JP2008536124A - カーボンナノチューブコントロールを用いる分子特性解析 - Google Patents
カーボンナノチューブコントロールを用いる分子特性解析 Download PDFInfo
- Publication number
- JP2008536124A JP2008536124A JP2008505513A JP2008505513A JP2008536124A JP 2008536124 A JP2008536124 A JP 2008536124A JP 2008505513 A JP2008505513 A JP 2008505513A JP 2008505513 A JP2008505513 A JP 2008505513A JP 2008536124 A JP2008536124 A JP 2008536124A
- Authority
- JP
- Japan
- Prior art keywords
- nanotube
- aperture
- molecule
- molecular
- probes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims abstract description 81
- 239000002041 carbon nanotube Substances 0.000 title claims abstract description 75
- 229910021393 carbon nanotube Inorganic materials 0.000 title claims abstract description 75
- 238000012512 characterization method Methods 0.000 title claims description 75
- 239000000523 sample Substances 0.000 claims abstract description 224
- 239000007787 solid Substances 0.000 claims abstract description 24
- 239000006193 liquid solution Substances 0.000 claims abstract description 18
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical group C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims abstract description 15
- 238000012544 monitoring process Methods 0.000 claims abstract description 5
- 239000002071 nanotube Substances 0.000 claims description 525
- 238000000034 method Methods 0.000 claims description 113
- 108020004414 DNA Proteins 0.000 claims description 101
- 239000002777 nucleoside Substances 0.000 claims description 55
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 52
- 238000004458 analytical method Methods 0.000 claims description 39
- 230000033001 locomotion Effects 0.000 claims description 38
- 239000007788 liquid Substances 0.000 claims description 34
- 230000008878 coupling Effects 0.000 claims description 28
- 238000010168 coupling process Methods 0.000 claims description 28
- 238000005859 coupling reaction Methods 0.000 claims description 28
- 229910052751 metal Inorganic materials 0.000 claims description 17
- 239000002184 metal Substances 0.000 claims description 17
- 229910052581 Si3N4 Inorganic materials 0.000 claims description 14
- 229920000642 polymer Polymers 0.000 claims description 14
- 239000011148 porous material Substances 0.000 claims description 14
- HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 claims description 14
- 238000001514 detection method Methods 0.000 claims description 12
- 230000005641 tunneling Effects 0.000 claims description 12
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 9
- 239000012530 fluid Substances 0.000 claims description 8
- 102000040430 polynucleotide Human genes 0.000 claims description 8
- 108091033319 polynucleotide Proteins 0.000 claims description 8
- 239000002109 single walled nanotube Substances 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 6
- 229920001222 biopolymer Polymers 0.000 claims description 5
- 230000008859 change Effects 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 239000004065 semiconductor Substances 0.000 claims description 5
- 238000004891 communication Methods 0.000 claims description 3
- 239000012777 electrically insulating material Substances 0.000 claims description 3
- 230000000903 blocking effect Effects 0.000 claims 1
- 230000005945 translocation Effects 0.000 abstract description 2
- 239000010410 layer Substances 0.000 description 89
- 239000000463 material Substances 0.000 description 69
- 239000003054 catalyst Substances 0.000 description 57
- 102000053602 DNA Human genes 0.000 description 44
- 239000012528 membrane Substances 0.000 description 40
- 238000004519 manufacturing process Methods 0.000 description 37
- 238000000231 atomic layer deposition Methods 0.000 description 36
- 239000010408 film Substances 0.000 description 35
- 238000000151 deposition Methods 0.000 description 32
- 239000002773 nucleotide Substances 0.000 description 29
- 125000003729 nucleotide group Chemical group 0.000 description 29
- 230000008021 deposition Effects 0.000 description 24
- 230000015572 biosynthetic process Effects 0.000 description 21
- 230000000873 masking effect Effects 0.000 description 19
- 238000005259 measurement Methods 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 19
- 238000010884 ion-beam technique Methods 0.000 description 18
- 238000006243 chemical reaction Methods 0.000 description 17
- 239000007789 gas Substances 0.000 description 16
- 239000008151 electrolyte solution Substances 0.000 description 15
- 230000008569 process Effects 0.000 description 14
- 238000005530 etching Methods 0.000 description 13
- 238000007479 molecular analysis Methods 0.000 description 13
- 239000000243 solution Substances 0.000 description 13
- 238000003786 synthesis reaction Methods 0.000 description 13
- 239000002243 precursor Substances 0.000 description 12
- VNWKTOKETHGBQD-UHFFFAOYSA-N methane Chemical compound C VNWKTOKETHGBQD-UHFFFAOYSA-N 0.000 description 11
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 10
- 238000012163 sequencing technique Methods 0.000 description 9
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
- 239000000758 substrate Substances 0.000 description 8
- 238000005520 cutting process Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 238000010894 electron beam technology Methods 0.000 description 7
- 238000011065 in-situ storage Methods 0.000 description 7
- 230000003993 interaction Effects 0.000 description 7
- 239000000178 monomer Substances 0.000 description 7
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 7
- 238000007740 vapor deposition Methods 0.000 description 7
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 6
- 239000011248 coating agent Substances 0.000 description 6
- 238000000576 coating method Methods 0.000 description 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 229920002120 photoresistant polymer Polymers 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 230000007723 transport mechanism Effects 0.000 description 6
- 229910000449 hafnium oxide Inorganic materials 0.000 description 5
- WIHZLLGSGQNAGK-UHFFFAOYSA-N hafnium(4+);oxygen(2-) Chemical compound [O-2].[O-2].[Hf+4] WIHZLLGSGQNAGK-UHFFFAOYSA-N 0.000 description 5
- 102000039446 nucleic acids Human genes 0.000 description 5
- 108020004707 nucleic acids Proteins 0.000 description 5
- 150000007523 nucleic acids Chemical class 0.000 description 5
- 239000002157 polynucleotide Substances 0.000 description 5
- 230000002829 reductive effect Effects 0.000 description 5
- 229910052710 silicon Inorganic materials 0.000 description 5
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 4
- 238000013459 approach Methods 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 238000001459 lithography Methods 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000010703 silicon Substances 0.000 description 4
- 229910018072 Al 2 O 3 Inorganic materials 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 229910003481 amorphous carbon Inorganic materials 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 230000003197 catalytic effect Effects 0.000 description 3
- 230000000295 complement effect Effects 0.000 description 3
- 239000002131 composite material Substances 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000005137 deposition process Methods 0.000 description 3
- 229910003472 fullerene Inorganic materials 0.000 description 3
- 229910002804 graphite Inorganic materials 0.000 description 3
- 239000010439 graphite Substances 0.000 description 3
- 238000009396 hybridization Methods 0.000 description 3
- 239000011810 insulating material Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000003446 ligand Substances 0.000 description 3
- 238000013508 migration Methods 0.000 description 3
- 230000005012 migration Effects 0.000 description 3
- 238000003801 milling Methods 0.000 description 3
- 125000003835 nucleoside group Chemical group 0.000 description 3
- 229910052763 palladium Inorganic materials 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000001020 plasma etching Methods 0.000 description 3
- 239000002356 single layer Substances 0.000 description 3
- 239000012808 vapor phase Substances 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 238000001712 DNA sequencing Methods 0.000 description 2
- 108091006149 Electron carriers Proteins 0.000 description 2
- 108091093037 Peptide nucleic acid Proteins 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229910021607 Silver chloride Inorganic materials 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000002800 charge carrier Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 238000004377 microelectronic Methods 0.000 description 2
- 238000000059 patterning Methods 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000036962 time dependent Effects 0.000 description 2
- 239000011800 void material Substances 0.000 description 2
- 238000001039 wet etching Methods 0.000 description 2
- SDGKUVSVPIIUCF-UHFFFAOYSA-N 2,6-dimethylpiperidine Chemical compound CC1CCCC(C)N1 SDGKUVSVPIIUCF-UHFFFAOYSA-N 0.000 description 1
