JP2010514839A - クロット結合化合物に関連する方法および組成物 - Google Patents

クロット結合化合物に関連する方法および組成物 Download PDF

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JP2010514839A
JP2010514839A JP2009544907A JP2009544907A JP2010514839A JP 2010514839 A JP2010514839 A JP 2010514839A JP 2009544907 A JP2009544907 A JP 2009544907A JP 2009544907 A JP2009544907 A JP 2009544907A JP 2010514839 A JP2010514839 A JP 2010514839A
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conjugate
amino acid
tumor
clot
peptide
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JP2010514839A5 (enExample
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エルッキ ルオスラーティ,
ディミトリ シムバーグ,
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バーナム インスティテュート フォー メディカル リサーチ
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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    • A61K47/6929Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
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    • A61K49/1866Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes particles, e.g. uncoated or non-functionalised microparticles or nanoparticles coated or functionalised microparticles or nanoparticles coated or functionalised nanoparticles having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle the nanoparticle having a (super)(para)magnetic core coated or functionalised with a peptide, e.g. protein, polyamino acid
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2009544907A 2007-01-03 2007-12-31 クロット結合化合物に関連する方法および組成物 Pending JP2010514839A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88322907P 2007-01-03 2007-01-03
US88389007P 2007-01-08 2007-01-08
PCT/US2007/089202 WO2008085794A2 (en) 2007-01-03 2007-12-31 Methods and compositions related to clot binding compounds

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JP2010514839A true JP2010514839A (ja) 2010-05-06
JP2010514839A5 JP2010514839A5 (enExample) 2011-02-24

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US (1) US9101671B2 (enExample)
EP (1) EP2117575A4 (enExample)
JP (1) JP2010514839A (enExample)
CA (1) CA2674378A1 (enExample)
WO (1) WO2008085794A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017536359A (ja) * 2014-11-21 2017-12-07 ゼネラル・エレクトリック・カンパニイ 診断及び治療用途のマイクロバブルテザー

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5366553B2 (ja) 2005-11-09 2013-12-11 クロックス テクノロジーズ インコーポレイテッド 歯のホワイトニング組成物及び方法
CA2638911C (en) * 2006-02-06 2018-01-23 Burnham Institute For Medical Research Methods and compositions related to targeting tumors and wounds
US20100266989A1 (en) 2006-11-09 2010-10-21 Klox Technologies Inc. Teeth whitening compositions and methods
US8466106B2 (en) 2008-10-27 2013-06-18 Trustees Of Tufts College Nucleic acids encoding peptides for treating wounds, anti-angiogenic compounds and uses thereof
NZ592651A (en) 2008-11-07 2013-05-31 Klox Technologies Inc Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin
US8580240B1 (en) 2008-11-19 2013-11-12 University Of Kentucky Research Foundation Compounds and methods for reducing the occurrence of post-surgical adhesions
US8580749B2 (en) * 2009-06-05 2013-11-12 Cell Targeting, Inc. Peptide-coated cell localization to diseased or damaged tissues and methods related thereto
PL2453922T3 (pl) * 2009-07-17 2018-03-30 Klox Technologies Inc. Przeciwbakteryjna doustna kompozycja
WO2011043980A1 (en) * 2009-10-07 2011-04-14 Sanford Burnham Medical Research Institute Methods and compositions related to clot-binding lipid compounds
CA2784145A1 (en) * 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds
WO2011127405A1 (en) 2010-04-08 2011-10-13 Sanford-Burnham Medical Research Institute Methods and compositions for enhanced delivery of compounds
US9913998B2 (en) 2011-03-10 2018-03-13 Adc Tech International Ltd Air purifier having an electret module
WO2013028548A2 (en) * 2011-08-19 2013-02-28 The Regents Of The University Of California Compositions and devices for the detection of biomarkers in the gastrointestinal tract and methods for making and using them
US20130281913A1 (en) 2012-04-20 2013-10-24 Klox Technologies Inc. Biophotonic compositions and methods for providing biophotonic treatment
US11116841B2 (en) 2012-04-20 2021-09-14 Klox Technologies Inc. Biophotonic compositions, kits and methods
EP2895139B1 (en) 2012-09-14 2019-10-23 Bausch Health Companies Inc. Methods for teeth whitening
US20140276354A1 (en) 2013-03-14 2014-09-18 Klox Technologies Inc. Biophotonic materials and uses thereof
HK1219890A1 (zh) 2013-07-03 2017-04-21 广东科洛克生物医药集团有限公司 治疗不癒合伤口的组合物和方法
JP2017509433A (ja) 2014-04-01 2017-04-06 クロックス テクノロジーズ インコーポレイテッドKlox Technologies Inc. 組織充填剤組成物および使用方法
US9545383B2 (en) 2014-04-01 2017-01-17 Massachusetts Institute Of Technology Blood clotting control
RU2017117187A (ru) 2014-10-31 2018-11-30 Клокс Текнолоджиз Инк. Фотоактивируемые волокна и тканые материалы
WO2016172515A1 (en) 2015-04-23 2016-10-27 Sanford Burnham Prebys Medical Discovery Institute Targeted delivery system and methods of use therefor
WO2018089756A1 (en) * 2016-11-11 2018-05-17 Northwestern University Targeted anticoagulant
KR102055390B1 (ko) * 2017-01-06 2019-12-12 경북대학교 산학협력단 혈전-표적성 펩타이드, 페리틴 단편 및 혈전 용해성 펩타이드를 포함하는 융합 펩타이드 및 이의 용도
CN109316608B (zh) * 2018-10-31 2021-09-28 重庆医科大学附属第二医院 一种低强度聚焦超声响应型相变溶栓纳米粒、应用及其制备方法
WO2020118271A1 (en) * 2018-12-07 2020-06-11 Nanovalent Pharmaceuticals, Inc. Fibrin-targeted polymerized shell lipid microbubbles
CN114699526B (zh) * 2022-04-12 2024-04-26 茂名市人民医院 一种藻蓝蛋白矿化纳米粒及其制备方法和应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508027A (ja) * 1999-07-29 2003-03-04 ダイアックス コーポレイション フィブリン結合性部分
JP2004523514A (ja) * 2000-12-23 2004-08-05 ダイアックス コーポレーション 造影剤として有用なフィブリン結合部分
US20050048063A1 (en) * 2002-08-28 2005-03-03 Erkki Ruoslahti Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
WO2005044224A2 (en) * 2003-05-02 2005-05-19 Case Western Reserve University Drug delivery system based on polymer nanoshells
JP2005536537A (ja) * 2002-08-20 2005-12-02 バーンズ−ジューイッシュ ホスピタル 血餅−標的ナノパーティクル
JP2009543806A (ja) * 2006-07-13 2009-12-10 バーナム インスティテュート フォー メディカル リサーチ gC1qR/p32を標的化するための方法および組成物

