RU2011143740A - Соединение пиримидина - Google Patents
Соединение пиримидина Download PDFInfo
- Publication number
- RU2011143740A RU2011143740A RU2011143740/04A RU2011143740A RU2011143740A RU 2011143740 A RU2011143740 A RU 2011143740A RU 2011143740/04 A RU2011143740/04 A RU 2011143740/04A RU 2011143740 A RU2011143740 A RU 2011143740A RU 2011143740 A RU2011143740 A RU 2011143740A
- Authority
- RU
- Russia
- Prior art keywords
- lower alkyl
- alkylene
- halogen
- cycloalkyl
- lower alkylene
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Reproductive Health (AREA)
- Otolaryngology (AREA)
- Obesity (AREA)
Abstract
1. Соединение формулы (I) или его сольгде Rнизший алкил, Сциклоалкил, -О-низший алкил, галоген-низший алкил, низший алкилен-Сциклоалкил или низший алкилен-О-низший алкил;R-С(О)R, -С(О)NRR, низший алкилен-R, низший алкилен-NRR, низший алкилен-NRC(О)R, низший алкилен-OR, -NRC(О)R, -NRC(О)OR, -NRC(О)NRR, -NRS(О)Rили -NRS(О)NRR;W -СН-, -NR-, -О- или -S(O)-;RСалкил; Салкенил; Салкинил; галоген-Салкил; Салкил, замещенный 1-5 группами, выбранными из группы G; R; -Салкилен-R; -Салкилен-О-R; -Салкилен-О-низший алкилен-R; -Салкилен-S(О)-R; -Х-С(R)(фенил)или -СН(фенил)-СН(ОН)-фенил;где Салкилен может содержать от 1 до 5 заместителей, выбранных из группы G;или W и R, объединенные друг с другом, представляют собойилиRодинаковые или отличаются друг от друга, при этом каждый представляет собой Н или низший алкил;Rазотсодержащая насыщенная гетероциклическая группа, которая может содержать от 1 до 5 заместителей, выбранных из группы G;Rнизший алкил, галоген-низший алкил, низший алкилен-OR, низший алкилен-О-низший алкилен-OR, низший алкилен-О-галоген-низший алкил или -Х-Сциклоалкил, низший алкилен-О-Сциклоалкил, -Х-Сциклоалкенил, низший алкилен-О-Сциклоалкенил, -Х-арил, низший алкилен-О-Х-арил, низший алкилен-S(О)-арил, -Х-гетероциклическая группа, низший алкилен-О-Х-гетероциклическая группа или низший алкилен-S(О)- гетероциклическая группа, каждый из которых может содержать от 1 до 5 заместителей, выбранных из группы Gв цикле;RН, низший алкил или низший алкилен-OR,RСциклоалкил, Сциклоалкенил, арил или гетероциклическая группа;где Rможет содержать от 1 до 5 заместителей, выбранных из группы G;Rодинаковые или отличаются друг от друга, при этом каждый представляет собой низший алкил, галоген, -О-низший алкил, галоген-ни�
Claims (15)
1. Соединение формулы (I) или его соль
где R1 низший алкил, С3-6 циклоалкил, -О-низший алкил, галоген-низший алкил, низший алкилен-С3-6 циклоалкил или низший алкилен-О-низший алкил;
R2 -С(О)R20, -С(О)NR21R22, низший алкилен-R20, низший алкилен-NR21R22, низший алкилен-NR0C(О)R21, низший алкилен-OR21, -NR0C(О)R21, -NR0C(О)OR21, -NR0C(О)NR21R22, -NR0S(О)2R21 или -NR0S(О)2NR21R22;
W -СН2-, -NR0-, -О- или -S(O)m-;
R3 С3-10 алкил; С2-6 алкенил; С2-6 алкинил; галоген-С3-6 алкил; С1-10 алкил, замещенный 1-5 группами, выбранными из группы G1; R30; -С1-10 алкилен-R30; -С1-10 алкилен-О-R30; -С1-10 алкилен-О-низший алкилен-R30; -С1-10 алкилен-S(О)2-R30; -Х-С(R0)(фенил)2 или -СН(фенил)-СН(ОН)-фенил;
