MX2007007103A - Derivados espiro como inhibidores de lipoxigenasa. - Google Patents

Derivados espiro como inhibidores de lipoxigenasa.

Info

Publication number
MX2007007103A
MX2007007103A MX2007007103A MX2007007103A MX2007007103A MX 2007007103 A MX2007007103 A MX 2007007103A MX 2007007103 A MX2007007103 A MX 2007007103A MX 2007007103 A MX2007007103 A MX 2007007103A MX 2007007103 A MX2007007103 A MX 2007007103A
Authority
MX
Mexico
Prior art keywords
lipoxygenase inhibitors
lipoxygenase
spiro derivatives
manufacture
useful
Prior art date
Application number
MX2007007103A
Other languages
English (en)
Spanish (es)
Inventor
Daniel T W Chu
Jian Chen
Qiang Cong
Donald R James
Xianfeng Li
Jiangao Song
Bing Wang
Wei Zhang
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2007007103A publication Critical patent/MX2007007103A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Psychology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
MX2007007103A 2004-12-13 2005-12-09 Derivados espiro como inhibidores de lipoxigenasa. MX2007007103A (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US63558104P 2004-12-13 2004-12-13
US65670905P 2005-02-25 2005-02-25
US65671005P 2005-02-25 2005-02-25
US67538605P 2005-04-27 2005-04-27
US70258005P 2005-07-26 2005-07-26
PCT/US2005/044768 WO2006065686A2 (en) 2004-12-13 2005-12-09 Spiro derivatives as lipoxygenase inhibitors

Publications (1)

Publication Number Publication Date
MX2007007103A true MX2007007103A (es) 2008-03-10

Family

ID=36370831

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007007103A MX2007007103A (es) 2004-12-13 2005-12-09 Derivados espiro como inhibidores de lipoxigenasa.

Country Status (8)

Country Link
US (1) US7576094B2 (enExample)
EP (1) EP1836183A2 (enExample)
JP (1) JP2008523145A (enExample)
AU (1) AU2005316739A1 (enExample)
BR (1) BRPI0519013A2 (enExample)
CA (1) CA2589363A1 (enExample)
MX (1) MX2007007103A (enExample)
WO (1) WO2006065686A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8338648B2 (en) * 2004-06-12 2012-12-25 Signum Biosciences, Inc. Topical compositions and methods for epithelial-related conditions
CA2600004A1 (en) * 2005-02-25 2006-09-08 Eli Lilly And Company Spiro-heterocyclic chromans, thiochromans and dihydroquinolines
AU2005328327A1 (en) * 2005-02-25 2006-09-08 Galileo Pharmaceuticals, Inc. Novel lipoxygenase inhibitors
AU2007238071B2 (en) * 2006-04-18 2012-06-07 Abbvie Inc. Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof
US7939690B2 (en) * 2006-11-15 2011-05-10 High Point Pharmaceuticals, Llc Haloalkylsulfone substituted compounds useful for treating obesity and diabetes
