633 carbohydrates Nutrition 0.000 claims 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 2
- 229920002678 cellulose Polymers 0.000 claims 2
- 239000001913 cellulose Substances 0.000 claims 2
- 239000003086 colorant Substances 0.000 claims 2
- 239000000796 flavoring agent Substances 0.000 claims 2
- 235000013355 food flavoring agent Nutrition 0.000 claims 2
- 235000008434 ginseng Nutrition 0.000 claims 2
- 150000002632 lipids Chemical class 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 239000011159 matrix material Substances 0.000 claims 2
- 235000013379 molasses Nutrition 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 239000007909 solid dosage form Substances 0.000 claims 2
- 239000003381 stabilizer Substances 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 239000011573 trace mineral Substances 0.000 claims 2
- 235000013619 trace mineral Nutrition 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 claims 1
- 244000215068 Acacia senegal Species 0.000 claims 1
- 208000010444 Acidosis Diseases 0.000 claims 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 1
- 229920000178 Acrylic resin Polymers 0.000 claims 1
- 239000004925 Acrylic resin Substances 0.000 claims 1
- 229920001817 Agar Polymers 0.000 claims 1
- 244000144927 Aloe barbadensis Species 0.000 claims 1
- 235000002961 Aloe barbadensis Nutrition 0.000 claims 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- 239000001856 Ethyl cellulose Substances 0.000 claims 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- 229920002581 Glucomannan Polymers 0.000 claims 1
- 229920002907 Guar gum Polymers 0.000 claims 1
- 229920000084 Gum arabic Polymers 0.000 claims 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 108010076876 Keratins Proteins 0.000 claims 1
- 102000011782 Keratins Human genes 0.000 claims 1
- 229920001543 Laminarin Polymers 0.000 claims 1
- 229920000161 Locust bean gum Polymers 0.000 claims 1
- 206010027417 Metabolic acidosis Diseases 0.000 claims 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920002125 Sokalan® Polymers 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- 229920002494 Zein Polymers 0.000 claims 1
- 235000010489 acacia gum Nutrition 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- 235000011399 aloe vera Nutrition 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 1
- 229940096529 carboxypolymethylene Drugs 0.000 claims 1
- 235000010418 carrageenan Nutrition 0.000 claims 1
- 239000000679 carrageenan Substances 0.000 claims 1
- 229920001525 carrageenan Polymers 0.000 claims 1
- 229940113118 carrageenan Drugs 0.000 claims 1
- 229920003086 cellulose ether Polymers 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940045110 chitosan Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 239000007933 dermal patch Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 150000002170 ethers Chemical class 0.000 claims 1
- 235000019325 ethyl cellulose Nutrition 0.000 claims 1
- 229920001249 ethyl cellulose Polymers 0.000 claims 1
- 239000000835 fiber Substances 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 229940046240 glucomannan Drugs 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000000665 guar gum Substances 0.000 claims 1
- 235000010417 guar gum Nutrition 0.000 claims 1
- 229960002154 guar gum Drugs 0.000 claims 1
- 235000012907 honey Nutrition 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- DBTMGCOVALSLOR-VPNXCSTESA-N laminarin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1O[C@@H]1[C@@H](O)C(O[C@H]2[C@@H]([C@@H](CO)OC(O)[C@@H]2O)O)O[C@H](CO)[C@H]1O DBTMGCOVALSLOR-VPNXCSTESA-N 0.000 claims 1
- 235000010420 locust bean gum Nutrition 0.000 claims 1
- 239000000711 locust bean gum Substances 0.000 claims 1
- 239000006210 lotion Substances 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 229920000609 methyl cellulose Polymers 0.000 claims 1
- 239000001923 methylcellulose Substances 0.000 claims 1
- 235000010981 methylcellulose Nutrition 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 229920001277 pectin Polymers 0.000 claims 1
- 239000001814 pectin Substances 0.000 claims 1
- 235000010987 pectin Nutrition 0.000 claims 1
- 229960000292 pectin Drugs 0.000 claims 1
- 239000006187 pill Substances 0.000 claims 1
- 229920002401 polyacrylamide Polymers 0.000 claims 1
- 239000004584 polyacrylic acid Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 229920006316 polyvinylpyrrolidine Polymers 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 229920001285 xanthan gum Polymers 0.000 claims 1
- 239000000230 xanthan gum Substances 0.000 claims 1
- 235000010493 xanthan gum Nutrition 0.000 claims 1
- 229940082509 xanthan gum Drugs 0.000 claims 1
- 239000005019 zein Substances 0.000 claims 1
- 229940093612 zein Drugs 0.000 claims 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68398505P | 2005-05-23 | 2005-05-23 | |
| US60/683,985 | 2005-05-23 | ||
| PCT/US2006/020104 WO2007073398A2 (en) | 2005-05-23 | 2006-05-23 | Compositions and methods for the sustained release of beta-alanine |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013127444A Division JP2013224310A (ja) | 2005-05-23 | 2013-06-18 | β−アラニンの徐放のための組成物及び方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542282A JP2008542282A (ja) | 2008-11-27 |
| JP2008542282A5 true JP2008542282A5 (enExample) | 2009-05-28 |
| JP5336180B2 JP5336180B2 (ja) | 2013-11-06 |
Family
ID=38189110
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513675A Expired - Lifetime JP5336180B2 (ja) | 2005-05-23 | 2006-05-23 | β−アラニンの徐放のための組成物及び方法 |
| JP2013127444A Pending JP2013224310A (ja) | 2005-05-23 | 2013-06-18 | β−アラニンの徐放のための組成物及び方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013127444A Pending JP2013224310A (ja) | 2005-05-23 | 2013-06-18 | β−アラニンの徐放のための組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US8329207B2 (enExample) |
| EP (2) | EP1883406B1 (enExample) |
| JP (2) | JP5336180B2 (enExample) |
| KR (2) | KR101190791B1 (enExample) |
| CN (2) | CN101309688B (enExample) |
| CA (1) | CA2621365C (enExample) |
| DK (2) | DK3081215T3 (enExample) |
| WO (1) | WO2007073398A2 (enExample) |
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| CA2621365C (en) | 2005-05-23 | 2012-09-04 | Natural Alternatives International | Compositions and methods for the sustained release of beta-alanine |
| US7956218B2 (en) * | 2007-12-12 | 2011-06-07 | Northern Innovations And Formulations Corp. | Organic salts of β-alanine |
| AU2007362357A1 (en) * | 2007-12-12 | 2009-06-18 | Northern Innovations And Formulations Corp. | Organic salts of beta-alanine |
| JP5519945B2 (ja) * | 2009-03-10 | 2014-06-11 | 株式会社ファンケル | 抗不安剤 |
| US20120010291A1 (en) * | 2009-08-12 | 2012-01-12 | Kneller Bruce W | CREATINE Beta-ALANINATE: A NOVEL SALT FOR INCREASING ATHLETIC PERFORMANCE |
| US9414615B2 (en) * | 2010-01-18 | 2016-08-16 | PepciCo, Inc. | Gel-based compositions and methods of making same |
| TW201201713A (en) * | 2010-04-05 | 2012-01-16 | Abbott Lab | Shelf stable nutritional liquids comprising beta alanine |
| TW201320908A (zh) * | 2011-10-13 | 2013-06-01 | Abbott Lab | 包含β－丙胺酸之營養產品 |
| CN104023557A (zh) * | 2012-01-03 | 2014-09-03 | 雀巢产品技术援助有限公司 | 用于食物基质中反应性氨基酸的稳定性的组合物和方法 |
| US8496979B1 (en) * | 2012-02-02 | 2013-07-30 | Reliv International, Inc. | Caffeine-free dietary supplements for increasing energy and methods of administering the same |
| EP2666365A1 (en) * | 2012-05-22 | 2013-11-27 | Taminco | Treatment of poultry, pigs or fish for reducing the feed conversion ratio. |
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| WO2017053171A1 (en) * | 2015-09-25 | 2017-03-30 | Natural Alternatives International, Inc. | Methods of improving physiological conditions related to pregnancy and development of offspring through dietary supplementation |
| CN105663081B (zh) * | 2015-12-30 | 2019-08-02 | 大连医诺生物股份有限公司 | 微囊化β-丙氨酸 |
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| WO2018226987A1 (en) * | 2017-06-07 | 2018-12-13 | The Regents Of The University Of California | Compositions for treating fungal and bacterial biofilms and methods of using the same |
| WO2020117755A1 (en) | 2018-12-03 | 2020-06-11 | The Regents Of The University Of California | Compositions and methods for treating biofilms |
| CN114302718A (zh) * | 2019-06-28 | 2022-04-08 | 有机合成药品工业株式会社 | 线粒体功能活化剂 |
| JP6749665B1 (ja) * | 2019-07-18 | 2020-09-02 | 株式会社東洋新薬 | 経口組成物 |
| WO2021041662A1 (en) * | 2019-08-29 | 2021-03-04 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Peripheral nerve agonists suppress inflammation |
| WO2021236440A1 (en) | 2020-05-20 | 2021-11-25 | Advanced Food Concepts, Inc. | Athletic performance enhancement composition using menthol |
| CN111956780A (zh) * | 2020-08-28 | 2020-11-20 | 黑龙江现代物联网科技有限公司 | 一种用鹅肌肽制成降低人体尿酸的饮用水及其制备方法 |
| CN113812635B (zh) * | 2021-09-22 | 2023-12-19 | 大连医诺生物股份有限公司 | 微囊化β-丙氨酸、其制备方法及应用 |
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2006
- 2006-05-23 CA CA2621365A patent/CA2621365C/en not_active Expired - Lifetime
- 2006-05-23 CN CN200680026773.0A patent/CN101309688B/zh not_active Expired - Lifetime
- 2006-05-23 DK DK16159734.9T patent/DK3081215T3/da active
- 2006-05-23 DK DK06848675.2T patent/DK1883406T3/en active
- 2006-05-23 EP EP06848675.2A patent/EP1883406B1/en not_active Expired - Lifetime
- 2006-05-23 KR KR1020077030038A patent/KR101190791B1/ko not_active Expired - Lifetime
- 2006-05-23 JP JP2008513675A patent/JP5336180B2/ja not_active Expired - Lifetime
- 2006-05-23 KR KR1020127017805A patent/KR101275660B1/ko not_active Expired - Lifetime
- 2006-05-23 US US12/064,005 patent/US8329207B2/en active Active
- 2006-05-23 WO PCT/US2006/020104 patent/WO2007073398A2/en not_active Ceased
- 2006-05-23 EP EP16159734.9A patent/EP3081215B9/en not_active Expired - Lifetime
- 2006-05-23 CN CN201610347735.0A patent/CN106038473A/zh active Pending
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2012
- 2012-10-05 US US13/646,184 patent/US8394402B2/en not_active Expired - Lifetime
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2013
- 2013-01-31 US US13/755,954 patent/US8496958B2/en not_active Expired - Lifetime
- 2013-06-18 JP JP2013127444A patent/JP2013224310A/ja active Pending
- 2013-06-27 US US13/929,251 patent/US8980307B2/en not_active Expired - Lifetime
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2015
- 2015-02-19 US US14/626,739 patent/US9636315B2/en not_active Expired - Lifetime
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2016
- 2016-08-18 US US15/240,460 patent/US9907769B2/en not_active Expired - Fee Related
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2018
- 2018-02-02 US US15/886,964 patent/US10828274B2/en not_active Expired - Lifetime
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2020
- 2020-10-06 US US17/064,506 patent/US12036196B2/en not_active Expired - Lifetime
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