JP2008538282A5 - - Google Patents

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Publication number
JP2008538282A5
JP2008538282A5 JP2008505508A JP2008505508A JP2008538282A5 JP 2008538282 A5 JP2008538282 A5 JP 2008538282A5 JP 2008505508 A JP2008505508 A JP 2008505508A JP 2008505508 A JP2008505508 A JP 2008505508A JP 2008538282 A5 JP2008538282 A5 JP 2008538282A5
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JP
Japan
Prior art keywords
cells
cell
sample
cancer
egfr
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Pending
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JP2008505508A
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English (en)
Japanese (ja)
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JP2008538282A (ja
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Priority claimed from US11/323,946 external-priority patent/US20070026415A1/en
Priority claimed from US11/324,041 external-priority patent/US20070026418A1/en
Priority claimed from US11/323,945 external-priority patent/US20070026414A1/en
Priority claimed from US11/323,962 external-priority patent/US20070026417A1/en
Priority claimed from US11/322,790 external-priority patent/US20070026413A1/en
Application filed filed Critical
Priority claimed from PCT/US2006/012778 external-priority patent/WO2006108087A2/en
Publication of JP2008538282A publication Critical patent/JP2008538282A/ja
Publication of JP2008538282A5 publication Critical patent/JP2008538282A5/ja
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JP2008505508A 2005-04-05 2006-04-05 装置および循環腫瘍細胞および他の粒子の濃縮および変更のための方法 Pending JP2008538282A (ja)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US66841505P 2005-04-05 2005-04-05
US70383305P 2005-07-29 2005-07-29
US11/323,946 US20070026415A1 (en) 2005-07-29 2005-12-29 Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US11/324,041 US20070026418A1 (en) 2005-07-29 2005-12-29 Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US11/323,945 US20070026414A1 (en) 2005-07-29 2005-12-29 Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US11/323,962 US20070026417A1 (en) 2005-07-29 2005-12-29 Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US11/322,790 US20070026413A1 (en) 2005-07-29 2005-12-29 Devices and methods for enrichment and alteration of circulating tumor cells and other particles
PCT/US2006/012778 WO2006108087A2 (en) 2005-04-05 2006-04-05 Devices and methods for enrichment and alteration of circulating tumor cells and other particles

Publications (2)

Publication Number Publication Date
JP2008538282A JP2008538282A (ja) 2008-10-23
JP2008538282A5 true JP2008538282A5 (enExample) 2010-10-14

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JP2008505508A Pending JP2008538282A (ja) 2005-04-05 2006-04-05 装置および循環腫瘍細胞および他の粒子の濃縮および変更のための方法

Country Status (5)

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US (2) US20070099207A1 (enExample)
EP (2) EP1874920A4 (enExample)
JP (1) JP2008538282A (enExample)
GB (1) GB2427468B (enExample)
WO (1) WO2006108087A2 (enExample)

Families Citing this family (92)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
EP1569510B1 (en) 2002-09-27 2011-11-02 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US20090136982A1 (en) 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US8158410B2 (en) 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
CN103382434B (zh) 2005-01-18 2016-05-25 生物概念股份有限公司 利用含排列成图案的立柱的微通道分离细胞
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
US20110052570A1 (en) * 2005-10-26 2011-03-03 Children's Medical Center Corporation Method to prognose response to anti-egfr therapeutics
US7695956B2 (en) 2006-01-12 2010-04-13 Biocept, Inc. Device for cell separation and analysis and method of using