- WNEODWDFDXWOLU-QHCPKHFHSA-N 3-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-[(2s)-2-methyl-4-(oxetan-3-yl)piperazin-1-yl]pyridin-2-yl]amino]-6-oxopyridin-3-yl]pyridin-2-yl]-7,7-dimethyl-1,2,6,8-tetrahydrocyclopenta[3,4]pyrrolo[3,5-b]pyrazin-4-one Chemical compound C([C@@H](N(CC1)C=2C=NC(NC=3C(N(C)C=C(C=3)C=3C(=C(N4C(C5=CC=6CC(C)(C)CC=6N5CC4)=O)N=CC=3)CO)=O)=CC=2)C)N1C1COC1 WNEODWDFDXWOLU-QHCPKHFHSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- 230000005653 Brownian motion process Effects 0.000 description 1
- 101710158075 Bucky ball Proteins 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 108091028043 Nucleic acid sequence Proteins 0.000 description 1
- 108091005461 Nucleic proteins Proteins 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 238000005411 Van der Waals force Methods 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 230000010062 adhesion mechanism Effects 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 125000000129 anionic group Chemical group 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000005537 brownian motion Methods 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 239000011247 coating layer Substances 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000001312 dry etching Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000000806 elastomer Substances 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000010292 electrical insulation Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000007772 electrode material Substances 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 238000005421 electrostatic potential Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000001502 gel electrophoresis Methods 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 238000012165 high-throughput sequencing Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 230000033444 hydroxylation Effects 0.000 description 1
- 238000005805 hydroxylation reaction Methods 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000001451 molecular beam epitaxy Methods 0.000 description 1
- 230000004001 molecular interaction Effects 0.000 description 1
- 229910021421 monocrystalline silicon Inorganic materials 0.000 description 1
- 239000002105 nanoparticle Substances 0.000 description 1
- 239000002070 nanowire Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 150000004767 nitrides Chemical class 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229910021420 polycrystalline silicon Inorganic materials 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 229920005591 polysilicon Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229910021430 silicon nanotube Inorganic materials 0.000 description 1
- 239000002210 silicon-based material Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000011949 solid catalyst Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 238000004544 sputter deposition Methods 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000001360 synchronised effect Effects 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 229910052715 tantalum Inorganic materials 0.000 description 1
- 238000002207 thermal evaporation Methods 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- JLTRXTDYQLMHGR-UHFFFAOYSA-N trimethylaluminium Chemical compound C[Al](C)C JLTRXTDYQLMHGR-UHFFFAOYSA-N 0.000 description 1
- WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
- 229910052721 tungsten Inorganic materials 0.000 description 1
- 239000010937 tungsten Substances 0.000 description 1
- 238000007704 wet chemistry method Methods 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
- G01N27/44743—Introducing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/762—Nanowire or quantum wire, i.e. axially elongated structure having two dimensions of 100 nm or less
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biophysics (AREA)
- Electrochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Microbiology (AREA)
- Nanotechnology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Dispersion Chemistry (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
【選択図】図1C
Description
65を電気的にバイアスするために第2外部回路52が設けられている。表面に位置するナノチューブ65の端部66,68は、表面に位置するナノチューブ65の電圧をコントロールするために電圧源54が設けられている第2外部回路52に接続されている。第2外部回路52には電流計または他の電流コントロール及び測定デバイス56も含まれ得る。
Claims (55)
- 特性解析しようとする分子を含む液体溶液を収容している第1リザーバー;
特性解析済みの分子を含む液体溶液を収容するための第2リザーバー;
第1リザーバーに流体接続を与える分子入口及び第2リザーバーに流体接続を与える分子出口を有するアパーチャを含む固体状態支持構造物;
第1及び第2電子輸送プローブであって、そのプローブの少なくとも1つはフラーレン構造物からなり、各プローブは支持構造物上に配置されており且つアパーチャの外周に接している表面を有している、プローブ;
電圧バイアスをアパーチャを横切って印加するためのプローブ間に接続されている電圧源;及び
アパーチャを通過する分子の移動に対応するプローブ間の電子輸送の変化をモニターするためにプローブ間に接続されている電流モニター;
を含む分子特性解析デバイス。 - 特性解析しようとする分子が生体分子からなる請求項1に記載の分子特性解析デバイス。
- 分子がポリマー分子からなる請求項1に記載の分子特性解析デバイス。
- 分子がバイオポリマー分子からなる請求項1に記載の分子特性解析デバイス。
- 分子がタンパク質、ポリ核酸、DNA及びRNAからなる群から選択される請求項4に記載の分子特性解析デバイス。
- 特性解析しようとする分子がカーボンナノチューブにカップリングしている分子からなる請求項1に記載の分子特性解析デバイス。
- カーボンナノチューブにカップリングしている分子がカーボンナノチューブにカップリングしているDNAの少なくとも1本の鎖からなる請求項6に記載の分子特性解析デバイス。
- カーボンナノチューブにカップリングしている分子がカーボンナノチューブにカップリングしているRNAの少なくとも1本の鎖からなる請求項6に記載の分子特性解析デバイス。
- 分子がカップリングしているカーボンナノチューブが、該ナノチューブをアパーチャを通って移動させるために片持ち式作動チップに接続されている請求項6に記載の分子特性解析デバイス
- 第1及び第2電子輸送プローブの各々がフラーレン構造物からなる請求項1に記載の分子特性解析デバイス。
- フラーレン構造物がカーボンナノチューブからなる請求項10に記載の分子特性解析デバイス。
- カーボンナノチューブが半導体ナノチューブからなる請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブが金属ナノチューブからなる請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブが単層ナノチューブからなる請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの少なくとも1つが、ナノチューブ端部がアパーチャ外周に接する向きに置かれている請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの各々が、ナノチューブ端部がアパーチャ外周に接する向きに置かれている請求項15に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの少なくとも1つが、ナノチューブ側面がアパーチャ外周に接する向きに置かれている請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの1つが、ナノチューブ端部がアパーチャ外周に接する向きに置かれており、カーボンナノチューブ電子輸送プローブの1つが、ナノチューブ側面がアパーチャ外周に接する向きに置かれている請求項17に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの1つが、第1ナノチューブ端部が分子入口でアパーチャ外周に接する向きに置かれており、第2ナノチューブ端部が分子出口でアパーチャ外周に接する向きに置かれている請求項11に記載の分子特性解析デバイス。
- カーボンナノチューブ電子輸送プローブの少なくとも1つが、分子がアパーチャを通って移動しながらカップリングし得るナノチューブ表面がアパーチャ外周に接する向きに置かれている請求項11に記載の分子特性解析デバイス。
- 分子が、アパーチャを通って移動しながらナノチューブ表面にカップリングし得るヌクレオシド塩基からなる請求項20に記載の分子特性解析デバイス。
- 更に、支持構造物上に配置されており、分子がカップリングし得る表面が分子入口でアパーチャ外周に接している分子移動速度コントロールナノチューブを含む請求項11に記載の分子特性解析デバイス。
- アパーチャが支持構造物の厚さを貫いて延びる細孔からなり、該細孔は一度に1つの分子しかその細孔を通って移動できないくらい十分に小さい直径を有している請求項1に記載の分子特性解析デバイス。
- 細孔が約100nm未満の直径を有するナノ細孔からなる請求項23に記載の分子特性解析デバイス。
- ナノ細孔が約50nm未満の直径を有する請求項24に記載の分子特性解析デバイス。
- ナノ細孔が約20nm未満の直径を有する請求項25に記載の分子特性解析デバイス。
- ナノ細孔が約10nm未満の直径を有する請求項26に記載の分子特性解析デバイス。
- アパーチャが電気絶縁材料層で被覆されている請求項1に記載の分子特性解析デバイス。
- 電子輸送プローブがアパーチャ外周に接している部分を除いて電気絶縁材料層で被覆されている請求項1に記載の分子特性解析デバイス。
- 支持構造物がアパーチャが設けられている電気絶縁膜からなる請求項1に記載の分子特性解析デバイス。
- 膜が窒化ケイ素膜からなる請求項30に記載の分子特性解析デバイス。
- プローブ間に接続されている電流モニターが、アパーチャを通過する分子の移動に対応するプローブ間の電子トンネリングの変調を検出するように構成されている請求項1に記載の分子特性解析デバイス。
- 特性解析しようとする分子−ナノチューブ複合体中のカーボンナノチューブにカップリングしている少なくとも1つの分子を含む液体溶液を収容している第1リザーバー;
特性解析済みの分子−ナノチューブ複合体を含む液体溶液を収容するための第2リザーバー;
第1リザーバーに対して流体接続を与える分子入口及び第2リザーバーに対して流体接続を与える分子出口を有するアパーチャを含む固体状態支持構造物;
アパーチャを通過する分子−ナノチューブ複合体の移動を検出するためのアパーチャに対する電気接続;
を含む分子特性解析デバイス。 - アパーチャに対する電気接続が、分子−ナノチューブ複合体がアパーチャを通って移動するときのアパーチャを通るイオン電流の遮断を検出するように構成されている請求項33に記載の分子特性解析デバイス。
- アパーチャが一度に1つの分子−ナノチューブ複合体しか細孔を通って移動できないくらい十分に小さい直径を有する細孔からなる請求項33に記載の分子特性解析デバイス。
- カーボンナノチューブにカップリングしている分子がタンパク質、ポリ核酸、DNA及びRNAからなる群から選択されるポリマー生体分子からなる請求項33に記載の分子特性解析デバイス。
- アパーチャへの電気接続が、第1及び第2電子輸送プローブからなり、その各プローブがアパーチャの外周に接して支持構造物上に設置されている請求項33に記載の分子特性解析デバイスであって、
更に、電圧バイアスをアパーチャを横切って印加するためにプローブ間に接続されている電圧源、及び
アパーチャを通過する分子−ナノチューブ複合体の移動に対応するプローブ間の電子輸送の変化をモニターするためにプローブ間に接続されている電流モニターを含む、
分子特性解析デバイス。 - 電子輸送プローブの少なくとも1つがフラーレン構造物からなる請求項37に記載の分子特性解析デバイス。
- 電子輸送プローブの各々がカーボンナノチューブからなる請求項38に記載の分子特性解析デバイス。
- 分子を、特性解析しようとする分子を含む液体溶液を収容している第1リザーバーから特性解析済みの分子を含む液体溶液を収容するための第2リザーバーに、支持構造物中のアパーチャを通って移動させ、
分子をカーボンナノチューブの表面にカップリングさせ、
アパーチャの外周にそれぞれ接している2つの電子輸送プローブ間の、アパーチャを通過する分子の移動に対応するアパーチャを横切る電子輸送の変化をモニターする
ことを含む分子特性解析方法。 - 分子がアパーチャを通って移動するときに、分子がカーボンナノチューブの表面にカップリングする、請求項40に記載の方法。
- 分子がカップリングするカーボンナノチューブ表面がアパーチャの外周に接している請求項40に記載の方法。
- 分子がカップリングするカーボンナノチューブ表面が、第1リザーバーと流体接続状態にあるアパーチャへの分子入口でアパーチャの外周に接している請求項40に記載の方法。
- 分子がカップリングするカーボンナノチューブ表面がナノチューブ端部である請求項40に記載の方法。
- 分子をカップリングさせるカーボンナノチューブ表面がナノチューブ側面である請求項40に記載の方法。
- 更に、アパーチャを通過する分子移動速度をコントロールするために液体溶液に対するナノチューブの電圧バイアスを一時的にコントロールすることを含む請求項40に記載の方法。
- 電子輸送プローブの各々がカーボンナノチューブからなる請求項40に記載の方法。
- 分子がDNAヌクレオシド塩基からなり、DNA塩基のカーボンナノチューブ表面へのカップリングがナノチューブ表面に対して塩基を空間的に配向させる請求項40に記載の方法。
- 分子がRNAヌクレオシド塩基からなり、RNA塩基のカーボンナノチューブ表面へのカップリングがナノチューブ表面に対して塩基を空間的に配向させる請求項40に記載の方法。
- 分子のカーボンナノチューブ表面へのカップリングが、まずアパーチャ分子入口でアパーチャ外周に接している第1カーボンナノチューブの表面に分子をカップリングさせ、次いで電子輸送プローブとして構成した第2カーボンナノチューブの表面に分子をカップリングさせることを含む請求項40に記載の方法。
- 分子を液体溶液中のカーボンナノチューブにカップリングさせて、分子−ナノチューブ複合体を形成し;
カップリングさせた分子−ナノチューブ複合体を、特性解析しようとするカップリングさせた分子−ナノチューブ複合体を含む液体溶液を収容する第1リザーバーから特性解析済みの分子−ナノチューブ複合体を含む液体溶液を収容するための第2リザーバーに、支持構造物中のアパーチャを通って移動させ;
アパーチャを通過する分子−ナノチューブ複合体の移動を検出すること
を含む分子特性解析方法。 - 分子−ナノチューブ複合体の移動の検出が、分子−ナノチューブ複合体がアパーチャを通って移動するときのアパーチャを通るイオン電流の遮断の検出を含む請求項51に記載の方法。
- 分子−ナノチューブ複合体の移動の検出が、支持構造物上に配置されており、各々がアパーチャの外周に接する表面を有している2つの電子輸送プローブ間の電子輸送の変化を、電圧バイアスをアパーチャを横切って印加しながらモニターすることを含む請求項51に記載の方法。
- カーボンナノチューブにカップリングさせる分子がタンパク質、ポリ核酸、DNA及びRNAからなる群から選択されるポリマー生体分子からなる請求項51に記載の方法。