Family Cites Families (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH588887A5 (enExample) 1974-07-19 1977-06-15 Battelle Memorial Institute
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4342566A (en) 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
NO812612L (no) 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4418052A (en) 1980-08-12 1983-11-29 Wong Dennis W Diagnostic compositions and method for radiologic imaging of fibrinogen deposition in the body
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4761288A (en) 1984-09-24 1988-08-02 Mezei Associates Limited Multiphase liposomal drug delivery system
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5474848A (en) 1987-03-13 1995-12-12 Micro-Pak, Inc. Paucilamellar lipid vesicles
US5628936A (en) 1987-03-13 1997-05-13 Micro-Pak, Inc. Hybrid paucilamellar lipid vesicles
US4853228A (en) 1987-07-28 1989-08-01 Micro-Pak, Inc. Method of manufacturing unilamellar lipid vesicles
US5011686A (en) 1987-09-21 1991-04-30 Creative Biomolecules, Inc. Thrombus specific conjugates
US5013497A (en) 1988-03-03 1991-05-07 Micro-Pak, Inc. Method and apparatus for producing lipid vesicles
US5024829A (en) 1988-11-21 1991-06-18 Centocor, Inc. Method of imaging coronary thrombi
ES2087997T3 (es) * 1990-01-12 1996-08-01 Cell Genesys Inc Generacion de anticuerpos xenogenicos.
US5084824A (en) 1990-03-29 1992-01-28 National Semiconductor Corporation Simulation model generation from a physical data base of a combinatorial circuit
WO1992003917A1 (en) 1990-08-29 1992-03-19 Genpharm International Homologous recombination in mammalian cells
JP3523252B2 (ja) 1990-11-21 2004-04-26 ホウテン ファーマシューティカルズ インコーポレイテッド 等モル多種オリゴマー混合物、特にオリゴペプチド混合物の合成
US5792742A (en) * 1991-06-14 1998-08-11 New York University Fibrin-binding peptide fragments of fibronectin
US5449754A (en) 1991-08-07 1995-09-12 H & N Instruments, Inc. Generation of combinatorial libraries
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
DE69233087T2 (de) 1991-11-22 2003-12-24 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Verfahren zur Herstellung von Polymerarrays
US6004555A (en) * 1992-03-05 1999-12-21 Board Of Regents, The University Of Texas System Methods for the specific coagulation of vasculature
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
GB9213077D0 (en) * 1992-06-19 1992-08-05 Erba Carlo Spa Polymerbound taxol derivatives
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5652138A (en) * 1992-09-30 1997-07-29 The Scripps Research Institute Human neutralizing monoclonal antibodies to human immunodeficiency virus
US5721099A (en) 1992-10-01 1998-02-24 Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
US5565324A (en) 1992-10-01 1996-10-15 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
ATE183513T1 (de) 1993-06-03 1999-09-15 Therapeutic Antibodies Inc Herstellung von antikörperfragmenten
US6180377B1 (en) * 1993-06-16 2001-01-30 Celltech Therapeutics Limited Humanized antibodies
DE69407292T2 (de) 1993-06-30 1998-06-25 Genentech Inc Verfahren zur herstellung von liposomen
US5712146A (en) 1993-09-20 1998-01-27 The Leland Stanford Junior University Recombinant combinatorial genetic library for the production of novel polyketides
US5683899A (en) 1994-02-03 1997-11-04 University Of Hawaii Methods and compositions for combinatorial-based discovery of new multimeric molecules
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
ES2199247T3 (es) 1994-03-11 2004-02-16 Pharmacopeia Drug Discovery, Inc. Derivados de sulfonamida y su uso.
WO1995027072A1 (en) 1994-04-05 1995-10-12 Pharmagenics, Inc. Determination and identification of active compounds in a compound library
US5789542A (en) 1994-04-22 1998-08-04 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Amphipathic peptides
US6017768A (en) * 1994-05-06 2000-01-25 Pharmacopeia, Inc. Combinatorial dihydrobenzopyran library
US5688997A (en) * 1994-05-06 1997-11-18 Pharmacopeia, Inc. Process for preparing intermediates for a combinatorial dihydrobenzopyran library
US5663046A (en) 1994-06-22 1997-09-02 Pharmacopeia, Inc. Synthesis of combinatorial libraries
US5619680A (en) 1994-11-25 1997-04-08 Berkovich; Semyon Methods and apparatus for concurrent execution of serial computing instructions using combinatorial architecture for program partitioning
US5688696A (en) 1994-12-12 1997-11-18 Selectide Corporation Combinatorial libraries having a predetermined frequency of each species of test compound
US5627210A (en) 1995-02-06 1997-05-06 Chiron Corporation Branched combinatorial libraries
