JP2008506709A5 - - Google Patents

Info

Publication number

JP2008506709A5

JP2008506709A5 JP2007521684A JP2007521684A JP2008506709A5 JP 2008506709 A5 JP2008506709 A5 JP 2008506709A5 JP 2007521684 A JP2007521684 A JP 2007521684A JP 2007521684 A JP2007521684 A JP 2007521684A JP 2008506709 A5 JP2008506709 A5 JP 2008506709A5

Authority

JP

Japan

Prior art keywords

group

peptidomimetic

seq

compound

sequence

Prior art date

2005-07-15

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• -1 t-butoxycarbonyl group Chemical group 0.000 claims 16
• 239000000816 peptidomimetic Substances 0.000 claims 15
• 150000001875 compounds Chemical class 0.000 claims 7
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 6
• 108090000765 processed proteins & peptides Proteins 0.000 claims 6
• 241000124008 Mammalia Species 0.000 claims 4
• 150000002632 lipids Chemical class 0.000 claims 4
• 125000006239 protecting group Chemical group 0.000 claims 4
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
• 239000008280 blood Substances 0.000 claims 3
• 210000004369 blood Anatomy 0.000 claims 3
• 239000003937 drug carrier Substances 0.000 claims 3
• 239000008194 pharmaceutical composition Substances 0.000 claims 3
• 201000001320 Atherosclerosis Diseases 0.000 claims 2
• 150000008574 D-amino acids Chemical group 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 claims 1
• 125000004217 4-methoxybenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1OC([H])([H])[H])C([H])([H])* 0.000 claims 1
• 125000006181 4-methyl benzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])C([H])([H])* 0.000 claims 1
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
• 239000013543 active substance Substances 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 125000003368 amide group Chemical group 0.000 claims 1
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
• 239000002220 antihypertensive agent Substances 0.000 claims 1
• 229940127088 antihypertensive drug Drugs 0.000 claims 1
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
• 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
• 239000002327 cardiovascular agent Substances 0.000 claims 1
• 229940125692 cardiovascular agent Drugs 0.000 claims 1
• 239000003405 delayed action preparation Substances 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 229940079593 drug Drugs 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 claims 1
• 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1
• 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims 1