- 分子を、特性解析しようとする分子を含む液体溶液を収容する第1リザーバーから特性解析済みの分子を含む液体溶液を収容するための第2リザーバーに、支持構造物中のアパーチャを通って移動させ;
分子をカーボンナノチューブの表面にカップリングさせ;
アパーチャを通過する分子の移動に対応するナノチューブのコンダクタンスの変化をモニターすることを含む
分子特性解析方法。
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66863205P | 2005-04-06 | 2005-04-06 | |
US60/668,632 | 2005-04-06 | ||
US68879905P | 2005-06-09 | 2005-06-09 | |
US60/688,799 | 2005-06-09 | ||
US72760305P | 2005-10-18 | 2005-10-18 | |
US60/727,603 | 2005-10-18 | ||
PCT/US2006/012800 WO2007084163A2 (en) | 2005-04-06 | 2006-04-06 | Molecular characterization with carbon nanotube control |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011174714A Division JP2012021996A (ja) | 2005-04-06 | 2011-08-10 | カーボンナノチューブコントロールを用いる分子特性解析 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2008536124A true JP2008536124A (ja) | 2008-09-04 |
JP2008536124A5 JP2008536124A5 (ja) | 2008-10-30 |
JP4891313B2 JP4891313B2 (ja) | 2012-03-07 |
Family
ID=44569842
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008505513A Active JP4891313B2 (ja) | 2005-04-06 | 2006-04-06 | カーボンナノチューブコントロールを用いる分子特性解析 |
JP2011174714A Pending JP2012021996A (ja) | 2005-04-06 | 2011-08-10 | カーボンナノチューブコントロールを用いる分子特性解析 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011174714A Pending JP2012021996A (ja) | 2005-04-06 | 2011-08-10 | カーボンナノチューブコントロールを用いる分子特性解析 |
Country Status (8)
Country | Link |
---|---|
US (5) | US7468271B2 (ja) |
EP (2) | EP2348300A3 (ja) |
JP (2) | JP4891313B2 (ja) |
CN (2) | CN102183630A (ja) |
AT (1) | ATE529734T1 (ja) |
AU (1) | AU2006336262B2 (ja) |
CA (1) | CA2603352C (ja) |
WO (1) | WO2007084163A2 (ja) |
Cited By (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010540263A (ja) * | 2007-10-02 | 2010-12-24 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | ナノポアデバイスのためのカーボンナノチューブ合成 |
WO2011067961A1 (ja) * | 2009-12-02 | 2011-06-09 | 独立行政法人科学技術振興機構 | 流路デバイス及びそれを含むサンプル処理装置 |
JP2011518047A (ja) * | 2008-03-24 | 2011-06-23 | 本田技研工業株式会社 | 原子間力顕微鏡を利用したナノ構造の堆積のための装置 |
JP2011188851A (ja) * | 2010-03-15 | 2011-09-29 | Internatl Business Mach Corp <Ibm> | ナノポア・デバイスを通るポリマーの動きを能動的に制御するための圧電ベースのナノポア・デバイス |
JP2012026986A (ja) * | 2010-07-28 | 2012-02-09 | Hitachi High-Technologies Corp | ナノポア式分析装置及び試料分析用チャンバ |
JP2012505400A (ja) * | 2008-10-10 | 2012-03-01 | チュンブク ナショナル ユニヴァーシティ インダストリー−アカデミック コーポレイション ファウンデーション | 超高速・高感度のdna塩基序列分析システム及びその分析方法 |
WO2012043109A1 (ja) * | 2010-09-30 | 2012-04-05 | Jsr株式会社 | マイクロアレイ用等の細孔板の製造方法、前記方法に用いられる感光性組成物、マイクロアレイ用等の細孔板およびマイクロアレイ用基板 |
WO2013021815A1 (ja) * | 2011-08-09 | 2013-02-14 | 株式会社日立ハイテクノロジーズ | ナノポア式分析装置 |
JP2013519074A (ja) * | 2010-02-02 | 2013-05-23 | アリゾナ ボード オブ リージェンツ | ポリマーの配列を決定するための制御されたトンネルギャップデバイス |
JP2013156167A (ja) * | 2012-01-30 | 2013-08-15 | Osaka Univ | 物質の移動速度の制御方法および制御装置、並びに、これらの利用 |
WO2014027580A1 (ja) * | 2012-08-17 | 2014-02-20 | 国立大学法人大阪大学 | 試料の分析方法 |
JP2014074599A (ja) * | 2012-10-03 | 2014-04-24 | Hitachi High-Technologies Corp | 分析装置及び分析方法 |
JP2014173935A (ja) * | 2013-03-07 | 2014-09-22 | Toshiba Corp | 半導体マイクロ分析チップ及びその製造方法 |
JP2014529082A (ja) * | 2011-09-28 | 2014-10-30 | コーニンクレッカ フィリップス エヌ ヴェ | 単一分子を処理するための装置 |
JP2015014613A (ja) * | 2009-09-18 | 2015-01-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 高感度分子検出及び分析を可能にする、ナノポアを有するベアの単層グラフェン膜 |
US9194838B2 (en) | 2010-03-03 | 2015-11-24 | Osaka University | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
JP2016522735A (ja) * | 2013-03-15 | 2016-08-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 極短電気パルスによる原子的に薄い膜中のナノ孔の製造 |
US9506894B2 (en) | 2012-12-27 | 2016-11-29 | Quantum Biosystems Inc. | Method for controlling substance moving speed and apparatus for controlling the same |
US9644236B2 (en) | 2013-09-18 | 2017-05-09 | Quantum Biosystems Inc. | Biomolecule sequencing devices, systems and methods |
JP2017123838A (ja) * | 2016-12-14 | 2017-07-20 | クオンタムバイオシステムズ株式会社 | 物質の移動速度の制御方法および制御装置、並びに、これらの利用 |
JP2017227657A (ja) * | 2011-07-27 | 2017-12-28 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | 生体分子を特徴付けるためのナノ細孔センサー |
US10261066B2 (en) | 2013-10-16 | 2019-04-16 | Quantum Biosystems Inc. | Nano-gap electrode pair and method of manufacturing same |
US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
WO2020184482A1 (ja) * | 2019-03-12 | 2020-09-17 | 国立大学法人東北大学 | エンドトキシン検出装置、及びエンドトキシンの検出方法 |
Families Citing this family (189)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20120160687A1 (en) | 1995-03-17 | 2012-06-28 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US6362002B1 (en) * | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US8206568B2 (en) * | 1999-06-22 | 2012-06-26 | President And Fellows Of Harvard College | Material deposition techniques for control of solid state aperture surface properties |
US20100022414A1 (en) | 2008-07-18 | 2010-01-28 | Raindance Technologies, Inc. | Droplet Libraries |
GB0307428D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Compartmentalised combinatorial chemistry |
GB0307403D0 (en) | 2003-03-31 | 2003-05-07 | Medical Res Council | Selection by compartmentalised screening |
US20060078893A1 (en) | 2004-10-12 | 2006-04-13 | Medical Research Council | Compartmentalised combinatorial chemistry by microfluidic control |
US7846738B2 (en) | 2003-08-15 | 2010-12-07 | President And Fellows Of Harvard College | Study of polymer molecules and conformations with a nanopore |
WO2006028508A2 (en) * | 2004-03-23 | 2006-03-16 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
US20050221339A1 (en) | 2004-03-31 | 2005-10-06 | Medical Research Council Harvard University | Compartmentalised screening by microfluidic control |
US7968287B2 (en) | 2004-10-08 | 2011-06-28 | Medical Research Council Harvard University | In vitro evolution in microfluidic systems |
US7435353B2 (en) * | 2004-12-09 | 2008-10-14 | President And Fellows Of Harvard College | Patterning by energetically-stimulated local removal of solid-condensed-gas layers and solid state chemical reactions produced with such layers |
EP2348300A3 (en) * | 2005-04-06 | 2011-10-12 | The President and Fellows of Harvard College | Molecular characterization with carbon nanotube control |
KR100691806B1 (ko) * | 2005-08-04 | 2007-03-12 | 삼성전자주식회사 | 비드 및 나노포어를 이용한 핵산 검출방법 및 검출장치 |
KR100730350B1 (ko) * | 2005-10-17 | 2007-06-19 | 삼성전자주식회사 | 표면처리된 나노포어를 이용한 dna 검출방법 및검출장치 |
EP3913375A1 (en) | 2006-01-11 | 2021-11-24 | Bio-Rad Laboratories, Inc. | Microfluidic devices and methods of use in the formation and control of nanoreactors |
WO2008085183A2 (en) * | 2006-02-07 | 2008-07-17 | President And Fellows Of Harvard College | Gas-phase functionalization of carbon nanotubes |
US8119032B2 (en) | 2006-02-07 | 2012-02-21 | President And Fellows Of Harvard College | Gas-phase functionalization of surfaces including carbon-based surfaces |
US20080003142A1 (en) | 2006-05-11 | 2008-01-03 | Link Darren R | Microfluidic devices |
US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
EP2077912B1 (en) | 2006-08-07 | 2019-03-27 | The President and Fellows of Harvard College | Fluorocarbon emulsion stabilizing surfactants |
US8968545B2 (en) * | 2012-04-02 | 2015-03-03 | Lux Bio Group, Inc. | Apparatus and method for molecular separation, purification, and sensing |
US8003319B2 (en) * | 2007-02-02 | 2011-08-23 | International Business Machines Corporation | Systems and methods for controlling position of charged polymer inside nanopore |
US8772046B2 (en) | 2007-02-06 | 2014-07-08 | Brandeis University | Manipulation of fluids and reactions in microfluidic systems |
US20110005918A1 (en) * | 2007-04-04 | 2011-01-13 | Akeson Mark A | Compositions, devices, systems, and methods for using a nanopore |
US9395352B2 (en) | 2007-04-06 | 2016-07-19 | Arizona Board Of Regents On Behalf Of Arizona State University | Devices and methods for target molecule characterization |
WO2008130623A1 (en) | 2007-04-19 | 2008-10-30 | Brandeis University | Manipulation of fluids, fluid components and reactions in microfluidic systems |
US9121843B2 (en) | 2007-05-08 | 2015-09-01 | Trustees Of Boston University | Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof |
US7709298B2 (en) * | 2007-07-18 | 2010-05-04 | Hewlett-Packard Development Company, L.P. | Selectively altering a predetermined portion or an external member in contact with the predetermined portion |
EP2195648B1 (en) * | 2007-09-12 | 2019-05-08 | President and Fellows of Harvard College | High-resolution molecular graphene sensor comprising an aperture in the graphene layer |
US8278047B2 (en) * | 2007-10-01 | 2012-10-02 | Nabsys, Inc. | Biopolymer sequencing by hybridization of probes to form ternary complexes and variable range alignment |
EP2205765B1 (en) * | 2007-10-02 | 2012-09-12 | President and Fellows of Harvard College | Capture, recapture, and trapping of molecules with a nanopore |
WO2009052214A2 (en) * | 2007-10-15 | 2009-04-23 | Complete Genomics, Inc. | Sequence analysis using decorated nucleic acids |
GB0724736D0 (en) * | 2007-12-19 | 2008-01-30 | Oxford Nanolabs Ltd | Formation of layers of amphiphilic molecules |
US8183648B2 (en) * | 2008-01-25 | 2012-05-22 | Ut-Battelle, Llc | Nanoscopic electrode molecular probes |