US6130364A (en) * 1995-03-29 2000-10-10 Abgenix, Inc. Production of antibodies using Cre-mediated site-specific recombination
IT1282797B1 (it) 1995-04-21 1998-03-31 Colla Paolo Pirril-(indolil)-aril-sulfoni e relativo processo di produzione ed impiego nella terapia delle infezioni da virus dell'aids
US5646285A (en) 1995-06-07 1997-07-08 Zymogenetics, Inc. Combinatorial non-peptide libraries
US5958792A (en) * 1995-06-07 1999-09-28 Chiron Corporation Combinatorial libraries of substrate-bound cyclic organic compounds
US6410690B1 (en) * 1995-06-07 2002-06-25 Medarex, Inc. Therapeutic compounds comprised of anti-Fc receptor antibodies
CA2225313A1 (en) 1995-06-21 1997-01-09 Martek Biosciences Corporation Combinatorial libraries of labeled biochemical compounds and methods for producing same
US5962337A (en) * 1995-06-29 1999-10-05 Pharmacopeia, Inc. Combinatorial 1,4-benzodiazepin-2,5-dione library
US5897945A (en) * 1996-02-26 1999-04-27 President And Fellows Of Harvard College Metal oxide nanorods
US5847150A (en) * 1996-04-24 1998-12-08 Novo Nordisk A/S Solid phase and combinatorial synthesis of substituted 2-methylene-2, 3-dihydrothiazoles and of arrays of substituted 2-methylene-2, 3-dihydrothiazoles
GB9610811D0 (en) * 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of indole derivatives
GB9610813D0 (en) * 1996-05-23 1996-07-31 Pharmacia Spa Combinatorial solid phase synthesis of a library of benzufuran derivatives
US5792431A (en) 1996-05-30 1998-08-11 Smithkline Beecham Corporation Multi-reactor synthesizer and method for combinatorial chemistry
US5840500A (en) * 1996-07-11 1998-11-24 Trega Biosciences, Inc. Quinoline derivatives and quinoline combinatorial libraries
US6506564B1 (en) * 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO1998008839A1 (en) * 1996-08-26 1998-03-05 Eli Lilly And Company Combinatorial process for preparing substituted thiophene libraries
US5916899A (en) * 1996-10-18 1999-06-29 Trega Biosciences, Inc. Isoquinoline derivatives and isoquinoline combinatorial libraries
GB9708265D0 (en) 1997-04-24 1997-06-18 Nycomed Imaging As Contrast agents
US6025371A (en) * 1996-10-28 2000-02-15 Versicor, Inc. Solid phase and combinatorial library syntheses of fused 2,4-pyrimidinediones
US5972719A (en) * 1996-11-05 1999-10-26 Pharmacopeia, Inc. Combinatorial hydroxy-amino acid amide libraries
US5965719A (en) * 1996-11-15 1999-10-12 Sunsorb Biotech, Inc. Combinatorial synthesis of carbohydrate libraries
US5859190A (en) * 1997-02-04 1999-01-12 Trega Biosciences, Inc. Combinatorial libraries of hydantoin and thiohydantoin derivatives, methods of making the libraries and compounds therein
US5856107A (en) * 1997-02-04 1999-01-05 Trega Biosciences, Inc. Combinatorial libraries of imidazol-pyrido-indole and imidazol-pyrido-benzothiophene derivatives, methods of making the libraries and compounds therein
US5925527A (en) * 1997-02-04 1999-07-20 Trega Biosciences, Inc. Tricyclic Tetrahydroquinoline derivatives and tricyclic tetrahydroquinoline combinatorial libraries
US5976894A (en) * 1997-04-14 1999-11-02 Pharmacopeia, Inc. Combinatorial amide alcohol libraries
US5948696A (en) * 1997-06-16 1999-09-07 Pharmacopeia, Inc. Combinatorial biaryl amino acid amide libraries
EP1086122B1 (en) 1998-06-11 2005-08-24 Johnson & Johnson Pharmaceutical Research & Development, L.L.C. Pyrazinone protease inhibitors
DE602004026071D1 (de) 2003-08-13 2010-04-29 Kudos Pharm Ltd Aminopyrone und ihre verwendung als atm inhibitoren
US7723474B2 (en) 2003-10-21 2010-05-25 The Regents Of The University Of California Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies
US20070275007A1 (en) 2003-11-05 2007-11-29 The Government Of The United States Of America, Represented By The Secretary Of Health And Human S Carbohydrate Antigen-Nanoparticle Conjugates and Uses Thereof as Antimetastatic Agents in Treating Cancer
WO2005089106A2 (en) * 2004-02-27 2005-09-29 Molecular Therapeutics, Inc. Degradable nanoparticles
ATE495197T1 (de) 2006-03-20 2011-01-15 Cepep Iii Ab Chimäre konstrukte zwischen auf krebs zielenden peptiden und zellpenetrierenden peptiden gekoppelt an antikrebsmittel und/oder diagnostische mittel
CA2672956C (en) 2006-10-26 2015-02-10 Amgen Inc. Calcium receptor modulating agents
WO2008136869A2 (en) * 2006-12-06 2008-11-13 Burnham Institute For Medical Research Methods and compositions related to targeting wounds, regenerating tissue, and tumors
CA2784145A1 (en) * 2009-12-18 2011-06-23 Sanford-Burnham Medical Research Institute Methods and compositions related to clot-binding compounds

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003508027A (ja) * 1999-07-29 2003-03-04 ダイアックス コーポレイション フィブリン結合性部分
JP2004523514A (ja) * 2000-12-23 2004-08-05 ダイアックス コーポレーション 造影剤として有用なフィブリン結合部分
JP2005536537A (ja) * 2002-08-20 2005-12-02 バーンズ−ジューイッシュ ホスピタル 血餅−標的ナノパーティクル
US20050048063A1 (en) * 2002-08-28 2005-03-03 Erkki Ruoslahti Collagen-binding molecules that selectively home to tumor vasculature and methods of using same
WO2005044224A2 (en) * 2003-05-02 2005-05-19 Case Western Reserve University Drug delivery system based on polymer nanoshells
JP2009543806A (ja) * 2006-07-13 2009-12-10 バーナム インスティテュート フォー メディカル リサーチ gC1qR/p32を標的化するための方法および組成物

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017536359A (ja) * 2014-11-21 2017-12-07 ゼネラル・エレクトリック・カンパニイ 診断及び治療用途のマイクロバブルテザー
US10751429B2 (en) 2014-11-21 2020-08-25 General Electric Company Microbubble tether for diagnostic and therapeutic applications
US11007285B2 (en) 2014-11-21 2021-05-18 General Electric Company Microbubble tether for diagnostic and therapeutic applications

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