EP2029779A4 (en) 2006-06-14 2010-01-20 Living Microsystems Inc HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
US20080050739A1 (en) 2006-06-14 2008-02-28 Roland Stoughton Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats
WO2008111990A1 (en) * 2006-06-14 2008-09-18 Cellpoint Diagnostics, Inc. Rare cell analysis using sample splitting and dna tags
US8137912B2 (en) 2006-06-14 2012-03-20 The General Hospital Corporation Methods for the diagnosis of fetal abnormalities
US8372584B2 (en) 2006-06-14 2013-02-12 The General Hospital Corporation Rare cell analysis using sample splitting and DNA tags
US20080007838A1 (en) * 2006-07-07 2008-01-10 Omnitech Partners, Inc. Field-of-view indicator, and optical system and associated method employing the same
US8014577B2 (en) * 2007-01-29 2011-09-06 Institut National D'optique Micro-array analysis system and method thereof
US8999634B2 (en) 2007-04-27 2015-04-07 Quest Diagnostics Investments Incorporated Nucleic acid detection combining amplification with fragmentation
WO2008153692A2 (en) * 2007-05-22 2008-12-18 The Brigham And Women's Hospital, Inc. Microrna expression profiling of cerebrospinal fluid
WO2009026566A1 (en) * 2007-08-23 2009-02-26 Cynvenio Biosystems, Llc Trapping magnetic sorting system for target species
US8008032B2 (en) 2008-02-25 2011-08-30 Cellective Dx Corporation Tagged ligands for enrichment of rare analytes from a mixed sample
EP2291509B1 (en) * 2008-05-16 2023-11-15 Board of Supervisors of Louisiana State University and Agricultural and Mechanical College Microfluidic isolation of tumor cells or other rare cells from whole blood or other liquids
WO2010016533A1 (ja) * 2008-08-08 2010-02-11 エーザイ・アール・アンド・ディー・マネジメント株式会社 Neph3(65B13)とE-カドヘリンを用いたプルキンエ前駆細胞の取得方法
WO2010033578A2 (en) 2008-09-20 2010-03-25 The Board Of Trustees Of The Leland Stanford Junior University Noninvasive diagnosis of fetal aneuploidy by sequencing
EP2350652A2 (en) 2008-10-10 2011-08-03 Cnrs-Dae Cell sorting device
EP2389455A4 (en) * 2009-01-26 2012-12-05 Verinata Health Inc METHODS AND COMPOSITIONS FOR IDENTIFYING A FETAL CELL
US20120270209A1 (en) * 2009-05-15 2012-10-25 Massachusetts Institute Of Technology Systems, devices, and methods for specific capture and release of biological sample components
FR2946895A1 (fr) * 2009-06-19 2010-12-24 Commissariat Energie Atomique Systeme microfluidique et procede correspondant pour le transfert d'elements entre phases liquides et utilisation de ce systeme pour extraire ces elements
US20120252022A1 (en) * 2009-09-21 2012-10-04 Paul Walfish Methods and compositions for the diagnosis and treatment of thyroid cancer
US9034658B2 (en) 2009-11-23 2015-05-19 The General Hospital Corporation Microfluidic devices for the capture of biological sample components
WO2012002447A1 (ja) * 2010-06-30 2012-01-05 武田薬品工業株式会社 変異ポリヌクレオチドの検出方法
CN102140518B (zh) * 2011-01-18 2013-02-06 杭州迪安医学检验中心有限公司 肺癌相关表皮生长因子受体egfr外显子突变定量检测试剂盒及方法
EP2689254A4 (en) * 2011-03-24 2014-09-03 Anpac Bio Medical Science Co Ltd MICRO-DEVICES FOR DISEASE RECOGNITION
JP5934921B2 (ja) * 2011-04-08 2016-06-15 パナソニックＩｐマネジメント株式会社 診断キット及びその使用方法
CN106929401B (zh) * 2011-05-05 2020-06-09 安派科生物医学科技有限公司 肿瘤细胞检测仪
CN107315086B (zh) 2011-06-29 2019-09-10 中央研究院 使用表面涂层对生物物质的捕获、纯化和释放
US8951484B2 (en) 2012-01-31 2015-02-10 The Regents Of The University Of Michigan Circulating tumor cell capturing techniques and devices
CA2864641C (en) 2012-02-16 2021-05-04 National Research Council Of Canada Centrifugal microfluidic mixing apparatus and method
US9689863B2 (en) * 2012-03-08 2017-06-27 Shanghai Xinshenpai Technology Co., Ltd. Micro-devices for improved disease detection
JP2016512197A (ja) 2013-03-05 2016-04-25 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 間葉及び上皮間葉形質転換循環腫瘍細胞のための特異的検出ツール