где С1-10 алкилен может содержать от 1 до 5 заместителей, выбранных из группы G1;
или W и R3, объединенные друг с другом, представляют собой
или
R0 одинаковые или отличаются друг от друга, при этом каждый представляет собой Н или низший алкил;
R20 азотсодержащая насыщенная гетероциклическая группа, которая может содержать от 1 до 5 заместителей, выбранных из группы G2;
R21 низший алкил, галоген-низший алкил, низший алкилен-OR0, низший алкилен-О-низший алкилен-OR0, низший алкилен-О-галоген-низший алкил или -Х-С3-10 циклоалкил, низший алкилен-О-С3-10 циклоалкил, -Х-С3-10 циклоалкенил, низший алкилен-О-С3-10 циклоалкенил, -Х-арил, низший алкилен-О-Х-арил, низший алкилен-S(О)m-арил, -Х-гетероциклическая группа, низший алкилен-О-Х-гетероциклическая группа или низший алкилен-S(О)m- гетероциклическая группа, каждый из которых может содержать от 1 до 5 заместителей, выбранных из группы G3 в цикле;
R22 Н, низший алкил или низший алкилен-OR0,
R30 С3-10 циклоалкил, С5-10 циклоалкенил, арил или гетероциклическая группа;
где R30 может содержать от 1 до 5 заместителей, выбранных из группы G3;
R31 одинаковые или отличаются друг от друга, при этом каждый представляет собой низший алкил, галоген, -О-низший алкил, галоген-низший алкил, -С(О)OR0 или нитро;
Группа G1: галоген, -С(О)OR0, -С(О)N(R0)2, -CN, -OR0, -О- низший алкилен-OR0, -О-галоген-низший алкил, -N(R0)2, -N(R0)-фенил, -N(низший алкилен-OR0)2, -NHC(O)-низший алкил, -N(R0)С(О)N(R0)2, -S(O)m-низший алкил и -S(O)2N(R0)2;
Группа G2: низший алкил, галоген, галоген-низший алкил, -С(О)OR0, -С(О)N(R0)2, -CN, -Х-OR0, -О-низший алкилен-OR0, -О-галоген-низший алкил, -ОС(О)-низший алкил, -Х-N(R0)2, оксо, -Х- С3-6 циклоалкил, -Х-О-Х-С3-6 циклоалкил, -Х-фенил и -Х-морфолинил;
Группа G3: низший алкил, С2-6 алкенил, С2-6 алкинил, галоген, галоген-низший алкил, -Х-С(О)OR0, -Х-С(О)N(R0)2, -CN, -Х-С(О)R0, -Х-OR0, -О-низший алкилен-О-R0, -О-галоген-низший алкил, -ОС(О)-низший алкил, -Х-N(R0)2, -Х-S(O)m-низший алкил, оксо, -Х-С3-10 циклоалкил, -Х-О-Х-С3-10 циклоалкил, -Х-арил, -Х-С(О)-арил, -Х-О-Х-арил, -Х-S(O)m-арил, -Х-гетероциклическая группа, -Х-О-Х-гетероциклическая группа, -Х-S(O)m-гетероциклическая группа и -О-СН2СН2-О-, связанная с одним и тем же атомом углерода;
где арил и гетероциклическая группа могут быть замещены низшим алкилом, галогеном, галоген-низшим алкилом, -О-низшим алкилом или оксо;
D: связь или -С(R31)2-;
Е: связь, -[C(R31)2]1-3- или -О-С(R31)2-;
где О связан с бензольным кольцом;
Х - одинаковые или отличаются друг от друга, при этом каждый представляет собой связь или низший алкилен;
m - одинаковые или отличаются друг от друга, при этом каждый равен 0, 1 или 2;
n - одинаковые или отличаются друг от друга, при этом каждый равен 0, 1 или 2;
при условии, что
(1) в случае, когда R2 представляет собой -С(О)R20, R1 представляет собой группу, отличающуюся от метила, и -W-R3 представляет собой группу, отличающуюся от -NH-фенила, который может быть замещен;
