JP2010514839A5 - - Google Patents
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- Publication number
- JP2010514839A5 JP2010514839A5 JP2009544907A JP2009544907A JP2010514839A5 JP 2010514839 A5 JP2010514839 A5 JP 2010514839A5 JP 2009544907 A JP2009544907 A JP 2009544907A JP 2009544907 A JP2009544907 A JP 2009544907A JP 2010514839 A5 JP2010514839 A5 JP 2010514839A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- amino acid
- tumor
- clot
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000001413 amino acids Chemical class 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 8
- 230000001225 therapeutic effect Effects 0.000 claims 8
- 102000009123 Fibrin Human genes 0.000 claims 5
- 108010073385 Fibrin Proteins 0.000 claims 5
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- 229950003499 fibrin Drugs 0.000 claims 5
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 102000004506 Blood Proteins Human genes 0.000 claims 4
- 108010017384 Blood Proteins Proteins 0.000 claims 4
- 206010052428 Wound Diseases 0.000 claims 4
- 208000027418 Wounds and injury Diseases 0.000 claims 4
- 238000009825 accumulation Methods 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 206010053567 Coagulopathies Diseases 0.000 claims 3
- 230000035602 clotting Effects 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical group O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
- 229930012538 Paclitaxel Natural products 0.000 claims 2
- 230000000740 bleeding effect Effects 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 229960001592 paclitaxel Drugs 0.000 claims 2
- 210000005166 vasculature Anatomy 0.000 claims 2
- 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- OKTJSMMVPCPJKN-OUBTZVSYSA-N Carbon-13 Chemical compound [13C] OKTJSMMVPCPJKN-OUBTZVSYSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims 1
- 229940028652 abraxane Drugs 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 229940124346 antiarthritic agent Drugs 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003435 antirheumatic agent Substances 0.000 claims 1
- 230000017531 blood circulation Effects 0.000 claims 1
- OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical compound [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 claims 1
- 230000015271 coagulation Effects 0.000 claims 1
- 238000005345 coagulation Methods 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 claims 1
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims 1
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 claims 1
- 229940055742 indium-111 Drugs 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000011859 microparticle Substances 0.000 claims 1
- 229940031182 nanoparticles iron oxide Drugs 0.000 claims 1
- 230000017074 necrotic cell death Effects 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001023 pro-angiogenic effect Effects 0.000 claims 1
- -1 radionuclide Chemical compound 0.000 claims 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 claims 1
- 231100000241 scar Toxicity 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- 238000007711 solidification Methods 0.000 claims 1
- 230000008023 solidification Effects 0.000 claims 1
- 230000008961 swelling Effects 0.000 claims 1
- 230000029663 wound healing Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88322907P | 2007-01-03 | 2007-01-03 | |
| US88389007P | 2007-01-08 | 2007-01-08 | |
| PCT/US2007/089202 WO2008085794A2 (en) | 2007-01-03 | 2007-12-31 | Methods and compositions related to clot binding compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010514839A JP2010514839A (ja) | 2010-05-06 |
| JP2010514839A5 true JP2010514839A5 (enExample) | 2011-02-24 |
Family
ID=39609247
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009544907A Pending JP2010514839A (ja) | 2007-01-03 | 2007-12-31 | クロット結合化合物に関連する方法および組成物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9101671B2 (enExample) |
| EP (1) | EP2117575A4 (enExample) |
| JP (1) | JP2010514839A (enExample) |
| CA (1) | CA2674378A1 (enExample) |
