PL2721045T3 - Kompozycie, metody syntezy i zastosowanie węglowodanowych środków ukierunkowanych - Google Patents
Kompozycie, metody syntezy i zastosowanie węglowodanowych środków ukierunkowanychInfo
- Publication number
- PL2721045T3 PL2721045T3 PL12803364T PL12803364T PL2721045T3 PL 2721045 T3 PL2721045 T3 PL 2721045T3 PL 12803364 T PL12803364 T PL 12803364T PL 12803364 T PL12803364 T PL 12803364T PL 2721045 T3 PL2721045 T3 PL 2721045T3
- Authority
- PL
- Poland
- Prior art keywords
- synthesis
- compositions
- methods
- targeted agents
- carbohydrate
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/0472—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/06—Benzopyran radicals
- C07H17/065—Benzo[b]pyrans
- C07H17/07—Benzo[b]pyran-4-ones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161498950P | 2011-06-20 | 2011-06-20 | |
| EP12803364.4A EP2721045B1 (en) | 2011-06-20 | 2012-06-20 | Compositions, methods of synthesis and use of carbohydrate targeted agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL2721045T3 true PL2721045T3 (pl) | 2017-11-30 |
Family
ID=47423183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL12803364T PL2721045T3 (pl) | 2011-06-20 | 2012-06-20 | Kompozycie, metody syntezy i zastosowanie węglowodanowych środków ukierunkowanych |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9550001B2 (pl) |
| EP (1) | EP2721045B1 (pl) |
| CA (1) | CA2843313C (pl) |
| DK (1) | DK2721045T3 (pl) |
| PL (1) | PL2721045T3 (pl) |
| WO (1) | WO2012177701A2 (pl) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008119036A2 (en) * | 2007-03-27 | 2008-10-02 | Radiomedix Inc. | Compositions for targeted imaging and therapy |
| EP2721045B1 (en) | 2011-06-20 | 2017-04-12 | Radiomedix Inc. | Compositions, methods of synthesis and use of carbohydrate targeted agents |
| GB201300707D0 (en) * | 2013-01-15 | 2013-02-27 | Novartis Ag | Compounds and processes |
| EP3140657A4 (en) * | 2014-05-09 | 2017-12-13 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Method and compositions for orally administered contrast agents for mr imaging |
| CN109562185A (zh) | 2016-06-02 | 2019-04-02 | 赛诺菲 | 药剂与能够结合葡萄糖感应蛋白的部分的新颖缀合物 |
| GB201610738D0 (en) * | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| AU2018207190B2 (en) | 2017-01-12 | 2020-12-03 | Orano Med | Treatment of cancer cells overexpressing somatostatin receptors using ocreotide derivatives chelated to radioisotopes |
| US10093741B1 (en) | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
| RU2019139432A (ru) | 2017-05-05 | 2021-06-07 | Сентр фор Проуб Девелопмент энд Коммерсиализэйшн | Фармакокинетическая оптимизация бифункциональных хелатов и их применение |
| JP7191938B2 (ja) | 2017-05-05 | 2022-12-19 | センター・フォー・プローブ・デベロップメント・アンド・コマーシャライゼイション | Ｉｇｆ－１ｒモノクローナル抗体及びその使用 |
| CN111433193A (zh) | 2017-12-01 | 2020-07-17 | 赛诺菲 | 药剂和能够结合至葡萄糖传感蛋白的部分的新型缀合物 |
| RU2730507C1 (ru) * | 2019-08-27 | 2020-08-24 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Соединение для диагностики опухолей, экспрессирующих псма, и композиция на его основе |
| CN114853827B (zh) * | 2022-06-02 | 2023-11-24 | 南京江原安迪科正电子研究发展有限公司 | 一种葡萄糖衍生配体化合物及其制备方法和应用 |
| CN116655715B (zh) * | 2023-07-27 | 2023-10-20 | 北京炫景瑞医药科技有限公司 | 一种GalNAc衍生物、缀合物、组合物以及它们的用途 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4141654A (en) | 1977-05-23 | 1979-02-27 | James V. Massey, III | Standard for calibrating and/or verifying instrument accuracy |
| US5648063A (en) | 1981-07-24 | 1997-07-15 | Schering Aktiengesellschaft | Sterile composition comprising a chelate complex for magnetic resonance imaging |
| US5175343A (en) | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5242679A (en) | 1985-01-14 | 1993-09-07 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US4988496A (en) | 1988-05-31 | 1991-01-29 | Neorx Corporation | Metal radionuclide chelating compounds for improved chelation kinetics |
| ZA894792B (en) | 1988-06-24 | 1991-04-24 | Dow Chemical Co | Macrocyclic bifunctional chelants,complexes thereof and their antibody conjugates |
| US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| US5605672A (en) | 1993-06-09 | 1997-02-25 | The General Hospital Corporation | Blood pool imaging composition and method of its use |
| FR2725382B1 (fr) * | 1994-10-05 | 1997-01-03 | Commissariat Energie Atomique | Polyazacycloalcanes, complexes tri-, tetra- ou pentaazamacrocycliques, procede de fabrication de ces polyazacycloalcanes substitues ou non et greffes sur un support et utilisations des polyazacycloalcanes |
| US5980862A (en) | 1995-06-02 | 1999-11-09 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US6770261B2 (en) | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
| US5707605A (en) * | 1995-06-02 | 1998-01-13 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US5739313A (en) | 1995-11-13 | 1998-04-14 | Regents Of The University Of Minnesota | Radionuclide labeling of vitamin B12 and coenzymes thereof |