WO2009117517A2 (en) * | 2008-03-18 | 2009-09-24 | Arizona Board Of Regents Acting For And On Behalf Of Arizona State University | Nanopore and carbon nanotube based dna sequencer |
WO2009117522A2 (en) * | 2008-03-18 | 2009-09-24 | Reinhart, Kevin | Nanopore and carbon nanotube based dna sequencer and a serial recognition sequencer |
CN102150037B (zh) * | 2008-07-11 | 2014-06-04 | 康奈尔大学 | 集成电荷传感器的纳米流体通道及基于该纳米流体通道的方法 |
US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
US8262879B2 (en) | 2008-09-03 | 2012-09-11 | Nabsys, Inc. | Devices and methods for determining the length of biopolymers and distances between probes bound thereto |
CN102186989B (zh) | 2008-09-03 | 2021-06-29 | 纳伯塞斯2.0有限责任公司 | 用于流体通道中生物分子和其它分析物的电压感测的纵向移位纳米级电极的使用 |
US9650668B2 (en) | 2008-09-03 | 2017-05-16 | Nabsys 2.0 Llc | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
IT1393996B1 (it) * | 2008-09-18 | 2012-05-17 | Univ Degli Studi Genova | Dispositivo di fuga di riferimento per la calibrazione delle perdite |
WO2010037097A1 (en) * | 2008-09-29 | 2010-04-01 | Wentworth Laboratories, Inc. | Probe cards including nanotube probes and methods of fabricating |
WO2010042514A1 (en) | 2008-10-06 | 2010-04-15 | Arizona Board Of Regents | Nanopore and carbon nanotube based dna sequencer and a serial recognition elements |
WO2013154750A1 (en) | 2012-04-10 | 2013-10-17 | The Trustees Of Columbia Unversity In The City Of New York | Systems and methods for biological ion channel interfaces |
WO2010062903A2 (en) * | 2008-11-26 | 2010-06-03 | Board Of Regents, The University Of Texas System | Genomic sequencing using modified protein pores and ionic liquids |
CA2750879C (en) | 2009-01-30 | 2018-05-22 | Oxford Nanopore Technologies Limited | Adaptors for nucleic acid constructs in transmembrane sequencing |
EP2391639A1 (en) | 2009-01-30 | 2011-12-07 | Oxford Nanopore Technologies Limited | Enzyme mutant |
EP3415235A1 (en) | 2009-03-23 | 2018-12-19 | Raindance Technologies Inc. | Manipulation of microfluidic droplets |
GB0905140D0 (en) | 2009-03-25 | 2009-05-06 | Isis Innovation | Method |
US8455260B2 (en) * | 2009-03-27 | 2013-06-04 | Massachusetts Institute Of Technology | Tagged-fragment map assembly |
WO2010111605A2 (en) * | 2009-03-27 | 2010-09-30 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
US9810680B2 (en) * | 2009-04-16 | 2017-11-07 | Nanonex Corporation | Nanogap electronic detector for measuring properties of a biomolecule stretched in a nanochannel, and method thereof |
US8926904B2 (en) | 2009-05-12 | 2015-01-06 | Daniel Wai-Cheong So | Method and apparatus for the analysis and identification of molecules |
US8246799B2 (en) * | 2009-05-28 | 2012-08-21 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
CN102858995B (zh) | 2009-09-10 | 2016-10-26 | 森特瑞隆技术控股公司 | 靶向测序方法 |
US10174368B2 (en) | 2009-09-10 | 2019-01-08 | Centrillion Technology Holdings Corporation | Methods and systems for sequencing long nucleic acids |
AU2010301128B2 (en) | 2009-09-30 | 2014-09-18 | Quantapore, Inc. | Ultrafast sequencing of biological polymers using a labeled nanopore |
EP2486409A1 (en) | 2009-10-09 | 2012-08-15 | Universite De Strasbourg | Labelled silica-based nanomaterial with enhanced properties and uses thereof |
AU2010326349B2 (en) | 2009-12-01 | 2015-10-29 | Oxford Nanopore Technologies Limited | Biochemical analysis instrument |
US10837883B2 (en) | 2009-12-23 | 2020-11-17 | Bio-Rad Laboratories, Inc. | Microfluidic systems and methods for reducing the exchange of molecules between droplets |
US8324914B2 (en) | 2010-02-08 | 2012-12-04 | Genia Technologies, Inc. | Systems and methods for characterizing a molecule |
US9605307B2 (en) | 2010-02-08 | 2017-03-28 | Genia Technologies, Inc. | Systems and methods for forming a nanopore in a lipid bilayer |
US9678055B2 (en) | 2010-02-08 | 2017-06-13 | Genia Technologies, Inc. | Methods for forming a nanopore in a lipid bilayer |
US20120052188A1 (en) | 2010-02-08 | 2012-03-01 | Genia Technologies, Inc. | Systems and methods for assembling a lipid bilayer on a substantially planar solid surface |
US20110192723A1 (en) * | 2010-02-08 | 2011-08-11 | Genia Technologies, Inc. | Systems and methods for manipulating a molecule in a nanopore |
US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
US9366632B2 (en) | 2010-02-12 | 2016-06-14 | Raindance Technologies, Inc. | Digital analyte analysis |
EP3392349A1 (en) | 2010-02-12 | 2018-10-24 | Raindance Technologies, Inc. | Digital analyte analysis |
US8084319B2 (en) * | 2010-02-12 | 2011-12-27 | International Business Machines Corporation | Precisely tuning feature sizes on hard masks via plasma treatment |
US10351905B2 (en) | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
US8603303B2 (en) | 2010-03-15 | 2013-12-10 | International Business Machines Corporation | Nanopore based device for cutting long DNA molecules into fragments |
US8557529B2 (en) | 2010-04-09 | 2013-10-15 | International Business Machines Corporation | Nanopore capture system |
KR101648417B1 (ko) * | 2010-05-14 | 2016-08-16 | 서울대학교산학협력단 | 절연된 박막 전극의 전위 측정을 통한 나노포어 입자 검출기 |
US8828138B2 (en) | 2010-05-17 | 2014-09-09 | International Business Machines Corporation | FET nanopore sensor |
CN103154729B (zh) | 2010-06-08 | 2015-01-07 | 哈佛大学校长及研究员协会 | 具有由石墨烯支持的人工脂质膜的纳米孔装置 |
US8940148B2 (en) | 2010-06-22 | 2015-01-27 | International Business Machines Corporation | Nano-fluidic field effective device to control DNA transport through the same |
US8354336B2 (en) * | 2010-06-22 | 2013-01-15 | International Business Machines Corporation | Forming an electrode having reduced corrosion and water decomposition on surface using an organic protective layer |
US8598018B2 (en) | 2010-06-22 | 2013-12-03 | International Business Machines Corporation | Forming an electrode having reduced corrosion and water decomposition on surface using a custom oxide layer |
US8715933B2 (en) | 2010-09-27 | 2014-05-06 | Nabsys, Inc. | Assay methods using nicking endonucleases |
EP2622103B2 (en) | 2010-09-30 | 2022-11-16 | Bio-Rad Laboratories, Inc. | Sandwich assays in droplets |
WO2012044857A2 (en) * | 2010-09-30 | 2012-04-05 | California Institute Of Technology | Devices and methods for sequencing nucleic acids |
WO2012042226A2 (en) | 2010-10-01 | 2012-04-05 | Oxford Nanopore Technologies Limited | Biochemical analysis apparatus and rotary valve |
JP5998148B2 (ja) | 2010-11-16 | 2016-09-28 | ナブシス 2.0 エルエルシー | ハイブリダイズされたプローブの相対位置を検出することによる生体分子のシークエンシングのための方法 |
CN102169105A (zh) * | 2010-12-22 | 2011-08-31 | 东南大学 | 一种基于石墨烯的纳米孔单分子传感器及其介质辨识方法 |
EP2663862A4 (en) | 2011-01-11 | 2015-01-21 | Univ Columbia | SYSTEMS AND METHODS FOR DETECTION OF A SINGLE MOLECULE USING NANOTUBES |
US8962242B2 (en) * | 2011-01-24 | 2015-02-24 | Genia Technologies, Inc. | System for detecting electrical properties of a molecular complex |
US8986524B2 (en) | 2011-01-28 | 2015-03-24 | International Business Machines Corporation | DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA |
US20120193231A1 (en) | 2011-01-28 | 2012-08-02 | International Business Machines Corporation | Dna sequencing using multiple metal layer structure with organic coatings forming transient bonding to dna bases |
US8852407B2 (en) | 2011-01-28 | 2014-10-07 | International Business Machines Corporation | Electron beam sculpting of tunneling junction for nanopore DNA sequencing |
EP3859011A1 (en) | 2011-02-11 | 2021-08-04 | Bio-Rad Laboratories, Inc. | Methods for forming mixed droplets |
US11274341B2 (en) | 2011-02-11 | 2022-03-15 | NABsys, 2.0 LLC | Assay methods using DNA binding proteins |
EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
CN103380369B (zh) | 2011-02-23 | 2016-12-28 | 纽约市哥伦比亚大学理事会 | 使用纳米孔进行单分子检测的系统和方法 |
WO2012122501A1 (en) * | 2011-03-09 | 2012-09-13 | Arizona Board Of Regents, For And On Behalf Of, Arizona State University | Molecular transistor |
US20120252682A1 (en) | 2011-04-01 | 2012-10-04 | Maples Corporate Services Limited | Methods and systems for sequencing nucleic acids |
US9702849B2 (en) | 2011-04-04 | 2017-07-11 | President And Fellows Of Harvard College | Nanopore sensing by local electrical potential measurement |
US8558326B2 (en) | 2011-04-06 | 2013-10-15 | International Business Machines Corporation | Semiconductor devices having nanochannels confined by nanometer-spaced electrodes |
US8518829B2 (en) * | 2011-04-22 | 2013-08-27 | International Business Machines Corporation | Self-sealed fluidic channels for nanopore array |
US9040311B2 (en) * | 2011-05-03 | 2015-05-26 | International Business Machines Corporation | Calibration assembly for aide in detection of analytes with electromagnetic read-write heads |
US8855957B2 (en) | 2011-05-03 | 2014-10-07 | International Business Machines Corporation | Method for calibrating read sensors of electromagnetic read-write heads |
KR101410127B1 (ko) * | 2011-05-04 | 2014-06-25 | 충북대학교 산학협력단 | 나노채널을 이용한 실시간 분자서열 분석시스템 및 방법 |
WO2012164270A1 (en) | 2011-05-27 | 2012-12-06 | Oxford Nanopore Technologies Limited | Coupling method |
DE202012013668U1 (de) | 2011-06-02 | 2019-04-18 | Raindance Technologies, Inc. | Enzymquantifizierung |
