JP2008519023A5 - - Google Patents
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- JP2008519023A5 JP2008519023A5 JP2007539647A JP2007539647A JP2008519023A5 JP 2008519023 A5 JP2008519023 A5 JP 2008519023A5 JP 2007539647 A JP2007539647 A JP 2007539647A JP 2007539647 A JP2007539647 A JP 2007539647A JP 2008519023 A5 JP2008519023 A5 JP 2008519023A5
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- Prior art keywords
- formula
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- organic solvent
- reaction mixture
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- Prior art date
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1207/MUM/2004 | 2004-11-08 | ||
| IN1207MU2004 | 2004-11-08 | ||
| PCT/IB2005/003237 WO2006048720A1 (en) | 2004-11-08 | 2005-10-29 | An efficient method for preparation of (s)-3-[(1-dimethyl amino)ethyl]-phenyl-n-ethyl-n-methyl-carbamate |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011259013A Division JP2012072171A (ja) | 2004-11-08 | 2011-11-28 | （ｓ）−３−［（１−ジメチルアミノ）エチル］−フェニル−ｎ−エチル−ｎ−メチル−カルバミン酸の効率的製造方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008519023A JP2008519023A (ja) | 2008-06-05 |
| JP2008519023A5 true JP2008519023A5 (https=) | 2008-11-27 |
| JP4954886B2 JP4954886B2 (ja) | 2012-06-20 |
Family
ID=35539313
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539647A Expired - Fee Related JP4954886B2 (ja) | 2004-11-08 | 2005-10-29 | （ｓ）−３−［（１−ジメチルアミノ）エチル］−フェニル−ｎ−エチル−ｎ−メチル−カルバミン酸の効率的製造方法 |
| JP2011259013A Pending JP2012072171A (ja) | 2004-11-08 | 2011-11-28 | （ｓ）−３−［（１−ジメチルアミノ）エチル］−フェニル−ｎ−エチル−ｎ−メチル−カルバミン酸の効率的製造方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011259013A Pending JP2012072171A (ja) | 2004-11-08 | 2011-11-28 | （ｓ）−３−［（１−ジメチルアミノ）エチル］−フェニル−ｎ−エチル−ｎ−メチル−カルバミン酸の効率的製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1856036B1 (https=) |
| JP (2) | JP4954886B2 (https=) |
| KR (1) | KR101168211B1 (https=) |
| ES (1) | ES2615487T3 (https=) |
| RU (1) | RU2393148C2 (https=) |
| WO (1) | WO2006048720A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2393148C2 (ru) * | 2004-11-08 | 2010-06-27 | Эмкюр Фармасьютикалз Лимитед | Способ получения (s)-3-[(1-диметиламино)этил]-фенил-n-этил-n-метил-карбамата |
| ES2267399B1 (es) * | 2005-08-04 | 2008-02-01 | Ragactives, S.L. | Procedimiento para la obtencion de carbamatos de fenilo. |
| US7767843B2 (en) * | 2006-03-02 | 2010-08-03 | Apotex Pharmachem Inc. | Process for the preparation of phenylcarbamates |
| CA2661009A1 (en) * | 2006-08-17 | 2008-02-21 | Alembic Limited | Improved process for the preparation of rivastigmine |
| WO2008037433A1 (en) | 2006-09-29 | 2008-04-03 | Synthon B.V. | Process for making aminoalkylphenyl carbamates and intermediates therefor |
| WO2008110339A2 (en) * | 2007-03-09 | 2008-09-18 | Synthon B.V. | Polymorphs of rivastigmine hydrogentartrate |
| CN101910110B (zh) * | 2008-01-10 | 2013-05-22 | 上海医药工业研究院 | 利凡斯的明的制备方法、其中间体以及中间体的制备方法 |
