JP2010514839A5 - - Google Patents

Download PDF

Info

Publication number
JP2010514839A5
JP2010514839A5 JP2009544907A JP2009544907A JP2010514839A5 JP 2010514839 A5 JP2010514839 A5 JP 2010514839A5 JP 2009544907 A JP2009544907 A JP 2009544907A JP 2009544907 A JP2009544907 A JP 2009544907A JP 2010514839 A5 JP2010514839 A5 JP 2010514839A5
Authority
JP
Japan
Prior art keywords
conjugate
amino acid
tumor
clot
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2009544907A
Other languages
English (en)
Japanese (ja)
Other versions
JP2010514839A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/089202 external-priority patent/WO2008085794A2/en
Publication of JP2010514839A publication Critical patent/JP2010514839A/ja
Publication of JP2010514839A5 publication Critical patent/JP2010514839A5/ja
Pending legal-status Critical Current

Links

JP2009544907A 2007-01-03 2007-12-31 クロット結合化合物に関連する方法および組成物 Pending JP2010514839A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88322907P 2007-01-03 2007-01-03
US88389007P 2007-01-08 2007-01-08
PCT/US2007/089202 WO2008085794A2 (en) 2007-01-03 2007-12-31 Methods and compositions related to clot binding compounds

Publications (2)

Publication Number Publication Date
JP2010514839A JP2010514839A (ja) 2010-05-06
JP2010514839A5 true JP2010514839A5 (enExample) 2011-02-24

Family

ID=39609247

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009544907A Pending JP2010514839A (ja) 2007-01-03 2007-12-31 クロット結合化合物に関連する方法および組成物

Country Status (5)

Country Link
US (1) US9101671B2 (enExample)
EP (1) EP2117575A4 (enExample)
JP (1) JP2010514839A (enExample)
CA (1) CA2674378A1 (enExample)
WO (1) WO2008085794A2 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103767886B (zh) 2005-11-09 2018-04-24 科洛斯科技公司 使牙齿增白的组合物及方法
WO2007092447A2 (en) * 2006-02-06 2007-08-16 Burnham Institute For Medical Research Methods and compositions related to targeting tumors and wounds
US20100266989A1 (en) 2006-11-09 2010-10-21 Klox Technologies Inc. Teeth whitening compositions and methods
AU2009320153B2 (en) 2008-10-27 2016-07-14 Trustees Of Tufts College Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds, and uses thereof
KR20180023070A (ko) * 2008-11-07 2018-03-06 클록스 테크놀로지스 인크. 히알루론산, 글루코사민 또는 알란토인을 포함하는 산화성의 광활성화된 피부 회춘용 조성물
US8580240B1 (en) 2008-11-19 2013-11-12 University Of Kentucky Research Foundation Compounds and methods for reducing the occurrence of post-surgical adhesions
US8580749B2 (en) * 2009-06-05 2013-11-12 Cell Targeting, Inc. Peptide-coated cell localization to diseased or damaged tissues and methods related thereto
SG177635A1 (en) 2009-07-17 2012-03-29 Klox Technologies Inc Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease
JP2013507365A (ja) 2009-10-07 2013-03-04 サンフォード−バーナム メディカル リサーチ インスティテュート 血餅結合脂質化合物に関する方法および組成物
EP2512497A1 (en) 2009-12-18 2012-10-24 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
JP2013525285A (ja) * 2010-04-08 2013-06-20 サンフォード−バーナム メディカル リサーチ インスティテュート 化合物の送達を増強するための方法および組成物
WO2012122500A1 (en) 2011-03-10 2012-09-13 Adc Tech International Ltd. Air purifier having an electret module
US9730637B2 (en) 2011-08-19 2017-08-15 The Regents Of The University Of California Layered particles for retrieving DNA released from cells from a gastrointestinal tract sample and methods for making and using them
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
US20130281913A1 (en) 2012-04-20 2013-10-24 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
BR112015005593B1 (pt) 2012-09-14 2019-09-24 Valeant Pharmaceuticals International, Inc. Método para branqueamento de dentes
US20140276354A1 (en) 2013-03-14 2014-09-18 Klox Technologies Inc. Biophotonic materials and uses thereof
WO2015000058A1 (en) 2013-07-03 2015-01-08 Klox Technologies Inc. Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds
JP2017509433A (ja) 2014-04-01 2017-04-06 クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． 組織充填剤組成物および使用方法
US9545383B2 (en) 2014-04-01 2017-01-17 Massachusetts Institute Of Technology Blood clotting control
EP3212826B1 (en) 2014-10-31 2020-10-14 Klox Technologies Inc. Photoactivatable fibers and fabric media
US10052394B2 (en) * 2014-11-21 2018-08-21 General Electric Company Microbubble tether for diagnostic and therapeutic applications
WO2016172515A1 (en) 2015-04-23 2016-10-27 Sanford Burnham Prebys Medical Discovery Institute Targeted delivery system and methods of use therefor
WO2018089756A1 (en) * 2016-11-11 2018-05-17 Northwestern University Targeted anticoagulant
KR102055390B1 (ko) * 2017-01-06 2019-12-12 경북대학교 산학협력단 혈전-표적성 펩타이드, 페리틴 단편 및 혈전 용해성 펩타이드를 포함하는 융합 펩타이드 및 이의 용도
CN109316608B (zh) * 2018-10-31 2021-09-28 重庆医科大学附属第二医院 一种低强度聚焦超声响应型相变溶栓纳米粒、应用及其制备方法
WO2020118271A1 (en) * 2018-12-07 2020-06-11 Nanovalent Pharmaceuticals, Inc. Fibrin-targeted polymerized shell lipid microbubbles
CN114699526B (zh) * 2022-04-12 2024-04-26 茂名市人民医院 一种藻蓝蛋白矿化纳米粒及其制备方法和应用