| IT1284046B1 (it) | 1996-06-21 | 1998-05-08 | Bracco Spa | Processo per la preparazione di tetraazamacrocicli |
| US20040170563A1 (en) | 1997-10-27 | 2004-09-02 | Meade Thomas J. | Magnetic resonance imaging agents for the delivery of therapeutic agents |
| AU752812B2 (en) | 1997-11-17 | 2002-10-03 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| US6071490A (en) | 1998-05-07 | 2000-06-06 | Immunomedics, Inc. | Position emission tomography using gallium-68 chelates |
| EP1148878A4 (en) | 1999-01-26 | 2003-04-02 | Fox Chase Cancer Ct | 1,4,8,11-TETRAAZA-CYCLOTETRADECANE DERIVATIVES AS RADIODIAGNOSTICS AND THE USE THEREOF FOR DETERMINING HYPOXIA AND RADIOR RESISTANCE OF TUMORS |
| US6692724B1 (en) | 1999-10-25 | 2004-02-17 | Board Of Regents, The University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
| US6565828B2 (en) | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
| US6673333B1 (en) * | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| EP2316494A1 (en) | 2000-06-02 | 2011-05-04 | Board Of Regents, The University Of Texas | Ethylenedicysteine (EC)-neomycin conjugates and their use in tissue specific disease imaging |
| US6641797B2 (en) | 2000-08-11 | 2003-11-04 | Schering Aktiengesellschaft | Perfluoroalkyl-containing complexes with sugar radicals, process for their production and their use |
| AU2002220082A1 (en) | 2000-10-19 | 2002-04-29 | The General Hospital Corporation | Imaging of enzymatic activity |
| JP2004537573A (ja) | 2001-08-08 | 2004-12-16 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | 心臓灌流およびビトロネクチン受容体を標的とするイメージング剤の同時イメージング |
| AU2003230750A1 (en) | 2002-03-29 | 2003-10-13 | Threshold Pharmaceuticals, Inc. | Compositions and methods for treating cancer |
| US20050232866A1 (en) * | 2004-03-26 | 2005-10-20 | Alerion Biomedical Inc. | Biochemically-activated contrast agents for magnetic resonance imaging |
| WO2006026855A1 (en) | 2004-09-07 | 2006-03-16 | Triumf, Operating As A Joint Venture By The Governors Of The University Of Alberta, The University Of British Columbia, Carleton | Synthesis of radiolabeled sugar metal complexes |
| JP2008531755A (ja) | 2005-01-05 | 2008-08-14 | ボード オブ リージェンツ， ザ ユニバーシティ オブ テキサス システム | 二重画像化および放射線化学療法のためのコンジュゲート：組成物、製造および適応 |
| US20060275217A1 (en) | 2005-05-06 | 2006-12-07 | Caravan Peter D | Chemical exchange saturation transfer contrast agents |
| US8845999B2 (en) | 2005-05-23 | 2014-09-30 | The Regents Of The University Of California | Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease |
| US8097237B2 (en) | 2005-08-23 | 2012-01-17 | Stc.Unm | Non-invasive diagnostic agents of cancer and methods of diagnosing cancer, especially leukemia and lymphoma |
| US8758723B2 (en) | 2006-04-19 | 2014-06-24 | The Board Of Regents Of The University Of Texas System | Compositions and methods for cellular imaging and therapy |
| US7586102B2 (en) | 2006-08-14 | 2009-09-08 | Board Of Regents The University Of Texas System | Automated system for formulating radiopharmaceuticals |
| US7842280B2 (en) | 2006-09-06 | 2010-11-30 | Case Western Reserve University | Flexibly labeling peptides |
| WO2008119036A2 (en) * | 2007-03-27 | 2008-10-02 | Radiomedix Inc. | Compositions for targeted imaging and therapy |
| WO2009054327A1 (ja) * | 2007-10-22 | 2009-04-30 | Osaka Foundation For Trade And Industry | Ｍｒｉ用プローブ |
| US20100316566A1 (en) | 2008-02-27 | 2010-12-16 | Radiomedix Inc. | Radiolabeled hedgehog derivatives for imaging and therapy |
| CA2738786C (en) * | 2008-09-30 | 2017-12-19 | Mallinckrodt Inc. | A version of fdg detectable by single-photon emission computed tomography |
| WO2011049961A2 (en) * | 2009-10-19 | 2011-04-28 | Case Western Reserve University | Compositions and methods for imaging cells |
| EP2721045B1 (en) | 2011-06-20 | 2017-04-12 | Radiomedix Inc. | Compositions, methods of synthesis and use of carbohydrate targeted agents |
| CA2903994C (en) | 2013-03-15 | 2017-08-22 | Philip S. Low | Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors |
-
2012
- 2012-06-20 EP EP12803364.4A patent/EP2721045B1/en not_active Not-in-force
- 2012-06-20 WO PCT/US2012/043255 patent/WO2012177701A2/en active Application Filing
- 2012-06-20 PL PL12803364T patent/PL2721045T3/pl unknown
- 2012-06-20 DK DK12803364.4T patent/DK2721045T3/en active
- 2012-06-20 US US14/128,347 patent/US9550001B2/en active Active
- 2012-06-20 CA CA2843313A patent/CA2843313C/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP2721045A4 (en) | 2014-11-12 |
| US9550001B2 (en) | 2017-01-24 |
| CA2843313C (en) | 2018-02-13 |
| DK2721045T3 (en) | 2017-07-24 |
| US20140228551A1 (en) | 2014-08-14 |
| CA2843313A1 (en) | 2012-12-27 |
| WO2012177701A2 (en) | 2012-12-27 |
| WO2012177701A3 (en) | 2013-05-10 |
| EP2721045B1 (en) | 2017-04-12 |
| EP2721045A2 (en) | 2014-04-23 |
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