JP2008528517A5 - - Google Patents

Download PDF

Info

Publication number
JP2008528517A5
JP2008528517A5 JP2007552407A JP2007552407A JP2008528517A5 JP 2008528517 A5 JP2008528517 A5 JP 2008528517A5 JP 2007552407 A JP2007552407 A JP 2007552407A JP 2007552407 A JP2007552407 A JP 2007552407A JP 2008528517 A5 JP2008528517 A5 JP 2008528517A5
Authority
JP
Japan
Prior art keywords
piperazin
phenyl
methylsulfonyl
ethyl
benzenamine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2007552407A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008528517A (ja
JP5186219B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/002718 external-priority patent/WO2006081332A1/en
Publication of JP2008528517A publication Critical patent/JP2008528517A/ja
Publication of JP2008528517A5 publication Critical patent/JP2008528517A5/ja
Application granted granted Critical
Publication of JP5186219B2 publication Critical patent/JP5186219B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2007552407A 2005-01-25 2006-01-25 置換アリールアミン化合物および5−ht6調節因子としてのその使用 Expired - Fee Related JP5186219B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US64695705P 2005-01-25 2005-01-25
US60/646,957 2005-01-25
US70185305P 2005-07-22 2005-07-22
US60/701,853 2005-07-22
PCT/US2006/002718 WO2006081332A1 (en) 2005-01-25 2006-01-25 Substituted arylamine compounds and their use as 5-ht6 modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012060984A Division JP2012111784A (ja) 2005-01-25 2012-03-16 置換アリールアミン化合物および5−ht6調節因子としてのその使用

Publications (3)

Publication Number Publication Date
JP2008528517A JP2008528517A (ja) 2008-07-31
JP2008528517A5 true JP2008528517A5 (enExample) 2009-03-12
JP5186219B2 JP5186219B2 (ja) 2013-04-17

Family

ID=36406535

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2007552407A Expired - Fee Related JP5186219B2 (ja) 2005-01-25 2006-01-25 置換アリールアミン化合物および5−ht6調節因子としてのその使用
JP2012060984A Withdrawn JP2012111784A (ja) 2005-01-25 2012-03-16 置換アリールアミン化合物および5−ht6調節因子としてのその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012060984A Withdrawn JP2012111784A (ja) 2005-01-25 2012-03-16 置換アリールアミン化合物および5−ht6調節因子としてのその使用

Country Status (14)

