JP2008528517A5 - - Google Patents
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- Publication number
- JP2008528517A5 JP2008528517A5 JP2007552407A JP2007552407A JP2008528517A5 JP 2008528517 A5 JP2008528517 A5 JP 2008528517A5 JP 2007552407 A JP2007552407 A JP 2007552407A JP 2007552407 A JP2007552407 A JP 2007552407A JP 2008528517 A5 JP2008528517 A5 JP 2008528517A5
- Authority
- JP
- Japan
- Prior art keywords
- piperazin
- phenyl
- methylsulfonyl
- ethyl
- benzenamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64695705P | 2005-01-25 | 2005-01-25 | |
| US60/646,957 | 2005-01-25 | ||
| US70185305P | 2005-07-22 | 2005-07-22 | |
| US60/701,853 | 2005-07-22 | ||
| PCT/US2006/002718 WO2006081332A1 (en) | 2005-01-25 | 2006-01-25 | Substituted arylamine compounds and their use as 5-ht6 modulators |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012060984A Division JP2012111784A (ja) | 2005-01-25 | 2012-03-16 | 置換アリールアミン化合物および5−ht6調節因子としてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528517A JP2008528517A (ja) | 2008-07-31 |
| JP2008528517A5 true JP2008528517A5 (enExample) | 2009-03-12 |
| JP5186219B2 JP5186219B2 (ja) | 2013-04-17 |
Family
ID=36406535
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007552407A Expired - Fee Related JP5186219B2 (ja) | 2005-01-25 | 2006-01-25 | 置換アリールアミン化合物および5−ht6調節因子としてのその使用 |
| JP2012060984A Withdrawn JP2012111784A (ja) | 2005-01-25 | 2012-03-16 | 置換アリールアミン化合物および5−ht6調節因子としてのその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012060984A Withdrawn JP2012111784A (ja) | 2005-01-25 | 2012-03-16 | 置換アリールアミン化合物および5−ht6調節因子としてのその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7968538B2 (enExample) |
| EP (1) | EP1856075A1 (enExample) |
| JP (2) | JP5186219B2 (enExample) |
| KR (1) | KR20070097590A (enExample) |
| AU (1) | AU2006209216A1 (enExample) |
| BR (1) | BRPI0606110A2 (enExample) |
| CA (1) | CA2595607C (enExample) |
| IL (1) | IL184705A0 (enExample) |
| MA (1) | MA29429B1 (enExample) |
| MX (1) | MX2007008279A (enExample) |
| NO (1) | NO20074324L (enExample) |
| NZ (1) | NZ556761A (enExample) |
| RU (1) | RU2440996C2 (enExample) |
| WO (1) | WO2006081332A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7482337B2 (en) * | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| US7153858B2 (en) * | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US7612078B2 (en) * | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| DE102004009039A1 (de) * | 2004-02-23 | 2005-09-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel |
| US7488736B2 (en) * | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| DE102004030502A1 (de) * | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel |
| US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| EP1676842A1 (en) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments |
| JP5186219B2 (ja) | 2005-01-25 | 2013-04-17 | エピックス デラウェア, インコーポレイテッド | 置換アリールアミン化合物および5−ht6調節因子としてのその使用 |
| AR061637A1 (es) * | 2006-06-26 | 2008-09-10 | Epix Delaware Inc | Composiciones y metodos de tratamiento de trastornos del snc |
| PT2354124E (pt) | 2006-12-19 | 2013-04-09 | Hoffmann La Roche | Derivados de heteroaril-pirrolidinilo e piperidinil-cetona |
| AU2008231789A1 (en) | 2007-03-23 | 2008-10-02 | Abbott Gmbh & Co. Kg | Azetidin compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor |
| EP2103596A1 (en) | 2008-03-18 | 2009-09-23 | Laboratorios Del. Dr. Esteve, S.A. | Process for the preparation of N-(phenylethyl) anilines salts and solvates thereof useful as serotonin 5-HT6 antagonists |
| ES2353297B1 (es) * | 2008-03-18 | 2011-09-26 | Laboratorios Del Dr. Esteve, S. A. | Procedimiento para la preparación de n-(1-feniletil)anilinas, sales, y solvatos de las mismas útiles como antagonistas de 5-ht6 de serotonina. |
| WO2010065743A2 (en) * | 2008-12-03 | 2010-06-10 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| MX2012009377A (es) * | 2010-02-11 | 2012-09-12 | Univ Vanderbilt | Benzotiazoles y azabenzotiazoles como potenciadores alostericos mglur4, composiciones y metodos para tratar la disfuncion neurologica. |
| TWI458145B (zh) | 2011-12-20 | 2014-10-21 | Ind Tech Res Inst | 超導材料的接合方法 |
| KR102967223B1 (ko) | 2013-12-03 | 2026-05-19 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| JP7013454B2 (ja) | 2016-10-12 | 2022-02-15 | イントラ-セルラー・セラピーズ・インコーポレイテッド | アモルファス固体分散体 |
| US11459308B2 (en) | 2016-12-05 | 2022-10-04 | Microbiotix, Inc. | Broad spectrum inhibitors of filoviruses |
| EP3600325A4 (en) | 2017-03-24 | 2021-01-06 | Intra-Cellular Therapies, Inc. | UNIQUE COMPOSITIONS AND PROCESSES |
| EP4092013A1 (en) | 2017-06-20 | 2022-11-23 | Imbria Pharmaceuticals, Inc. | Compositions and methods for increasing efficiency of cardiac metabolism |
| KR101992621B1 (ko) | 2017-12-07 | 2019-09-27 | 주식회사 온코빅스 | 암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물 |
| SMT202600133T1 (it) | 2018-03-23 | 2026-05-12 | Intra Cellular Therapies Inc | Composti organici |
| US12144808B2 (en) | 2018-08-29 | 2024-11-19 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| AU2019328528B2 (en) | 2018-08-31 | 2025-01-23 | Intra-Cellular Therapies, Inc. | Novel methods |
| WO2020047408A1 (en) | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
| US12318382B2 (en) | 2018-10-17 | 2025-06-03 | Imbria Pharmaceuticals, Inc. | Methods of treating rheumatic diseases using trimetazidine-based compounds |
| EP3976101A4 (en) | 2019-05-31 | 2023-06-21 | Imbria Pharmaceuticals, Inc. | FIBROSIS TREATMENT METHODS USING COMPOUNDS THAT PROMOTE GLUCOSE OXIDATION |
| EP4134101A1 (en) | 2019-07-07 | 2023-02-15 | Intra-Cellular Therapies, Inc. | Deuterated lumateperone for the treatment of the bipolar ii disorder |
| GB2606804B (en) | 2019-07-17 | 2023-12-27 | 2692372 Ontario Inc | Benzenesulfonamide derivatives and uses thereof |
| CN112574201B (zh) * | 2019-09-29 | 2024-04-19 | 四川科伦博泰生物医药股份有限公司 | 芳基胺类化合物、包含其的药物组合物及其制备方法和用途 |
| US11780811B2 (en) | 2020-06-30 | 2023-10-10 | Imbria Pharmaceuticals, Inc. | Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US11530184B2 (en) | 2020-06-30 | 2022-12-20 | Imbria Pharmaceuticals, Inc. | Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate |
| US12029718B2 (en) | 2021-11-09 | 2024-07-09 | Cct Sciences, Llc | Process for production of essentially pure delta-9-tetrahydrocannabinol |
| MX2023005971A (es) | 2020-11-20 | 2023-06-07 | 2692372 Ontario Inc | Metodos y composicion para las modificaciones de kras. |
| US11883396B2 (en) | 2021-05-03 | 2024-01-30 | Imbria Pharmaceuticals, Inc. | Methods of treating kidney conditions using modified forms of trimetazidine |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1211359B (de) * | 1955-11-29 | 1966-02-24 | Oreal | Oxydationsmittelfreies Kaltfaerbemittel fuer menschliches Haar |
| JPH0413669A (ja) * | 1990-04-27 | 1992-01-17 | Mitsui Toatsu Chem Inc | 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤 |
| DE4238994A1 (de) * | 1992-11-19 | 1994-05-26 | Basf Ag | Aniline als Markierungsmittel für Mineralöle |
| JPH07300474A (ja) * | 1994-05-02 | 1995-11-14 | Asahi Chem Ind Co Ltd | テトラハイドロキノキサリン誘導体およびその用途 |
| FR2722788B1 (fr) * | 1994-07-20 | 1996-10-04 | Pf Medicament | Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
| WO1997005131A1 (en) * | 1995-08-02 | 1997-02-13 | J. Uriach & Cia. S.A. | New carboxamides with antifungal activity |
| FR2740134B1 (fr) * | 1995-10-18 | 1998-01-09 | Pf Medicament | Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant |
| US6391871B1 (en) * | 1996-09-20 | 2002-05-21 | John W. Olney | Preventing neuronal degeneration in Alzheimer's disease |
| US20010051719A1 (en) | 1996-12-19 | 2001-12-13 | Smithkline Beecham P.L.C. | Novel compounds |
| DE69815090T2 (de) * | 1997-03-03 | 2004-02-19 | Eisai Co., Ltd. | Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen |
| FR2761064B1 (fr) * | 1997-03-20 | 1999-06-04 | Pf Medicament | Piperazines derivees d'amines cycliques, leur preparation et leur application comme medicaments |
| KR100607838B1 (ko) * | 1997-10-27 | 2006-08-04 | 뉴로서치 에이/에스 | 니코틴 작용성 아세틸콜린 수용체상의 콜린 작용성 리간드로서의 호모피페라진 유도체 및 이를 포함하는 약제학적 조성물 |
| ATE401312T1 (de) * | 1997-12-15 | 2008-08-15 | Astellas Pharma Inc | Pyrimidin-5-carboxamid-derivate |
| IT1304904B1 (it) * | 1998-09-11 | 2001-04-05 | Eisai Co Ltd | Derivati anticolinesterasici per il trattamento delle sindromidolorose funzionali e/o organiche |
| WO2000040554A1 (en) | 1999-01-07 | 2000-07-13 | American Home Products Corporation | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
| US6972287B1 (en) * | 1999-06-10 | 2005-12-06 | Pfizer Inc. | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits |
| BR0011823A (pt) | 1999-06-22 | 2002-03-19 | Neurosearch As | Derivado de benzimidazol, composto, composição farmacêutica, uso de um derivado de benzimidazol, e, método para tratamento, prevenção ou alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo animal vivo |
| US6610713B2 (en) * | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| PE20020063A1 (es) * | 2000-06-20 | 2002-01-30 | Upjohn Co | Bis-arilsulfonas como ligandos del receptor de 5-ht |
| US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
| JP2004532200A (ja) * | 2001-03-15 | 2004-10-21 | サエジス ファーマシューティカルズ, インコーポレイテッド | 全身性ストレスの後に認識機能を回復するための方法 |
| JP2004534017A (ja) * | 2001-04-27 | 2004-11-11 | バーテックス ファーマシューティカルズ インコーポレイテッド | Baceのインヒビター |
| MXPA03010232A (es) * | 2001-05-11 | 2004-03-16 | Biovitrum Ab | Compuestos de arilsulfonamida, para el tratamiento de la obesidad, de la diabetes tipo ii y de trastornos del sistema nervioso central. |
| US6825198B2 (en) * | 2001-06-21 | 2004-11-30 | Pfizer Inc | 5-HT receptor ligands and uses thereof |
| US6638981B2 (en) * | 2001-08-17 | 2003-10-28 | Epicept Corporation | Topical compositions and methods for treating pain |
| CA2465978C (en) * | 2001-09-14 | 2015-04-07 | Soon Hyung Woo | Inhibitors of histone deacetylase |
| AU2003220184A1 (en) * | 2002-03-20 | 2003-10-08 | Schering Aktiengesellschaft | Substituted piperazine antithrombotic pai-1 inhibitors |
| WO2004034963A2 (en) * | 2002-05-17 | 2004-04-29 | Eisai Co., Ltd. | Methods and compositions using cholinesterase inhibitors |
| TW200403243A (en) | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| IL166241A0 (en) | 2002-07-29 | 2006-01-15 | Rigel Pharmaceuticals Inc | Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds |
| AU2004218260A1 (en) * | 2003-01-28 | 2004-09-16 | Aventis Pharma S.A. | N-aryl heteroaromatic products, compositions containing same and use thereof |
| US7153858B2 (en) * | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| AR043467A1 (es) * | 2003-03-05 | 2005-07-27 | Osmotica Argentina S A | Combinacion de drogas para la disfuncion motora en la enfermedad de parkinson |
| GB0305929D0 (en) * | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| BRPI0408988A (pt) * | 2003-03-31 | 2006-03-28 | Predix Pharmaceuticals Holding | composto de piperidinilamino-tieno[2,3-d]pirimidina |
| US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US7612078B2 (en) * | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US20060148721A1 (en) * | 2003-06-06 | 2006-07-06 | Erondu Ngozi E | Combination therapy for the treatment of dyslipidemia |
| US20060188618A1 (en) | 2003-07-24 | 2006-08-24 | John Van De Sype | Food composition contain lecithin |
| ES2222827B1 (es) | 2003-07-30 | 2006-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| GB0321710D0 (en) * | 2003-09-16 | 2003-10-15 | Novartis Ag | Organic compounds |