| US8420846B2 (en) | 2008-08-25 | 2013-04-16 | Jubilant Life Sciences Limited | Process for producing (S)-3-[(1-dimethylamino)ethyl] phenyl-N-ethyl-N-methyl-carbamate via novel intermediates |
| GB0823554D0 (en) * | 2008-12-24 | 2009-01-28 | Novartis Ag | Process for the preparation of optically active compounds using transfer hydrogenation |
| CN103664703A (zh) * | 2013-12-18 | 2014-03-26 | 成都医路康医学技术服务有限公司 | 一种酒石酸卡巴拉汀的合成工艺 |
| CN103664702A (zh) * | 2013-12-18 | 2014-03-26 | 成都医路康医学技术服务有限公司 | 一种卡巴拉汀的生产工艺 |
| CN104987294B (zh) * | 2015-07-27 | 2017-08-15 | 浙江京新药业股份有限公司 | 一种3‑[1‑(二甲基氨基)乙基]苯酚的制备方法 |
| CN105439906A (zh) * | 2015-12-08 | 2016-03-30 | 哈药集团三精制药有限公司 | 一种重酒石酸卡巴拉汀的合成方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS495325B1 (https=) * | 1965-09-29 | 1974-02-06 | ||
| IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
| US4791107A (en) * | 1986-07-16 | 1988-12-13 | Hoechst-Roussel Pharmaceuticals, Inc. | Memory enhancing and analgesic 1,2,3,3A,8,8A-hexahydro-3A,8 (and) 1,3A,8)-di(and tri)methylpyrrolo(2,3-B)indoles, compositions and use |
| HU201906B (en) * | 1987-03-04 | 1991-01-28 | Sandoz Ag | Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them |
| JPH07119189B2 (ja) * | 1989-09-28 | 1995-12-20 | 北陸製薬株式会社 | 光学活性なベンジルアルコール誘導体及びその用途 |
| SE8904064D0 (sv) * | 1989-12-01 | 1989-12-01 | Astra Ab | Improved method of preparing an intermediate for the manufacture of bambuterol |
| JP3705657B2 (ja) * | 1996-09-05 | 2005-10-12 | 信越化学工業株式会社 | Ｎ，ｎ−ジアルキルカルバミン酸２−ニトロベンジルエステル類の製造方法 |
| US6479495B1 (en) * | 1997-09-29 | 2002-11-12 | Aventis Pharmaceuticals Inc. | Aminoalkylphenol derivatives and related compounds |
| WO2002024676A1 (en) * | 2000-09-21 | 2002-03-28 | Teva Pharmaceuticals Industries, Ltd. | N-disubstituted carbamoyloxy flavones |
| CZ20023555A3 (cs) * | 2002-10-24 | 2004-01-14 | Léčiva, A.S. | Způsob výroby (-)-(S)-3-[1-(dimethylamino)ethyl]fenyl-N-ethyl-N-methylkarbamátu |
| US7795307B2 (en) * | 2003-10-21 | 2010-09-14 | Colucid Pharmaceuticals, Inc. | Carbamoyl esters that inhibit cholinesterase and release pharmacologically active agents |
| RU2393148C2 (ru) * | 2004-11-08 | 2010-06-27 | Эмкюр Фармасьютикалз Лимитед | Способ получения (s)-3-[(1-диметиламино)этил]-фенил-n-этил-n-метил-карбамата |
-
2005
- 2005-10-29 RU RU2007115398/04A patent/RU2393148C2/ru not_active IP Right Cessation
- 2005-10-29 EP EP05797945.2A patent/EP1856036B1/en not_active Expired - Lifetime
- 2005-10-29 WO PCT/IB2005/003237 patent/WO2006048720A1/en not_active Ceased
- 2005-10-29 JP JP2007539647A patent/JP4954886B2/ja not_active Expired - Fee Related
- 2005-10-29 KR KR1020077009495A patent/KR101168211B1/ko not_active Expired - Fee Related
- 2005-10-29 ES ES05797945.2T patent/ES2615487T3/es not_active Expired - Lifetime
-
2011
- 2011-11-28 JP JP2011259013A patent/JP2012072171A/ja active Pending
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