US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
US8546080B2 (en) | 2011-06-17 | 2013-10-01 | International Business Machines Corporation | Molecular dispensers |
KR101910978B1 (ko) * | 2011-06-22 | 2018-10-24 | 삼성전자주식회사 | 나노 센서 및 그의 제조 방법 |
US8658430B2 (en) | 2011-07-20 | 2014-02-25 | Raindance Technologies, Inc. | Manipulating droplet size |
EP2562135A1 (de) * | 2011-08-22 | 2013-02-27 | ETH Zurich | Verfahren zur Herstellung und Ausrichtung von Nanowires und Anwendungen eines solchen Verfahrens |
US8557097B2 (en) | 2011-09-09 | 2013-10-15 | International Business Machines Corporation | Embedding a nanotube inside a nanopore for DNA translocation |
WO2013043545A1 (en) | 2011-09-19 | 2013-03-28 | California Institute Of Technology | Using a field effect device for identifying translocating charge-tagged molecules in a nanopore sequencing device |
WO2013056182A1 (en) * | 2011-10-12 | 2013-04-18 | Devernoe David | Piezoelectric devices and methods |
KR101933619B1 (ko) | 2011-12-26 | 2018-12-31 | 삼성전자주식회사 | 나노포어 소자 및 그 제조 방법, 나노포어 소자를 포함하는 핵산 검출 장치 |
US8986629B2 (en) | 2012-02-27 | 2015-03-24 | Genia Technologies, Inc. | Sensor circuit for controlling, detecting, and measuring a molecular complex |
US20130256139A1 (en) * | 2012-03-30 | 2013-10-03 | International Business Machines Corporation | Functionalized graphene or graphene oxide nanopore for bio-molecular sensing and dna sequencing |
US10029915B2 (en) | 2012-04-04 | 2018-07-24 | International Business Machines Corporation | Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores |
KR20130114435A (ko) | 2012-04-09 | 2013-10-17 | 삼성전자주식회사 | 다수의 전극을 갖는 생분자 검출 장치 |
WO2013158280A1 (en) | 2012-04-20 | 2013-10-24 | The Trustees Of Columbia University In The City Of New York | Systems and methods for single-molecule nucleic-acid assay platforms |
CN103424457B (zh) * | 2012-05-18 | 2016-02-10 | 中国科学院微电子研究所 | 生物传感器及其dna测序方法 |
KR101882865B1 (ko) | 2012-07-03 | 2018-07-27 | 삼성전자주식회사 | 핵산의 염기 서열을 결정하는 방법 |
KR20140012506A (ko) * | 2012-07-20 | 2014-02-03 | 삼성전자주식회사 | 비대칭 전해질 농도를 이용하여 생물분자를 분석하는 방법 |
US8765609B2 (en) | 2012-07-25 | 2014-07-01 | Power Integrations, Inc. | Deposit/etch for tapered oxide |
US8702940B2 (en) | 2012-07-27 | 2014-04-22 | International Business Machines Corporation | Increased molecule capture rate into a nanopore |
JP6033602B2 (ja) * | 2012-08-08 | 2016-11-30 | 株式会社日立ハイテクノロジーズ | 生体分子検出方法、生体分子検出装置、および分析用デバイス |
US10876157B2 (en) * | 2012-09-27 | 2020-12-29 | The Trustees Of The University Of Pennsylvania | Insulated nanoelectrode-nanopore devices and related methods |
WO2014105246A2 (en) | 2012-10-05 | 2014-07-03 | Massachusetts Institute Of Technology | Nanofluidic sorting system for gene synthesis and pcr reaction products |
US9274430B2 (en) | 2012-10-10 | 2016-03-01 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and devices for molecule sensing and method of manufacturing thereof |
US9651539B2 (en) | 2012-10-28 | 2017-05-16 | Quantapore, Inc. | Reducing background fluorescence in MEMS materials by low energy ion beam treatment |
US8968582B2 (en) | 2012-11-12 | 2015-03-03 | International Business Machines Corporation | Device for electrical characterization of molecules using CNT-nanoparticle-molecule-nanoparticle-CNT structure |
US8963215B2 (en) | 2012-11-30 | 2015-02-24 | International Business Machines Corporation | Integrated carbon nanotube field effect transistor and nanochannel for sequencing |
US9914966B1 (en) | 2012-12-20 | 2018-03-13 | Nabsys 2.0 Llc | Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation |
EP2956550B1 (en) | 2013-01-18 | 2020-04-08 | Nabsys 2.0 LLC | Enhanced probe binding |
US9759711B2 (en) | 2013-02-05 | 2017-09-12 | Genia Technologies, Inc. | Nanopore arrays |
CN103193189B (zh) * | 2013-02-21 | 2015-08-26 | 东南大学 | 一种用于dna检测的多电极纳米孔装置及其制造方法 |
US9046511B2 (en) | 2013-04-18 | 2015-06-02 | International Business Machines Corporation | Fabrication of tunneling junction for nanopore DNA sequencing |
US9541541B2 (en) | 2013-04-30 | 2017-01-10 | Globalfoundries Inc. | Nanopore device for drug-like molecule screening or lead optimization to a targeted protein |
US9372171B2 (en) | 2013-04-30 | 2016-06-21 | International Business Machines Corporation | Nanopore sensor for detecting molecular interactions |
US8890121B1 (en) | 2013-05-06 | 2014-11-18 | International Business Machines Corporation | Integrated nanowire/nanosheet nanogap and nanopore for DNA and RNA sequencing |
CN105283560B (zh) | 2013-05-24 | 2018-11-30 | 昆塔波尔公司 | 基于纳米孔的通过混合的fret检测的核酸分析 |
US9182369B2 (en) | 2013-06-19 | 2015-11-10 | Globalfoundries Inc. | Manufacturable sub-3 nanometer palladium gap devices for fixed electrode tunneling recognition |
US9188578B2 (en) | 2013-06-19 | 2015-11-17 | Globalfoundries Inc. | Nanogap device with capped nanowire structures |
US10041930B2 (en) * | 2013-06-28 | 2018-08-07 | Globalfoundries Inc. | Tunneling junction to distinguish targeted DNA segment |
EP3042187A4 (en) * | 2013-08-27 | 2017-09-13 | Quantum Biosystems Inc. | Nano-gap electrode and methods for manufacturing same |
US9371561B2 (en) | 2013-08-30 | 2016-06-21 | Globalfoundries Inc. | DNA sequencing using a suspended carbon nanotube |
CA2924021A1 (en) * | 2013-09-13 | 2015-03-19 | The Regents Of The University Of Colorado, A Body Corporate | Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications |
US11901041B2 (en) | 2013-10-04 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Digital analysis of nucleic acid modification |
US9551697B2 (en) | 2013-10-17 | 2017-01-24 | Genia Technologies, Inc. | Non-faradaic, capacitively coupled measurement in a nanopore cell array |
US9944977B2 (en) | 2013-12-12 | 2018-04-17 | Raindance Technologies, Inc. | Distinguishing rare variations in a nucleic acid sequence from a sample |
US11193176B2 (en) | 2013-12-31 | 2021-12-07 | Bio-Rad Laboratories, Inc. | Method for detecting and quantifying latent retroviral RNA species |
GB201406155D0 (en) | 2014-04-04 | 2014-05-21 | Oxford Nanopore Tech Ltd | Method |
US10336713B2 (en) | 2014-02-27 | 2019-07-02 | Arizona Board Of Regents, Acting For And On Behalf Of, Arizona State University | Triazole-based reader molecules and methods for synthesizing and use thereof |
US10344324B2 (en) * | 2014-03-26 | 2019-07-09 | International Business Machines Corporation | Electrical trapping and stretching of charged biomolecules by single electrode gating structure |
US10337060B2 (en) | 2014-04-04 | 2019-07-02 | Oxford Nanopore Technologies Ltd. | Method for characterising a double stranded nucleic acid using a nano-pore and anchor molecules at both ends of said nucleic acid |
CN106471359A (zh) * | 2014-04-28 | 2017-03-01 | 量子生物有限公司 | 纳米间隙电极装置和系统及其形成方法 |
WO2015170782A1 (en) | 2014-05-08 | 2015-11-12 | Osaka University | Devices, systems and methods for linearization of polymers |
WO2016057829A1 (en) | 2014-10-10 | 2016-04-14 | Quantapore, Inc. | Nanopore-based polymer analysis with mutually-quenching fluorescent labels |
GB201418469D0 (en) | 2014-10-17 | 2014-12-03 | Oxford Nanopore Tech Ltd | Method |
US9624537B2 (en) | 2014-10-24 | 2017-04-18 | Quantapore, Inc. | Efficient optical analysis of polymers using arrays of nanostructures |
AU2015361032A1 (en) * | 2014-12-01 | 2017-06-29 | Cornell University | Nanopore-containing substrates with aligned nanoscale electronic elements and methods of making and using same |
CN107223074B (zh) * | 2014-12-08 | 2019-10-18 | 伯克利之光生命科技公司 | 包含横向/纵向晶体管结构的微流体装置及其制造和使用方法 |
WO2016094294A1 (en) | 2014-12-08 | 2016-06-16 | The Regents Of The University Of Colorado | Quantum molecular sequencing (qm-seq): identification of unique nanoelectronic tunneling spectroscopy fingerprints for dna, rna, and single nucleotide modifications |
CN112816679B (zh) * | 2015-02-05 | 2024-05-28 | 哈佛大学校长及研究员协会 | 一种用于感测分子穿过纳米孔的移位的方法 |
DE102015205435B4 (de) * | 2015-03-25 | 2023-02-16 | Robert Bosch Gmbh | Sequenziervorrichtung und Verfahren zum Betreiben einer Sequenziervorrichtung |
US10647981B1 (en) | 2015-09-08 | 2020-05-12 | Bio-Rad Laboratories, Inc. | Nucleic acid library generation methods and compositions |
CA3002886A1 (en) * | 2015-10-21 | 2017-04-27 | F. Hoffmann-La Roche Ag | Use of fluoropolymers as a hydrophobic layer to support lipid bilayer formation for nanopore based dna sequencing |
GB201610190D0 (en) * | 2016-06-10 | 2016-07-27 | Univ Leiden | Structure |
CN106092409A (zh) * | 2016-06-13 | 2016-11-09 | 常州大学 | 利用光学快速测量dna分子间作用力的方法 |
WO2018009346A1 (en) | 2016-07-05 | 2018-01-11 | Quantapore, Inc. | Optically based nanopore sequencing |
US10507053B2 (en) * | 2016-07-15 | 2019-12-17 | I.C. Medical, Inc. | Ultrapolar electrosurgery blade assembly and ultrapolar electrosurgery pencil with argon beam capability |
EP3519097A4 (en) | 2016-10-03 | 2020-04-29 | Genvida Technology Company Limited | METHOD AND DEVICE FOR ANALYZING AND IDENTIFYING MOLECULES |
US10641726B2 (en) | 2017-02-01 | 2020-05-05 | Seagate Technology Llc | Fabrication of a nanochannel for DNA sequencing using electrical plating to achieve tunneling electrode gap |