Country Link
US (2) US7968538B2 (enExample)
EP (1) EP1856075A1 (enExample)
JP (2) JP5186219B2 (enExample)
KR (1) KR20070097590A (enExample)
AU (1) AU2006209216A1 (enExample)
BR (1) BRPI0606110A2 (enExample)
CA (1) CA2595607C (enExample)
IL (1) IL184705A0 (enExample)
MA (1) MA29429B1 (enExample)
MX (1) MX2007008279A (enExample)
NO (1) NO20074324L (enExample)
NZ (1) NZ556761A (enExample)
RU (1) RU2440996C2 (enExample)
WO (1) WO2006081332A1 (enExample)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7482337B2 (en) * 2002-11-08 2009-01-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions
US7153858B2 (en) * 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
DE102004009039A1 (de) * 2004-02-23 2005-09-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
DE102004030502A1 (de) * 2004-06-24 2006-01-12 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7576211B2 (en) * 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
EP1676842A1 (en) * 2004-12-30 2006-07-05 Laboratorios Del Dr. Esteve, S.A. Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments
JP5186219B2 (ja) 2005-01-25 2013-04-17 エピックス デラウェア, インコーポレイテッド 置換アリールアミン化合物および5−ht6調節因子としてのその使用
AR061637A1 (es) * 2006-06-26 2008-09-10 Epix Delaware Inc Composiciones y metodos de tratamiento de trastornos del snc
PT2354124E (pt) 2006-12-19 2013-04-09 Hoffmann La Roche Derivados de heteroaril-pirrolidinilo e piperidinil-cetona
AU2008231789A1 (en) 2007-03-23 2008-10-02 Abbott Gmbh & Co. Kg Azetidin compounds suitable for treating disorders that respond to modulation of the serotonin 5-HT6 receptor
EP2103596A1 (en) 2008-03-18 2009-09-23 Laboratorios Del. Dr. Esteve, S.A. Process for the preparation of N-(phenylethyl) anilines salts and solvates thereof useful as serotonin 5-HT6 antagonists
ES2353297B1 (es) * 2008-03-18 2011-09-26 Laboratorios Del Dr. Esteve, S. A. Procedimiento para la preparación de n-(1-feniletil)anilinas, sales, y solvatos de las mismas útiles como antagonistas de 5-ht6 de serotonina.
WO2010065743A2 (en) * 2008-12-03 2010-06-10 Nanotherapeutics, Inc. Bicyclic compounds and methods of making and using same
MX2012009377A (es) * 2010-02-11 2012-09-12 Univ Vanderbilt Benzotiazoles y azabenzotiazoles como potenciadores alostericos mglur4, composiciones y metodos para tratar la disfuncion neurologica.
TWI458145B (zh) 2011-12-20 2014-10-21 Ind Tech Res Inst 超導材料的接合方法
KR102967223B1 (ko) 2013-12-03 2026-05-19 인트라-셀룰라 써래피스, 인코퍼레이티드. 신규한 방법
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ-セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
US11459308B2 (en) 2016-12-05 2022-10-04 Microbiotix, Inc. Broad spectrum inhibitors of filoviruses
EP3600325A4 (en) 2017-03-24 2021-01-06 Intra-Cellular Therapies, Inc. UNIQUE COMPOSITIONS AND PROCESSES
EP4092013A1 (en) 2017-06-20 2022-11-23 Imbria Pharmaceuticals, Inc. Compositions and methods for increasing efficiency of cardiac metabolism
KR101992621B1 (ko) 2017-12-07 2019-09-27 주식회사 온코빅스 암세포 성장 억제 효과를 나타내는 신규한 피리미딘 유도체 및 그를 포함하는 약제학적 조성물
SMT202600133T1 (it) 2018-03-23 2026-05-12 Intra Cellular Therapies Inc Composti organici
US12144808B2 (en) 2018-08-29 2024-11-19 Intra-Cellular Therapies, Inc. Compositions and methods
AU2019328528B2 (en) 2018-08-31 2025-01-23 Intra-Cellular Therapies, Inc. Novel methods
WO2020047408A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
US12318382B2 (en) 2018-10-17 2025-06-03 Imbria Pharmaceuticals, Inc. Methods of treating rheumatic diseases using trimetazidine-based compounds
EP3976101A4 (en) 2019-05-31 2023-06-21 Imbria Pharmaceuticals, Inc. FIBROSIS TREATMENT METHODS USING COMPOUNDS THAT PROMOTE GLUCOSE OXIDATION
EP4134101A1 (en) 2019-07-07 2023-02-15 Intra-Cellular Therapies, Inc. Deuterated lumateperone for the treatment of the bipolar ii disorder
GB2606804B (en) 2019-07-17 2023-12-27 2692372 Ontario Inc Benzenesulfonamide derivatives and uses thereof
CN112574201B (zh) * 2019-09-29 2024-04-19 四川科伦博泰生物医药股份有限公司 芳基胺类化合物、包含其的药物组合物及其制备方法和用途