US20100249161A1 (en) * 2006-11-15 2010-09-30 Anders Klarskov Petersen 2- ( 2 -hydroxyphenyl) -quinazolin-4-ones useful for treating obesity and diabetes
WO2008059026A1 (en) * 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc Novel 2-(2-hydroxyphenyl)benzimidazoles useful for treating obesity and diabetes
CA2669874A1 (en) * 2006-11-15 2008-05-22 High Point Pharmaceuticals, Llc Novel 2-(2-hydroxyphenyl) benzothiadiazines useful for treating obesity and diabetes
EA201000675A1 (ru) * 2007-12-18 2011-06-30 Гленмарк Фармасьютикалс, С.А. Производные хромана как модуляторы trpv3
GEP20125574B (en) 2008-01-11 2012-07-10 Glenmark Pharmaceuticals Sa Fused pyrimidine derivatives as trpv3 modulators
CA2728405A1 (en) * 2008-06-17 2010-01-14 Glenmark Pharmaceuticals, S.A. Chromane derivatives as trpv3 modulators
US8318928B2 (en) 2008-12-15 2012-11-27 Glenmark Pharmaceuticals, S.A. Fused imidazole carboxamides as TRPV3 modulators
NZ595775A (en) 2008-12-26 2013-07-26 Glenmark Pharmaceuticals Sa Fused imidazole derivatives as trpv3 antagonist
CA2924141C (en) 2013-08-22 2022-06-07 The General Hospital Corporation 5-amino 4-cyano substituted oxazole and thiazole derivatives as inhibitors of human 12/15-lipoxygenase
EP3417851B1 (en) 2013-09-09 2020-07-22 Peloton Therapeutics, Inc. Aryl ethers and uses thereof
CA2931085C (en) 2013-12-16 2021-10-19 Peloton Therapeutics, Inc. Cyclic sulfone and sulfoximine analogs and uses thereof
JP2017502961A (ja) * 2013-12-23 2017-01-26 アレクトス セラピューティックス インコーポレイテッド グルコセレブロシダーゼモジュレーターおよびその使用
EP3268362B1 (en) 2015-03-11 2021-10-20 Peloton Therapeutics, Inc. Substituted pyridines and uses thereof
US10512626B2 (en) 2015-03-11 2019-12-24 Peloton Therapeautics, Inc. Compositions for use in treating glioblastoma
WO2016145032A1 (en) 2015-03-11 2016-09-15 Peloton Therapeutics, Inc. Compositions for use in treating pulmonary arterial hypertension
US10807948B2 (en) 2015-03-11 2020-10-20 Peloton Therapeutics, Inc. Aromatic compounds and uses thereof
US10335388B2 (en) 2015-04-17 2019-07-02 Peloton Therapeutics, Inc. Combination therapy of a HIF-2-alpha inhibitor and an immunotherapeutic agent and uses thereof
US9796697B2 (en) 2015-06-12 2017-10-24 Peloton Therapeutics, Inc. Tricyclic inhibitors of HIF-2-alpha and uses thereof
EP3377179B1 (en) 2015-11-19 2021-04-07 Concert Pharmaceuticals Inc. Deuterated epi-743
CA3173831A1 (en) * 2020-03-19 2021-09-23 Arcus Biosciences, Inc. Tetralin and tetrahydroquinoline compounds as inhibitors of hif-2alpha
JP2025500506A (ja) * 2021-12-23 2025-01-09 ザ・カトリック・ユニヴェルシテイト・ルーバン Ｙａｐ／ｔａｚ－ｔｅａｄを阻害するためのスピロ及び関連類似体