Family Cites Families (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH588887A5 (enExample) 1974-07-19 1977-06-15 Battelle Memorial Institute
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4418052A (en) 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4761288A (en) 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5628936A (en) 1987-03-13 1997-05-13 Micro-Pak, Inc. Hybrid paucilamellar lipid vesicles
US5474848A (en) 1987-03-13 1995-12-12 Micro-Pak, Inc. Paucilamellar lipid vesicles
US4853228A (en) 1987-07-28 1989-08-01 Micro-Pak, Inc. Method of manufacturing unilamellar lipid vesicles
US5011686A (en) 1987-09-21 1991-04-30 Creative Biomolecules, Inc. Thrombus specific conjugates
US5013497A (en) 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5024829A (en) 1988-11-21 1991-06-18 Centocor, Inc. Method of imaging coronary thrombi
EP1690935A3 (en) 1990-01-12 2008-07-30 Abgenix, Inc. Generation of xenogeneic antibodies
US5084824A (en) 1990-03-29 1992-01-28 National Semiconductor Corporation Simulation model generation from a physical data base of a combinatorial circuit
CA2090473A1 (en) 1990-08-29 1992-03-01 Robert M. Kay Homologous recombinatin in mammalian cells
AU668347B2 (en) 1990-11-21 1996-05-02 Torrey Pines Institute For Molecular Studies Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures
US5792742A (en) 1991-06-14 1998-08-11 New York University Fibrin-binding peptide fragments of fibronectin
US5449754A (en) 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verfahren zur Herstellung von Polymerarrays
US6004555A (en) 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
GB9213077D0 (en) * 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5652138A (en) 1992-09-30 1997-07-29 The Scripps Research Institute Human neutralizing monoclonal antibodies to human immunodeficiency virus
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5721099A (en) 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
CA2163032C (en) 1993-06-03 2001-02-06 John Landon Antibody fragments in therapy
US6180377B1 (en) 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
CA2163860A1 (en) 1993-06-30 1995-01-12 Chung C. Hsu Method for preparing liposomes
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5683899A (en) 1994-02-03 1997-11-04 University Of Hawaii Methods and compositions for combinatorial-based discovery of new multimeric molecules
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
DE69530683T2 (de) 1994-03-11 2004-03-25 Pharmacopeia, Inc. Sulfonamid derivate und deren verwendung
EP0754238A4 (en) 1994-04-05 1998-01-28 Pharmagenics Inc DETERMINATION AND IDENTIFICATION OF ACTIVE SUBSTANCES IN SUBSTANCE LIBRARIES
US5789542A (en) 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
US5688997A (en) 1994-05-06 1997-11-18 Pharmacopeia, Inc. Process for preparing intermediates for a combinatorial dihydrobenzopyran library
US6017768A (en) 1994-05-06 2000-01-25 Pharmacopeia, Inc. Combinatorial dihydrobenzopyran library
US5663046A (en) 1994-06-22 1997-09-02 Pharmacopeia, Inc. Synthesis of combinatorial libraries
US5619680A (en) 1994-11-25 1997-04-08 Berkovich; Semyon Methods and apparatus for concurrent execution of serial computing instructions using combinatorial architecture for program partitioning
US5688696A (en) 1994-12-12 1997-11-18 Selectide Corporation Combinatorial libraries having a predetermined frequency of each species of test compound
US5627210A (en) 1995-02-06 1997-05-06 Chiron Corporation Branched combinatorial libraries
US6130364A (en) 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
IT1282797B1 (it) 1995-04-21 1998-03-31 Colla Paolo Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids
US5958792A (en) 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
US6410690B1 (en) 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