US10640827B2 (en) | 2017-02-01 | 2020-05-05 | Seagate Technology Llc | Fabrication of wedge shaped electrode for enhanced DNA sequencing using tunneling current |
US10889857B2 (en) | 2017-02-01 | 2021-01-12 | Seagate Technology Llc | Method to fabricate a nanochannel for DNA sequencing based on narrow trench patterning process |
US10731210B2 (en) | 2017-02-01 | 2020-08-04 | Seagate Technology Llc | Fabrication of nanochannel with integrated electrodes for DNA sequencing using tunneling current |
US10752947B2 (en) | 2017-03-09 | 2020-08-25 | Seagate Technology Llc | Method to amplify transverse tunneling current discrimination of DNA nucleotides via nucleotide site specific attachment of dye-peptide |
US10830721B2 (en) * | 2017-04-28 | 2020-11-10 | Palo Alto Research Center Incorporated | Metal nanoparticle-decorated nanotubes for gas sensing |
WO2019006214A1 (en) | 2017-06-29 | 2019-01-03 | President And Fellows Of Harvard College | DETERMINISTIC PROGRESSION OF POLYMERS THROUGH A NANOPORE |
JPWO2020013256A1 (ja) * | 2018-07-11 | 2021-07-15 | アイポア株式会社 | 流路、流路の製造方法、電極構造体、および、電極構造体の製造方法 |
GB201811623D0 (en) | 2018-07-16 | 2018-08-29 | Univ Oxford Innovation Ltd | Molecular hopper |
CN109455662B (zh) * | 2018-11-26 | 2020-07-03 | 广东工业大学 | 一种固态纳米孔结构 |
GB201821155D0 (en) | 2018-12-21 | 2019-02-06 | Oxford Nanopore Tech Ltd | Method |
CN109852678A (zh) * | 2019-03-01 | 2019-06-07 | 天津大学 | 基于碳纳米管和单链dna缠绕结构的dna测序方法 |
US20220347749A1 (en) * | 2019-05-02 | 2022-11-03 | The Board Of Trustees Of The University Of Illinois | Atomic-to-nanoscale matter emission / flow regulation device |
US20200393407A1 (en) * | 2019-06-13 | 2020-12-17 | University Of Kentucky Research Foundation | Cross-gap-nanopore heterostructure device and method for identifying chemical substance |
CN111398137B (zh) * | 2020-04-02 | 2022-07-05 | 武汉生之源生物科技股份有限公司 | 一种基于电阻微米孔颗粒计数器的检测方法及其应用 |
US11892445B2 (en) * | 2021-12-08 | 2024-02-06 | Western Digital Technologies, Inc. | Devices, systems, and methods of using smart fluids to control translocation speed through a nanopore |
US11946894B2 (en) * | 2022-02-16 | 2024-04-02 | Western Digital Technologies, Inc. | Low noise amplifiers with feedback for nanopore applications |
US11940404B2 (en) | 2022-02-16 | 2024-03-26 | Western Digital Technologies, Inc. | Low noise amplifiers with shields for nanopore Applications |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003531592A (ja) * | 2000-04-24 | 2003-10-28 | イーグル リサーチ アンド ディベロップメント,リミティッド ライアビリティー カンパニー | 超高速の核酸配列決定のための電界効果トランジスタ装置 |
JP2003533676A (ja) * | 2000-04-24 | 2003-11-11 | イーグル リサーチ アンド ディベロップメント,リミティッド ライアビリティー カンパニー | 超高速の核酸配列決定のための電界効果トランジスタ装置 |
WO2004035211A1 (en) * | 2002-10-15 | 2004-04-29 | Advanced Research Corporation | Solid state membrane channel device for the measurement and characterization of atomic and molecular sized samples |
WO2004050967A1 (en) * | 2002-12-03 | 2004-06-17 | Motorola Inc | Linkage of nanomorphic carbon to a nucleic acid |
JP2004233356A (ja) * | 2003-01-27 | 2004-08-19 | Agilent Technol Inc | ナノポアを通って移動するバイオポリマーの識別装置及び方法 |
Family Cites Families (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57182449A (en) | 1981-05-07 | 1982-11-10 | Fuji Xerox Co Ltd | Forming method of ink jet multinozzle |
US4728591A (en) | 1986-03-07 | 1988-03-01 | Trustees Of Boston University | Self-assembled nanometer lithographic masks and templates and method for parallel fabrication of nanometer scale multi-device structures |
EP0244496B1 (de) | 1986-05-06 | 1991-01-16 | Ibm Deutschland Gmbh | Maske für die Ionen-, Elektronen- oder Röntgenstrahllithographie und Verfahren zur ihrer Herstellung |
JP2753306B2 (ja) | 1988-03-18 | 1998-05-20 | 株式会社日立製作所 | イオンビーム加工方法及び集束イオンビーム装置 |
US5420067A (en) | 1990-09-28 | 1995-05-30 | The United States Of America As Represented By The Secretary Of The Navy | Method of fabricatring sub-half-micron trenches and holes |
US5683547A (en) | 1990-11-21 | 1997-11-04 | Hitachi, Ltd. | Processing method and apparatus using focused energy beam |
US5242537A (en) | 1991-04-30 | 1993-09-07 | The United States Of America As Represented By The Secretary Of The Navy | Ion beam etching of metal oxide ceramics |
TW284911B (ja) | 1992-08-18 | 1996-09-01 | At & T Corp | |
NL9401260A (nl) | 1993-11-12 | 1995-06-01 | Cornelis Johannes Maria Van Ri | Membraan voor microfiltratie, ultrafiltratie, gasscheiding en katalyse, werkwijze ter vervaardiging van een dergelijk membraan, mal ter vervaardiging van een dergelijk membraan, alsmede diverse scheidingssystemen omvattende een dergelijk membraan. |
US5798042A (en) | 1994-03-07 | 1998-08-25 | Regents Of The University Of California | Microfabricated filter with specially constructed channel walls, and containment well and capsule constructed with such filters |
US5893974A (en) | 1994-03-07 | 1999-04-13 | Regents Of University Of California | Microfabricated capsules for immunological isolation of cell transplants |
US5795782A (en) | 1995-03-17 | 1998-08-18 | President & Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
US6362002B1 (en) | 1995-03-17 | 2002-03-26 | President And Fellows Of Harvard College | Characterization of individual polymer molecules based on monomer-interface interactions |
SE9502258D0 (sv) | 1995-06-21 | 1995-06-21 | Pharmacia Biotech Ab | Method for the manufacture of a membrane-containing microstructure |
US5888591A (en) | 1996-05-06 | 1999-03-30 | Massachusetts Institute Of Technology | Chemical vapor deposition of fluorocarbon polymer thin films |
GB9609815D0 (en) | 1996-05-10 | 1996-07-17 | Scient Generics Ltd | Denaturation of double-stranded nucleic acids |
US6346189B1 (en) | 1998-08-14 | 2002-02-12 | The Board Of Trustees Of The Leland Stanford Junior University | Carbon nanotube structures made using catalyst islands |
US6200893B1 (en) | 1999-03-11 | 2001-03-13 | Genus, Inc | Radical-assisted sequential CVD |
US6333016B1 (en) | 1999-06-02 | 2001-12-25 | The Board Of Regents Of The University Of Oklahoma | Method of producing carbon nanotubes |
EP1059266A3 (en) | 1999-06-11 | 2000-12-20 | Iljin Nanotech Co., Ltd. | Mass synthesis method of high purity carbon nanotubes vertically aligned over large-size substrate using thermal chemical vapor deposition |
US6361861B2 (en) | 1999-06-14 | 2002-03-26 | Battelle Memorial Institute | Carbon nanotubes on a substrate |
US7582490B2 (en) | 1999-06-22 | 2009-09-01 | President And Fellows Of Harvard College | Controlled fabrication of gaps in electrically conducting structures |
US6783643B2 (en) | 1999-06-22 | 2004-08-31 | President And Fellows Of Harvard College | Control of solid state dimensional features |
US8206568B2 (en) | 1999-06-22 | 2012-06-26 | President And Fellows Of Harvard College | Material deposition techniques for control of solid state aperture surface properties |
US6464842B1 (en) | 1999-06-22 | 2002-10-15 | President And Fellows Of Harvard College | Control of solid state dimensional features |
JP2003502166A (ja) | 1999-06-22 | 2003-01-21 | プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | 固体状態の次元的特徴の制御 |
US7118657B2 (en) | 1999-06-22 | 2006-10-10 | President And Fellows Of Harvard College | Pulsed ion beam control of solid state features |
US6544463B1 (en) | 1999-07-26 | 2003-04-08 | The Trustees Of The University Of Pennsylvania | Hybrid materials and methods for producing the same |
US6696022B1 (en) | 1999-08-13 | 2004-02-24 | U.S. Genomics, Inc. | Methods and apparatuses for stretching polymers |
US6297063B1 (en) | 1999-10-25 | 2001-10-02 | Agere Systems Guardian Corp. | In-situ nano-interconnected circuit devices and method for making the same |
US6897009B2 (en) | 1999-11-29 | 2005-05-24 | Trustees Of The University Of Pennsylvania | Fabrication of nanometer size gaps on an electrode |
JP2003517604A (ja) | 1999-12-15 | 2003-05-27 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | カーボンナノチューブデバイス |
EP1149932A3 (en) | 2000-01-26 | 2003-09-10 | Iljin Nanotech Co., Ltd. | Thermal chemical vapor deposition apparatus and method of synthesizing carbon nanotubes using the same |
EP2261240B1 (en) | 2000-02-11 | 2015-09-02 | The Texas A & M University System | Biosensor compositions and methods of use |
IT1317842B1 (it) | 2000-02-18 | 2003-07-15 | Attilio Citterio | Procedimenti di modifica superficiale della silice per elettroforesicapillare e cromatografia. |
US7001792B2 (en) | 2000-04-24 | 2006-02-21 | Eagle Research & Development, Llc | Ultra-fast nucleic acid sequencing device and a method for making and using the same |
KR100360476B1 (ko) * | 2000-06-27 | 2002-11-08 | 삼성전자 주식회사 | 탄소나노튜브를 이용한 나노 크기 수직 트랜지스터 및 그제조방법 |
GB2364933B (en) * | 2000-07-18 | 2002-12-31 | Lg Electronics Inc | Method of horizontally growing carbon nanotubes |
AU2001286655A1 (en) | 2000-08-24 | 2002-03-04 | William Marsh Rice University | Polymer-wrapped single wall carbon nanotubes |
US6566983B2 (en) | 2000-09-02 | 2003-05-20 | Lg Electronics Inc. | Saw filter using a carbon nanotube and method for manufacturing the same |
AU2001294876A1 (en) | 2000-09-29 | 2002-04-08 | President And Fellows Of Harvard College | Direct growth of nanotubes, and their use in nanotweezers |