(2) в случае, когда R2 представляет собой -С(О)NR21R22, R3 представляет собой С5-10 циклоалкил или низший алкилен-С5-10 циклоалкил, и С5-10 циклоалкил может содержать от 1 до 5 заместителей, выбранных из группы G3;
(3) в случае, когда R2 представляет собой низший алкилен-R20 или низший алкилен-NR21R22, и W представляет собой -СН2-, -NR0-, -О- или -S(O)m-, R3 представляет собой С7-10 циклоалкил или низший алкилен-С7-10 циклоалкил, и С7-10 циклоалкил может содержать от 1 до 5 заместителей, выбранных из группы G3;
(4) в случае, когда R2 представляет собой низший алкилен-NR0C(О)R21, R1 представляет собой группу, отличающуюся от метила;
(5) в случае, когда R2 представляет собой -NR0C(О)R21, -NR0C(О)OR21, -NR0C(О)NR21R22, -NR0S(O)2R21 или -NR0S(O)2NR21R22, R1 представляет собой группу, отличающуюся от метила, и -W-R3 представляет собой группу, отличающуюся от -СН2-1Н-пиразол-1-ила, который может быть замещен, и -СН2-1Н-1,2,4-триазол-1-ила, который может быть замещен; и
следующие соединения исключаются:
2-(циклогексиламино)-N-(3,5-дихлорфенил)-4-(трифторметил)пиримидин-5-карбоксамид;
2-(циклогексиламино)-N,N-диэтил-4-изопропилпиримидин-5-карбоксамид;
N-циклогексил-2-(циклогексиламино)-4-метилпиримидин-5-карбоксамид;
трет-бутил({2-[(3-хлор-4-фторфенил)амино]-4-(трифторметил)-5-пиримидинил}метил)(циклопропилметил)карбамат,
1-{[5-(метоксиметил)-4-(трифторметил)-2-пиримидинил]амино}-3-метил-1Н-пиррол-2,5-дион,
1-{[4-этил-5-(метоксиметил)-2-пиримидинил](метил)амино}-3-метил-1Н-пиррол-2,5-дион,
N-бутил-5-(феноксиметил)-4-(трифторметил)пиримидин-2-амин,
2-хлор-5-гидрокси-N-[2-[[4-[2-(1-пирролидинил)этокси]фенил]амино]-4-(трифторметил)-5-пиримидинил]бензамид,
N-{4-метокси-2-[2-(пропиламино)этокси]-5-пиримидинил}-4-(трифторметокси)бензолсульфонамид и
N-{4-метокси-2-[2-(пропиламино)этокси]-5-пиримидинил}-4-изопропилбензолсульфонамид].
2. Соединение или его соль по п.1, где R1 представляет собой низший алкил, С3-6 циклоалкил или галоген-низший алкил, R2 представляет собой -С(О)R20, W представляет собой -NH-, и R3 представляет собой С7-10 циклоалкил, который может содержать от 1 до 5 заместителей, выбранных из низшего алкила, галогена и ОН.
3. Соединение или его соль по п.2, где R1 представляет собой низший алкил или С3-6 циклоалкил.
4. Соединение или его соль по п.2, где R1 представляет собой галоген-низший алкил.
5. Соединение или его соль по п.2, где R20 представляет собой 1-пирролидил, 1-пиперидил, морфолин-4-ил, тиоморфолин-4-ил или 1,1-диоксидотиоморфолин-4-ил, которые могут содержать от 1 до 5 заместителей, выбранных из низшего алкила и галогена.
6. Соединение или его соль по п.5, где R20 представляет собой морфолин-4-ил или 1,1-диоксидотиоморфолин-4-ил.
7. Соединение или его соль по п.6, где R3 представляет собой С7-10 циклоалкил, который может содержать от 1 до 5 заместителей, выбранных из низшего алкила, галогена и ОН на кольце, и имеет мостик.