US11493428B2 (en) 2013-03-15 2022-11-08 Gpb Scientific, Inc. On-chip microfluidic processing of particles
CN113512522A (zh) 2013-03-15 2021-10-19 普林斯顿大学理事会 用于高通量纯化的方法和设备
US12590955B2 (en) 2013-03-15 2026-03-31 Zeon Corporation Methods and systems for processing particles
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
WO2015010019A1 (en) 2013-07-18 2015-01-22 The General Hospital Corporation Selective capture and release of rare mammalian cells using photodegradable hydrogels in a microfluidic platform
KR102113310B1 (ko) * 2013-09-03 2020-05-20 아주대학교 산학협력단 암 세포 분리용 조성물, 키트 및 이를 이용한 분리 방법
EP3502270B1 (en) 2013-10-21 2020-03-18 The General Hospital Corporation Methods relating to circulating tumor cell clusters and the treatment of cancer
JP2014158468A (ja) * 2014-03-05 2014-09-04 Clinical Genomics Pty Ltd 検出方法
TW201623605A (zh) 2014-04-01 2016-07-01 中央研究院 用於癌症診斷及預後之方法及系統
WO2015161231A1 (en) * 2014-04-17 2015-10-22 Siemens Healthcare Diagnostics Inc. Method to screen out false positives in a circulating tumor cell assay
US10502674B2 (en) * 2014-06-27 2019-12-10 The Regents Of The University Of California Apparatus and method for label-free analysis of rare cells from bodily fluids
JP6339432B2 (ja) * 2014-07-16 2018-06-06 オリンパス株式会社 細胞観察情報処理システム、細胞観察情報処理方法、細胞観察情報処理プログラム
US10112198B2 (en) 2014-08-26 2018-10-30 Academia Sinica Collector architecture layout design
US10656157B2 (en) * 2014-09-24 2020-05-19 Purdue Research Foundation Rare event detection using mass tags
CN107407626B (zh) * 2014-09-26 2020-10-30 加利福尼亚大学董事会 评估癌症的疾病状况的方法
JP6649377B2 (ja) 2014-11-03 2020-02-19 ザ ジェネラル ホスピタル コーポレイション ミクロ流体装置による粒子の複合式分類および濃縮
US10304188B1 (en) 2015-03-27 2019-05-28 Caleb J. Kumar Apparatus and method for automated cell analysis
JP6615499B2 (ja) * 2015-06-05 2019-12-04 国立大学法人 東京大学 細胞またはリポソーム粒子の分離捕捉装置
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
WO2017121832A1 (en) * 2016-01-14 2017-07-20 European Molecular Biology Laboratory Microfluidic analysis of ligand induced cell expression
KR20170099739A (ko) 2016-02-23 2017-09-01 노을 주식회사 접촉식 염색 보조 패치, 그 제조 방법 및 이를 이용하는 염색 방법
KR102478639B1 (ko) 2016-02-23 2022-12-19 노을 주식회사 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치
KR20170099787A (ko) * 2016-02-23 2017-09-01 노을 주식회사 표지 물질을 저장하는 패치, 이를 이용하는 조직 진단 방법 및 장치
US10371610B2 (en) 2016-02-23 2019-08-06 Noul Co., Ltd. Contact-type patch, staining method using the same, and manufacturing method thereof
KR102406596B1 (ko) * 2016-02-23 2022-06-10 노을 주식회사 패치를 이용하는 ctc 진단 방법 및 장치
US10107726B2 (en) 2016-03-16 2018-10-23 Cellmax, Ltd. Collection of suspended cells using a transferable membrane
US10010883B2 (en) * 2016-09-20 2018-07-03 International Business Machines Corporation Deterministic lateral displacement arrays
JP6518985B2 (ja) * 2016-09-29 2019-05-29 住友ゴム工業株式会社 がん細胞捕捉方法
JP6779483B2 (ja) 2016-09-29 2020-11-04 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
CA3041522A1 (en) * 2016-10-24 2018-05-03 Gpb Scientific, Llc Deterministic lateral displacement in the preparation of cells and compositions for therapeutic uses
CN107041361A (zh) * 2017-04-20 2017-08-15 北京奥康华医学检验所有限公司 一种肿瘤组织的保存方法及保存试剂
US10844353B2 (en) 2017-09-01 2020-11-24 Gpb Scientific, Inc. Methods for preparing therapeutically active cells using microfluidics
EP3691536A4 (en) 2017-10-03 2021-03-17 The Regents of the University of California DEVICE AND METHOD FOR DETERMINING THE SPATIAL LIKELIHOOD OF CANCER WITHIN THE PROSTATE
US20190226953A1 (en) 2018-01-19 2019-07-25 International Business Machines Corporation Microscale and mesoscale condenser devices
US10946380B2 (en) * 2018-01-19 2021-03-16 International Business Machines Corporation Microfluidic chips for particle purification and fractionation
