CA2574007A1 - Apolipoprotein a1 mimetics and uses thereof - Google Patents
Apolipoprotein a1 mimetics and uses thereof Download PDFInfo
- Publication number
- CA2574007A1 CA2574007A1 CA002574007A CA2574007A CA2574007A1 CA 2574007 A1 CA2574007 A1 CA 2574007A1 CA 002574007 A CA002574007 A CA 002574007A CA 2574007 A CA2574007 A CA 2574007A CA 2574007 A1 CA2574007 A1 CA 2574007A1
- Authority
- CA
- Canada
- Prior art keywords
- peptidomimetic
- composition
- cholesterol
- subject
- active agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 239000004474 valine Substances 0.000 description 1
- 230000000304 vasodilatating effect Effects 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/775—Apolipopeptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Marine Sciences & Fisheries (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58872204P | 2004-07-16 | 2004-07-16 | |
| US60/588722 | 2004-07-16 | ||
| PCT/US2005/025182 WO2006020040A2 (en) | 2004-07-16 | 2005-07-15 | Apolipoprotein a1 mimetics and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2574007A1 true CA2574007A1 (en) | 2006-02-23 |
Family
ID=35907926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002574007A Abandoned CA2574007A1 (en) | 2004-07-16 | 2005-07-15 | Apolipoprotein a1 mimetics and uses thereof |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US7569546B2 (https=) |
| EP (1) | EP1771473B1 (https=) |
| JP (1) | JP5048486B2 (https=) |
| KR (1) | KR101185609B1 (https=) |
| CN (1) | CN101076541A (https=) |
| AU (1) | AU2005275009B2 (https=) |
| BR (1) | BRPI0513402A (https=) |
| CA (1) | CA2574007A1 (https=) |
| IL (1) | IL180733A (https=) |
| NO (1) | NO20070876L (https=) |
| TW (1) | TWI377066B (https=) |
| WO (1) | WO2006020040A2 (https=) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8568766B2 (en) | 2000-08-24 | 2013-10-29 | Gattadahalli M. Anantharamaiah | Peptides and peptide mimetics to treat pathologies associated with eye disease |
| US7723303B2 (en) * | 2000-08-24 | 2010-05-25 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| US7148197B2 (en) * | 2000-08-24 | 2006-12-12 | The Regents Of The University Of California | Orally administered small peptides synergize statin activity |
| US7199102B2 (en) | 2000-08-24 | 2007-04-03 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
| KR101185609B1 (ko) * | 2004-07-16 | 2012-09-24 | 트러스티즈 오브 터프츠 칼리지 | 아포리포단백질 ａ１ 미메틱 및 이의 용도 |
| AU2005287004B2 (en) * | 2004-09-16 | 2011-03-17 | The Regents Of The University Of California | G-type peptides and other agents to ameliorate atherosclerosis and other pathologies |
| KR20070089996A (ko) | 2004-12-06 | 2007-09-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 세동맥의 구조 및 기능의 개선 방법 |
| US20080293639A1 (en) * | 2005-04-29 | 2008-11-27 | The Regents Of The University Of California | Peptides and peptide mimetics to treat pathologies characterized by an inflammatory response |
| MX2007013430A (es) * | 2005-04-29 | 2008-03-19 | Univ California | Peptidos y peptidos mimeticos para tratar patologias caracterizadas por una respuesta inflamatoria. |
| ES2402823T3 (es) * | 2006-06-01 | 2013-05-09 | Institut De Cardiologie De Montreal | Compuesto para uso en el tratamiento de estenosis valvular |