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3331846A (en) 1963-08-28 1967-07-18 Lilly Co Eli Metal catalyst process for converting alpha-amino-acetylenes to dihydroquinoline
US3574627A (en) 1969-02-06 1971-04-13 Eastman Kodak Co Color photographic elements
JPS5265267A (en) 1975-11-26 1977-05-30 Takeda Chem Ind Ltd Synthesis of spiro compounds
JPS6030671B2 (ja) 1976-12-13 1985-07-17 武田薬品工業株式会社 スピロ化合物
US4284644A (en) 1977-01-12 1981-08-18 Takeda Chemical Industries, Ltd. Spirobenzofuranone compounds
US4342779A (en) 1977-12-27 1982-08-03 Takeda Chemical Industries, Ltd. 7-Acetylspirobenzofuranone compound
HU179601B (en) 1977-12-27 1982-11-29 Takeda Chemical Industries Ltd Process for producing spirobenzofuranone derivatives
JPS5646879A (en) 1979-09-25 1981-04-28 Takeda Chem Ind Ltd Spiro compound, its preparation, and preventive and remedy for circulatory system disorder
US4330554A (en) 1980-04-23 1982-05-18 Takeda Chemical Industries, Ltd. Spirobenzofuranone compounds
FI79535C (fi) 1982-05-06 1990-01-10 Erba Farmitalia Foerfarande foer framstaellning av dihydrobensopyrans och dihydrobensotiopyrans substituerade iminoderivat.
EP0095316B1 (en) 1982-05-21 1986-12-03 Beecham Group Plc Pharmaceutically active aminobenzopyrans
EP0126311B1 (en) 1983-05-18 1989-09-13 Beecham Group Plc Benzopyran derivatives.
CA1261835A (en) 1984-08-20 1989-09-26 Masaaki Toda (fused) benz(thio)amides
US4761403A (en) 1986-04-09 1988-08-02 Abbott Laboratories Lipoxygenase inhibiting compounds
DE3777656D1 (de) 1986-08-08 1992-04-23 Upjohn Co Mittel zur behandlung von alopezien.
GB8625185D0 (en) 1986-10-21 1986-11-26 Beecham Group Plc Active compounds
GB8626344D0 (en) 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
US5387587A (en) 1986-12-23 1995-02-07 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
DE3777366D1 (de) 1986-12-27 1992-04-16 Takeda Chemical Industries Ltd 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung.
GB8701022D0 (en) 1987-01-19 1987-02-18 Beecham Group Plc Treatment
GB8723157D0 (en) 1987-10-02 1987-11-04 Beecham Group Plc Compounds
US5059609A (en) 1987-10-19 1991-10-22 Pfizer Inc. Substituted tetralins, chromans and related compounds in the treatment of asthma, arthritis and related diseases
GB8800199D0 (en) 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
JPH07121936B2 (ja) 1988-03-28 1995-12-25 キッセイ薬品工業株式会社 ジヒドロベンゾフラノン誘導体
US5021432A (en) 1988-04-26 1991-06-04 Yoshitomi Pharmaceutical Industries, Ltd. Benzopyran compound and its pharmaceutical use
AU628331B2 (en) 1988-05-06 1992-09-17 Merck Patent Gesellschaft Mit Beschrankter Haftung Chroman derivatives
US4950684A (en) 1988-05-20 1990-08-21 G. D. Searle & Co. 2,2-di-substituted benzopyran leukotriene-D4 antagonists
US5015661A (en) 1988-08-09 1991-05-14 Hoffmann-La Roche Inc. Chromanes and their pharmaceutical compositions and methods
GB8902118D0 (en) 1989-02-01 1989-03-22 Beecham Group Plc Chemical process
US5232938A (en) 1989-05-24 1993-08-03 Beecham Group P.L.C. Certain 1,2,4-triazole(oxy or amino)benzopyran derivatives having pharmacological activity
DE3918041A1 (de) 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
GB8915315D0 (en) 1989-07-04 1989-08-23 Sandoz Ltd Pharmaceutical compositions for use against hypertension and congestive heart failure
US5350747A (en) 1989-07-07 1994-09-27 Pfizer Inc Heteroaryl piperazine antipsychotic agents
JPH0366669A (ja) 1989-08-03 1991-03-22 Shionogi & Co Ltd 複素環式化合物
GB8924373D0 (en) 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
GB8928837D0 (en) 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
GB2242628A (en) 1990-04-06 1991-10-09 Sandoz Ltd Asthma prophylactic use of K+ channel activators
JPH05506222A (ja) 1990-04-23 1993-09-16 ローヌ―プーラン　ローラー　インターナショナル　（ホウルディングス）インコーポレイテッド ５ｈｔ↓３拮抗物質としてのスピロ〔ベンゾフランシクロアルカン〕カルボキサミド
BE1004295A3 (fr) 1990-05-17 1992-10-27 Sandoz Sa Utilisation des activateurs des canaux potassiques pour la prophylaxie de l'asthme.
US5076835A (en) 1990-05-31 1991-12-31 America Cyanamid Company Aryloxyspiroalkylindolinone herbicides