US11458474B2 (en) 2018-01-19 2022-10-04 International Business Machines Corporation Microfluidic chips with one or more vias
JP7158671B2 (ja) 2018-02-14 2022-10-24 住友ゴム工業株式会社 特定細胞捕捉方法
JP7170254B2 (ja) * 2018-02-14 2022-11-14 住友ゴム工業株式会社 特定細胞捕捉方法
JP7109719B2 (ja) 2018-02-14 2022-08-01 住友ゴム工業株式会社 特定細胞捕捉方法
WO2020056162A1 (en) * 2018-09-12 2020-03-19 Oregon Health & Science University Detecting and/or subtyping circulating hybrid cells that correlate with stage and survival
WO2020139936A1 (en) * 2018-12-27 2020-07-02 The General Hospital Corporation Size-based particle separation and concentration using particle size amplification
US11614440B2 (en) 2019-01-24 2023-03-28 Sumitomo Rubber Industries, Ltd. Specific cell fractionating and capturing methods
US20220267726A1 (en) 2019-07-18 2022-08-25 Gpb Scientific, Inc. Ordered processing of blood products to produce therapeutically active cells
WO2021133897A1 (en) 2019-12-28 2021-07-01 Gpb Scientific, Inc. Microfluidic cartridges for processing particles and cells
CN111537422B (zh) * 2020-06-10 2022-09-23 兰州大学 表征及调控包晶合金定向凝固时糊状区内渗透率的方法
CN111676289A (zh) * 2020-06-19 2020-09-18 安徽微分基因科技有限公司 一种egfr基因19号外显子e746-a750突变基因的检测方法
JP2023532053A (ja) * 2020-06-25 2023-07-26 アライブ・プライベート・リミテッド 細胞および微小環境を特性付けるためのシステムおよび方法
CN116018522B (zh) * 2020-09-29 2025-09-16 Nok株式会社 白细胞捕获设备
CN118922704A (zh) * 2022-03-28 2024-11-08 国立大学法人茨城大学 白血球捕捉设备
CN116286268B (zh) * 2023-03-21 2025-07-08 中国科学院上海微系统与信息技术研究所 一种基于微流控技术的外泌体分离装置及其方法

Family Cites Families (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3906929A (en) * 1973-11-23 1975-09-23 Lynn Lawrence Augspurger Processes for reproduction of cellular bodies
US4508625A (en) * 1982-10-18 1985-04-02 Graham Marshall D Magnetic separation using chelated magnetic ions
US4675286A (en) * 1985-01-28 1987-06-23 Aspen Diagnostics, Inc. Fetal cell separation and testing
US4999283A (en) * 1986-01-10 1991-03-12 University Of Kentucky Research Foundation Method for x and y spermatozoa separation
US5459039A (en) 1989-05-12 1995-10-17 Duke University Methods for mapping genetic mutations
US5641628A (en) * 1989-11-13 1997-06-24 Children's Medical Center Corporation Non-invasive method for isolation and detection of fetal DNA
US5153117A (en) * 1990-03-27 1992-10-06 Genetype A.G. Fetal cell recovery method
US5726026A (en) * 1992-05-01 1998-03-10 Trustees Of The University Of Pennsylvania Mesoscale sample preparation device and systems for determination and processing of analytes
US5296375A (en) * 1992-05-01 1994-03-22 Trustees Of The University Of Pennsylvania Mesoscale sperm handling devices
US5304487A (en) * 1992-05-01 1994-04-19 Trustees Of The University Of Pennsylvania Fluid handling in mesoscale analytical devices
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
US5629147A (en) * 1992-07-17 1997-05-13 Aprogenex, Inc. Enriching and identifying fetal cells in maternal blood for in situ hybridization
US5457024A (en) * 1993-01-22 1995-10-10 Aprogenex, Inc. Isolation of fetal erythrocytes
US5427663A (en) 1993-06-08 1995-06-27 British Technology Group Usa Inc. Microlithographic array for macromolecule and cell fractionation
EP0657811B1 (en) 1993-12-09 1998-09-02 STMicroelectronics S.r.l. Integrated circuitry for checking the utilization rate of redundancy memory elements in a semiconductor memory device
US5432054A (en) * 1994-01-31 1995-07-11 Applied Imaging Method for separating rare cells from a population of cells
US20020042079A1 (en) * 1994-02-01 2002-04-11 Sanford M. Simon Methods and agents for measuring and controlling multidrug resistance
US5750339A (en) * 1994-11-30 1998-05-12 Thomas Jefferson University Methods for identifying fetal cells
