ATE495197T1 - Chimäre konstrukte zwischen auf krebs zielenden peptiden und zellpenetrierenden peptiden gekoppelt an antikrebsmittel und/oder diagnostische mittel - Google Patents
Chimäre konstrukte zwischen auf krebs zielenden peptiden und zellpenetrierenden peptiden gekoppelt an antikrebsmittel und/oder diagnostische mittelInfo
- Publication number
- ATE495197T1 ATE495197T1 AT07716076T AT07716076T ATE495197T1 AT E495197 T1 ATE495197 T1 AT E495197T1 AT 07716076 T AT07716076 T AT 07716076T AT 07716076 T AT07716076 T AT 07716076T AT E495197 T1 ATE495197 T1 AT E495197T1
- Authority
- AT
- Austria
- Prior art keywords
- cell
- seq
- peptides
- cancer
- targing
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title abstract 4
- 229940039227 diagnostic agent Drugs 0.000 title abstract 4
- 239000000032 diagnostic agent Substances 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000020313 Cell-Penetrating Peptides Human genes 0.000 title abstract 3
- 108010051109 Cell-Penetrating Peptides Proteins 0.000 title abstract 3
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
- 229940041181 antineoplastic drug Drugs 0.000 abstract 3
- 239000002168 alkylating agent Substances 0.000 abstract 1
- 229940100198 alkylating agent Drugs 0.000 abstract 1
- 230000000340 anti-metabolite Effects 0.000 abstract 1
- 229940100197 antimetabolite Drugs 0.000 abstract 1
- 239000002256 antimetabolite Substances 0.000 abstract 1
- 239000003972 antineoplastic antibiotic Substances 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000007850 fluorescent dye Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0041—Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal
- A61K49/0043—Fluorescein, used in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78339606P | 2006-03-20 | 2006-03-20 | |
| PCT/SE2007/000268 WO2007108749A1 (en) | 2006-03-20 | 2007-03-20 | Chimeric constructs between cancer-homing peptides and cell-penetrating peptides coupled to anticancer drugs and/or diagnostic agent/agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE495197T1 true ATE495197T1 (de) | 2011-01-15 |
Family
ID=38522712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07716076T ATE495197T1 (de) | 2006-03-20 | 2007-03-20 | Chimäre konstrukte zwischen auf krebs zielenden peptiden und zellpenetrierenden peptiden gekoppelt an antikrebsmittel und/oder diagnostische mittel |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100279918A1 (de) |
| EP (1) | EP1991586B1 (de) |
| AT (1) | ATE495197T1 (de) |
| DE (1) | DE602007011901D1 (de) |
| WO (1) | WO2007108749A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008085794A2 (en) | 2007-01-03 | 2008-07-17 | Burnham Institute For Medical Research | Methods and compositions related to clot binding compounds |
| AU2009215426B2 (en) * | 2008-02-21 | 2015-06-11 | Burnham Institute For Medical Research | Methods and compositions related to peptides and proteins with C-terminal elements |
| CN102869384B (zh) | 2009-06-22 | 2016-01-13 | 伯纳姆医学研究所 | 使用带有c-端元件的肽和蛋白质的方法和组合物 |
| WO2011020107A2 (en) * | 2009-08-14 | 2011-02-17 | Georgetown University | Compositions and methods for detection and treatment of breast cancer |
| EP2512497A1 (de) | 2009-12-18 | 2012-10-24 | Sanford-Burnham Medical Research Institute | Verfahren und zusammensetzungen im zusammenhang mit gerinnselbindenden verbndungen |
| CA2800741C (en) * | 2010-05-30 | 2018-07-24 | The Governing Council Of The University Of Toronto | Mitochondrial penetrating peptides as carriers for anticancer compounds |