| AU2007284801A1 (en) * | 2006-08-08 | 2008-02-21 | The Regents Of The University Of Californina | Salicylanilides enhance oral delivery of therapeutic peptides |
| CA2672131C (en) * | 2006-12-13 | 2016-06-07 | The Regents Of The University Of California | Potent and selective mediators of cholesterol efflux |
| WO2009032702A2 (en) | 2007-08-28 | 2009-03-12 | Uab Research Foundation | Synthetic apolipoprotein e mimicking polypeptides and methods of use |
| EP2195331B1 (en) | 2007-08-28 | 2013-11-20 | Uab Research Foundation | Synthetic apolipoprotein e mimicking polypeptides and methods of use |
| WO2009036460A2 (en) * | 2007-09-14 | 2009-03-19 | Ambrx, Inc. | Modified human apolipoprotein a-i polypeptides and their uses |
| US7985728B1 (en) | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
| US7985727B1 (en) * | 2007-09-20 | 2011-07-26 | Abbott Cardiovascular Systems Inc. | Apo A-I mimetic peptides and methods of treatment |
| US9173890B2 (en) | 2007-09-20 | 2015-11-03 | Abbott Cardiovascular Systems Inc. | Sustained release of Apo A-I mimetic peptides and methods of treatment |
| CN105903029A (zh) * | 2007-12-12 | 2016-08-31 | 大学健康网络 | 高密度脂蛋白样肽磷脂支架（“hpps”）纳米颗粒 |
| AU2014268255B2 (en) * | 2009-02-16 | 2016-04-21 | Cerenis Therapeutics Holding Sa | Apolipoprotein a-i mimics |
| JP5719783B2 (ja) * | 2009-02-16 | 2015-05-20 | セレニス セラピューティクス ホールディング エスアー | アポリポタンパクａ−ｉ模倣物 |
| US20130310304A1 (en) * | 2010-06-15 | 2013-11-21 | Matthew C. Lawyer | Compositions and methods for the treatment of atherosclerosis |
| HUE042314T2 (hu) * | 2011-02-07 | 2019-06-28 | Cerenis Therapeutics Holding Sa | Lipoprotein komplexek és azok gyártása és alkalmazásai |
| JP6549554B2 (ja) | 2013-03-15 | 2019-07-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | コレステロール流出を刺激する、減少した毒性を有するペプチド |
| CN103910802B (zh) * | 2014-04-24 | 2017-01-11 | 华中科技大学 | 一种促进树突细胞摄取抗原肽的多肽、促进树突细胞摄取抗原肽的纳米颗粒及其应用 |
| WO2016018665A1 (en) | 2014-07-31 | 2016-02-04 | Uab Research Foundation | Apoe mimetic peptides and higher potency to clear plasma cholesterol |
| FR3026409B1 (fr) * | 2014-09-26 | 2018-03-30 | Centre National De La Recherche Scientifique (Cnrs) | Procede de criblage de molecules interferentes |
| JP2018516847A (ja) | 2015-03-25 | 2018-06-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 生体高分子薬を送達するための組成物及び方法 |
| US12257352B2 (en) | 2016-06-20 | 2025-03-25 | The Regents Of The University Of Michigan | Compositions and methods for delivery of biomacromolecule agents |
| TW202130652A (zh) * | 2017-01-19 | 2021-08-16 | 美國衛生與公眾服務部 | Apoc-ii擬肽 |
| MX2022012969A (es) | 2020-04-16 | 2022-11-09 | Abionyx Pharma Sa | Metodos para el tratamiento de condiciones agudas usando complejos basados en proteinas de union a lipidos. |
| IL301769A (en) | 2020-10-01 | 2023-05-01 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| MX2023012223A (es) | 2021-04-15 | 2023-10-26 | Abionyx Pharma Sa | Uso de complejos a base de proteinas de union a lipidos en soluciones de conservacion de organos. |
| CN119317440A (zh) | 2022-04-06 | 2025-01-14 | 阿比奥尼克斯制药公司 | 使用基于脂质结合蛋白的复合物治疗白细胞增多、内皮功能障碍和心脏炎的方法 |
| AU2023250345A1 (en) | 2022-04-06 | 2024-11-14 | Abionyx Pharma Sa | Methods for treating eye diseases using lipid binding protein-based complexes |