| US20050143350A1 (en) * | 2003-11-19 | 2005-06-30 | Seed John C. | Combination drug therapy to treat obesity |
| WO2005079756A2 (en) * | 2004-02-13 | 2005-09-01 | Neuromolecular, Inc. | Combination of a nmda receptor antagonist and an anti-depressive drug mao-inhibitor or a gadph-inhibitor for the treatment of psychiatric conditions |
| US7488736B2 (en) * | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| GB0411791D0 (en) | 2004-05-26 | 2004-06-30 | Cyclacel Ltd | Compounds |
| US7713954B2 (en) * | 2004-09-30 | 2010-05-11 | Roche Palo Alto Llc | Compositions and methods for treating cognitive disorders |
| US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| WO2006042249A2 (en) * | 2004-10-08 | 2006-04-20 | Neuromolecular Pharmaceuticals, Inc. | Methods and compositions for treating migraine pain |
| WO2006068826A2 (en) * | 2004-12-21 | 2006-06-29 | Smithkline Beecham Corporation | 2-pyrimidinyl pyrazolopyridine erbb kinase inhibitors |
| PL1836169T3 (pl) | 2004-12-28 | 2012-07-31 | Kinex Pharmaceuticals Llc | Kompozycje i sposoby leczenia zaburzeń związanych z proliferacją komórek |
| EP1676842A1 (en) * | 2004-12-30 | 2006-07-05 | Laboratorios Del Dr. Esteve, S.A. | Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments |
| EP1695971A1 (en) * | 2004-12-30 | 2006-08-30 | Laboratorios Del Dr. Esteve, S.A. | Substituted phenyl-piperazine compounds, their preparation and use in medicaments |
| JP5186219B2 (ja) | 2005-01-25 | 2013-04-17 | エピックス デラウェア, インコーポレイテッド | 置換アリールアミン化合物および5−ht6調節因子としてのその使用 |
| WO2006086698A2 (en) * | 2005-02-11 | 2006-08-17 | Stephen Wills | Treating microvasculature diseases with acetyl cholinesterase inhibitors |
| US20060194723A1 (en) * | 2005-02-28 | 2006-08-31 | Rabinoff Michael D | Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement |
| ES2819303T3 (es) * | 2005-04-05 | 2021-04-15 | Univ Yale | Agentes moduladores del glutamato en el tratamiento de trastornos mentales |
| US20060270650A1 (en) * | 2005-05-26 | 2006-11-30 | Macneil Tanya | Combination therapy for the treatment of obesity |
| US7919519B2 (en) * | 2005-11-23 | 2011-04-05 | Epix Pharmaceuticals Inc. | S1P receptor modulating compounds and use thereof |
| CA2630714C (en) * | 2005-11-23 | 2014-01-14 | Epix Delaware, Inc. | S1p receptor modulating compounds and use thereof |
| WO2007109330A2 (en) * | 2006-03-21 | 2007-09-27 | Epix Delaware, Inc. | S1p receptor modulating compounds |
-
2006
- 2006-01-25 JP JP2007552407A patent/JP5186219B2/ja not_active Expired - Fee Related
- 2006-01-25 EP EP06719542A patent/EP1856075A1/en not_active Withdrawn
- 2006-01-25 US US11/340,079 patent/US7968538B2/en not_active Expired - Fee Related
- 2006-01-25 NZ NZ556761A patent/NZ556761A/en not_active IP Right Cessation
- 2006-01-25 WO PCT/US2006/002718 patent/WO2006081332A1/en not_active Ceased
- 2006-01-25 RU RU2007132161/04A patent/RU2440996C2/ru not_active IP Right Cessation
- 2006-01-25 BR BRPI0606110-9A patent/BRPI0606110A2/pt not_active IP Right Cessation
- 2006-01-25 CA CA2595607A patent/CA2595607C/en not_active Expired - Fee Related
- 2006-01-25 KR KR1020077019390A patent/KR20070097590A/ko not_active Ceased
- 2006-01-25 AU AU2006209216A patent/AU2006209216A1/en not_active Abandoned
- 2006-01-25 MX MX2007008279A patent/MX2007008279A/es active IP Right Grant
-
2007
- 2007-07-18 IL IL184705A patent/IL184705A0/en unknown
- 2007-08-07 MA MA30129A patent/MA29429B1/fr unknown
- 2007-08-24 NO NO20074324A patent/NO20074324L/no not_active Application Discontinuation
-
2011
- 2011-05-10 US US13/104,450 patent/US8604021B2/en not_active Expired - Fee Related
-
2012
- 2012-03-16 JP JP2012060984A patent/JP2012111784A/ja not_active Withdrawn
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