PL417159A1 - Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby Alzheimera - Google Patents
Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby AlzheimeraInfo
- Publication number
- PL417159A1 PL417159A1 PL417159A PL41715916A PL417159A1 PL 417159 A1 PL417159 A1 PL 417159A1 PL 417159 A PL417159 A PL 417159A PL 41715916 A PL41715916 A PL 41715916A PL 417159 A1 PL417159 A1 PL 417159A1
- Authority
- PL
- Poland
- Prior art keywords
- seq
- treatment
- dendrimers
- conjugates
- application
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Niniejsze zgłoszenie dotyczy: pochodzących z PrP fragmentów peptydowych o SEQ ID NO: 1 lub SEQ ID NO: 2 lub SEQ ID NO: 3 lub SEQ ID NO: 4 do zastosowania jako lek w leczeniu patologii związanych z amyloidogenezą Aß i/lub związanej z Aß toksyczności, w szczególności choroby Alzheimera (AD); koniugatu obejmującego pochodzące z PrP fragmenty peptydowe o SEQ ID NO: 1 lub SEQ ID NO: 3 i/lub SEQ ID NO: 2 lub SEQ ID NO: 4 oraz cząsteczkę nośnika, przy czym cząsteczką nośnika jest cząsteczka farmakologicznie dopuszczalna, korzystnie dendrymer niskiej generacji, taki jak dendrymer PAMAM oraz sposobu wytwarzania powyższego koniugatu.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL417159A PL417159A1 (pl) | 2016-05-11 | 2016-05-11 | Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby Alzheimera |
US16/300,214 US10815292B2 (en) | 2016-05-11 | 2017-05-10 | Prion protein-dendrimer conjugates for use in treatment of alzheimer disease |
PL17728263T PL3468577T3 (pl) | 2016-05-11 | 2017-05-10 | Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby alzheimera |
PCT/IB2017/052733 WO2017195131A1 (en) | 2016-05-11 | 2017-05-10 | Prion protein-dendrimer conjugates for use in treatment of alzheimer disease |
EP17728263.9A EP3468577B1 (en) | 2016-05-11 | 2017-05-10 | Prion protein-dendrimer conjugates for use in treatment of alzheimer disease |
ES17728263T ES2901053T3 (es) | 2016-05-11 | 2017-05-10 | Conjugados proteína priónica-dendrímero para uso en el tratamiento de la enfermedad de Alzheimer |
IL262902A IL262902B2 (en) | 2016-05-11 | 2018-11-08 | Prion protein-dendrimer conjugates for use in the treatment of Alzheimer's disease |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL417159A PL417159A1 (pl) | 2016-05-11 | 2016-05-11 | Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby Alzheimera |
Publications (1)
Publication Number | Publication Date |
---|---|
PL417159A1 true PL417159A1 (pl) | 2017-11-20 |
Family
ID=59014670
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL417159A PL417159A1 (pl) | 2016-05-11 | 2016-05-11 | Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby Alzheimera |
PL17728263T PL3468577T3 (pl) | 2016-05-11 | 2017-05-10 | Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby alzheimera |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL17728263T PL3468577T3 (pl) | 2016-05-11 | 2017-05-10 | Koniugaty białka prionowego z dendrymerami do zastosowania w leczeniu choroby alzheimera |
Country Status (6)
Country | Link |
---|---|
US (1) | US10815292B2 (pl) |
EP (1) | EP3468577B1 (pl) |
ES (1) | ES2901053T3 (pl) |
IL (1) | IL262902B2 (pl) |
PL (2) | PL417159A1 (pl) |
WO (1) | WO2017195131A1 (pl) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN112439074B (zh) * | 2020-12-03 | 2022-09-13 | 浙江大学 | 可快速提高功能多肽亲和力的偶联物及其制备方法和应用 |
CN115737787B (zh) * | 2022-12-15 | 2024-04-19 | 四川大学 | 乳铁蛋白联合胆碱在制备预防和/或治疗阿尔兹海默症的药物中的用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9504664A (es) | 1994-03-07 | 1997-05-31 | Dow Chemical Co | Conjugados de dendrimeros bioactivos y/o dirigidos. |
KR19990029749A (ko) | 1997-09-17 | 1999-04-26 | 미우라 아끼라 | 2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체 |
PT1346041E (pt) * | 2000-11-27 | 2007-06-05 | Praecis Pharm Inc | Agentes terapêuticos e métodos para a sua utilização no tratamento de uma doença amiloidogénica. |
US7217845B2 (en) | 2002-11-25 | 2007-05-15 | Sun Bio, Inc. | Bifunctional polyethylene glycol derivatives |
US20050267029A1 (en) * | 2004-04-02 | 2005-12-01 | Ancsin John B | Compounds which modulate amyloidogenesis and methods for their identification and use |
JP5175108B2 (ja) | 2005-02-18 | 2013-04-03 | アンジオケム・インコーポレーテッド | 血液脳関門を介して化合物を輸送するためのアプロチニンポリペプチド |
WO2008134034A1 (en) * | 2007-04-26 | 2008-11-06 | Yale University | Prion protein as a receptor for amyloid-beta oligomers |
WO2009041902A1 (en) | 2007-09-25 | 2009-04-02 | Loefgren Kajsa | Prion protein derived cell penetrating peptides and their uses |
WO2014026283A1 (en) * | 2012-08-14 | 2014-02-20 | Angiochem Inc. | Peptide-dendrimer conjugates and uses thereof |
-
2016
- 2016-05-11 PL PL417159A patent/PL417159A1/pl unknown
-
2017
- 2017-05-10 PL PL17728263T patent/PL3468577T3/pl unknown
- 2017-05-10 WO PCT/IB2017/052733 patent/WO2017195131A1/en unknown
- 2017-05-10 US US16/300,214 patent/US10815292B2/en active Active
- 2017-05-10 ES ES17728263T patent/ES2901053T3/es active Active
- 2017-05-10 EP EP17728263.9A patent/EP3468577B1/en active Active
-
2018
- 2018-11-08 IL IL262902A patent/IL262902B2/en unknown
Also Published As
Publication number | Publication date |
---|---|
IL262902B (en) | 2022-10-01 |
EP3468577B1 (en) | 2021-09-15 |
US20190092837A1 (en) | 2019-03-28 |
IL262902A (en) | 2019-03-31 |
IL262902B2 (en) | 2023-02-01 |
US10815292B2 (en) | 2020-10-27 |
WO2017195131A1 (en) | 2017-11-16 |
EP3468577A1 (en) | 2019-04-17 |
PL3468577T3 (pl) | 2022-02-14 |
ES2901053T3 (es) | 2022-03-21 |
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