US11780811B2 (en) 2020-06-30 2023-10-10 Imbria Pharmaceuticals, Inc. Methods of synthesizing 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US11530184B2 (en) 2020-06-30 2022-12-20 Imbria Pharmaceuticals, Inc. Crystal forms of 2-[4-[(2,3,4-trimethoxyphenyl)methyl]piperazin-1-yl]ethyl pyridine-3-carboxylate
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol
MX2023005971A (es) 2020-11-20 2023-06-07 2692372 Ontario Inc Metodos y composicion para las modificaciones de kras.
US11883396B2 (en) 2021-05-03 2024-01-30 Imbria Pharmaceuticals, Inc. Methods of treating kidney conditions using modified forms of trimetazidine
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1211359B (de) * 1955-11-29 1966-02-24 Oreal Oxydationsmittelfreies Kaltfaerbemittel fuer menschliches Haar
JPH0413669A (ja) * 1990-04-27 1992-01-17 Mitsui Toatsu Chem Inc 新規ピリミジンジオン誘導体及び該化合物を含有する抗不整脈剤
DE4238994A1 (de) * 1992-11-19 1994-05-26 Basf Ag Aniline als Markierungsmittel für Mineralöle
JPH07300474A (ja) * 1994-05-02 1995-11-14 Asahi Chem Ind Co Ltd テトラハイドロキノキサリン誘導体およびその用途
FR2722788B1 (fr) * 1994-07-20 1996-10-04 Pf Medicament Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant
WO1997005131A1 (en) * 1995-08-02 1997-02-13 J. Uriach & Cia. S.A. New carboxamides with antifungal activity
FR2740134B1 (fr) * 1995-10-18 1998-01-09 Pf Medicament Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant
US6391871B1 (en) * 1996-09-20 2002-05-21 John W. Olney Preventing neuronal degeneration in Alzheimer's disease
US20010051719A1 (en) 1996-12-19 2001-12-13 Smithkline Beecham P.L.C. Novel compounds
DE69815090T2 (de) * 1997-03-03 2004-02-19 Eisai Co., Ltd. Verwendung von cholinesterasehemmer zur behandlung von konzentrationsstörungen
FR2761064B1 (fr) * 1997-03-20 1999-06-04 Pf Medicament Piperazines derivees d'amines cycliques, leur preparation et leur application comme medicaments
KR100607838B1 (ko) * 1997-10-27 2006-08-04 뉴로서치 에이/에스 니코틴 작용성 아세틸콜린 수용체상의 콜린 작용성 리간드로서의 호모피페라진 유도체 및 이를 포함하는 약제학적 조성물
ATE401312T1 (de) * 1997-12-15 2008-08-15 Astellas Pharma Inc Pyrimidin-5-carboxamid-derivate
IT1304904B1 (it) * 1998-09-11 2001-04-05 Eisai Co Ltd Derivati anticolinesterasici per il trattamento delle sindromidolorose funzionali e/o organiche
WO2000040554A1 (en) 1999-01-07 2000-07-13 American Home Products Corporation Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
US6972287B1 (en) * 1999-06-10 2005-12-06 Pfizer Inc. Method of inhibiting amyloid protein aggregation and imaging amyloid deposits
BR0011823A (pt) 1999-06-22 2002-03-19 Neurosearch As Derivado de benzimidazol, composto, composição farmacêutica, uso de um derivado de benzimidazol, e, método para tratamento, prevenção ou alìvio de uma doença ou de um distúrbio ou de uma condição de um corpo animal vivo
US6610713B2 (en) * 2000-05-23 2003-08-26 North Shore - Long Island Jewish Research Institute Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
PE20020063A1 (es) * 2000-06-20 2002-01-30 Upjohn Co Bis-arilsulfonas como ligandos del receptor de 5-ht
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
JP2004532200A (ja) * 2001-03-15 2004-10-21 サエジス ファーマシューティカルズ, インコーポレイテッド 全身性ストレスの後に認識機能を回復するための方法
JP2004534017A (ja) * 2001-04-27 2004-11-11 バーテックス ファーマシューティカルズ インコーポレイテッド Baceのインヒビター
MXPA03010232A (es) * 2001-05-11 2004-03-16 Biovitrum Ab Compuestos de arilsulfonamida, para el tratamiento de la obesidad, de la diabetes tipo ii y de trastornos del sistema nervioso central.
US6825198B2 (en) * 2001-06-21 2004-11-30 Pfizer Inc 5-HT receptor ligands and uses thereof
US6638981B2 (en) * 2001-08-17 2003-10-28 Epicept Corporation Topical compositions and methods for treating pain
CA2465978C (en) * 2001-09-14 2015-04-07 Soon Hyung Woo Inhibitors of histone deacetylase
AU2003220184A1 (en) * 2002-03-20 2003-10-08 Schering Aktiengesellschaft Substituted piperazine antithrombotic pai-1 inhibitors
WO2004034963A2 (en) * 2002-05-17 2004-04-29 Eisai Co., Ltd. Methods and compositions using cholinesterase inhibitors
TW200403243A (en) 2002-07-18 2004-03-01 Wyeth Corp 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands
IL166241A0 (en) 2002-07-29 2006-01-15 Rigel Pharmaceuticals Inc Method of treating or preventing autoimmune diseases with 2,4-pyrimidinedinediamine compounds
AU2004218260A1 (en) * 2003-01-28 2004-09-16 Aventis Pharma S.A. N-aryl heteroaromatic products, compositions containing same and use thereof
US7153858B2 (en) * 2003-01-31 2006-12-26 Epix Delaware, Inc. Arylpiperazinyl compounds
AR043467A1 (es) * 2003-03-05 2005-07-27 Osmotica Argentina S A Combinacion de drogas para la disfuncion motora en la enfermedad de parkinson
GB0305929D0 (en) * 2003-03-14 2003-04-23 Novartis Ag Organic compounds
BRPI0408988A (pt) * 2003-03-31 2006-03-28 Predix Pharmaceuticals Holding composto de piperidinilamino-tieno[2,3-d]pirimidina
US20050222175A1 (en) * 2004-03-31 2005-10-06 Dhanoa Dale S New piperidinylamino-thieno[2,3-D] pyrimidine compounds
US7612078B2 (en) * 2003-03-31 2009-11-03 Epix Delaware, Inc. Piperidinylamino-thieno[2,3-D] pyrimidine compounds
US20060148721A1 (en) * 2003-06-06 2006-07-06 Erondu Ngozi E Combination therapy for the treatment of dyslipidemia
US20060188618A1 (en) 2003-07-24 2006-08-24 John Van De Sype Food composition contain lecithin
ES2222827B1 (es) 2003-07-30 2006-03-01 Laboratorios Del Dr. Esteve, S.A. Derivados de 5-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos.
GB0321710D0 (en) * 2003-09-16 2003-10-15 Novartis Ag Organic compounds
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
WO2005079756A2 (en) * 2004-02-13 2005-09-01 Neuromolecular, Inc. Combination of a nmda receptor antagonist and an anti-depressive drug mao-inhibitor or a gadph-inhibitor for the treatment of psychiatric conditions
US7488736B2 (en) * 2004-05-17 2009-02-10 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
GB0411791D0 (en) 2004-05-26 2004-06-30 Cyclacel Ltd Compounds
US7713954B2 (en) * 2004-09-30 2010-05-11 Roche Palo Alto Llc Compositions and methods for treating cognitive disorders
US7407966B2 (en) * 2004-10-07 2008-08-05 Epix Delaware, Inc. Thienopyridinone compounds and methods of treatment
US7598265B2 (en) * 2004-09-30 2009-10-06 Epix Delaware, Inc. Compositions and methods for treating CNS disorders
US7576211B2 (en) * 2004-09-30 2009-08-18 Epix Delaware, Inc. Synthesis of thienopyridinone compounds and related intermediates
WO2006042249A2 (en) * 2004-10-08 2006-04-20 Neuromolecular Pharmaceuticals, Inc. Methods and compositions for treating migraine pain
WO2006068826A2 (en) * 2004-12-21 2006-06-29 Smithkline Beecham Corporation 2-pyrimidinyl pyrazolopyridine erbb kinase inhibitors
PL1836169T3 (pl) 2004-12-28 2012-07-31 Kinex Pharmaceuticals Llc Kompozycje i sposoby leczenia zaburzeń związanych z proliferacją komórek
EP1676842A1 (en) * 2004-12-30 2006-07-05 Laboratorios Del Dr. Esteve, S.A. Nitro-substituted phenyl-piperazine compounds, their preparation and use in medicaments
EP1695971A1 (en) * 2004-12-30 2006-08-30 Laboratorios Del Dr. Esteve, S.A. Substituted phenyl-piperazine compounds, their preparation and use in medicaments
JP5186219B2 (ja) 2005-01-25 2013-04-17 エピックス デラウェア, インコーポレイテッド 置換アリールアミン化合物および5−ht6調節因子としてのその使用
WO2006086698A2 (en) * 2005-02-11 2006-08-17 Stephen Wills Treating microvasculature diseases with acetyl cholinesterase inhibitors
US20060194723A1 (en) * 2005-02-28 2006-08-31 Rabinoff Michael D Novel medication treatment and delivery strategies for Alzheimer's Disease, other disorders with memory impairment, and possible treatment strategies for memory improvement
ES2819303T3 (es) * 2005-04-05 2021-04-15 Univ Yale Agentes moduladores del glutamato en el tratamiento de trastornos mentales
US20060270650A1 (en) * 2005-05-26 2006-11-30 Macneil Tanya Combination therapy for the treatment of obesity
US7919519B2 (en) * 2005-11-23 2011-04-05 Epix Pharmaceuticals Inc. S1P receptor modulating compounds and use thereof
CA2630714C (en) * 2005-11-23 2014-01-14 Epix Delaware, Inc. S1p receptor modulating compounds and use thereof
WO2007109330A2 (en) * 2006-03-21 2007-09-27 Epix Delaware, Inc. S1p receptor modulating compounds

