JP2011523662A5 - - Google Patents
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- JP2011523662A5 JP2011523662A5 JP2011512657A JP2011512657A JP2011523662A5 JP 2011523662 A5 JP2011523662 A5 JP 2011523662A5 JP 2011512657 A JP2011512657 A JP 2011512657A JP 2011512657 A JP2011512657 A JP 2011512657A JP 2011523662 A5 JP2011523662 A5 JP 2011523662A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cgmp
- seq
- group
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5888808P | 2008-06-04 | 2008-06-04 | |
| US61/058,888 | 2008-06-04 | ||
| PCT/US2009/046287 WO2009149278A1 (en) | 2008-06-04 | 2009-06-04 | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011523662A JP2011523662A (ja) | 2011-08-18 |
| JP2011523662A5 true JP2011523662A5 (https=) | 2013-05-02 |
Family
ID=41026379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011512657A Pending JP2011523662A (ja) | 2008-06-04 | 2009-06-04 | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8207295B2 (https=) |
| EP (1) | EP2296685B1 (https=) |
| JP (1) | JP2011523662A (https=) |
| AU (1) | AU2009256156B2 (https=) |
| CA (1) | CA2726913C (https=) |
| ES (1) | ES2559840T3 (https=) |
| WO (1) | WO2009149278A1 (https=) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103641892B (zh) | 2001-03-29 | 2015-06-17 | 药物协和公司 | 用于治疗组织炎症和癌变的鸟苷酸环化酶受体激动剂 |
| EP2527360B1 (en) | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| US8969514B2 (en) * | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| EP2296685B1 (en) | 2008-06-04 | 2015-09-02 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CA2994066A1 (en) * | 2008-12-03 | 2010-06-10 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
| WO2010141349A1 (en) | 2009-05-30 | 2010-12-09 | University Of Toledo | Soluble guanylyl cyclase a1 and a-8r peptide as diagnostic markers of and therapeutic targets for prostate cancer |
| US9301991B2 (en) | 2009-05-30 | 2016-04-05 | The University Of Toledo | sGCalphal inhibiting compositions |
| MY173390A (en) | 2009-10-23 | 2020-01-22 | Takeda Pharmaceuticals Co | Anti-gcc antibody molecules and related compositions and methods |
| AT509267A1 (de) * | 2010-01-14 | 2011-07-15 | Apeptico Forschung & Entwicklung Gmbh | Organische verbindungen zur regulierung von vektoriellen ionenkanälen |
| SI2531187T1 (sl) * | 2010-02-05 | 2016-01-29 | Adverio Pharma Gmbh | Stimulatorji sGC ali aktivatorji sGC sami in v kombinaciji z inhibitorji PDE5 za zdravljenje cistične fibroze |
| EP2621509A4 (en) | 2010-09-15 | 2016-08-03 | Synergy Pharmaceuticals Inc | FORMULATIONS OF GUANYLATE CYCLASE C AGONISTS AND METHOD OF USE |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| ES2664873T3 (es) | 2011-03-01 | 2018-04-23 | Synergy Pharmaceuticals Inc. | Proceso de preparación de agonistas de guanilato ciclasa C |
| ME03560B (me) | 2012-04-27 | 2020-07-20 | Millennium Pharm Inc | MOLEKULI ANTI-GCC ANTITELA l NJIHOVA UPOTREBA U ISPITIVANJU OSETLJIVOSTI NA GCC-CILJANU TERAPIJU |
| US9545446B2 (en) | 2013-02-25 | 2017-01-17 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| SI3004138T1 (sl) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Limited | Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo |
| EP3024455A1 (en) | 2013-07-25 | 2016-06-01 | Bayer Pharma Aktiengesellschaft | Sgc stimulators or sgc activators and pde5 inhibitors in combination with additional treatment for the therapy of cystic fibrosis |
| KR102456567B1 (ko) * | 2013-08-09 | 2022-10-19 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
| CN106061494A (zh) * | 2013-10-10 | 2016-10-26 | 辛纳吉制药公司 | 可用于治疗阿片样物质诱导的功能障碍的鸟苷酸环化酶的激动剂 |
| WO2015066285A2 (en) * | 2013-11-01 | 2015-05-07 | The University Of Toledo | sGCα1 INHIBITING COMPOSITIONS, AND METHODS OF TREATMENT OF CANCERS THEREWITH |
| WO2017123634A1 (en) | 2016-01-11 | 2017-07-20 | Synergy Pharmaceuticals, Inc. | Formulations and methods for treating ulcerative colitis |
| US20210393621A1 (en) | 2018-10-26 | 2021-12-23 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| WO2020237096A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Combination for lowering serum phosphate in a patient |
| EA202193345A1 (ru) | 2019-06-12 | 2022-03-16 | Новартис Аг | Антитела к рецептору-1 натрийуретического пептида и способы их применения |
| US12569481B2 (en) | 2020-06-12 | 2026-03-10 | Vanderbilt University | Methods of treatment for gastrointestinal motility disorders |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5969097A (en) | 1992-06-23 | 1999-10-19 | G. D. Searle & Co. | Human guanylin |
| ATE163230T1 (de) | 1993-03-09 | 1998-02-15 | Epic Therapeutics Inc | Makromolekulare mikropartikel und verfahren zu ihrer herstellung |
| US5518888A (en) | 1993-10-26 | 1996-05-21 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
| US5879656A (en) | 1993-10-26 | 1999-03-09 | Thomas Jefferson University | Methods of treating metastatic colorectal cancer with ST receptor binding compounds |
| EP0734264B1 (en) | 1993-10-26 | 2004-02-18 | Thomas Jefferson University | Compositions that specifically bind to colorectal cancer cells and methods of using the same |
| US5601990A (en) | 1994-09-13 | 1997-02-11 | Thomas Jefferson University | Methods of diagnosing colorectal tumors and metastasis thereof |
| US5489670A (en) | 1993-10-29 | 1996-02-06 | G. D. Searle & Co. | Human uroguanylin |
| US6180604B1 (en) * | 1996-08-21 | 2001-01-30 | Micrologix Biotech Inc. | Compositions and methods for treating infections using analogues of indolicidin |
| US6203513B1 (en) | 1997-11-20 | 2001-03-20 | Optonol Ltd. | Flow regulating implant, method of manufacture, and delivery device |
| US6235782B1 (en) | 1998-11-12 | 2001-05-22 | Rifat Pamukcu | Method for treating a patient with neoplasia by treatment with a platinum coordination complex |
| DE19903087A1 (de) | 1999-01-27 | 2000-08-10 | Forssmann Wolf Georg | Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern |
| AU7700400A (en) | 1999-10-06 | 2001-05-10 | Pharmacia Corporation | Uroguanylin as an intestinal cancer inhibiting agent |
| JP4088412B2 (ja) | 2000-12-26 | 2008-05-21 | トヨタ自動車株式会社 | 内燃機関の空燃比制御装置 |
| CA2435835A1 (en) | 2001-02-02 | 2002-08-15 | Pharmacia Corporation | Uroguanylin and cyclooxygenase-2 inhibitor combinations for inhibition of intestinal cancer |
| EP1367968A4 (en) | 2001-03-16 | 2006-12-13 | Glaukos Corp | APPLICATOR AND METHOD FOR SETTING A TRABECULAR SHUNT FOR GLUCKOM TREATMENT |
| CN103641892B (zh) | 2001-03-29 | 2015-06-17 | 药物协和公司 | 用于治疗组织炎症和癌变的鸟苷酸环化酶受体激动剂 |
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| WO2002098912A2 (de) | 2001-06-05 | 2002-12-12 | Yalcin Cetin | Luftseitig verabreichte guanylat cyclase c liganden für atemwegserkrankungen |
| US6991726B2 (en) | 2002-07-01 | 2006-01-31 | Usfilter Corporation | Filter having a media retaining plate |
| AU2003256657A1 (en) | 2002-07-19 | 2004-02-09 | Yale University | Uveoscleral drainage device |
