BRPI0621580B8 - composto derivado de n4 e kit compreendendo o referido composto e um agente redutor - Google Patents

composto derivado de n4 e kit compreendendo o referido composto e um agente redutor

Info

Publication number
BRPI0621580B8
BRPI0621580B8 BRPI0621580A BRPI0621580A BRPI0621580B8 BR PI0621580 B8 BRPI0621580 B8 BR PI0621580B8 BR PI0621580 A BRPI0621580 A BR PI0621580A BR PI0621580 A BRPI0621580 A BR PI0621580A BR PI0621580 B8 BRPI0621580 B8 BR PI0621580B8
Authority
BR
Brazil
Prior art keywords
compound
kit
reducing agent
derived
imaging
Prior art date
Application number
BRPI0621580A
Other languages
English (en)
Inventor
Azhdarinia Ali
Sok Oh Chang
J Yang David
Yu Dong-Fang
Kohanim Saady
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Publication of BRPI0621580A2 publication Critical patent/BRPI0621580A2/pt
Publication of BRPI0621580B1 publication Critical patent/BRPI0621580B1/pt
Publication of BRPI0621580B8 publication Critical patent/BRPI0621580B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0493—Steroids, e.g. cholesterol, testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System

Abstract

composições e métodos para imagem celular e terapia. a presente invenção está relacionada geralmente aos campos de química e imagem radionuclídea. mais particularmente, trata de composições, kits, e métodos para imagem e terapia envolvendo compostos e derivados de n4.
BRPI0621580A 2006-04-19 2006-05-04 composto derivado de n4 e kit compreendendo o referido composto e um agente redutor BRPI0621580B8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US74514806P 2006-04-19 2006-04-19
US60/745.148 2006-04-19
US60/745,148 2006-04-19
PCT/US2006/016784 WO2007120153A1 (en) 2006-04-19 2006-05-04 Compositions and methods for cellular imaging and therapy

Publications (3)

Publication Number Publication Date
BRPI0621580A2 BRPI0621580A2 (pt) 2011-05-10
BRPI0621580B1 BRPI0621580B1 (pt) 2021-05-11
BRPI0621580B8 true BRPI0621580B8 (pt) 2021-05-25

Family

ID=38609808

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0621580A BRPI0621580B8 (pt) 2006-04-19 2006-05-04 composto derivado de n4 e kit compreendendo o referido composto e um agente redutor

Country Status (13)