US5648220A (en) * 1995-02-14 1997-07-15 New England Medical Center Hospitals, Inc. Methods for labeling intracytoplasmic molecules
US5715946A (en) * 1995-06-07 1998-02-10 Reichenbach; Steven H. Method and apparatus for sorting particles suspended in a fluid
EP0861334B2 (de) * 1995-11-16 2008-04-09 Michael W. Dahm Verfahren zur quantifizierung von tumorzellen in einer körperflüssigkeit und dazu geeignete testkits
US5972721A (en) * 1996-03-14 1999-10-26 The United States Of America As Represented By The Secretary Of The Air Force Immunomagnetic assay system for clinical diagnosis and other purposes
US5891651A (en) * 1996-03-29 1999-04-06 Mayo Foundation For Medical Education And Research Methods of recovering colorectal epithelial cells or fragments thereof from stool
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
EP0929658A4 (en) * 1996-08-26 2005-11-02 Univ Princeton REVERSIBLE SEALABLE DEVICE FOR SORTING MICROSTRUCTURES
EP0925494B1 (en) * 1996-09-04 2001-12-19 Scandinavian Micro Biodevices A/S A micro flow system for particle separation and analysis
GB9704876D0 (en) * 1997-03-08 1997-04-23 Univ Dundee Diagnostic methods
US6066449A (en) * 1997-04-15 2000-05-23 The Trustees Of Columbia University In The City Of New York Method of detecting metastatic thyroid cancer
US6156273A (en) * 1997-05-27 2000-12-05 Purdue Research Corporation Separation columns and methods for manufacturing the improved separation columns
US6368871B1 (en) * 1997-08-13 2002-04-09 Cepheid Non-planar microstructures for manipulation of fluid samples
US6197523B1 (en) * 1997-11-24 2001-03-06 Robert A. Levine Method for the detection, identification, enumeration and confirmation of circulating cancer and/or hematologic progenitor cells in whole blood
SE521415C2 (sv) * 1998-02-17 2003-10-28 Hans Goeran Evald Martin Metod för att framställa en gassensortillhörig detektor, samt en detektor framställd enligt metoden
US6537505B1 (en) * 1998-02-20 2003-03-25 Bio Dot, Inc. Reagent dispensing valve
US6036857A (en) * 1998-02-20 2000-03-14 Florida State University Research Foundation, Inc. Apparatus for continuous magnetic separation of components from a mixture
US6027623A (en) * 1998-04-22 2000-02-22 Toyo Technologies, Inc. Device and method for electrophoretic fraction
US6200765B1 (en) * 1998-05-04 2001-03-13 Pacific Northwest Cancer Foundation Non-invasive methods to detect prostate cancer
CA2333201A1 (en) * 1998-05-22 1999-12-02 California Institute Of Technology Microfabricated cell sorter
WO1999063332A1 (en) * 1998-06-05 1999-12-09 Sarnoff Corporation Apparatus for separating molecules
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
AU768810B2 (en) 1998-07-20 2004-01-08 Century Technology, Inc. Gene sequence variances with utility in determining the treatment of disease
US6337472B1 (en) * 1998-10-19 2002-01-08 The University Of Texas System Board Of Regents Light imaging microscope having spatially resolved images
ATE508200T1 (de) * 1999-02-23 2011-05-15 Caliper Life Sciences Inc Sequenzierung durch inkorporation
US6291249B1 (en) * 1999-03-02 2001-09-18 Qualigen, Inc. Method using an apparatus for separation of biological fluids
US6942978B1 (en) * 1999-03-03 2005-09-13 The Board Of Trustees Of The University Of Arkansas Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
US6858439B1 (en) * 1999-03-15 2005-02-22 Aviva Biosciences Compositions and methods for separation of moieties on chips
US6368562B1 (en) * 1999-04-16 2002-04-09 Orchid Biosciences, Inc. Liquid transportation system for microfluidic device
US6589791B1 (en) * 1999-05-20 2003-07-08 Cartesian Technologies, Inc. State-variable control system
US6395232B1 (en) * 1999-07-09 2002-05-28 Orchid Biosciences, Inc. Fluid delivery system for a microfluidic device using a pressure pulse
US6623945B1 (en) * 1999-09-16 2003-09-23 Motorola, Inc. System and method for microwave cell lysing of small samples
US6692952B1 (en) 1999-11-10 2004-02-17 Massachusetts Institute Of Technology Cell analysis and sorting apparatus for manipulation of cells
US6361958B1 (en) * 1999-11-12 2002-03-26 Motorola, Inc. Biochannel assay for hybridization with biomaterial
US20030170631A1 (en) * 2000-04-03 2003-09-11 Corixa Corporation Methods, compositions and kits for the detection and monitoring of breast cancer
SE0001790D0 (sv) * 2000-05-12 2000-05-12 Aamic Ab Hydrophobic barrier
US7785810B2 (en) * 2000-09-09 2010-08-31 The Research Foundation Of State University Of New York Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof
US6689615B1 (en) * 2000-10-04 2004-02-10 James Murto Methods and devices for processing blood samples
EP1328342A4 (en) * 2000-10-10 2006-03-15 Aviva Biosciences Corp INTEGRATED BIOCHIP SYSTEM FOR SAMPLE PREPARATION AND ANALYSIS
US6521188B1 (en) * 2000-11-22 2003-02-18 Industrial Technology Research Institute Microfluidic actuator
US6778724B2 (en) * 2000-11-28 2004-08-17 The Regents Of The University Of California Optical switching and sorting of biological samples and microparticles transported in a micro-fluidic device, including integrated bio-chip devices
FR2817967B1 (fr) * 2000-12-08 2003-02-28 Diagast Procede de magnetisation de marqueurs chimiques ou biologiques
US6453928B1 (en) * 2001-01-08 2002-09-24 Nanolab Ltd. Apparatus, and method for propelling fluids
KR20030094281A (ko) * 2001-03-12 2003-12-11 모노젠, 인크. 세포에 기초한 질병상태의 검출 및 질병상태의 구별
US7323140B2 (en) * 2001-03-28 2008-01-29 Handylab, Inc. Moving microdroplets in a microfluidic device
EP1377811B1 (en) * 2001-04-03 2008-07-16 Micronics, Inc. Split focusing cytometer
FR2824144B1 (fr) * 2001-04-30 2004-09-17 Metagenex S A R L Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel
US6743636B2 (en) * 2001-05-24 2004-06-01 Industrial Technology Research Institute Microfluid driving device
US20050026167A1 (en) * 2001-06-11 2005-02-03 Mark Birch-Machin Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
JP3695431B2 (ja) * 2001-08-03 2005-09-14 日本電気株式会社 分離装置および分離装置の製造方法
EP1413346A4 (en) * 2001-08-03 2005-05-25 Nec Corp SEPARATING DEVICE AND METHOD FOR PRODUCING THE SEPARATOR
US7863012B2 (en) * 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
DE60219642T2 (de) * 2001-09-04 2008-01-17 Iq Corp. B.V. Bestimung und quantifizierung von erythrocytenpopulation in proben
WO2003044224A1 (de) * 2001-11-22 2003-05-30 Adnagen Ag Diagnose-kit, dns-chip sowie verfahren zur diagnostik oder behandlungskontrolle bei hodenkrebs
DE10143776A1 (de) * 2001-09-06 2003-04-03 Adnagen Ag Verfahren und Kit zur Diagnostik oder Behandlungskontrolle von Brustkrebs
CA2466896A1 (en) * 2001-09-06 2003-03-20 Adnagen Ag Method and diagnosis kit for selecting and or qualitative and/or quantitative detection of cells
US6783647B2 (en) * 2001-10-19 2004-08-31 Ut-Battelle, Llc Microfluidic systems and methods of transport and lysis of cells and analysis of cell lysate
CN1606628A (zh) * 2001-11-30 2005-04-13 辉瑞产品公司 检测染色体数量异常细胞的方法
EP1495106A2 (en) * 2002-03-20 2005-01-12 Advanced Sensor Technologies, Inc. Personal monitor to detect exposure to toxic agents
EP1499706A4 (en) * 2002-04-01 2010-11-03 Fluidigm Corp MICROFLUIDIC PARTICLE ANALYSIS SYSTEMS
SE0201738D0 (sv) * 2002-06-07 2002-06-07 Aamic Ab Micro-fluid structures
US20040101444A1 (en) * 2002-07-15 2004-05-27 Xeotron Corporation Apparatus and method for fluid delivery to a hybridization station
US20060008807A1 (en) * 2002-08-23 2006-01-12 O'hara Shawn M Multiparameter analysis of comprehensive nucleic acids and morphological features on the same sample
US7455770B2 (en) * 2002-09-09 2008-11-25 Cytonome, Inc. Implementation of microfluidic components in a microfluidic system
EP1569510B1 (en) * 2002-09-27 2011-11-02 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
DE60332046D1 (de) 2002-10-23 2010-05-20 Univ Princeton Verfahren zur kontinuierlichen teilchentrennung unter verwendungvon zu feldern asymmetrisch ausgerichteten hindernisarrays
AU2004250131A1 (en) 2003-06-13 2004-12-29 The General Hospital Corporation Microfluidic systems for size based removal of red blood cells and platelets from blood
KR20060054412A (ko) 2003-08-01 2006-05-22 와이어쓰 홀딩스 코포레이션 암 치료 및 억제용 표피 성장인자 수용체 키나제 억제제와세포독성제의 배합물 용도
US20050069528A1 (en) * 2003-08-21 2005-03-31 Genzyme Corporation Mammalian endothelial cell model systems
US7745221B2 (en) * 2003-08-28 2010-06-29 Celula, Inc. Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network
AU2004286284B2 (en) * 2003-10-29 2011-08-25 Mec Dynamics Corp. Micro mechanical methods and systems for performing assays
US7939249B2 (en) * 2003-12-24 2011-05-10 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and concentration step
US20050181353A1 (en) * 2004-02-17 2005-08-18 Rao Galla C. Stabilization of cells and biological specimens for analysis
US20060121624A1 (en) * 2004-03-03 2006-06-08 Huang Lotien R Methods and systems for fluid delivery
EP1765503A2 (en) 2004-03-03 2007-03-28 The General Hospital Corporation System for delivering a diluted solution
EP1776449A4 (en) 2004-03-03 2009-08-12 Gen Hospital Corp MAGNETIC DEVICE FOR ISOLATING CELLS AND BIOMOLECULES IN A MICROFLUIDIC ENVIRONMENT
US7390388B2 (en) * 2004-03-25 2008-06-24 Hewlett-Packard Development Company, L.P. Method of sorting cells on a biodevice
EP2439284B1 (en) 2004-03-31 2019-05-08 The General Hospital Corporation Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments
US20080213821A1 (en) * 2004-05-06 2008-09-04 Nanyang Technological University Microfluidic Cell Sorter System
DE102004047953A1 (de) * 2004-10-01 2006-04-20 Rudolf Rigler Selektion von Partikeln im laminaren Fluss
US20060246575A1 (en) * 2005-01-13 2006-11-02 Micronics, Inc. Microfluidic rare cell detection device
US8158410B2 (en) * 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20070026418A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026414A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070196820A1 (en) * 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
US20070026413A1 (en) * 2005-07-29 2007-02-01 Mehmet Toner Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026415A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026417A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059680A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for cell enrichment
US20070026419A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8921102B2 (en) * 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070026416A1 (en) * 2005-07-29 2007-02-01 Martin Fuchs Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US20070059716A1 (en) * 2005-09-15 2007-03-15 Ulysses Balis Methods for detecting fetal abnormality
US20070059718A1 (en) * 2005-09-15 2007-03-15 Mehmet Toner Systems and methods for enrichment of analytes
US20070059774A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Kits for Prenatal Testing
US20070059719A1 (en) * 2005-09-15 2007-03-15 Michael Grisham Business methods for prenatal Diagnosis
US20070059683A1 (en) * 2005-09-15 2007-03-15 Tom Barber Veterinary diagnostic system
US20070059781A1 (en) * 2005-09-15 2007-03-15 Ravi Kapur System for size based separation and analysis
WO2007035585A2 (en) * 2005-09-15 2007-03-29 Artemis Health, Inc. Systems and methods for enrichment of analytes

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