JP2008536124A - カーボンナノチューブコントロールを用いる分子特性解析 - Google Patents
カーボンナノチューブコントロールを用いる分子特性解析 Download PDFInfo
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Abstract
【選択図】図1C
Description
65を電気的にバイアスするために第2外部回路52が設けられている。表面に位置するナノチューブ65の端部66,68は、表面に位置するナノチューブ65の電圧をコントロールするために電圧源54が設けられている第2外部回路52に接続されている。第2外部回路52には電流計または他の電流コントロール及び測定デバイス56も含まれ得る。
Claims (55)
- 特性解析しようとする分子を含む液体溶液を収容している第1リザーバー;
特性解析済みの分子を含む液体溶液を収容するための第2リザーバー;
第1リザーバーに流体接続を与える分子入口及び第2リザーバーに流体接続を与える分子出口を有するアパーチャを含む固体状態支持構造物;
第1及び第2電子輸送プローブであって、そのプローブの少なくとも1つはフラーレン構造物からなり、各プローブは支持構造物上に配置されており且つアパーチャの外周に接している表面を有している、プローブ;
電圧バイアスをアパーチャを横切って印加するためのプローブ間に接続されている電圧源;及び
アパーチャを通過する分子の移動に対応するプローブ間の電子輸送の変化をモニターするためにプローブ間に接続されている電流モニター;
を含む分子特性解析デバイス。 - 特性解析しようとする分子が生体分子からなる請求項1に記載の分子特性解析デバイス。
- 分子がポリマー分子からなる請求項1に記載の分子特性解析デバイス。
- 分子がバイオポリマー分子からなる請求項1に記載の分子特性解析デバイス。
- 分子がタンパク質、ポリ核酸、DNA及びRNAからなる群から選択される請求項4に記載の分子特性解析デバイス。
- 特性解析しようとする分子がカーボンナノチューブにカップリングしている分子からなる請求項1に記載の分子特性解析デバイス。
- カーボンナノチューブにカップリングしている分子がカーボンナノチューブにカップリングしているDNAの少なくとも1本の鎖からなる請求項6に記載の分子特性解析デバイス。
- カーボンナノチューブにカップリングしている分子がカーボンナノチューブにカップリングしているRNAの少なくとも1本の鎖からなる請求項6に記載の分子特性解析デバイス。
- 分子がカップリングしているカーボンナノチューブが、該ナノチューブをアパーチャを通って移動させるために片持ち式作動チップに接続されている請求項6に記載の分子特性解析デバイス
- 第1及び第2電子輸送プローブの各々がフラーレン構造物からなる請求項1に記載の分子特性解析デバイス。
- フラーレン構造物がカーボンナノチューブからなる請求項10に記載の分子特性解析デバイス。
- カーボンナノチューブが半導体ナノチューブからなる請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブが金属ナノチューブからなる請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブが単層ナノチューブからなる請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの少なくとも1つが、ナノチューブ端部がアパーチャ外周に接する向きに置かれている請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの各々が、ナノチューブ端部がアパーチャ外周に接する向きに置かれている請求項15に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの少なくとも1つが、ナノチューブ側面がアパーチャ外周に接する向きに置かれている請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの1つが、ナノチューブ端部がアパーチャ外周に接する向きに置かれており、カーボンナノチューブ電子輸送プローブの1つが、ナノチューブ側面がアパーチャ外周に接する向きに置かれている請求項17に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの1つが、第1ナノチューブ端部が分子入口でアパーチャ外周に接する向きに置かれており、第2ナノチューブ端部が分子出口でアパーチャ外周に接する向きに置かれている請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの少なくとも1つが、分子がアパーチャを通って移動しながらカップリングし得るナノチューブ表面がアパーチャ外周に接する向きに置かれている請求項11に記載の分子特性解析デバイス。
- 分子が、アパーチャを通って移動しながらナノチューブ表面にカップリングし得るヌクレオシド塩基からなる請求項20に記載の分子特性解析デバイス。
- 更に、支持構造物上に配置されており、分子がカップリングし得る表面が分子入口でアパーチャ外周に接している分子移動速度コントロールナノチューブを含む請求項11に記載の分子特性解析デバイス。
- アパーチャが支持構造物の厚さを貫いて延びる細孔からなり、該細孔は一度に1つの分子しかその細孔を通って移動できないくらい十分に小さい直径を有している請求項1に記載の分子特性解析デバイス。
- 細孔が約100nm未満の直径を有するナノ細孔からなる請求項23に記載の分子特性解析デバイス。
- ナノ細孔が約50nm未満の直径を有する請求項24に記載の分子特性解析デバイス。
- ナノ細孔が約20nm未満の直径を有する請求項25に記載の分子特性解析デバイス。
- ナノ細孔が約10nm未満の直径を有する請求項26に記載の分子特性解析デバイス。
- アパーチャが電気絶縁材料層で被覆されている請求項1に記載の分子特性解析デバイス。
- 電子輸送プローブがアパーチャ外周に接している部分を除いて電気絶縁材料層で被覆されている請求項1に記載の分子特性解析デバイス。
- 支持構造物がアパーチャが設けられている電気絶縁膜からなる請求項1に記載の分子特性解析デバイス。
- 膜が窒化ケイ素膜からなる請求項30に記載の分子特性解析デバイス。
- プローブ間に接続されている電流モニターが、アパーチャを通過する分子の移動に対応するプローブ間の電子トンネリングの変調を検出するように構成されている請求項1に記載の分子特性解析デバイス。
- 特性解析しようとする分子−ナノチューブ複合体中のカーボンナノチューブにカップリングしている少なくとも1つの分子を含む液体溶液を収容している第1リザーバー;
特性解析済みの分子−ナノチューブ複合体を含む液体溶液を収容するための第2リザーバー;
第1リザーバーに対して流体接続を与える分子入口及び第2リザーバーに対して流体接続を与える分子出口を有するアパーチャを含む固体状態支持構造物;
アパーチャを通過する分子−ナノチューブ複合体の移動を検出するためのアパーチャに対する電気接続;
を含む分子特性解析デバイス。 - アパーチャに対する電気接続が、分子−ナノチューブ複合体がアパーチャを通って移動するときのアパーチャを通るイオン電流の遮断を検出するように構成されている請求項33に記載の分子特性解析デバイス。
- アパーチャが一度に1つの分子−ナノチューブ複合体しか細孔を通って移動できないくらい十分に小さい直径を有する細孔からなる請求項33に記載の分子特性解析デバイス。
- カーボンナノチューブにカップリングしている分子がタンパク質、ポリ核酸、DNA及びRNAからなる群から選択されるポリマー生体分子からなる請求項33に記載の分子特性解析デバイス。
- アパーチャへの電気接続が、第1及び第2電子輸送プローブからなり、その各プローブがアパーチャの外周に接して支持構造物上に設置されている請求項33に記載の分子特性解析デバイスであって、
更に、電圧バイアスをアパーチャを横切って印加するためにプローブ間に接続されている電圧源、及び
アパーチャを通過する分子−ナノチューブ複合体の移動に対応するプローブ間の電子輸送の変化をモニターするためにプローブ間に接続されている電流モニターを含む、
分子特性解析デバイス。 - 電子輸送プローブの少なくとも1つがフラーレン構造物からなる請求項37に記載の分子特性解析デバイス。
- 電子輸送プローブの各々がカーボンナノチューブからなる請求項38に記載の分子特性解析デバイス。
- 分子を、特性解析しようとする分子を含む液体溶液を収容している第1リザーバーから特性解析済みの分子を含む液体溶液を収容するための第2リザーバーに、支持構造物中のアパーチャを通って移動させ、
分子をカーボンナノチューブの表面にカップリングさせ、
アパーチャの外周にそれぞれ接している2つの電子輸送プローブ間の、アパーチャを通過する分子の移動に対応するアパーチャを横切る電子輸送の変化をモニターする
ことを含む分子特性解析方法。 - 分子がアパーチャを通って移動するときに、分子がカーボンナノチューブの表面にカップリングする、請求項40に記載の方法。
- 分子がカップリングするカーボンナノチューブ表面がアパーチャの外周に接している請求項40に記載の方法。
- 分子がカップリングするカーボンナノチューブ表面が、第1リザーバーと流体接続状態にあるアパーチャへの分子入口でアパーチャの外周に接している請求項40に記載の方法。
- 分子がカップリングするカーボンナノチューブ表面がナノチューブ端部である請求項40に記載の方法。
- 分子をカップリングさせるカーボンナノチューブ表面がナノチューブ側面である請求項40に記載の方法。
