JP2008531755A5 - - Google Patents
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- JP2008531755A5 JP2008531755A5 JP2007550450A JP2007550450A JP2008531755A5 JP 2008531755 A5 JP2008531755 A5 JP 2008531755A5 JP 2007550450 A JP2007550450 A JP 2007550450A JP 2007550450 A JP2007550450 A JP 2007550450A JP 2008531755 A5 JP2008531755 A5 JP 2008531755A5
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- Prior art keywords
- skeleton
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- composition
- compound
- cancer
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- 239000000203 mixture Substances 0.000 claims 28
- 150000001875 compounds Chemical class 0.000 claims 25
- 239000002738 chelating agent Substances 0.000 claims 20
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- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims 17
- 239000003446 ligand Substances 0.000 claims 15
- 230000008685 targeting Effects 0.000 claims 13
- 230000001225 therapeutic effect Effects 0.000 claims 13
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- 229910021645 metal ion Inorganic materials 0.000 claims 7
- -1 DOTA-MA Chemical compound 0.000 claims 6
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- UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 2
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- 102000009151 Luteinizing Hormone Human genes 0.000 claims 2
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- MXNRLFUSFKVQSK-QMMMGPOBSA-O N(6),N(6),N(6)-trimethyl-L-lysine Chemical compound C[N+](C)(C)CCCC[C@H]([NH3+])C([O-])=O MXNRLFUSFKVQSK-QMMMGPOBSA-O 0.000 claims 2
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 2
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- 102000004338 Transferrin Human genes 0.000 claims 2
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- 230000006907 apoptotic process Effects 0.000 claims 2
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- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
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- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 2
- 229910003472 fullerene Inorganic materials 0.000 claims 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N glucosamine group Chemical group OC1[C@H](N)[C@@H](O)[C@H](O)[C@H](O1)CO MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims 2
- 239000008103 glucose Substances 0.000 claims 2
- 229940022353 herceptin Drugs 0.000 claims 2
- 230000007954 hypoxia Effects 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
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- 239000000463 material Substances 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- 125000004437 phosphorous atom Chemical group 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- 229960003581 pyridoxal Drugs 0.000 claims 2
- 235000008164 pyridoxal Nutrition 0.000 claims 2
- 239000011674 pyridoxal Substances 0.000 claims 2
- JWVCLYRUEFBMGU-UHFFFAOYSA-N quinazoline Chemical compound N1=CN=CC2=CC=CC=C21 JWVCLYRUEFBMGU-UHFFFAOYSA-N 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
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- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 2
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- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 claims 2
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- YJGVMLPVUAXIQN-LGWHJFRWSA-N (5s,5ar,8ar,9r)-5-hydroxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[5,6-f][1,3]benzodioxol-8-one Chemical compound COC1=C(OC)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O)[C@@H]3[C@@H]2C(OC3)=O)=C1 YJGVMLPVUAXIQN-LGWHJFRWSA-N 0.000 claims 1
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- MDAXKAUIABOHTD-UHFFFAOYSA-N 1,4,8,11-tetraazacyclotetradecane Chemical group C1CNCCNCCCNCCNC1 MDAXKAUIABOHTD-UHFFFAOYSA-N 0.000 claims 1
- VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 claims 1
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- BNBQQYFXBLBYJK-UHFFFAOYSA-N 2-pyridin-2-yl-1,3-oxazole Chemical class C1=COC(C=2N=CC=CC=2)=N1 BNBQQYFXBLBYJK-UHFFFAOYSA-N 0.000 claims 1
- GDUPEBYNYVOFRE-UHFFFAOYSA-N 3h-dithiole;phosphane Chemical compound P.P.C1SSC=C1 GDUPEBYNYVOFRE-UHFFFAOYSA-N 0.000 claims 1
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- STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 claims 1
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-
2006
- 2006-01-05 AU AU2006204045A patent/AU2006204045B2/en not_active Ceased
- 2006-01-05 JP JP2007550450A patent/JP2008531755A/ja active Pending
- 2006-01-05 CN CN200680005698XA patent/CN101137398B/zh not_active Expired - Lifetime
- 2006-01-05 EP EP06733616A patent/EP1846042A2/en not_active Withdrawn
- 2006-01-05 BR BRPI0606395-0A patent/BRPI0606395A2/pt not_active IP Right Cessation
- 2006-01-05 KR KR1020077018015A patent/KR101313712B1/ko not_active Expired - Lifetime
- 2006-01-05 US US11/326,117 patent/US8147805B2/en active Active
- 2006-01-05 CA CA002593256A patent/CA2593256A1/en not_active Abandoned
- 2006-01-05 WO PCT/US2006/000269 patent/WO2006074272A2/en not_active Ceased
-
2007
- 2007-07-04 IL IL184415A patent/IL184415A0/en unknown
- 2007-08-03 NO NO20074025A patent/NO20074025L/no not_active Application Discontinuation
-
2011
- 2011-01-13 AU AU2011200132A patent/AU2011200132B2/en not_active Expired
-
2012
- 2012-04-03 US US13/438,641 patent/US20120276005A1/en not_active Abandoned
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