8. Соединение или его соль по п.1, которое выбирают из группы, включающей:
N-адамантан-1-ил-5-[(4,4-дифторпиперидин-1-ил)карбонил]-4-(трифторметил)пиримидин-2-амин,
1-{5-[(1,1-диоксидотиоморфолин-4-ил)карбонил]-4-(трифторметил)пиримидин-2-ил}-4,4-диметил-1,2,3,4-тетрагидрохинолин,
рац-N-[(1R,2R,4S)-бицикло[2.2.1]гепт-2-ил]-4-изопропил-5-(морфолин-4-илкарбонил)пиримидин-2-амин,
рац-N-[(1R,2R,4S)-бицикло[2.2.1]гепт-2-ил]-4-циклопропил-5-[(1,1-диоксидотиоморфолин-4-ил)карбонил]пиримидин-2-амин,
рац-N-[(1R,2R,4S)-бицикло[2.2.1]гепт-2-ил]-4-трет-бутил-5-(морфолин-4-илкарбонил)пиримидин-2-амин,
N-[(1S,2S,4R)-бицикло[2.2.1]гепт-2-ил]-4-изопропил-5-(морфолин-4-илкарбонил)пиримидин-2-амин,
N-[(1R,2R,4S)-бицикло[2.2.1]гепт-2-ил]-4-изопропил-5-(морфолин-4-илкарбонил)пиримидин-2-амин,
3-({5-[(3,3,4,4-тетрафторпирролидин-1-ил)карбонил]-4-(трифторметил)пиримидин-2-ил}амино)адамантан-1-ол,
рац-N-[(1R,2R,4S)-бицикло[2.2.1]гепт-2-ил]-5-[(1,1-диоксидотиоморфолин-4-ил)карбонил]-4-(трифторметил)пиримидин-2-амин,
5-[(1,1-диоксидотиоморфолин-4-ил)карбонил]-4-(трифторметил)-N-[(1R,2S,4R)-1,7,7-триметилбицикло[2.2.1]гепт-2-ил]пиримидин-2-амин,
5-[(1,1-диоксидотиоморфолин-4-ил)карбонил]-N-(3,5,7-трифторадамантан-1-ил)-4-(трифторметил)пиримидин-2-амин,
N-[(1R,2R,4S)-бицикло[2.2.1]гепт-2-ил]-5-[(1,1-диоксидотиоморфолин-4-ил)карбонил]-4-(трифторметил)пиримидин-2-амин,
N-[(1S,2S,4R)-бицикло[2.2.1]гепт-2-ил]-5-[(1,1-диоксидотиоморфолин-4-ил)карбонил]-4-(трифторметил)пиримидин-2-амин,
N-бицикло[2.2.2]окт-1-ил-5-[(1,1-диоксидотиоморфолин-4-ил)карбонил]-4-(трифторметил)пиримидин-2-амин,
N-адамантан-1-ил-5-(морфолин-4-илкарбонил)-4-(трифторметил)пиримидин-2-амин,
рац-N-[(1R,2R,4S)-бицикло[2.2.1]гепт-2-ил]-5-[(4,4-дифторпиперидин-1-ил)метил]-4-(трифторметил)пиримидин-2-амин и
N-адамантан-1-ил-5-[(1,1-диоксидотиоморфолин-4-ил)метил]-4-(трифторметил)пиримидин-2-амин.
9. Фармацевтическая композиция, содержащая соединение или его соль по п.1, и фармацевтически приемлемый эксципиент.
10. Фармацевтическая композиция для предупреждения или лечения заболевания, связанного с каннабиноидным рецептором 2 типа, содержащая соединение или его соль по п.1.
11. Фармацевтическая композиция по п.10, где заболевание, связанное с каннабиноидным рецептором 2 типа, представляет собой воспалительное заболевание.
12. Фармацевтическая композиция по п.10, где заболевание, связанное с каннабиноидным рецептором 2 типа, представляет собой боль.
13. Применение соединения или его соли по п.1 для получения фармацевтической композиции для предупреждения или лечения заболевания, связанного с каннабиноидным рецептором 2 типа.
14. Применение соединения или его соли по п.1 для предупреждения или лечения заболевания, связанного с каннабиноидным рецептором 2 типа.