US6355561B1 (en) | 2000-11-21 | 2002-03-12 | Micron Technology, Inc. | ALD method to improve surface coverage |
KR100362377B1 (ko) | 2000-12-05 | 2002-11-23 | 한국전자통신연구원 | 탄소 나노 튜브를 이용한 전계 방출 소자 및 그 제조 방법 |
US6423583B1 (en) | 2001-01-03 | 2002-07-23 | International Business Machines Corporation | Methodology for electrically induced selective breakdown of nanotubes |
US6958216B2 (en) | 2001-01-10 | 2005-10-25 | The Trustees Of Boston College | DNA-bridged carbon nanotube arrays |
US6939579B2 (en) | 2001-03-07 | 2005-09-06 | Asm International N.V. | ALD reactor and method with controlled wall temperature |
WO2002080360A1 (en) | 2001-03-30 | 2002-10-10 | California Institute Of Technology | Pattern-aligned carbon nanotube growth and tunable resonator apparatus |
US20020172767A1 (en) | 2001-04-05 | 2002-11-21 | Leonid Grigorian | Chemical vapor deposition growth of single-wall carbon nanotubes |
JP2002340538A (ja) * | 2001-05-14 | 2002-11-27 | Matsushita Electric Ind Co Ltd | 薄板材の平坦度測定装置および方法 |
DE10123876A1 (de) | 2001-05-16 | 2002-11-28 | Infineon Technologies Ag | Nanoröhren-Anordnung und Verfahren zum Herstellen einer Nanoröhren-Anordnung |
JP3948223B2 (ja) | 2001-05-30 | 2007-07-25 | 株式会社日立製作所 | 遺伝子配列の読み取り装置 |
US6706402B2 (en) | 2001-07-25 | 2004-03-16 | Nantero, Inc. | Nanotube films and articles |
US6919592B2 (en) | 2001-07-25 | 2005-07-19 | Nantero, Inc. | Electromechanical memory array using nanotube ribbons and method for making same |
US6643165B2 (en) | 2001-07-25 | 2003-11-04 | Nantero, Inc. | Electromechanical memory having cell selection circuitry constructed with nanotube technology |
US6982165B2 (en) | 2001-09-24 | 2006-01-03 | Intel Corporation | Nucleic acid sequencing by raman monitoring of molecular deconstruction |
US6911260B2 (en) | 2002-01-11 | 2005-06-28 | Trustees Of Boston College | Reinforced carbon nanotubes |
US20040132070A1 (en) | 2002-01-16 | 2004-07-08 | Nanomix, Inc. | Nonotube-based electronic detection of biological molecules |
US6894359B2 (en) | 2002-09-04 | 2005-05-17 | Nanomix, Inc. | Sensitivity control for nanotube sensors |
US20030148289A1 (en) | 2002-02-04 | 2003-08-07 | Intel Corporation | Modified carbon nanotubes as molecular labels with application to DNA sequencing |
US6891227B2 (en) | 2002-03-20 | 2005-05-10 | International Business Machines Corporation | Self-aligned nanotube field effect transistor and method of fabricating same |
US7476501B2 (en) | 2002-03-26 | 2009-01-13 | Intel Corporation | Methods and device for DNA sequencing using surface enhanced raman scattering (SERS) |
US20040038260A1 (en) | 2002-04-18 | 2004-02-26 | Imedd, Inc. | Nanopump device for analyzing DNA sequences |
US7744816B2 (en) * | 2002-05-01 | 2010-06-29 | Intel Corporation | Methods and device for biomolecule characterization |
US6689674B2 (en) | 2002-05-07 | 2004-02-10 | Motorola, Inc. | Method for selective chemical vapor deposition of nanotubes |
US6919002B2 (en) | 2002-05-17 | 2005-07-19 | Agilent Technologies, Inc. | Nanopore system using nanotubes and C60 molecules |
US7005264B2 (en) | 2002-05-20 | 2006-02-28 | Intel Corporation | Method and apparatus for nucleic acid sequencing and identification |
JP4974263B2 (ja) | 2002-05-20 | 2012-07-11 | 富士通株式会社 | 半導体装置の製造方法 |
AU2002951274A0 (en) | 2002-08-30 | 2002-09-19 | Commonwealth Scientific And Industrial Research Organisation | Methods for the chemical and physical modification of nanotubes, methods for linking the nanotubes, methods for the directed positioning of nanotubes, and uses thereof |
WO2004028673A1 (en) * | 2002-09-25 | 2004-04-08 | Gesellschaft Fuer Schwerionenforschung Mbh | Nanodevice for controlled charged particle flow and method for producing same |
US7135728B2 (en) | 2002-09-30 | 2006-11-14 | Nanosys, Inc. | Large-area nanoenabled macroelectronic substrates and uses therefor |
US20040144972A1 (en) | 2002-10-04 | 2004-07-29 | Hongjie Dai | Carbon nanotube circuits with high-kappa dielectrics |
JP5025132B2 (ja) * | 2002-10-29 | 2012-09-12 | プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | カーボンナノチューブ素子の製造 |
US7253434B2 (en) | 2002-10-29 | 2007-08-07 | President And Fellows Of Harvard College | Suspended carbon nanotube field effect transistor |
DE10250984A1 (de) | 2002-10-29 | 2004-05-19 | Hahn-Meitner-Institut Berlin Gmbh | Feldeffekttransistor sowie Verfahren zu seiner Herstellung |
DE10250829B4 (de) | 2002-10-31 | 2006-11-02 | Infineon Technologies Ag | Nichtflüchtige Speicherzelle, Speicherzellen-Anordnung und Verfahren zum Herstellen einer nichtflüchtigen Speicherzelle |
US7374649B2 (en) | 2002-11-21 | 2008-05-20 | E. I. Du Pont De Nemours And Company | Dispersion of carbon nanotubes by nucleic acids |
US7898005B2 (en) * | 2002-12-09 | 2011-03-01 | The Regents Of The University Of California | Inorganic nanotubes and electro-fluidic devices fabricated therefrom |
US20040200734A1 (en) | 2002-12-19 | 2004-10-14 | Co Man Sung | Nanotube-based sensors for biomolecules |
US6870361B2 (en) * | 2002-12-21 | 2005-03-22 | Agilent Technologies, Inc. | System with nano-scale conductor and nano-opening |
US7282130B2 (en) | 2003-01-31 | 2007-10-16 | Agilent Technologies, Inc. | Apparatus and method for control of biopolymer translocation through a nanopore |
WO2004077503A2 (en) * | 2003-02-03 | 2004-09-10 | President And Fellows Of Harvard College | Controlled fabrication of gaps in electrically conducting structures |
NL1022855C2 (nl) | 2003-03-05 | 2004-09-07 | Univ Delft Tech | Werkwijze en inrichting voor het gecontroleerd vervaardigen van openingen op nanometerschaal. |
ITTO20030425A1 (it) | 2003-06-06 | 2004-12-07 | St Microelectronics Srl | Dispositivo interruttore elettrico a comando ottico basato su nanotubi di carbonio e sistema interruttore elettrico utilizzante tale dispositivo interruttore. |
JP4130385B2 (ja) | 2003-07-23 | 2008-08-06 | 独立行政法人科学技術振興機構 | ゲスト分子を内包した単層カーボンナノチューブの製造方法 |
US7625840B2 (en) | 2003-09-17 | 2009-12-01 | Uchicago Argonne, Llc. | Catalytic nanoporous membranes |
US20050164211A1 (en) | 2004-01-22 | 2005-07-28 | Hannah Eric C. | Carbon nanotube molecular labels |
WO2006028508A2 (en) * | 2004-03-23 | 2006-03-16 | President And Fellows Of Harvard College | Methods and apparatus for characterizing polynucleotides |
DE112005000688T5 (de) | 2004-03-26 | 2007-03-22 | Forster-Miller, Inc., Waltham | Durch elektrolytische Abscheidung auf Basis von Kohlenstoffnanoröhren hergestellte elektronische Bauteile und Anwendungen davon |
US7312155B2 (en) | 2004-04-07 | 2007-12-25 | Intel Corporation | Forming self-aligned nano-electrodes |
US20060073489A1 (en) | 2004-10-05 | 2006-04-06 | Gangqiang Li | Nanopore separation devices and methods of using same |
US7473943B2 (en) | 2004-10-15 | 2009-01-06 | Nanosys, Inc. | Gate configuration for nanowire electronic devices |
US7435353B2 (en) | 2004-12-09 | 2008-10-14 | President And Fellows Of Harvard College | Patterning by energetically-stimulated local removal of solid-condensed-gas layers and solid state chemical reactions produced with such layers |
US7524431B2 (en) | 2004-12-09 | 2009-04-28 | President And Fellows Of Harvard College | Lift-off patterning processing employing energetically-stimulated local removal of solid-condensed-gas layers |
EP2348300A3 (en) * | 2005-04-06 | 2011-10-12 | The President and Fellows of Harvard College | Molecular characterization with carbon nanotube control |
US7625702B2 (en) * | 2005-12-20 | 2009-12-01 | International Business Machines Corporation | Helical wrapping of single-walled carbon nanotubes by genomic DNA |
WO2008085183A2 (en) | 2006-02-07 | 2008-07-17 | President And Fellows Of Harvard College | Gas-phase functionalization of carbon nanotubes |
US20070275396A1 (en) * | 2006-03-17 | 2007-11-29 | Ming Zheng | Detection of DNA hybridization with a carbon nanotube label |
AU2008307486B2 (en) * | 2007-10-02 | 2014-08-14 | President And Fellows Of Harvard College | Carbon nanotube synthesis for nanopore devices |
EP2205765B1 (en) | 2007-10-02 | 2012-09-12 | President and Fellows of Harvard College | Capture, recapture, and trapping of molecules with a nanopore |
US8986928B2 (en) * | 2009-04-10 | 2015-03-24 | Pacific Biosciences Of California, Inc. | Nanopore sequencing devices and methods |
US8864969B2 (en) * | 2009-06-25 | 2014-10-21 | The Board Of Trustees Of The Leland Stanford Junior University | Electro-diffusion enhanced bio-molecule charge detection using electrostatic interaction |
CA2855824C (en) * | 2011-11-14 | 2021-07-20 | The Regents Of The University Of California | Device for polymer sequencing through a nanopore by measuring iconic current and methods thereof |
-
2006
- 2006-04-06 EP EP11004003A patent/EP2348300A3/en not_active Withdrawn
- 2006-04-06 US US11/399,663 patent/US7468271B2/en active Active
- 2006-04-06 AT AT06849305T patent/ATE529734T1/de not_active IP Right Cessation
- 2006-04-06 EP EP06849305A patent/EP1877762B1/en active Active
- 2006-04-06 WO PCT/US2006/012800 patent/WO2007084163A2/en active Application Filing
- 2006-04-06 CA CA2603352A patent/CA2603352C/en active Active
