JP2008539235A5 - - Google Patents
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- JP2008539235A5 JP2008539235A5 JP2008508931A JP2008508931A JP2008539235A5 JP 2008539235 A5 JP2008539235 A5 JP 2008539235A5 JP 2008508931 A JP2008508931 A JP 2008508931A JP 2008508931 A JP2008508931 A JP 2008508931A JP 2008539235 A5 JP2008539235 A5 JP 2008539235A5
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- JP
- Japan
- Prior art keywords
- peptide
- protecting group
- group
- amino acid
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000765 processed proteins & peptides Proteins 0.000 claims 20
- -1 4-methyltrityl Chemical group 0.000 claims 15
- 125000006239 protecting group Chemical group 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 5
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 239000000556 agonist Substances 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- WTKQMHWYSBWUBE-UHFFFAOYSA-N (3-nitropyridin-2-yl) thiohypochlorite Chemical group [O-][N+](=O)C1=CC=CN=C1SCl WTKQMHWYSBWUBE-UHFFFAOYSA-N 0.000 claims 2
- 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 208000010353 central nervous system vasculitis Diseases 0.000 claims 2
- 125000002933 cyclohexyloxy group Chemical group C1(CCCCC1)O* 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
- WSNDAYQNZRJGMJ-UHFFFAOYSA-N 2,2,2-trifluoroethanone Chemical compound FC(F)(F)[C]=O WSNDAYQNZRJGMJ-UHFFFAOYSA-N 0.000 claims 1
- 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims 1
- CBEFMGJHEKAMNI-UHFFFAOYSA-N 9-oxofluorene-1-carboxylic acid Chemical group C12=CC=CC=C2C(=O)C2=C1C=CC=C2C(=O)O CBEFMGJHEKAMNI-UHFFFAOYSA-N 0.000 claims 1
- HTPXFGUCAUTOEL-UHFFFAOYSA-N 9h-fluorene-1-carboxylic acid Chemical compound C1C2=CC=CC=C2C2=C1C(C(=O)O)=CC=C2 HTPXFGUCAUTOEL-UHFFFAOYSA-N 0.000 claims 1
- DNVJGJUGFFYUPT-UHFFFAOYSA-N 9h-fluorene-9-carboxylic acid Chemical group C1=CC=C2C(C(=O)O)C3=CC=CC=C3C2=C1 DNVJGJUGFFYUPT-UHFFFAOYSA-N 0.000 claims 1
- 101150092476 ABCA1 gene Proteins 0.000 claims 1
- 102000055510 ATP Binding Cassette Transporter 1 Human genes 0.000 claims 1
- 108700005241 ATP Binding Cassette Transporter 1 Proteins 0.000 claims 1
- 208000036487 Arthropathies Diseases 0.000 claims 1
- 206010006895 Cachexia Diseases 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 206010009900 Colitis ulcerative Diseases 0.000 claims 1
- 208000032170 Congenital Abnormalities Diseases 0.000 claims 1
- 208000011231 Crohn disease Diseases 0.000 claims 1
- 206010061619 Deformity Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010014561 Emphysema Diseases 0.000 claims 1
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 1
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
- 206010072579 Granulomatosis with polyangiitis Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000012659 Joint disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 208000027868 Paget disease Diseases 0.000 claims 1
- 208000018737 Parkinson disease Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 206010039085 Rhinitis allergic Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 1
- 206010064996 Ulcerative keratitis Diseases 0.000 claims 1
- 201000010105 allergic rhinitis Diseases 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003354 cholesterol ester transfer protein inhibitor Substances 0.000 claims 1
- 229940125881 cholesteryl ester transfer protein inhibitor Drugs 0.000 claims 1
- 201000007717 corneal ulcer Diseases 0.000 claims 1
- 229940090124 dipeptidyl peptidase 4 (dpp-4) inhibitors for blood glucose lowering Drugs 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229960005167 everolimus Drugs 0.000 claims 1
- 229940121360 farnesoid X receptor (fxr) agonists Drugs 0.000 claims 1
- 229960000556 fingolimod Drugs 0.000 claims 1
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims 1
- 201000001881 impotence Diseases 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000000302 ischemic effect Effects 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 208000027202 mammary Paget disease Diseases 0.000 claims 1
- 230000000116 mitigating effect Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67643105P | 2005-04-29 | 2005-04-29 | |
| US69749505P | 2005-07-07 | 2005-07-07 | |
| PCT/US2006/014839 WO2006118805A2 (en) | 2005-04-29 | 2006-04-18 | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008539235A JP2008539235A (ja) | 2008-11-13 |
| JP2008539235A5 true JP2008539235A5 (https=) | 2009-06-04 |
Family
ID=37308461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008508931A Pending JP2008539235A (ja) | 2005-04-29 | 2006-04-18 | 炎症反応によって特徴付けられる病状を処置するためのペプチドおよびペプチド模倣物 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20100227825A1 (https=) |
| EP (3) | EP1890715A4 (https=) |
| JP (1) | JP2008539235A (https=) |
| KR (1) | KR20080007491A (https=) |
| AU (1) | AU2006242651B2 (https=) |
| BR (1) | BRPI0610983A2 (https=) |
| CA (1) | CA2607483A1 (https=) |
| EA (2) | EA012440B1 (https=) |
| EC (1) | ECSP077829A (https=) |
| IL (1) | IL186959A0 (https=) |
| MA (1) | MA29488B1 (https=) |
| MX (1) | MX2007013430A (https=) |
| NO (1) | NO20076022L (https=) |
| NZ (2) | NZ563187A (https=) |
| SG (1) | SG173373A1 (https=) |
| TN (1) | TNSN07396A1 (https=) |
| WO (1) | WO2006118805A2 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7199102B2 (en) | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| WO2012047930A2 (en) | 2010-10-04 | 2012-04-12 | The Regents Of The University Of California | Compositions and methods for treatment of gynecologic cancers |
| KR20070089996A (ko) | 2004-12-06 | 2007-09-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 세동맥의 구조 및 기능의 개선 방법 |
| AU2007284801A1 (en) | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
| EP2977452A3 (en) * | 2007-05-11 | 2016-05-25 | Thomas Jefferson University | Methods of treatment and prevention of neurodegenerative diseases and disorders |
| AU2014200542B2 (en) * | 2007-05-11 | 2016-08-25 | Rowan University | Methods of treatment and prevention of neurodegenerative diseases and disorders |
| EP2195331B1 (en) * | 2007-08-28 | 2013-11-20 | Uab Research Foundation | Synthetic apolipoprotein e mimicking polypeptides and methods of use |
| US7985728B1 (en) | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
| US9173890B2 (en) | 2007-09-20 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
| US7985727B1 (en) * | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Apo A-I mimetic peptides and methods of treatment |
| WO2009093246A2 (en) * | 2008-01-22 | 2009-07-30 | Compugen Ltd. | Novel clusterin derived peptide |
| WO2010020822A1 (en) * | 2008-08-19 | 2010-02-25 | University Of Patras | Therapy for apolipoprotein-induced hypertriglyceridemia |
| WO2010049103A1 (en) * | 2008-10-31 | 2010-05-06 | Eth Zurich | Soluble truncated apom proteins and medical uses thereof |
| US20120270771A1 (en) * | 2009-09-30 | 2012-10-25 | Snu R&Db Foundation | Apolipoprotein a-1 mimic peptides, and therapeutic agent for treating hyperlipidemia and diseases related to hyperlipidemia comprising same |
| US9241976B2 (en) | 2011-08-29 | 2016-01-26 | The Regents Of The University Of California | Use of HDL-related molecules to treat and prevent proinflammatory conditions |
| US9539300B2 (en) | 2012-03-31 | 2017-01-10 | The Regents Of The University Of California | Modulating disease through genetic engineering of plants |
| KR102017026B1 (ko) * | 2013-01-10 | 2019-09-02 | (주) 수파드엘릭사 | 염증 또는 알러지의 예방 또는 치료용 약학 조성물 및 염증 또는 알러지 개선용 화장료 조성물 |
| WO2016018665A1 (en) | 2014-07-31 | 2016-02-04 | Uab Research Foundation | Apoe mimetic peptides and higher potency to clear plasma cholesterol |
| CN115919996A (zh) * | 2015-05-01 | 2023-04-07 | 雅利斯塔制药公司 | 用于治疗眼科疾病的脂联素拟肽 |
| AU2016260190A1 (en) * | 2015-05-12 | 2017-11-23 | The Regents Of The University Of California | Peptide treatment for inflammation and fibrosis |
| DK3395354T3 (da) | 2015-12-18 | 2024-06-03 | Talengen Int Ltd | Plasminogen til anvendelse i behandling af diabetisk nefropati |
| WO2018063796A1 (en) | 2016-09-28 | 2018-04-05 | The Regents Of The University Of California | Ezetimibe-associated apoa-1 mimetic peptides showing enhanced synergism |
| US10426817B2 (en) | 2017-01-24 | 2019-10-01 | Macregen, Inc. | Treatment of age-related macular degeneration and other eye diseases with apolipoprotein mimetics |
| CA3075471C (en) * | 2017-09-15 | 2024-02-20 | Kine Sciences Co., Ltd. | Use of peptides as therapeutic agent for autoimmune diseases and bone diseases |
| GB2576705A (en) * | 2018-08-17 | 2020-03-04 | E Miller Norman | Improvements in or relating to organic material |
| SG11202111311WA (en) | 2019-06-14 | 2021-12-30 | Zealand Pharma As | Pharmaceutical parenteral composition of dual glp1/2 agonist |
| CN111796098B (zh) * | 2020-05-29 | 2021-06-01 | 中国科学院武汉病毒研究所 | 诊断新冠肺炎由重症转危重症的血浆蛋白标志物、检测试剂或检测工具 |
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-
2006
- 2006-04-18 MX MX2007013430A patent/MX2007013430A/es active IP Right Grant
- 2006-04-18 EA EA200702392A patent/EA012440B1/ru not_active IP Right Cessation
- 2006-04-18 WO PCT/US2006/014839 patent/WO2006118805A2/en not_active Ceased
- 2006-04-18 KR KR1020077027948A patent/KR20080007491A/ko not_active Ceased
- 2006-04-18 EP EP06750791A patent/EP1890715A4/en not_active Withdrawn
- 2006-04-18 SG SG2011051224A patent/SG173373A1/en unknown
- 2006-04-18 NZ NZ563187A patent/NZ563187A/en not_active IP Right Cessation
- 2006-04-18 EP EP11155927.4A patent/EP2368561B1/en not_active Expired - Lifetime
- 2006-04-18 AU AU2006242651A patent/AU2006242651B2/en not_active Ceased
- 2006-04-18 EP EP10177858A patent/EP2269623A1/en not_active Withdrawn
- 2006-04-18 BR BRPI0610983-7A patent/BRPI0610983A2/pt not_active Application Discontinuation
- 2006-04-18 EA EA200900786A patent/EA200900786A1/ru unknown
- 2006-04-18 JP JP2008508931A patent/JP2008539235A/ja active Pending
- 2006-04-18 NZ NZ580954A patent/NZ580954A/en not_active IP Right Cessation
- 2006-04-18 CA CA002607483A patent/CA2607483A1/en not_active Abandoned
-
2007
- 2007-10-24 TN TNP2007000396A patent/TNSN07396A1/en unknown
- 2007-10-26 EC EC2007007829A patent/ECSP077829A/es unknown
- 2007-10-28 IL IL186959A patent/IL186959A0/en unknown
- 2007-11-22 NO NO20076022A patent/NO20076022L/no not_active Application Discontinuation
- 2007-11-27 MA MA30425A patent/MA29488B1/fr unknown
-
2010
- 2010-03-10 US US12/721,366 patent/US20100227825A1/en not_active Abandoned
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