DE4018552A1 (de) 1990-06-09 1991-12-12 Sandoz Ag Asthma-prophylaktische verwendung von k(pfeil hoch)+(pfeil hoch) kanal-activatoren
ES2030627A6 (es) 1990-11-28 1992-11-01 Uriach & Cia Sa J Procedimiento para la obtencion de compuestos benzopiranicos.
JP2612971B2 (ja) 1991-02-19 1997-05-21 吉富製薬株式会社 ベンゾピラン化合物
DE4115521A1 (de) 1991-05-11 1992-11-12 Beiersdorf Ag Isoindolyl- und isochinolylsubstituierte benzopyran-derivate, zwischenprodukte, sowie verfahren zu ihrer herstellung
GB9112721D0 (en) 1991-06-13 1991-07-31 Smithkline Beecham Plc Novel treatment
US5624954A (en) 1991-06-13 1997-04-29 Smithkline Beecham P.L.C. Benzo- and pyridopyran derivatives having anxiolytic and anti-convulsant activity
US5250547A (en) 1991-08-29 1993-10-05 Syntex (U.S.A.) Inc. Benzopyran derivatives
CA2053962A1 (en) 1991-10-22 1993-04-23 Theo Schotten Benzopyran derivatives, process for their preparation and use thereof and preparations containing the compounds
EP0543417A1 (en) 1991-11-22 1993-05-26 Lipogenics, Incorporated Tocotrienols and tocotrienol-like compounds and methods for their use
US5686624A (en) 1992-01-30 1997-11-11 Sanofi 1-benzenesulfonyl-1,3-dihydro-indol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
US5849780A (en) 1992-01-30 1998-12-15 Sanofi 1-benzenesulfonyl-1-1,3-dihydroindol-2-one derivatives, their preparation and pharmaceutical compositions in which they are present
FR2708605A1 (fr) 1993-07-30 1995-02-10 Sanofi Sa Dérivés du N-sulfonylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
AU661159B2 (en) 1992-07-15 1995-07-13 Sumitomo Chemical Company, Limited N-acyldihydroquinoline derivatives, a method for producing the same and their use as herbicides
FR2695387B1 (fr) 1992-09-09 1994-10-21 Adir Nouveaux composés benzopyraniques, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
WO1994007867A1 (en) 1992-09-28 1994-04-14 Pfizer Inc. Substituted pyrimidines for control of diabetic complications
US5939346A (en) 1992-11-02 1999-08-17 Akzo Nobel N.V. Catalyst system comprising an aryloxyaluminoxane containing an electron withdrawing group
WO1994012173A1 (en) 1992-11-30 1994-06-09 Smithkline Beecham Plc Benzopyron analogues for the treatment of anxiety, mania, depression or withdrawal symptoms
GB9225859D0 (en) 1992-12-11 1993-02-03 Smithkline Beecham Plc Novel treatment
DE69327965T2 (de) 1992-12-11 2000-10-19 Smithkline Beecham Corp., Philadelphia Pharmazeutische zusammenstellung enthaltende bizyklisch typ verbindungen
KR100326968B1 (ko) 1992-12-11 2002-07-27 스미스클라인비이참피이엘시이 약학적 활성을 가진 이환식 화합물
FR2708606B1 (fr) 1993-07-30 1995-10-27 Sanofi Sa Dérivés du N-phénylalkylindol-2-one, leur préparation, les compositions pharmaceutiques en contenant.
JPH07188210A (ja) 1993-11-19 1995-07-25 Chugai Pharmaceut Co Ltd ベンゾピラン−４−カルボン酸誘導体の製造法
US5399562A (en) 1994-02-04 1995-03-21 G. D. Searle & Co. Indolones useful as serotonergic agents
TW279878B (enExample) 1994-03-18 1996-07-01 Sumitomo Chemical Co
JP3528242B2 (ja) 1994-06-23 2004-05-17 住友化学工業株式会社 ヒドロキシフラバン化合物の製造方法
DE4428932A1 (de) 1994-08-16 1996-02-22 Hoechst Ag Substituierte-Chinolinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
EP0700959A1 (en) 1994-09-07 1996-03-13 Sumitomo Chemical Company, Limited A rubber composition and a vulcanizing adhesion method using the same
CN1160399A (zh) 1994-10-13 1997-09-24 美国辉瑞有限公司 苯并吡喃和苯并稠合化合物、其制备方法和它们作为白三烯b4(ltb4)拮抗剂的用途
MX9702734A (es) 1994-10-13 1997-06-28 Pfizer Benzopirano y compuestos benzocondensados, su preparacion y su uso como antagonistas de leucotrieno b4 (ltb4).
US5688808A (en) 1994-12-22 1997-11-18 Ligand Pharmaceuticals Incorporated Steroid receptor modulator compounds and methods
US5925673A (en) 1994-12-23 1999-07-20 Alcon Laboratories, Inc. Benzofurans and benzopyrans as cytoprotective agents
US5674876A (en) 1995-01-20 1997-10-07 Research Development Foundation ρ-heteroatom-substituted phenols and uses thereof
FR2740136B1 (fr) 1995-10-24 1998-01-09 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et les compositions pharmaceutiques les contenant