US5646285A (en) 1995-06-07 1997-07-08 Zymogenetics, Inc. Combinatorial non-peptide libraries
CA2225313A1 (en) 1995-06-21 1997-01-09 Martek Biosciences Corporation Combinatorial libraries of labeled biochemical compounds and methods for producing same
US5962337A (en) 1995-06-29 1999-10-05 Pharmacopeia, Inc. Combinatorial 1,4-benzodiazepin-2,5-dione library
US5897945A (en) 1996-02-26 1999-04-27 President And Fellows Of Harvard College Metal oxide nanorods
US5847150A (en) 1996-04-24 1998-12-08 Novo Nordisk A/S Solid phase and combinatorial synthesis of substituted 2-methylene-2, 3-dihydrothiazoles and of arrays of substituted 2-methylene-2, 3-dihydrothiazoles
GB9610813D0 (en) 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of benzufuran derivatives
GB9610811D0 (en) 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of indole derivatives
US5792431A (en) 1996-05-30 1998-08-11 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
US5840500A (en) 1996-07-11 1998-11-24 Trega Biosciences, Inc. Quinoline derivatives and quinoline combinatorial libraries
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
AU4153497A (en) 1996-08-26 1998-03-19 Eli Lilly And Company Combinatorial process for preparing substituted thiophene libraries
US5916899A (en) 1996-10-18 1999-06-29 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
US6025371A (en) 1996-10-28 2000-02-15 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
US5972719A (en) 1996-11-05 1999-10-26 Pharmacopeia, Inc. Combinatorial hydroxy-amino acid amide libraries
US5965719A (en) 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US5856107A (en) 1997-02-04 1999-01-05 Trega Biosciences, Inc. Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
US5925527A (en) 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
US5859190A (en) 1997-02-04 1999-01-12 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
US5976894A (en) 1997-04-14 1999-11-02 Pharmacopeia, Inc. Combinatorial amide alcohol libraries
US5948696A (en) 1997-06-16 1999-09-07 Pharmacopeia, Inc. Combinatorial biaryl amino acid amide libraries
NZ508669A (en) 1998-06-11 2003-06-30 Dimensional Pharm Inc Pyrazinone protease inhibitors
EP1203026A4 (en) * 1999-07-29 2005-03-16 Dyax Corp BINDING CENTERS FOR FIBRIN
US7220401B2 (en) * 1999-09-24 2007-05-22 Barnes-Jewish Hospital Blood clot-targeted nanoparticles
AU2002248222B2 (en) * 2000-12-23 2006-04-27 Dyax Corp. Fibrin binding polypeptides useful inter alia in medical imaging processes
US7488792B2 (en) * 2002-08-28 2009-02-10 Burnham Institute For Medical Research Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
WO2005044224A2 (en) * 2003-05-02 2005-05-19 Case Western Reserve University Drug delivery system based on polymer nanoshells
KR20060066722A (ko) 2003-08-13 2006-06-16 쿠도스 파마슈티칼스 리미티드 아미노피론 및 ａｔｍ억제제로서의 이의 용도
US7723474B2 (en) 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
WO2005046722A2 (en) 2003-11-05 2005-05-26 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Carbohydrate antigen-nanoparticle conjugates and uses thereof as antimetastatic agents in treating cancer
US20050196343A1 (en) * 2004-02-27 2005-09-08 Molecular Therapeutics, Inc. Degradable nanoparticles
US20100279918A1 (en) 2006-03-20 2010-11-04 Burnham Institute For Medical Research Chimeric Constructs Between Cancer-Homing Peptides and Cell-Penetrating Peptides Coupled to Anticancer Drugs and/or Diagnostic Agent/Agents
WO2008100328A2 (en) * 2006-07-13 2008-08-21 Burnham Institute For Medical Research METHODS AND COMPOSITIONS FOR TARGETING gC1qR/p32
MX2009003981A (es) 2006-10-26 2009-04-27 Amgen Inc Agentes moduladores del receptor de calcio.
US8188220B2 (en) 2006-12-06 2012-05-29 Sanford-Burnham Medical Research Institute Methods and compositions related to targeting wounds, regenerating tissue, and tumors
EP2512497A1 (en) 2009-12-18 2012-10-24 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds

Similar Documents

Publication Publication Date Title
JP2009500431A5 (enExample)
JP2025066807A (ja) 生体直交型組成物
Mastria et al. Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma
Ferber et al. Co-targeting the tumor endothelium and P-selectin-expressing glioblastoma cells leads to a remarkable therapeutic outcome
Huile et al. A cascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein
JP4903036B2 (ja) 血液脳関門を通過する担体としてのアプロチニンおよび類似体
Morgan et al. Tissue-factor targeted peptide amphiphile nanofibers as an injectable therapy to control hemorrhage
RU2611193C2 (ru) Полипептиды апротинина для транспорта соединения через гематоэнцефалический барьер
JP2008529539A5 (enExample)
JP2011530599A5 (enExample)
JP2019535651A (ja) Ｔｉｅ２シグナル伝達を活性化するための化合物及び方法
JP2011525917A5 (enExample)
JP2006513992A5 (enExample)
JP2009533317A5 (enExample)
JP2013163674A5 (enExample)
JP2010534193A (ja) 血小板を用いるミクロ及びナノ粒子の送達
JP2012533560A5 (enExample)
JP2010524849A5 (enExample)
KR20190053206A (ko) 혈소판 조성물 및 치료제의 전달 방법
McGonigle et al. Neuropilin-1 drives tumor-specific uptake of chlorotoxin
CN106659798A (zh) 树枝状聚合物组合物和在治疗神经与cns病症中的用途
Wu et al. Synergetic regulation of kupffer cells, extracellular matrix and hepatic stellate cells with versatile CXCR4-inhibiting nanocomplex for magnified therapy in liver fibrosis
Liang et al. Targeting docetaxel-PLA nanoparticles simultaneously inhibit tumor growth and liver metastases of small cell lung cancer
CN106573049A (zh) 用于治疗纤维化疾病的trail受体激动剂
JP2013515008A5 (enExample)