15. Способ предупреждения или лечения заболевания, связанного с каннабиноидным рецептором 2 типа, включающий введение пациенту эффективного количества соединения по п.1 или его фармацевтически приемлемой соли.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009-082282 | 2009-03-30 | ||
JP2009082282 | 2009-03-30 | ||
PCT/JP2010/055506 WO2010113834A1 (ja) | 2009-03-30 | 2010-03-29 | ピリミジン化合物 |
Publications (1)
Publication Number | Publication Date |
---|---|
RU2011143740A true RU2011143740A (ru) | 2013-05-10 |
Family
ID=42828124
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2011143740/04A RU2011143740A (ru) | 2009-03-30 | 2010-03-29 | Соединение пиримидина |
Country Status (14)
Country | Link |
---|---|
US (2) | US8524727B2 (ru) |
EP (1) | EP2415765A4 (ru) |
JP (1) | JPWO2010113834A1 (ru) |
KR (1) | KR20120002581A (ru) |
CN (1) | CN102378757A (ru) |
AU (1) | AU2010231694A1 (ru) |
BR (1) | BRPI1013493A2 (ru) |
CA (1) | CA2757188A1 (ru) |
IL (1) | IL215073A0 (ru) |
MX (1) | MX2011010396A (ru) |
RU (1) | RU2011143740A (ru) |
TW (1) | TW201035070A (ru) |
WO (1) | WO2010113834A1 (ru) |
ZA (1) | ZA201106585B (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2560729C2 (ru) | 2010-01-11 | 2015-08-20 | АСТРАЕА ТЕРАПЕУТИКС, ЭлЭлСи | Модуляторы никотиновых ацетилхолиновых рецепторов |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
EP2560488B1 (en) | 2010-04-23 | 2015-10-28 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
AR081331A1 (es) * | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
LT3124483T (lt) * | 2010-11-10 | 2019-09-25 | Genentech, Inc. | Pirazolo aminopirimidino dariniai, kaip lrrk2 moduliatoriai |
CN102283845B (zh) * | 2011-07-07 | 2012-10-03 | 济南环肽医药科技有限公司 | 1,4,5,6-四氢-2-甲基-4-嘧啶羧酸及1,4,5,6-四氢-2-甲基-5-羟基-4-嘧啶羧酸在制备肺结核治疗药物中的应用 |
CN104470515B (zh) | 2012-05-03 | 2016-12-07 | 圣路易斯药学院 | 用于增加神经营养肽的组合物和方法 |
RU2688193C1 (ru) * | 2013-11-27 | 2019-05-21 | Саншайн Лейк Фарма Ко., Лтд. | Процессы приготовления производных дигидропиримидина и их промежуточных соединений |
GB201511382D0 (en) | 2015-06-29 | 2015-08-12 | Imp Innovations Ltd | Novel compounds and their use in therapy |
EP3484876A1 (en) * | 2016-07-14 | 2019-05-22 | Pfizer Inc | Novel pyrimidine carboxamides as inhibitors of vanin-1 enzyme |
CN114206443B (zh) * | 2019-05-10 | 2024-02-09 | 浙江海正药业股份有限公司 | 芳环或杂芳环类衍生物及其制备方法和用途 |
EP4265599A1 (en) * | 2020-12-17 | 2023-10-25 | Shanghai Meiyue Biotech Development Co., Ltd. | Pyrimidine carboxamide compound and use thereof |
WO2022140677A1 (en) | 2020-12-23 | 2022-06-30 | The Broad Institute, Inc. | Compositions and methods related to di-substituted bicyclo[2.2.1] heptanamine-containing compounds |
WO2022140654A1 (en) * | 2020-12-23 | 2022-06-30 | The Broad Institute, Inc. | Compositions and methods related to bicyclo[2.2.1] heptanamine-containing compounds |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4539324A (en) * | 1982-02-24 | 1985-09-03 | Nyegaard & Co. A/S | Substituted pyrimidin-2-ones and the salts thereof |
HUT63941A (en) * | 1992-05-15 | 1993-11-29 | Hoechst Ag | Process for producing 4-alkyl-substituted pyrimidine-5-carboxanilide derivatives, and fungicidal compositions comprising same |
US5532237A (en) | 1995-02-15 | 1996-07-02 | Merck Frosst Canada, Inc. | Indole derivatives with affinity for the cannabinoid receptor |
EP0850228A1 (en) | 1995-09-01 | 1998-07-01 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions |
WO1997009325A1 (en) | 1995-09-01 | 1997-03-13 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
US5811428A (en) | 1995-12-18 | 1998-09-22 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxamides and related compounds and methods for treating inflammatory conditions |
US5935966A (en) | 1995-09-01 | 1999-08-10 | Signal Pharmaceuticals, Inc. | Pyrimidine carboxylates and related compounds and methods for treating inflammatory conditions |
DE60008550T2 (de) * | 1999-09-09 | 2004-08-05 | Kumiai Chemical Industry Co., Ltd. | Pyrimidinderivate und herbizide welche diese enthalten |
ES2316383T3 (es) | 1999-09-17 | 2009-04-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
WO2004009027A2 (en) | 2002-07-19 | 2004-01-29 | Myriad Genetics, Inc | Method and composition for treating and preventing herpesvirus infection |
UY27939A1 (es) | 2002-08-21 | 2004-03-31 | Glaxo Group Ltd | Compuestos |
EP1534687B1 (en) * | 2002-08-21 | 2006-09-27 | Glaxo Group Limited | 2-phenylamino-4-trifluoromethyl-5-(benzyl- or pyridin-4-ylmethyl)carbamoylpyrimidine derivatives as selective cb2 cannabinoid receptor modulators |
JP2006510597A (ja) * | 2002-09-27 | 2006-03-30 | メルク エンド カムパニー インコーポレーテッド | 置換ピリミジン類 |
GB0222495D0 (en) | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
GB0222493D0 (en) | 2002-09-27 | 2002-11-06 | Glaxo Group Ltd | Compounds |
AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
GB0402356D0 (en) | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
GB0402357D0 (en) | 2004-02-03 | 2004-03-10 | Glaxo Group Ltd | Novel compounds |
US20080261977A1 (en) | 2004-02-23 | 2008-10-23 | Andrew John Eatherton | Pyrimidine Derivatives as Cannabinoid Receptor Modulators |
ES2313304T3 (es) | 2004-02-24 | 2009-03-01 | Glaxo Group Limited | Derivados de piridina y su uso como moduladores del receptor cb2. |
GB0404105D0 (en) | 2004-02-24 | 2004-03-31 | Glaxo Group Ltd | Novel compounds |
ATE412651T1 (de) | 2004-06-09 | 2008-11-15 | Glaxo Group Ltd | Pyrrolopyridinderivate |
CN101076324A (zh) | 2004-10-22 | 2007-11-21 | 法玛氏公司 | 口服有效的大麻素类似物 |
JP2008519034A (ja) | 2004-11-03 | 2008-06-05 | バーテックス ファーマシューティカルズ インコーポレイテッド | イオンチャネル調節剤としてのピリミジン誘導体および使用方法 |
GB0516379D0 (en) | 2005-08-09 | 2005-09-14 | Glaxo Group Ltd | Compounds |
BRPI0614272A2 (pt) | 2005-08-09 | 2011-03-22 | Glaxo Group Ltd | derivados de imidazopiridinas como ligantes de receptores canabinóides |
GB0602042D0 (en) | 2006-02-01 | 2006-03-15 | Glaxo Group Ltd | Compounds |
UY30284A1 (es) | 2006-04-14 | 2007-11-30 | Abbott Gmbh & Amp | Compuestos de ariloxietilamina apropiados para tratar trastornos que responden a la modulacion del receptor de dopamina d3 |
WO2008027812A2 (en) | 2006-08-28 | 2008-03-06 | Forest Laboratories Holdings Limited | Imidazopyridine and imidazopyrimidine derivatives |
GB0705803D0 (en) | 2007-03-28 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
US8703811B2 (en) | 2008-05-07 | 2014-04-22 | Genzyme Corporation | Small molecule inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase |
AU2009327127C1 (en) * | 2008-12-19 | 2017-03-09 | Centrexion Therapeutics Corporation | Cyclic pyrimidin-4-carboxamides as CCR2 receptor antagonists for treatment of inflammation, asthma and COPD |
-
2010
- 2010-03-29 AU AU2010231694A patent/AU2010231694A1/en not_active Abandoned
- 2010-03-29 RU RU2011143740/04A patent/RU2011143740A/ru not_active Application Discontinuation
- 2010-03-29 MX MX2011010396A patent/MX2011010396A/es not_active Application Discontinuation
- 2010-03-29 CA CA2757188A patent/CA2757188A1/en not_active Abandoned
- 2010-03-29 KR KR1020117023010A patent/KR20120002581A/ko unknown
- 2010-03-29 CN CN2010800150776A patent/CN102378757A/zh active Pending
- 2010-03-29 US US12/933,137 patent/US8524727B2/en active Active
- 2010-03-29 JP JP2011507171A patent/JPWO2010113834A1/ja not_active Withdrawn
- 2010-03-29 WO PCT/JP2010/055506 patent/WO2010113834A1/ja active Application Filing
- 2010-03-29 BR BRPI1013493A patent/BRPI1013493A2/pt not_active IP Right Cessation
- 2010-03-29 EP EP10758605A patent/EP2415765A4/en not_active Withdrawn
- 2010-03-30 TW TW099109530A patent/TW201035070A/zh unknown
-
2011
- 2011-09-08 ZA ZA2011/06585A patent/ZA201106585B/en unknown
- 2011-09-11 IL IL215073A patent/IL215073A0/en unknown
-
2013
- 2013-07-24 US US13/949,471 patent/US20130310373A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20120002581A (ko) | 2012-01-06 |
EP2415765A4 (en) | 2012-08-15 |
BRPI1013493A2 (pt) | 2016-04-05 |
US20110053912A1 (en) | 2011-03-03 |
US20130310373A1 (en) | 2013-11-21 |
CN102378757A (zh) | 2012-03-14 |
AU2010231694A1 (en) | 2011-10-06 |
MX2011010396A (es) | 2011-10-24 |
EP2415765A1 (en) | 2012-02-08 |
US8524727B2 (en) | 2013-09-03 |
CA2757188A1 (en) | 2010-10-07 |
WO2010113834A1 (ja) | 2010-10-07 |
IL215073A0 (en) | 2011-11-30 |
TW201035070A (en) | 2010-10-01 |
JPWO2010113834A1 (ja) | 2012-10-11 |
ZA201106585B (en) | 2012-11-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
RU2011143740A (ru) | Соединение пиримидина | |
RU2411238C2 (ru) | Цис-2,4,5-триарилимидазолины и их применение в качестве противораковых лекарственных средств | |
RU2436776C2 (ru) | ДИАРИЛАМИН-СОДЕРЖАЩИЕ СОЕДИНЕНИЯ, КОМПОЗИЦИИ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ РЕЦЕПТОРОВ с-КIT | |
RU2203897C2 (ru) | Производные бензамидина, способ их получения, фармацевтическая композиция, способ ее получения и лекарственное средство | |
RU2455288C2 (ru) | Соединения и композиции 5-(4-(галогеналкокси)фенил)пиримидин-2-амина в качестве ингибиторов киназ | |
RU2013143028A (ru) | Тиазолилфенилбензолсульфонамидопроизводные в качестве ингибиторов киназ | |
RU2439068C2 (ru) | Модуляторы mglur5 | |
RU2016133626A (ru) | 2-амино-3,5,5-трифтор-3,4,5,6-тетрагидропиридины в качестве ингибиторов bace1 для лечения болезни альцгеймера | |
RU2007108861A (ru) | Трифтометилзамещенные бензамиды в качестве ингибиторов киназ | |
CA2618511A1 (en) | Novel benzothiazolone derivatives | |
JP2005511543A5 (ru) | ||
JP2017523972A5 (ru) | ||
JP2015514073A5 (ru) | ||
RU2013108641A (ru) | Способ лечения офтальмологических заболеваний с использованием соединений ингибиторов киназы в пролекарственных формах | |
JP2015524837A5 (ru) | ||
JP2011504497A5 (ru) | ||
JP2015509510A5 (ru) | ||
JP2010506918A5 (ru) | ||
JP2010540462A5 (ru) | ||
RU2008110949A (ru) | Соединения и композиции-иммуносупрессанты | |
RU2008135690A (ru) | Соединения и композиции в качестве ингибиторов протеинкиназы | |
JP2007519754A5 (ru) | ||
PE20141375A1 (es) | Activadores de glucoquinasa | |
RU2008116828A (ru) | Комбинированный метод терапии замещенными оксазолидинонами для профилактики и лечения нарушений церебрального местного кровообращения | |
RU2009118254A (ru) | Фенилацетамиды в качестве ингибиторов протеинкиназ |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20140814 |