| IL317448A (en) | 2022-06-10 | 2025-02-01 | Abionyx Pharma Sa | Methods for treating hyperinflammatory conditions using complexes based on lipid-binding proteins |
| JP2025519606A (ja) | 2022-06-10 | 2025-06-26 | アビオニクス ファーマ エスエー | 脂質結合タンパク質に基づく複合体を使用して急性状態を処置するための方法 |
| IL322074A (en) | 2023-01-13 | 2025-09-01 | Abionyx Pharma Sa | Treatment using a lipid-binding protein molecule |
| WO2025093929A1 (en) | 2023-10-31 | 2025-05-08 | Abionyx Pharma Sa | Lipid binding protein molecule therapy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5854204A (en) * | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals, Inc. | Aβ peptides that modulate β-amyloid aggregation |
| US6664230B1 (en) | 2000-08-24 | 2003-12-16 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
| US7105635B2 (en) * | 2002-06-04 | 2006-09-12 | The University Of Toledo | Cyclic beta-sheet peptides useful as apoptotic/cytotoxic cancer agents |
| KR101185609B1 (ko) * | 2004-07-16 | 2012-09-24 | 트러스티즈 오브 터프츠 칼리지 | 아포리포단백질 ａ１ 미메틱 및 이의 용도 |
| AU2005287004B2 (en) * | 2004-09-16 | 2011-03-17 | The Regents Of The University Of California | G-type peptides and other agents to ameliorate atherosclerosis and other pathologies |
| KR20070089996A (ko) * | 2004-12-06 | 2007-09-04 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 세동맥의 구조 및 기능의 개선 방법 |
-
2005
- 2005-07-15 KR KR1020077003757A patent/KR101185609B1/ko not_active Expired - Fee Related
- 2005-07-15 AU AU2005275009A patent/AU2005275009B2/en not_active Ceased
- 2005-07-15 CN CNA2005800311531A patent/CN101076541A/zh active Pending
- 2005-07-15 CA CA002574007A patent/CA2574007A1/en not_active Abandoned
- 2005-07-15 US US11/182,490 patent/US7569546B2/en not_active Expired - Fee Related
- 2005-07-15 BR BRPI0513402-1A patent/BRPI0513402A/pt not_active IP Right Cessation
- 2005-07-15 EP EP05772288A patent/EP1771473B1/en not_active Expired - Lifetime
- 2005-07-15 WO PCT/US2005/025182 patent/WO2006020040A2/en not_active Ceased
- 2005-07-15 JP JP2007521684A patent/JP5048486B2/ja not_active Expired - Fee Related
- 2005-07-19 TW TW094124388A patent/TWI377066B/zh not_active IP Right Cessation
-
2007
- 2007-01-16 IL IL180733A patent/IL180733A/en not_active IP Right Cessation
- 2007-02-15 NO NO20070876A patent/NO20070876L/no not_active Application Discontinuation
-
2009
- 2009-05-21 US US12/469,942 patent/US8124580B2/en not_active Expired - Fee Related
-
2012
- 2012-02-28 US US13/406,880 patent/US20120259091A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200612977A (en) | 2006-05-01 |
| WO2006020040A2 (en) | 2006-02-23 |
| EP1771473B1 (en) | 2012-12-26 |
| EP1771473A2 (en) | 2007-04-11 |
| AU2005275009B2 (en) | 2011-12-08 |
| KR20070095862A (ko) | 2007-10-01 |
| CN101076541A (zh) | 2007-11-21 |
| JP2008506709A (ja) | 2008-03-06 |
| NO20070876L (no) | 2007-03-30 |
| TWI377066B (en) | 2012-11-21 |
| WO2006020040A3 (en) | 2006-07-06 |
| AU2005275009A1 (en) | 2006-02-23 |
| US20100009919A1 (en) | 2010-01-14 |
| IL180733A0 (en) | 2007-06-03 |
| US7569546B2 (en) | 2009-08-04 |
| JP5048486B2 (ja) | 2012-10-17 |
| US20120259091A1 (en) | 2012-10-11 |
| IL180733A (en) | 2013-01-31 |
| KR101185609B1 (ko) | 2012-09-24 |
| US20060069030A1 (en) | 2006-03-30 |
| BRPI0513402A (pt) | 2008-05-06 |
| US8124580B2 (en) | 2012-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20180202 |