JP2008523145A - リポキシゲナーゼ阻害剤としてのスピロ誘導体 - Google Patents

リポキシゲナーゼ阻害剤としてのスピロ誘導体 Download PDF

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JP2008523145A
JP2008523145A JP2007546793A JP2007546793A JP2008523145A JP 2008523145 A JP2008523145 A JP 2008523145A JP 2007546793 A JP2007546793 A JP 2007546793A JP 2007546793 A JP2007546793 A JP 2007546793A JP 2008523145 A JP2008523145 A JP 2008523145A
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cyclobutane
chromene
dihydrospiro
dimethyl
hydroxy
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JP2008523145A5 (enExample
Inventor
ダニエル・ティ・ダブリュー・チュ
チェン・ジャン
コン・キアン
ドナルド・アール・ジェイムズ
シャンフェン・リ
ソン・ジャンガオ
ビン・ワン
チャン・ウェイ
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イーライ リリー アンド カンパニー
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Publication of JP2008523145A5 publication Critical patent/JP2008523145A5/ja
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    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
JP2007546793A 2004-12-13 2005-12-09 リポキシゲナーゼ阻害剤としてのスピロ誘導体 Pending JP2008523145A (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63558104P 2004-12-13 2004-12-13
US65670905P 2005-02-25 2005-02-25
US65671005P 2005-02-25 2005-02-25
US67538605P 2005-04-27 2005-04-27
US70258005P 2005-07-26 2005-07-26
PCT/US2005/044768 WO2006065686A2 (en) 2004-12-13 2005-12-09 Spiro derivatives as lipoxygenase inhibitors

Publications (2)

Publication Number Publication Date
JP2008523145A true JP2008523145A (ja) 2008-07-03
JP2008523145A5 JP2008523145A5 (enExample) 2009-02-05

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JP2007546793A Pending JP2008523145A (ja) 2004-12-13 2005-12-09 リポキシゲナーゼ阻害剤としてのスピロ誘導体

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Country Link
US (1) US7576094B2 (enExample)
EP (1) EP1836183A2 (enExample)
JP (1) JP2008523145A (enExample)
AU (1) AU2005316739A1 (enExample)
BR (1) BRPI0519013A2 (enExample)
CA (1) CA2589363A1 (enExample)
MX (1) MX2007007103A (enExample)
WO (1) WO2006065686A2 (enExample)

Cited By (2)

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JP2017502961A (ja) * 2013-12-23 2017-01-26 アレクトス セラピューティックス インコーポレイテッド グルコセレブロシダーゼモジュレーターおよびその使用
JP2024096875A (ja) * 2020-03-19 2024-07-17 アーカス バイオサイエンシーズ，インコーポレーテッド Ｈｉｆ－２アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物

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AU2005328327A1 (en) * 2005-02-25 2006-09-08 Galileo Pharmaceuticals, Inc. Novel lipoxygenase inhibitors
US20080207588A1 (en) * 2005-02-25 2008-08-28 Chu Daniel T W Spiro-Heterocyclic Chromans, Thiochromans and Dihydroquinolines
BRPI0710507A2 (pt) * 2006-04-18 2011-08-16 Abbott Lab Antagonistas do receptor vanilóide de subtipo 1 (vr1) e usos destes
EP2097380A1 (en) * 2006-11-15 2009-09-09 High Point Pharmaceuticals, LLC New haloalkylsulfone substituted compounds useful for treating obesity and diabetes
CA2669867A1 (en) * 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc 2- ( 2 -hydroxyphenyl) -quinazolin-4-ones useful for treating obesity and diabetes
EP2097388B1 (en) * 2006-11-15 2011-09-07 High Point Pharmaceuticals, LLC Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes
US8022066B2 (en) * 2006-11-15 2011-09-20 High Point Pharmaceuticals, Llc 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes
NZ595776A (en) * 2007-12-18 2013-08-30 Glenmark Pharmaceuticals Sa Chromane derivatives as trpv3 modulators
EP2229388A4 (en) 2008-01-11 2012-03-07 Glenmark Pharmaceuticals Sa CONDENSED PYRIMIDINE DERIVATIVES AS TRPV3 MODULATORS
UA104861C2 (uk) * 2008-06-17 2014-03-25 Гленмарк Фармас'Ютікалз С.А. Похідні хроману як модулятори trpv3
US8318928B2 (en) 2008-12-15 2012-11-27 Glenmark Pharmaceuticals, S.A. Fused imidazole carboxamides as TRPV3 modulators
CA2744911A1 (en) 2008-12-26 2010-07-01 Glenmark Pharmaceuticals, S.A. Fused imidazole derivatives as trpv3 antagonist
CA2924141C (en) 2013-08-22 2022-06-07 The General Hospital Corporation 5-amino 4-cyano substituted oxazole and thiazole derivatives as inhibitors of human 12/15-lipoxygenase
SI3417851T1 (sl) 2013-09-09 2020-11-30 Peloton Therapeutics, Inc. Aril etri in njihova uporaba
WO2015095048A1 (en) * 2013-12-16 2015-06-25 Peloton Therapeutics, Inc. Cyclic sulfone and sulfoximine analogs and uses thereof
WO2016145045A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Compositions for use in treating glioblastoma
US10278942B2 (en) 2015-03-11 2019-05-07 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
EP3268362B1 (en) 2015-03-11 2021-10-20 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
WO2016144825A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
WO2016168510A1 (en) 2015-04-17 2016-10-20 Peloton Therapeutics, Inc. Combination therapy of a hif-2-alpha inhibitor and an immunotherapeutic agent and uses thereof
US9796697B2 (en) 2015-06-12 2017-10-24 Peloton Therapeutics, Inc. Tricyclic inhibitors of HIF-2-alpha and uses thereof
WO2017087795A1 (en) 2015-11-19 2017-05-26 Concert Pharmaceuticals, Inc. Deuterated epi-743
MX2024007932A (es) * 2021-12-23 2024-09-18 Univ Leuven Kath Spiros y analogos relacionados para inhibir yap/taz-tead.

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JP2017502961A (ja) * 2013-12-23 2017-01-26 アレクトス セラピューティックス インコーポレイテッド グルコセレブロシダーゼモジュレーターおよびその使用
JP2024096875A (ja) * 2020-03-19 2024-07-17 アーカス バイオサイエンシーズ，インコーポレーテッド Ｈｉｆ－２アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物
JP7648828B2 (ja) 2020-03-19 2025-03-18 アーカス バイオサイエンシーズ，インコーポレーテッド Ｈｉｆ－２アルファの阻害剤としてのテトラリン化合物及びテトラヒドロキノリン化合物

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