Country Link
EP (1) EP2013221B1 (pt)
JP (1) JP2009534381A (pt)
KR (2) KR101653182B1 (pt)
CN (1) CN101516899B (pt)
AU (1) AU2006342202C1 (pt)
BR (1) BRPI0621580B8 (pt)
CA (1) CA2649869C (pt)
DK (1) DK2013221T3 (pt)
ES (1) ES2544244T3 (pt)
HK (1) HK1123306A1 (pt)
IL (1) IL194826A (pt)
NO (1) NO341574B1 (pt)
WO (1) WO2007120153A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8758723B2 (en) * 2006-04-19 2014-06-24 The Board Of Regents Of The University Of Texas System Compositions and methods for cellular imaging and therapy
EP2114461A2 (en) * 2007-01-19 2009-11-11 Mallinckrodt Inc. Diagnostic and therapeutic cyclooxygenase-2 binding ligands
US9585841B2 (en) 2013-10-22 2017-03-07 Tyme, Inc. Tyrosine derivatives and compositions comprising them
JPWO2015152128A1 (ja) * 2014-03-31 2017-04-13 長瀬産業株式会社 アミノ酸前駆体、アミノ酸およびその製造方法、ならびに該アミノ酸を用いたｐｅｔ診断用トレーサー
GB201417067D0 (en) 2014-09-26 2014-11-12 South African Nuclear Energy Radiopharmaceutical conjugate
CA3045110A1 (en) * 2016-11-30 2018-06-07 Tyme, Inc. Tyrosine derivatives and compositions comprising them
EP3654971A4 (en) * 2017-07-18 2021-04-21 Vyripharm Enterprises, LLC COMPOSITIONS CONTAINING CONJUGATES OF CANNABINOID ANALOGUES AND ASSOCIATED PROCEDURES FOR USE
US11090395B2 (en) 2018-09-14 2021-08-17 SeeCure Taiwan Co., Ltd. Composition for cross talk between estrogen receptors and cannabinoid receptors
WO2020232227A1 (en) 2019-05-14 2020-11-19 Tyme, Inc. Compositions and methods for treating cancer
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
US11554184B2 (en) 2021-03-26 2023-01-17 Vyripharm Enterprises, Inc. Synthetic cannabinoid combination therapy compositions and methods for personalized and targeted therapies including the treatment of infectious diseases
CN117088825A (zh) * 2023-10-12 2023-11-21 成都威斯津生物医药科技有限公司 一种可离子化脂质、含该可离子化脂质的药物组合物及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4988496A (en) * 1988-05-31 1991-01-29 Neorx Corporation Metal radionuclide chelating compounds for improved chelation kinetics
US5650133A (en) * 1990-01-19 1997-07-22 Nycomed Salutar Macrocyclic polyaza dichelates linked through ring nitrogens via an amide or ester functionality
US5684149A (en) * 1993-01-22 1997-11-04 Research Foundation Of State University Of New York Metal complexes for promoting catalytic cleavage of RNA by transesterification
US6770261B2 (en) * 1995-06-02 2004-08-03 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
AU2371400A (en) * 1998-12-18 2000-07-03 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6673333B1 (en) * 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
ES2221903T3 (es) * 2000-05-12 2005-01-16 University Hospital Agentes pro-quelantes para la preparacion de moleculas marcadas con metales radiactivos que tienen propiedades biologicas mejoradas.
RU2311413C2 (ru) * 2000-09-29 2007-11-27 Анормед, Инк. Циклические полиамины, содержащие в кольце n атомов азота, защищенных по принципу "все, кроме одного (n-1)", и способы их получения
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
WO2003086475A1 (en) * 2002-04-12 2003-10-23 A & D Bioscience, Inc. Conjugates comprising cancer cell specific ligands, a sugar and diagnostic agents, and uses thereof
WO2004062574A2 (en) * 2003-01-13 2004-07-29 Bracco Imaging S.P.A. Improved linkers for radiopharmaceutical compounds
KR101313712B1 (ko) * 2005-01-05 2013-10-01 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 이중 영상화 및 방사선화학요법용 접합체: 조성물,제조방법 및 적용

Also Published As

Publication number Publication date
IL194826A (en) 2013-08-29
EP2013221A1 (en) 2009-01-14
NO341574B1 (no) 2017-12-04
CN101516899A (zh) 2009-08-26
ES2544244T3 (es) 2015-08-28
BRPI0621580B1 (pt) 2021-05-11
NO20084821L (no) 2009-01-16
DK2013221T3 (en) 2015-09-28
CN101516899B (zh) 2016-07-06
HK1123306A1 (en) 2009-06-12
CA2649869A1 (en) 2007-10-25
IL194826A0 (en) 2009-08-03
CA2649869C (en) 2014-11-18
EP2013221A4 (en) 2010-12-15
EP2013221B1 (en) 2015-06-24
AU2006342202C1 (en) 2013-09-26
WO2007120153A1 (en) 2007-10-25
AU2006342202A1 (en) 2007-10-25
KR20140099557A (ko) 2014-08-12
KR20090014164A (ko) 2009-02-06
JP2009534381A (ja) 2009-09-24
KR101653182B1 (ko) 2016-09-01
AU2006342202B2 (en) 2013-03-07
BRPI0621580A2 (pt) 2011-05-10

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B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]

Free format text: ESCLARECA E/OU COMPROVE DIVERGENCIA ENTRE INVENTORES CONSTANTES DO PEDIDO E DA PUBLICACAO WO 2007/120153 DE 25/10/2007 (AUSENCIA DO PRIMEIRO INVENTOR DO WO).

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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B08H Application fees: decision cancelled [chapter 8.8 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2163 DE 19/06/2012.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 04/05/2006, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

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