| SG168407A1 (en) | 2003-01-28 | 2011-02-28 | Ironwood Pharmaceuticals Inc | Methods and compositions for the treatment of gastrointestinal disorders |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7073363B2 (en) | 2003-05-20 | 2006-07-11 | Schumag Ag | Method for processing drawn material and drawn material production installation |
| US7494979B2 (en) | 2003-06-13 | 2009-02-24 | Ironwood Pharmaceuticals, Inc. | Method for treating congestive heart failure and other disorders |
| PL1644021T3 (pl) * | 2003-06-13 | 2013-01-31 | Ironwood Pharmaceuticals Inc | Sposoby i kompozycje do leczenia zaburzeń żołądkowo-jelitowych |
| EP1675555A4 (en) * | 2003-09-30 | 2011-03-09 | Shire Llc | PHARMACEUTICAL COMPOSITIONS FOR PREVENTING EXCESSIVE DOSE OR ABUSE |
| US7291125B2 (en) | 2003-11-14 | 2007-11-06 | Transcend Medical, Inc. | Ocular pressure regulation |
| TWI649790B (zh) | 2004-11-18 | 2019-02-01 | Nikon Corporation | 位置測量方法、位置控制方法、測量方法、裝載方法、曝光方法及曝光裝置、及元件製造方法 |
| DE102004062773A1 (de) | 2004-12-21 | 2006-06-22 | Röhm GmbH & Co. KG | Beschichtungsmittel zur Herstellung von umformbaren Kratzfestbeschichtungen mit schmutzabweisender Wirkung, kratzfeste umformbare schmutzabweisende Formkörper sowie Verfahren zu deren Herstellung |
| EP1940441A4 (en) | 2005-08-19 | 2010-01-27 | Ironwood Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR TREATING GASTROINTESTINAL DISORDERS |
| US20070101158A1 (en) | 2005-10-28 | 2007-05-03 | Elliott Robert C | Security region in a non-volatile memory |
| US20090192083A1 (en) * | 2006-02-24 | 2009-07-30 | Currie Mark G | Methods and compositions for the treatment of gastrointestinal disorders |
| US7692307B2 (en) | 2006-12-08 | 2010-04-06 | Intel Corporation | Compliant structure for an electronic device, method of manufacturing same, and system containing same |
| US8779090B2 (en) | 2007-02-26 | 2014-07-15 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of heart failure and other disorders |
| RU2009144972A (ru) * | 2007-05-04 | 2011-06-10 | Айронвуд Фармасьютикалз, Инк. (Us) | Композиции и способы лечения нарушений, ассоциированных с задержкой соли или жидкости |
| EP2527360B1 (en) * | 2007-06-04 | 2015-10-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2296685B1 (en) | 2008-06-04 | 2015-09-02 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2810951B1 (en) | 2008-06-04 | 2017-03-15 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP3241839B1 (en) | 2008-07-16 | 2019-09-04 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders |
| CA2994066A1 (en) | 2008-12-03 | 2010-06-10 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase c agonists and methods of use |
-
2009
- 2009-06-04 EP EP09759437.8A patent/EP2296685B1/en active Active
- 2009-06-04 AU AU2009256156A patent/AU2009256156B2/en active Active
- 2009-06-04 CA CA2726913A patent/CA2726913C/en active Active
- 2009-06-04 US US12/478,505 patent/US8207295B2/en active Active
- 2009-06-04 ES ES09759437.8T patent/ES2559840T3/es active Active
- 2009-06-04 JP JP2011512657A patent/JP2011523662A/ja active Pending
- 2009-06-04 WO PCT/US2009/046287 patent/WO2009149278A1/en not_active Ceased
-
2012
- 2012-05-09 US US13/467,703 patent/US8357775B2/en active Active
- 2012-12-17 US US13/716,874 patent/US8497348B2/en active Active
-
2013
- 2013-06-27 US US13/928,830 patent/US20130274204A1/en not_active Abandoned
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