| WO (1) | WO2008085794A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2338465A1 (en) | 2005-11-09 | 2011-06-29 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| CA2638911C (en) * | 2006-02-06 | 2018-01-23 | Burnham Institute For Medical Research | Methods and compositions related to targeting tumors and wounds |
| US20100266989A1 (en) | 2006-11-09 | 2010-10-21 | Klox Technologies Inc. | Teeth whitening compositions and methods |
| CA2743999A1 (en) | 2008-10-27 | 2010-06-03 | Trustees Of Tufts College | Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds, and uses thereof |
| LT2352488T (lt) | 2008-11-07 | 2017-05-25 | Klox Technologies Inc. | Oksidacinė fotoaktyvuojama odos atjauninimo kompozicija, apimanti hialurono rūgštį, gliukozaminą arba alantoiną |
| US8580240B1 (en) | 2008-11-19 | 2013-11-12 | University Of Kentucky Research Foundation | Compounds and methods for reducing the occurrence of post-surgical adhesions |
| US8580749B2 (en) * | 2009-06-05 | 2013-11-12 | Cell Targeting, Inc. | Peptide-coated cell localization to diseased or damaged tissues and methods related thereto |
| SMT201700575T1 (it) * | 2009-07-17 | 2018-01-11 | Klox Tech Inc | Composizione orale antibatterica |
| EP2485768A1 (en) * | 2009-10-07 | 2012-08-15 | Sanford-Burnham Medical Research Institute | Methods and compositions related to clot-binding lipid compounds |
| JP2013515008A (ja) * | 2009-12-18 | 2013-05-02 | サンフォード−バーナム メディカル リサーチ インスティテュート | 凝血塊結合化合物に関連する方法および組成物 |
| US20110262347A1 (en) * | 2010-04-08 | 2011-10-27 | The Salk Institute For Biological Studies | Methods and compositions for enhanced delivery of compounds |
| GB2502762B (en) | 2011-03-10 | 2018-12-26 | Adc Tech Int Ltd | Air purifier having an electret module |
| WO2013028548A2 (en) * | 2011-08-19 | 2013-02-28 | The Regents Of The University Of California | Compositions and devices for the detection of biomarkers in the gastrointestinal tract and methods for making and using them |
| US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
| US20130281913A1 (en) | 2012-04-20 | 2013-10-24 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
| CA2884349C (en) | 2012-09-14 | 2019-03-26 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
| US20140276354A1 (en) | 2013-03-14 | 2014-09-18 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
| WO2015000058A1 (en) | 2013-07-03 | 2015-01-08 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
| US9545383B2 (en) | 2014-04-01 | 2017-01-17 | Massachusetts Institute Of Technology | Blood clotting control |
| AU2015240385B2 (en) | 2014-04-01 | 2019-02-28 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
| JP2018500468A (ja) | 2014-10-31 | 2018-01-11 | クロックス テクノロジーズ インコーポレイテッドＫｌｏｘ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃ． | 光活性性の繊維および織物媒体 |
| US10052394B2 (en) | 2014-11-21 | 2018-08-21 | General Electric Company | Microbubble tether for diagnostic and therapeutic applications |
| WO2016172515A1 (en) | 2015-04-23 | 2016-10-27 | Sanford Burnham Prebys Medical Discovery Institute | Targeted delivery system and methods of use therefor |
| US20190345262A1 (en) * | 2016-11-11 | 2019-11-14 | Northwestern University | Targeted anticoagulant |
| KR102055390B1 (ko) * | 2017-01-06 | 2019-12-12 | 경북대학교 산학협력단 | 혈전-표적성 펩타이드, 페리틴 단편 및 혈전 용해성 펩타이드를 포함하는 융합 펩타이드 및 이의 용도 |
| CN109316608B (zh) * | 2018-10-31 | 2021-09-28 | 重庆医科大学附属第二医院 | 一种低强度聚焦超声响应型相变溶栓纳米粒、应用及其制备方法 |
| US20220023447A1 (en) * | 2018-12-07 | 2022-01-27 | Nanovalent Pharmaceuticals Inc. | Fibrin-targeted polymerized shell lipid microbubbles for diagnostic and therapeutic applications |
| CN114699526B (zh) * | 2022-04-12 | 2024-04-26 | 茂名市人民医院 | 一种藻蓝蛋白矿化纳米粒及其制备方法和应用 |
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| JP2013515008A (ja) | 2009-12-18 | 2013-05-02 | サンフォード−バーナム メディカル リサーチ インスティテュート | 凝血塊結合化合物に関連する方法および組成物 |
-
2007
- 2007-12-31 JP JP2009544907A patent/JP2010514839A/ja active Pending
- 2007-12-31 WO PCT/US2007/089202 patent/WO2008085794A2/en not_active Ceased
- 2007-12-31 EP EP07870130.7A patent/EP2117575A4/en not_active Withdrawn
- 2007-12-31 CA CA002674378A patent/CA2674378A1/en not_active Abandoned
- 2007-12-31 US US11/967,509 patent/US9101671B2/en not_active Expired - Fee Related
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