| US9173952B2 (en) * | 2010-05-30 | 2015-11-03 | The Governing Council Of The University Of Toronto | Mitochondrial penetrating peptides as carriers for antimicrobials |
| EP2671597A1 (de) * | 2012-06-07 | 2013-12-11 | Cepep III AB | Chimäre Konstrukte zwischen gliomabzielendem Peptid und zellpenetrierenden Peptiden, gHoPe2 |
| JP6320382B2 (ja) | 2012-08-13 | 2018-05-09 | ザ ロックフェラー ユニヴァーシティ | メラノーマの処置および診断 |
| CN103981147B (zh) | 2013-02-08 | 2017-11-10 | 中国科学院上海生命科学研究院 | 一种新的制备肝实质细胞的方法 |
| WO2014147193A1 (en) * | 2013-03-20 | 2014-09-25 | Centre National De La Recherche Scientifique (Cnrs) | New cell-penetrating peptide motifs |
| US10815276B2 (en) | 2014-05-21 | 2020-10-27 | Entrada Therapeutics, Inc. | Cell penetrating peptides and methods of making and using thereof |
| CN106852146B (zh) * | 2014-05-21 | 2021-08-13 | 恩特拉达治疗学股份有限公司 | 细胞穿透肽及其制备和使用方法 |
| WO2016033368A1 (en) | 2014-08-27 | 2016-03-03 | Ohio State Innovation Foundation | Improved peptidyl calcineurin inhibitors |
| US10669311B2 (en) | 2015-04-23 | 2020-06-02 | Sanford Burnham Prebys Medical Discovery Institute | Targeted delivery system and methods of use therefor |
| WO2018227112A1 (en) * | 2017-06-09 | 2018-12-13 | The Trustees Of Columbia University In The City Of New York | Short tat oligomers for drug delivery |
| WO2019104062A1 (en) | 2017-11-21 | 2019-05-31 | Rgenix, Inc. | Polymorphs and uses thereof |
| EP3749365A4 (de) | 2018-01-29 | 2022-01-12 | Ohio State Innovation Foundation | Peptidylinhibitoren der calcineurin-nfat-interaktion |
| EP3755351A4 (de) | 2018-02-22 | 2021-11-24 | Entrada Therapeutics, Inc. | Zusammensetzungen und verfahren zur behandlung von mitochondrialer neurogastrointestinaler enzephalopathie |
| CN112386707B (zh) * | 2019-08-19 | 2023-08-11 | 辽宁医学诊疗科技研发中心有限公司 | 一种肿瘤靶向多肽药物偶联物及其制备方法 |
| US11174220B2 (en) | 2019-12-13 | 2021-11-16 | Inspirna, Inc. | Metal salts and uses thereof |
| EP4281034A1 (de) | 2021-01-24 | 2023-11-29 | Forrest, Michael, David | Inhibitoren der atp-synthase kosmetische und therapeutische verwendungen |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030077826A1 (en) * | 2001-02-02 | 2003-04-24 | Lena Edelman | Chimeric molecules containing a module able to target specific cells and a module regulating the apoptogenic function of the permeability transition pore complex (PTPC) |
| US7488792B2 (en) * | 2002-08-28 | 2009-02-10 | Burnham Institute For Medical Research | Collagen-binding molecules that selectively home to tumor vasculature and methods of using same |
| WO2004106370A1 (en) * | 2003-05-28 | 2004-12-09 | Theraptosis Sa | M11l derived peptides and therapeutic use thereof |
| US20060182736A1 (en) * | 2003-06-10 | 2006-08-17 | Kim Jin-Soo | Transducible dna-binding proteins |
| JP2009519033A (ja) * | 2005-12-16 | 2009-05-14 | ディアト | 核酸を細胞に送達するための細胞貫通ペプチド結合体 |
-
2007
- 2007-03-20 WO PCT/SE2007/000268 patent/WO2007108749A1/en active Application Filing
- 2007-03-20 US US12/225,367 patent/US20100279918A1/en not_active Abandoned
- 2007-03-20 AT AT07716076T patent/ATE495197T1/de not_active IP Right Cessation
- 2007-03-20 EP EP07716076A patent/EP1991586B1/de not_active Not-in-force
- 2007-03-20 DE DE602007011901T patent/DE602007011901D1/de active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007108749A1 (en) | 2007-09-27 |
| EP1991586B1 (de) | 2011-01-12 |
| WO2007108749A8 (en) | 2009-08-13 |
| DE602007011901D1 (de) | 2011-02-24 |
| US20100279918A1 (en) | 2010-11-04 |
| EP1991586A1 (de) | 2008-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |