JP2008529539A5 - - Google Patents
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- JP2008529539A5 JP2008529539A5 JP2007555430A JP2007555430A JP2008529539A5 JP 2008529539 A5 JP2008529539 A5 JP 2008529539A5 JP 2007555430 A JP2007555430 A JP 2007555430A JP 2007555430 A JP2007555430 A JP 2007555430A JP 2008529539 A5 JP2008529539 A5 JP 2008529539A5
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- Japan
- Prior art keywords
- composition
- amino acid
- acid sequence
- polypeptide
- compound
- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65392805P | 2005-02-18 | 2005-02-18 | |
| US60/653,928 | 2005-02-18 | ||
| PCT/CA2005/001158 WO2006086870A1 (en) | 2005-02-18 | 2005-07-21 | Aprotinin polypeptides for transporting a compound across the blood-brain barrier |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011004842A Division JP5462193B2 (ja) | 2005-02-18 | 2011-01-13 | 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008529539A JP2008529539A (ja) | 2008-08-07 |
| JP2008529539A5 true JP2008529539A5 (enExample) | 2008-09-18 |
| JP5175108B2 JP5175108B2 (ja) | 2013-04-03 |
Family
ID=36916132
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555430A Expired - Fee Related JP5175108B2 (ja) | 2005-02-18 | 2005-07-21 | 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド |
| JP2011004842A Expired - Fee Related JP5462193B2 (ja) | 2005-02-18 | 2011-01-13 | 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド |
| JP2013245690A Pending JP2014088386A (ja) | 2005-02-18 | 2013-11-28 | 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011004842A Expired - Fee Related JP5462193B2 (ja) | 2005-02-18 | 2011-01-13 | 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド |
| JP2013245690A Pending JP2014088386A (ja) | 2005-02-18 | 2013-11-28 | 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド |
Country Status (18)
| Country | Link |
|---|---|
| US (4) | US7902156B2 (enExample) |
| EP (2) | EP1859041B2 (enExample) |
| JP (3) | JP5175108B2 (enExample) |
| CN (2) | CN101160403B (enExample) |
| AT (1) | ATE551422T1 (enExample) |
| AU (1) | AU2005327497B2 (enExample) |
| BR (1) | BRPI0520032A2 (enExample) |
| CA (1) | CA2597958C (enExample) |
| CY (1) | CY1113299T1 (enExample) |
| DK (2) | DK2360258T3 (enExample) |
| ES (2) | ES2527634T3 (enExample) |
| MX (1) | MX2007010113A (enExample) |
| PL (2) | PL2360258T3 (enExample) |
| PT (2) | PT2360258E (enExample) |
| RU (2) | RU2408605C2 (enExample) |
| SI (2) | SI1859041T2 (enExample) |
| WO (1) | WO2006086870A1 (enExample) |
| ZA (1) | ZA200706917B (enExample) |
Families Citing this family (60)
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| JP4903036B2 (ja) | 2003-01-06 | 2012-03-21 | アンジオケム・インコーポレーテッド | 血液脳関門を通過する担体としてのアプロチニンおよび類似体 |
| US7485706B2 (en) * | 2003-07-30 | 2009-02-03 | The Board Of Trustees Of The Leland Stanford Junior University | Neurodegenerative protein aggregation inhibition methods and compounds |
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| US20090016959A1 (en) * | 2005-02-18 | 2009-01-15 | Richard Beliveau | Delivery of antibodies to the central nervous system |
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| DK2164866T3 (da) * | 2007-05-29 | 2014-07-28 | Angiochem Inc | Aprotininlignende polypeptider til fremføring af midler, der er konjugeret dertil, til væv |
| US9365634B2 (en) | 2007-05-29 | 2016-06-14 | Angiochem Inc. | Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues |
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| CA2709354C (en) | 2007-12-21 | 2014-06-17 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
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| RU2011125367A (ru) * | 2008-12-05 | 2013-01-10 | Ангиочем Инк. | Конъюгаты лептина и аналогов лептина и их применение |
| US9914754B2 (en) | 2008-12-05 | 2018-03-13 | Angiochem Inc. | Conjugates of neurotensin or neurotensin analogs and uses thereof |
| CN103665170A (zh) * | 2008-12-05 | 2014-03-26 | 安吉奥开米公司 | 肽治疗剂轭合物及其应用 |
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| US20130280281A1 (en) * | 2010-07-02 | 2013-10-24 | Jean-Paul Castaigne | Short and d-amino acid-containing polypeptides for therapeutic conjugates and uses thereof |
| JP2013540694A (ja) | 2010-08-06 | 2013-11-07 | ウー3・フアルマ・ゲー・エム・ベー・ハー | Her3結合剤の前立腺治療における使用 |
| CN102614524A (zh) * | 2011-02-01 | 2012-08-01 | 复旦大学 | 低密度脂蛋白受体相关蛋白配体多肽修饰的脑肿瘤靶向基因递释复合物 |
| WO2013056096A1 (en) * | 2011-10-13 | 2013-04-18 | Angiochem Inc. | Polypeptide-opioid conjugates and uses thereof |
| JP2015526434A (ja) | 2012-08-14 | 2015-09-10 | アンジオケム インコーポレーテッド | ペプチド−デンドリマーコンジュゲート及びその使用 |
| JP6108265B2 (ja) * | 2012-11-19 | 2017-04-05 | 国立大学法人 千葉大学 | 脳送達用キャリアおよびその用途 |
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| WO2015124540A1 (en) * | 2014-02-19 | 2015-08-27 | F. Hoffmann-La Roche Ag | Blood brain barrier shuttle |
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| US9655998B2 (en) | 2014-08-07 | 2017-05-23 | Cook Medical Technologies Llc | Encapsulated drug compositions and methods of use thereof |
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| US10711270B2 (en) | 2014-10-03 | 2020-07-14 | University Of Massachusetts | High efficiency library-identified AAV vectors |
| US10370432B2 (en) | 2014-10-03 | 2019-08-06 | University Of Massachusetts | Heterologous targeting peptide grafted AAVS |
| EP3222291B1 (en) * | 2014-10-24 | 2020-08-19 | University of Science and Technology of China | Angiopeptin conjugates for amyloid protein targeting |
| EP3215184B1 (en) * | 2014-11-06 | 2021-03-03 | OSE Immunotherapeutics | Therapeutic multi-peptides t specific immune therapy for treatment of brain metastasis |
| EP3256170B1 (en) | 2015-02-13 | 2020-09-23 | University of Massachusetts | Compositions and methods for transient delivery of nucleases |
| JP6612063B2 (ja) * | 2015-06-11 | 2019-11-27 | 国立大学法人滋賀医科大学 | 悪性神経膠腫分子標的ペプチド |
| EP3307326B9 (en) | 2015-06-15 | 2021-02-24 | Angiochem Inc. | Methods for the treatment of leptomeningeal carcinomatosis |
| PL417159A1 (pl) | 2016-05-11 | 2017-11-20 | Instytut Biologii Doświadczalnej Im. Marcelego Nenckiego | Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby Alzheimera |
| CN110267674A (zh) * | 2016-07-08 | 2019-09-20 | 奥美药业有限公司 | 包含瘦素的融合蛋白及其生产和使用方法 |
| US10702589B2 (en) | 2016-10-04 | 2020-07-07 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Compositions and methods of treating neurological disorder and stress-induced conditions |
| EP3565603B1 (en) | 2017-01-09 | 2022-12-07 | Aposense Ltd. | Compounds and methods for trans-membrane delivery of molecules |
| JP2021509406A (ja) | 2018-01-01 | 2021-03-25 | アポセンス リミテッドAposense Ltd. | 分子の膜貫通送達のための化合物および方法 |
| US10688191B2 (en) | 2018-01-19 | 2020-06-23 | Hr Biomed, Llc | Delivery of a chemotherapy agent across the blood-brain barrier |
| CN109666973B (zh) * | 2018-11-21 | 2022-11-04 | 北京大学 | 一种穿过血脑屏障的肽库及其筛选方法 |
| WO2021188802A1 (en) * | 2020-03-18 | 2021-09-23 | Brown Kathlynn C | Molecular transport system to the central nervous system |
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| WO2022156531A1 (zh) * | 2021-01-19 | 2022-07-28 | 中国人民解放军军事科学院军事医学研究院 | 一种能够透过生物屏障的动力蛋白结合肽及其应用 |
| CN112851789B (zh) * | 2021-02-04 | 2022-10-18 | 大理大学 | 一种脑靶向hiv进入抑制剂多肽及其应用 |
| WO2022178425A1 (en) * | 2021-02-22 | 2022-08-25 | Yale University | Targeted bifunctional degraders |
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- 2005-07-21 EP EP05770546.9A patent/EP1859041B2/en not_active Expired - Lifetime
- 2005-07-21 WO PCT/CA2005/001158 patent/WO2006086870A1/en not_active Ceased
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