US5606006A (en) 1996-04-08 1997-02-25 Shell Oil Company Trisepoxy resin compositions
AU4136897A (en) 1996-09-09 1998-03-26 Dainippon Pharmaceutical Co. Ltd. 2,3-dihydrobenzofuran derivative and hepatopathy remedy comprising the same as active ingredient
FR2757157B1 (fr) 1996-12-13 1999-12-31 Sanofi Sa Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
US6005007A (en) 1997-07-18 1999-12-21 Farmer; Luc J. Retinoids, methods for their production and use
HUP0100926A3 (en) 1998-02-26 2003-03-28 Neurogen Corp Branford Benzylpiperazinyl- and benzylpiperidinyl ethanone derivatives, their preparation and their use as dopamine d4 receptor antagonists
FR2784988B1 (fr) 1998-10-23 2002-09-20 Adir Nouveaux composes dihydro et tetrahydroquinoleiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
DE19854147A1 (de) 1998-11-24 2000-05-25 Basf Ag Verwendung von N-substituierten Azabicycloalkan-Derivaten zur Verwendung bei der Bekämpfung der Cocainsucht
FR2787451B1 (fr) 1998-12-18 2001-01-26 Adir Nouveaux composes imidazoliniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
FR2787789B1 (fr) 1998-12-29 2002-06-14 Lipha Benzopyranes et benzoxepines utilisables dans le traitement de dyslipidemies, de l'atherosclerose et du diabete, compositions pharmaceutiques les contenant et procedes de preparations
DE10007948A1 (de) 2000-02-22 2001-09-06 Wella Ag Mittel zur Färbung von Fasern
US20030212109A1 (en) 2000-06-02 2003-11-13 Mitchell Stephen Nicholas Pharmaceutical compositions and their use
WO2002010135A1 (en) 2000-08-01 2002-02-07 Ono Pharmaceutical Co., Ltd. 3,4-dihydroisoquinoline derivative compounds and drugs containing these compounds as the active ingredient
CA2420869A1 (en) 2000-08-29 2002-03-07 Allergan, Inc. Compounds having activity as inhibitors of cytochrome p450rai
US6369225B1 (en) 2000-08-29 2002-04-09 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6252090B1 (en) 2000-08-29 2001-06-26 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6291677B1 (en) 2000-08-29 2001-09-18 Allergan Sales, Inc. Compounds having activity as inhibitors of cytochrome P450RAI
US6313107B1 (en) 2000-08-29 2001-11-06 Allergan Sales, Inc. Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI
GB0028697D0 (en) 2000-11-23 2001-01-10 S P A Novel process
JP2005514366A (ja) 2001-11-20 2005-05-19 イーライ・リリー・アンド・カンパニー ３−置換オキシインドールβ３アゴニスト
US6953787B2 (en) 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
US7205328B2 (en) 2002-10-21 2007-04-17 Irm Llc Oxindoles with anti-HIV activity
DE10335450A1 (de) 2003-08-02 2005-02-17 Bayer Ag Indolin-Sulfanilsäureamide
DE10335449A1 (de) 2003-08-02 2005-02-17 Bayer Healthcare Ag Bicyclische Indolinsulfonamid-Derivate
WO2005033092A1 (en) 2003-09-19 2005-04-14 Galileo Pharmaceuticals, Inc. Chroman derivatives
AU2004309419A1 (en) 2003-12-23 2005-07-14 Arena Pharmaceuticals, Inc. Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof
AU2005205016B2 (en) 2004-01-16 2010-07-15 F. Hoffmann-La Roche Ag 1-benzyl-5-piperazin-1-yl-3,4 dihydro-1H-quinazolin-2-one derivatives and the respective 1H-benzo(1,2,6)thiadiazine-2,2-dioxide and 1,4-dihydro-benzo(D) (1,3)oxazin-2-one derivatives as modulators of the 5-hydroxytryptamine receptor (5-HT) for the treatment of diseases of the central nervous system
EP1589015A1 (en) 2004-02-03 2005-10-26 Université de Liège Benzopyran derivatives, method of production and use thereof
WO2006044556A2 (en) 2004-10-14 2006-04-27 Galileo Pharmaceuticals, Inc. Dual inhibitors of lipoxygenase for treating diabetes
AU2005328327A1 (en) 2005-02-25 2006-09-08 Galileo Pharmaceuticals, Inc. Novel lipoxygenase inhibitors
CA2600004A1 (en) 2005-02-25 2006-09-08 Eli Lilly And Company Spiro-heterocyclic chromans, thiochromans and dihydroquinolines

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JP2008523145A (ja) 2008-07-03
CA2589363A1 (en) 2006-06-22
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US7576094B2 (en) 2009-08-18
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