- 2006-04-06 CN CN2011100264059A patent/CN102183630A/zh active Pending
- 2006-04-06 JP JP2008505513A patent/JP4891313B2/ja active Active
- 2006-04-06 AU AU2006336262A patent/AU2006336262B2/en active Active
- 2006-04-06 CN CN2006800201574A patent/CN101203740B/zh active Active
-
2008
- 2008-06-11 US US12/157,570 patent/US7803607B2/en active Active
- 2008-06-16 US US12/214,046 patent/US8092697B2/en active Active
-
2011
- 2011-03-04 US US13/040,537 patent/US9274097B2/en active Active
- 2011-08-10 JP JP2011174714A patent/JP2012021996A/ja active Pending
-
2016
- 2016-01-22 US US15/004,248 patent/US10228348B2/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2003531592A (ja) * | 2000-04-24 | 2003-10-28 | イーグル リサーチ アンド ディベロップメント,リミティッド ライアビリティー カンパニー | 超高速の核酸配列決定のための電界効果トランジスタ装置 |
JP2003533676A (ja) * | 2000-04-24 | 2003-11-11 | イーグル リサーチ アンド ディベロップメント,リミティッド ライアビリティー カンパニー | 超高速の核酸配列決定のための電界効果トランジスタ装置 |
WO2004035211A1 (en) * | 2002-10-15 | 2004-04-29 | Advanced Research Corporation | Solid state membrane channel device for the measurement and characterization of atomic and molecular sized samples |
WO2004050967A1 (en) * | 2002-12-03 | 2004-06-17 | Motorola Inc | Linkage of nanomorphic carbon to a nucleic acid |
JP2004233356A (ja) * | 2003-01-27 | 2004-08-19 | Agilent Technol Inc | ナノポアを通って移動するバイオポリマーの識別装置及び方法 |
Cited By (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010540263A (ja) * | 2007-10-02 | 2010-12-24 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | ナノポアデバイスのためのカーボンナノチューブ合成 |
JP2011518047A (ja) * | 2008-03-24 | 2011-06-23 | 本田技研工業株式会社 | 原子間力顕微鏡を利用したナノ構造の堆積のための装置 |
JP2012505400A (ja) * | 2008-10-10 | 2012-03-01 | チュンブク ナショナル ユニヴァーシティ インダストリー−アカデミック コーポレイション ファウンデーション | 超高速・高感度のdna塩基序列分析システム及びその分析方法 |
JP2015014613A (ja) * | 2009-09-18 | 2015-01-22 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 高感度分子検出及び分析を可能にする、ナノポアを有するベアの単層グラフェン膜 |
WO2011067961A1 (ja) * | 2009-12-02 | 2011-06-09 | 独立行政法人科学技術振興機構 | 流路デバイス及びそれを含むサンプル処理装置 |
JP4932066B2 (ja) * | 2009-12-02 | 2012-05-16 | 独立行政法人科学技術振興機構 | 流路デバイス及びそれを含むサンプル処理装置 |
JP2012137492A (ja) * | 2009-12-02 | 2012-07-19 | Japan Science & Technology Agency | 流路デバイス |
US9114402B2 (en) | 2009-12-02 | 2015-08-25 | Japan Science And Technology Agency | Channel device and sample treatment apparatus including the same |
JPWO2011067961A1 (ja) * | 2009-12-02 | 2013-04-18 | 独立行政法人科学技術振興機構 | 流路デバイス及びそれを含むサンプル処理装置 |
JP2013519074A (ja) * | 2010-02-02 | 2013-05-23 | アリゾナ ボード オブ リージェンツ | ポリマーの配列を決定するための制御されたトンネルギャップデバイス |
US10444220B2 (en) | 2010-02-02 | 2019-10-15 | Arizona Board Of Regents On Behalf Of Arizona State University | Controlled tunnel gap device for sequencing polymers |
US9810681B2 (en) | 2010-02-02 | 2017-11-07 | Arizona Board Of Regents On Behalf Of Arizona State University | Controlled tunnel gap device for sequencing polymers |
US9194838B2 (en) | 2010-03-03 | 2015-11-24 | Osaka University | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
US10876159B2 (en) | 2010-03-03 | 2020-12-29 | Quantum Biosystems Inc. | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
US10202644B2 (en) | 2010-03-03 | 2019-02-12 | Quantum Biosystems Inc. | Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide |
JP2011188851A (ja) * | 2010-03-15 | 2011-09-29 | Internatl Business Mach Corp <Ibm> | ナノポア・デバイスを通るポリマーの動きを能動的に制御するための圧電ベースのナノポア・デバイス |
JP2012026986A (ja) * | 2010-07-28 | 2012-02-09 | Hitachi High-Technologies Corp | ナノポア式分析装置及び試料分析用チャンバ |
WO2012043109A1 (ja) * | 2010-09-30 | 2012-04-05 | Jsr株式会社 | マイクロアレイ用等の細孔板の製造方法、前記方法に用いられる感光性組成物、マイクロアレイ用等の細孔板およびマイクロアレイ用基板 |
JPWO2012043109A1 (ja) * | 2010-09-30 | 2014-02-06 | Jsr株式会社 | マイクロアレイ用等の細孔板の製造方法、前記方法に用いられる感光性組成物、マイクロアレイ用等の細孔板およびマイクロアレイ用基板 |
JP5682627B2 (ja) * | 2010-09-30 | 2015-03-11 | Jsr株式会社 | マイクロアレイ用等の細孔板の製造方法、前記方法に用いられる感光性組成物、マイクロアレイ用等の細孔板およびマイクロアレイ用基板 |
US11698359B2 (en) | 2011-07-27 | 2023-07-11 | The Board Of Trustees Of The University Of Illinois | Nanopore sensors for biomolecular characterization |
JP2017227657A (ja) * | 2011-07-27 | 2017-12-28 | ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ イリノイ | 生体分子を特徴付けるためのナノ細孔センサー |
WO2013021815A1 (ja) * | 2011-08-09 | 2013-02-14 | 株式会社日立ハイテクノロジーズ | ナノポア式分析装置 |
JP2013036865A (ja) * | 2011-08-09 | 2013-02-21 | Hitachi High-Technologies Corp | ナノポア式分析装置 |
US10222348B2 (en) | 2011-08-09 | 2019-03-05 | Hitachi High-Technologies Corporation | Nanopore-based analysis device |
US10281453B2 (en) | 2011-09-28 | 2019-05-07 | Koninklijke Philips N.V. | Apparatus for the processing of single molecules |
JP2014529082A (ja) * | 2011-09-28 | 2014-10-30 | コーニンクレッカ フィリップス エヌ ヴェ | 単一分子を処理するための装置 |
JP2013156167A (ja) * | 2012-01-30 | 2013-08-15 | Osaka Univ | 物質の移動速度の制御方法および制御装置、並びに、これらの利用 |
WO2014027580A1 (ja) * | 2012-08-17 | 2014-02-20 | 国立大学法人大阪大学 | 試料の分析方法 |
US9535033B2 (en) | 2012-08-17 | 2017-01-03 | Quantum Biosystems Inc. | Sample analysis method |
JPWO2014027580A1 (ja) * | 2012-08-17 | 2016-07-25 | クオンタムバイオシステムズ株式会社 | 試料の分析方法 |
JP2014074599A (ja) * | 2012-10-03 | 2014-04-24 | Hitachi High-Technologies Corp | 分析装置及び分析方法 |
US9506894B2 (en) | 2012-12-27 | 2016-11-29 | Quantum Biosystems Inc. | Method for controlling substance moving speed and apparatus for controlling the same |
JP2014173935A (ja) * | 2013-03-07 | 2014-09-22 | Toshiba Corp | 半導体マイクロ分析チップ及びその製造方法 |
JP2016522735A (ja) * | 2013-03-15 | 2016-08-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 極短電気パルスによる原子的に薄い膜中のナノ孔の製造 |
US10557167B2 (en) | 2013-09-18 | 2020-02-11 | Quantum Biosystems Inc. | Biomolecule sequencing devices, systems and methods |
US9644236B2 (en) | 2013-09-18 | 2017-05-09 | Quantum Biosystems Inc. | Biomolecule sequencing devices, systems and methods |
US10261066B2 (en) | 2013-10-16 | 2019-04-16 | Quantum Biosystems Inc. | Nano-gap electrode pair and method of manufacturing same |
US10466228B2 (en) | 2013-10-16 | 2019-11-05 | Quantum Biosystems Inc. | Nano-gap electrode pair and method of manufacturing same |
US10438811B1 (en) | 2014-04-15 | 2019-10-08 | Quantum Biosystems Inc. | Methods for forming nano-gap electrodes for use in nanosensors |
JP2017123838A (ja) * | 2016-12-14 | 2017-07-20 | クオンタムバイオシステムズ株式会社 | 物質の移動速度の制御方法および制御装置、並びに、これらの利用 |
WO2020184482A1 (ja) * | 2019-03-12 | 2020-09-17 | 国立大学法人東北大学 | エンドトキシン検出装置、及びエンドトキシンの検出方法 |
JP6795245B1 (ja) * | 2019-03-12 | 2020-12-02 | 国立大学法人東北大学 | エンドトキシン検出装置、及びエンドトキシンの検出方法 |
CN113508285A (zh) * | 2019-03-12 | 2021-10-15 | 国立大学法人东北大学 | 内毒素检测装置、及内毒素的检测方法 |
US11460437B2 (en) | 2019-03-12 | 2022-10-04 | Tohoku University | Endotoxin detection device and endotoxin detection method |
Also Published As
Publication number | Publication date |
---|---|
US7468271B2 (en) | 2008-12-23 |
CN102183630A (zh) | 2011-09-14 |
EP1877762B1 (en) | 2011-10-19 |
EP2348300A3 (en) | 2011-10-12 |
EP2348300A2 (en) | 2011-07-27 |
EP1877762A2 (en) | 2008-01-16 |
US20080257859A1 (en) | 2008-10-23 |
US20160139079A1 (en) | 2016-05-19 |
ATE529734T1 (de) | 2011-11-15 |
WO2007084163A2 (en) | 2007-07-26 |
US20110155574A1 (en) | 2011-06-30 |
CA2603352C (en) | 2013-10-01 |
US20080171316A1 (en) | 2008-07-17 |
US10228348B2 (en) | 2019-03-12 |
US8092697B2 (en) | 2012-01-10 |
JP2012021996A (ja) | 2012-02-02 |
CA2603352A1 (en) | 2007-07-26 |
AU2006336262A1 (en) | 2007-07-26 |
US20080248561A1 (en) | 2008-10-09 |
JP4891313B2 (ja) | 2012-03-07 |
CN101203740A (zh) | 2008-06-18 |
AU2006336262B2 (en) | 2011-10-13 |
CN101203740B (zh) | 2011-03-23 |
US9274097B2 (en) | 2016-03-01 |
WO2007084163A3 (en) | 2008-03-06 |
US7803607B2 (en) | 2010-09-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4891313B2 (ja) | カーボンナノチューブコントロールを用いる分子特性解析 | |
EP1433744B1 (en) | System with nano-scale conductor and nano-opening | |
US11959904B2 (en) | Nanopore sensing with a fluidic passage | |
US7238594B2 (en) | Controlled nanowire growth in permanent, integrated nano-templates and methods of fabricating sensor and transducer structures | |
EP2205522B1 (en) | Carbon nanotube synthesis for nanopore devices | |
EP2195648B1 (en) | High-resolution molecular graphene sensor comprising an aperture in the graphene layer | |
US20090142472A1 (en) | Methods of fabrication employing nanoscale mandrels | |
US8592225B2 (en) | Array-based bioactivated nanopore devices | |
US20050007002A1 (en) | Carbon nanotube device fabrication | |
WO2007066954A1 (en) | Fet based sensor for detecting biomolecule, method for preparing the same, and method for detecting biomolecule using the fet based sensor | |
WO2009117517A2 (en) | Nanopore and carbon nanotube based dna sequencer | |
WO2012073009A2 (en) | Nanopore devices |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080908 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20081209 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110510 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110810 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20111122 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20111215 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4891313 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20141222 Year of fee payment: 3 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |