JP2008526883A5 - - Google Patents

Info

Publication number

JP2008526883A5

JP2008526883A5 JP2007550521A JP2007550521A JP2008526883A5 JP 2008526883 A5 JP2008526883 A5 JP 2008526883A5 JP 2007550521 A JP2007550521 A JP 2007550521A JP 2007550521 A JP2007550521 A JP 2007550521A JP 2008526883 A5 JP2008526883 A5 JP 2008526883A5

Authority

JP

Japan

Prior art keywords

antibody

use according

cancer

ovr110

cancer cells

Prior art date

2006-01-09

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 238000000034 method Methods 0.000 claims 12
• 201000010536 head and neck cancer Diseases 0.000 claims 11
• 208000014829 head and neck neoplasm Diseases 0.000 claims 11
• 206010028980 Neoplasm Diseases 0.000 claims 10
• 201000011510 cancer Diseases 0.000 claims 8
• 229940127089 cytotoxic agent Drugs 0.000 claims 8
• 206010014733 Endometrial cancer Diseases 0.000 claims 7
• 206010014759 Endometrial neoplasm Diseases 0.000 claims 7
• 239000002254 cytotoxic agent Substances 0.000 claims 6
• 231100000599 cytotoxic agent Toxicity 0.000 claims 6
• 230000028993 immune response Effects 0.000 claims 6
• 210000004698 lymphocyte Anatomy 0.000 claims 5
• 239000003053 toxin Substances 0.000 claims 4
• 231100000765 toxin Toxicity 0.000 claims 4
• 108700012359 toxins Proteins 0.000 claims 4
• 208000002517 adenoid cystic carcinoma Diseases 0.000 claims 3
• 239000003814 drug Substances 0.000 claims 3
• 230000036737 immune function Effects 0.000 claims 3
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• 201000007416 salivary gland adenoid cystic carcinoma Diseases 0.000 claims 3
• 230000001629 suppression Effects 0.000 claims 3
• 108090000790 Enzymes Proteins 0.000 claims 2
• 102000004190 Enzymes Human genes 0.000 claims 2
• 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 2
• 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 2
• 108010039491 Ricin Proteins 0.000 claims 2
• 108010084592 Saporins Proteins 0.000 claims 2
• 230000004913 activation Effects 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 229940088710 antibiotic agent Drugs 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 230000027455 binding Effects 0.000 claims 2
• HXCHCVDVKSCDHU-LULTVBGHSA-N calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 2
• 229930195731 calicheamicin Natural products 0.000 claims 2
• 230000001394 metastastic effect Effects 0.000 claims 2
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• 230000001293 nucleolytic effect Effects 0.000 claims 2
• 206010006187 Breast cancer Diseases 0.000 claims 1
• 208000026310 Breast neoplasm Diseases 0.000 claims 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
• 206010033128 Ovarian cancer Diseases 0.000 claims 1
• 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
• 210000001744 T-lymphocyte Anatomy 0.000 claims 1
• 210000001124 body fluid Anatomy 0.000 claims 1
• 239000010839 body fluid Substances 0.000 claims 1
• 210000003467 cheek Anatomy 0.000 claims 1
• 210000002409 epiglottis Anatomy 0.000 claims 1
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• 210000004408 hybridoma Anatomy 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 230000008595 infiltration Effects 0.000 claims 1
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• 210000000867 larynx Anatomy 0.000 claims 1
• 201000005202 lung cancer Diseases 0.000 claims 1
• 208000020816 lung neoplasm Diseases 0.000 claims 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
• 210000000214 mouth Anatomy 0.000 claims 1
• 210000003739 neck Anatomy 0.000 claims 1
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• 210000001331 nose Anatomy 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 210000003254 palate Anatomy 0.000 claims 1
• 201000002528 pancreatic cancer Diseases 0.000 claims 1
• 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
• 210000003681 parotid gland Anatomy 0.000 claims 1
• 210000003800 pharynx Anatomy 0.000 claims 1
• 210000003491 skin Anatomy 0.000 claims 1
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• 210000001913 submandibular gland Anatomy 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 210000002105 tongue Anatomy 0.000 claims 1