- 更に、アパーチャを通過する分子移動速度をコントロールするために液体溶液に対するナノチューブの電圧バイアスを一時的にコントロールすることを含む請求項40に記載の方法。
- 電子輸送プローブの各々がカーボンナノチューブからなる請求項40に記載の方法。
- 分子がDNAヌクレオシド塩基からなり、DNA塩基のカーボンナノチューブ表面へのカップリングがナノチューブ表面に対して塩基を空間的に配向させる請求項40に記載の方法。
- 分子がRNAヌクレオシド塩基からなり、RNA塩基のカーボンナノチューブ表面へのカップリングがナノチューブ表面に対して塩基を空間的に配向させる請求項40に記載の方法。
- 分子のカーボンナノチューブ表面へのカップリングが、まずアパーチャ分子入口でアパーチャ外周に接している第1カーボンナノチューブの表面に分子をカップリングさせ、次いで電子輸送プローブとして構成した第2カーボンナノチューブの表面に分子をカップリングさせることを含む請求項40に記載の方法。
- 分子を液体溶液中のカーボンナノチューブにカップリングさせて、分子−ナノチューブ複合体を形成し;
カップリングさせた分子−ナノチューブ複合体を、特性解析しようとするカップリングさせた分子−ナノチューブ複合体を含む液体溶液を収容する第1リザーバーから特性解析済みの分子−ナノチューブ複合体を含む液体溶液を収容するための第2リザーバーに、支持構造物中のアパーチャを通って移動させ;
アパーチャを通過する分子−ナノチューブ複合体の移動を検出すること
を含む分子特性解析方法。 - 分子−ナノチューブ複合体の移動の検出が、分子−ナノチューブ複合体がアパーチャを通って移動するときのアパーチャを通るイオン電流の遮断の検出を含む請求項51に記載の方法。
- 分子−ナノチューブ複合体の移動の検出が、支持構造物上に配置されており、各々がアパーチャの外周に接する表面を有している2つの電子輸送プローブ間の電子輸送の変化を、電圧バイアスをアパーチャを横切って印加しながらモニターすることを含む請求項51に記載の方法。
- カーボンナノチューブにカップリングさせる分子がタンパク質、ポリ核酸、DNA及びRNAからなる群から選択されるポリマー生体分子からなる請求項51に記載の方法。
- 分子を、特性解析しようとする分子を含む液体溶液を収容する第1リザーバーから特性解析済みの分子を含む液体溶液を収容するための第2リザーバーに、支持構造物中のアパーチャを通って移動させ;
分子をカーボンナノチューブの表面にカップリングさせ;
アパーチャを通過する分子の移動に対応するナノチューブのコンダクタンスの変化をモニターすることを含む
分子特性解析方法。
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US7803607B2 (en) | 2010-09-28 |
AU2006336262B2 (en) | 2011-10-13 |
CN101203740B (zh) | 2011-03-23 |
US20080257859A1 (en) | 2008-10-23 |
EP2348300A3 (en) | 2011-10-12 |
JP2012021996A (ja) | 2012-02-02 |
US9274097B2 (en) | 2016-03-01 |
EP1877762A2 (en) | 2008-01-16 |
US7468271B2 (en) | 2008-12-23 |
US10228348B2 (en) | 2019-03-12 |
US20110155574A1 (en) | 2011-06-30 |
ATE529734T1 (de) | 2011-11-15 |
US20080248561A1 (en) | 2008-10-09 |
US20080171316A1 (en) | 2008-07-17 |
AU2006336262A1 (en) | 2007-07-26 |
WO2007084163A2 (en) | 2007-07-26 |
CN102183630A (zh) | 2011-09-14 |
EP1877762B1 (en) | 2011-10-19 |
US20160139079A1 (en) | 2016-05-19 |
US8092697B2 (en) | 2012-01-10 |
EP2348300A2 (en) | 2011-07-27 |
CA2603352A1 (en) | 2007-07-26 |
JP4891313B2 (ja) | 2012-03-07 |
CA2603352C (en) | 2013-10-01 |
WO2007084163A3 (en) | 2008-03-06 |
CN101203740A (zh) | 2008-06-18 |
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