Similar Documents

Publication Publication Date Title
RU2007132161A (ru) Замещенные ариламины и их применение в качестве модуляторов 5-ht6-рецептора
RU2439068C2 (ru) Модуляторы mglur5
RU2447060C2 (ru) Ингибиторы сфингозинкиназы
RU2451675C2 (ru) ПРОИЗВОДНЫЕ 4-(2-АМИНО-1-ГИДРОКСИЭТИЛ)ФЕНОЛА В КАЧЕСТВЕ АГОНИСТОВ β2-АДРЕНЕРГИЧЕСКОГО РЕЦЕПТОРА
RU2008108984A (ru) Терапевтический агент от диабета
JP2005532982A5 (enExample)
RU2004127925A (ru) N3-алкилированные бензимидазольные производные в качестве ингибиторов мек
RU2010142937A (ru) НОВЫЕ ПРОИЗВОДНЫЕ ПИПЕРИДИНА В КАЧЕСТВЕ ИНГИБИТОРОВ СТЕАРОИЛ-КоА ДЕСАТУРАЗЫ
NZ614305A (en) Sulfonamide derivatives as bcl-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases
JP2011518774A5 (enExample)
JP2004534755A5 (enExample)
RU2005117789A (ru) Производные 4,5-диарилтиазола в качестве лигандов св-1
JP2010526025A5 (enExample)
JP2004525951A5 (enExample)
JP2008513515A5 (enExample)
JP2008537741A5 (enExample)
RU2000105266A (ru) Производные 1-(n-фениламиноалкил)-пиперазина, замещенные в положении 2 фенильного кольца
AR063327A1 (es) Aminometil-4-imidazoles. procesos de obtencion y composiciones farmaceuticas
RU2011143740A (ru) Соединение пиримидина
JP2010519216A (ja) Ccr5拮抗薬のための医薬組成物および方法
JP2009526000A (ja) 神経変性疾患を治療するためのチアジアゾール誘導体
JP2007528387A (ja) 置換されたヘテロアリール−およびフェニルスルファモイル化合物
HRP20020664A2 (en) 1,2-diaryl benzimidazoles for treating illnesses associated with a microglia activation
JP2015524483A5 (enExample)
JP2009542661A5 (enExample)