|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4002531A
(en)
|
1976-01-22 |
1977-01-11 |
Pierce Chemical Company |
Modifying enzymes with polyethylene glycol and product produced thereby
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
GB8510219D0
(en)
|
1985-04-22 |
1985-05-30 |
Bass Plc |
Isolation of fermentation products
|
|
DE3675588D1
(de)
|
1985-06-19 |
1990-12-20 |
Ajinomoto Kk |
Haemoglobin, das an ein poly(alkenylenoxid) gebunden ist.
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
US5092885A
(en)
|
1987-02-12 |
1992-03-03 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Peptides with laminin activity
|
|
GB8725529D0
(en)
|
1987-10-30 |
1987-12-02 |
Delta Biotechnology Ltd |
Polypeptides
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5530101A
(en)
*
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5096815A
(en)
|
1989-01-06 |
1992-03-17 |
Protein Engineering Corporation |
Generation and selection of novel dna-binding proteins and polypeptides
|
|
US5198346A
(en)
|
1989-01-06 |
1993-03-30 |
Protein Engineering Corp. |
Generation and selection of novel DNA-binding proteins and polypeptides
|
|
US5766883A
(en)
|
1989-04-29 |
1998-06-16 |
Delta Biotechnology Limited |
Polypeptides
|
|
US5112946A
(en)
|
1989-07-06 |
1992-05-12 |
Repligen Corporation |
Modified pf4 compositions and methods of use
|
|
US5192744A
(en)
|
1990-01-12 |
1993-03-09 |
Northwestern University |
Method of inhibiting angiogenesis of tumors
|
|
JPH04218000A
(ja)
*
|
1990-02-13 |
1992-08-07 |
Kirin Amgen Inc |
修飾ポリペプチド
|
|
US5766897A
(en)
|
1990-06-21 |
1998-06-16 |
Incyte Pharmaceuticals, Inc. |
Cysteine-pegylated proteins
|
|
DE69114782T2
(de)
|
1990-08-08 |
1996-04-18 |
Takeda Chemical Industries Ltd |
Intravaskulär embolisierendes Mittel mit Gehalt an einem die Angiogenesis hemmenden Stoff.
|
|
JP3051145B2
(ja)
|
1990-08-28 |
2000-06-12 |
住友製薬株式会社 |
新規なポリエチレングリコール誘導体修飾ペプチド
|
|
WO1992012717A2
(en)
|
1991-01-15 |
1992-08-06 |
|
A composition containing a tetracycline and use for inhibiting angiogenesis
|
|
CA2111006C
(en)
|
1991-06-21 |
2008-04-08 |
Andrew D. Boyd |
A novel receptor-type tyrosine kinase and use thereof
|
|
US5281698A
(en)
|
1991-07-23 |
1994-01-25 |
Cetus Oncology Corporation |
Preparation of an activated polymer ester for protein conjugation
|
|
US6331302B1
(en)
*
|
1992-01-22 |
2001-12-18 |
Genentech, Inc. |
Protein tyrosine kinase agonist antibodies
|
|
CA2128722A1
(en)
|
1992-01-22 |
1993-08-05 |
William I. Wood |
Novel protein tyrosine kinases
|
|
US5635177A
(en)
*
|
1992-01-22 |
1997-06-03 |
Genentech, Inc. |
Protein tyrosine kinase agonist antibodies
|
|
FR2686899B1
(fr)
|
1992-01-31 |
1995-09-01 |
Rhone Poulenc Rorer Sa |
Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
|
|
DE69332377T2
(de)
|
1992-07-13 |
2003-07-03 |
Bionebraska, Inc. |
Verfahren zur modifizierung rekombinanter polypeptide
|
|
US5506194A
(en)
|
1992-07-13 |
1996-04-09 |
Idemitsu Kosan Co., Ltd. |
Pyrazole derivatives and herbicidal compositions
|
|
US5382657A
(en)
|
1992-08-26 |
1995-01-17 |
Hoffmann-La Roche Inc. |
Peg-interferon conjugates
|
|
DK1975181T3
(da)
|
1992-10-28 |
2011-06-06 |
Genentech Inc |
Anvendelse af vaskulære endothelcelle-vækstfaktor-antagonister
|
|
AU685765B2
(en)
|
1992-11-13 |
1998-01-29 |
Amgen, Inc. |
(Eck) receptor ligands
|
|
US5824303A
(en)
|
1992-11-13 |
1998-10-20 |
Amgen Inc. |
Eck receptor ligands
|
|
US5512591A
(en)
*
|
1993-02-18 |
1996-04-30 |
President And Fellows Of Harvard College |
Treatments for diseases characterized by neovascularization
|
|
US6228879B1
(en)
|
1997-10-16 |
2001-05-08 |
The Children's Medical Center |
Methods and compositions for inhibition of angiogenesis
|
|
ES2152753B1
(es)
|
1993-03-29 |
2001-09-01 |
Ct Investig Energeticas Ciemat |
Animales transgenicos para la determinacion de agentes que estimulan o reprimen la hiperproliferacion epidermica y el crecimiento del pelo
|
|
US5446090A
(en)
|
1993-11-12 |
1995-08-29 |
Shearwater Polymers, Inc. |
Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
|
|
GB9404270D0
(en)
|
1994-03-05 |
1994-04-20 |
Delta Biotechnology Ltd |
Yeast strains and modified albumins
|
|
US5837682A
(en)
|
1996-03-08 |
1998-11-17 |
The Children's Medical Center Corporation |
Angiostatin fragments and method of use
|
|
US6303769B1
(en)
*
|
1994-07-08 |
2001-10-16 |
Immunex Corporation |
Lerk-5 dna
|
|
US5624899A
(en)
*
|
1994-07-20 |
1997-04-29 |
Genentech Inc. |
Method for using Htk ligand
|
|
AU3144195A
(en)
|
1994-07-26 |
1996-02-22 |
Rutgers, The State University Of New Jersey |
Human brain specific kinase
|
|
US5541087A
(en)
|
1994-09-14 |
1996-07-30 |
Fuji Immunopharmaceuticals Corporation |
Expression and export technology of proteins as immunofusins
|
|
US5795734A
(en)
*
|
1994-09-19 |
1998-08-18 |
President And Fellows Of Harvard College |
EPH receptor ligands, and uses related thereto
|
|
US5824784A
(en)
|
1994-10-12 |
1998-10-20 |
Amgen Inc. |
N-terminally chemically modified protein compositions and methods
|
|
WO1996013518A1
(en)
|
1994-10-27 |
1996-05-09 |
Genentech, Inc. |
Al-1 neurotrophic factor, a ligand for an eph-related tyrosine kinase receptor
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
US6057124A
(en)
|
1995-01-27 |
2000-05-02 |
Amgen Inc. |
Nucleic acids encoding ligands for HEK4 receptors
|
|
WO1996026958A2
(en)
|
1995-02-27 |
1996-09-06 |
President And Fellows Of Harvard College |
Eph RECEPTOR LIGAND ELF-2
|
|
GB9508538D0
(en)
*
|
1995-04-27 |
1995-06-14 |
Zeneca Ltd |
Quinazoline derivatives
|
|
ES2202469T5
(es)
|
1995-09-08 |
2011-06-06 |
Genentech, Inc. |
Proteína relacionada con el vegf.
|
|
JP3840262B2
(ja)
|
1995-10-23 |
2006-11-01 |
ザ チルドレンズ メディカル センター コーポレイション |
治療用の抗血管新生組成物および方法
|
|
US5837534A
(en)
*
|
1995-11-14 |
1998-11-17 |
The Board Of Regents Of The University Of Texas System |
Smooth muscle 22α promoter, gene transfer vectors containing the same, and method of use of the same to target gene expression in arterial smooth muscle cells
|
|
AUPN727795A0
(en)
|
1995-12-22 |
1996-01-18 |
Walter And Eliza Hall Institute Of Medical Research, The |
A novel receptor-type tyrosine kinase and use thereof
|
|
GB9526733D0
(en)
|
1995-12-30 |
1996-02-28 |
Delta Biotechnology Ltd |
Fusion proteins
|
|
US6465431B1
(en)
|
1999-11-17 |
2002-10-15 |
Boston Life Sciences, Inc. |
Pharmaceutical compositions comprising troponin subunits, fragments and homologs thereof and methods of their use to inhibit angiogenesis
|
|
US6696557B1
(en)
|
1996-04-19 |
2004-02-24 |
Genentech, Inc. |
AL-2 neurotrophic factor nucleic acid
|
|
US6100071A
(en)
|
1996-05-07 |
2000-08-08 |
Genentech, Inc. |
Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production
|
|
US5797954A
(en)
|
1996-05-24 |
1998-08-25 |
Shaffer; Terry M. |
Accessing and deaccessing tools and methods
|
|
PT951295E
(pt)
|
1996-05-31 |
2010-07-29 |
Scripps Research Inst |
COMPOSIÃES PARA UTILIZAÃO NA INIBIÃO DE ANGIOGéNESE MEDIADA POR ALFA-V-BETA3
|
|
US6413730B1
(en)
*
|
1996-07-05 |
2002-07-02 |
Mount Sinai Hospital Corporation |
Method for identifying compounds that inhibit or enhance activation of a transmembrane ligand for a receptor tyrosine kinase
|
|
US6573256B2
(en)
|
1996-12-30 |
2003-06-03 |
Bone Care International, Inc. |
Method of inhibiting angiogenesis using active vitamin D analogues
|
|
UA73073C2
(uk)
|
1997-04-03 |
2005-06-15 |
Уайт Холдінгз Корпорейшн |
Заміщені 3-ціанохіноліни, спосіб їх одержання та фармацевтична композиція
|
|
IL132240A0
(en)
|
1997-04-07 |
2001-03-19 |
Genentech Inc |
Anti-vegf antibodies
|
|
WO1998045708A1
(en)
|
1997-04-08 |
1998-10-15 |
Sugen, Inc. |
Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases
|
|
US6440954B1
(en)
*
|
1997-04-18 |
2002-08-27 |
President And Fellows Of Harvard College |
Inhibition of vascular smooth muscle cell proliferation
|
|
WO1999008696A1
(en)
|
1997-08-19 |
1999-02-25 |
Vanderbilt University |
METHODS FOR DETERMINING CELL RESPONSES THROUGH EphB RECEPTORS
|
|
EP1019080A2
(en)
*
|
1997-10-02 |
2000-07-19 |
Leukosite, Inc. |
Modulation of lerk-2-mediated cell adhesion
|
|
AU1690399A
(en)
|
1997-12-26 |
1999-07-19 |
Mochida Pharmaceutical Co., Ltd. |
Neovascularization inhibitor containing dienogest as the active ingredient
|
|
JPH11215126A
(ja)
|
1998-01-28 |
1999-08-06 |
Sharp Corp |
情報処理装置
|
|
DE69921102T2
(de)
*
|
1998-03-05 |
2006-02-02 |
Chiron Corp., Emeryville |
Verfahren zur verbesserung der serum-halbwertszeit von biologisch aktiven molekülen
|
|
US6864227B1
(en)
*
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
|
US6887674B1
(en)
*
|
1998-04-13 |
2005-05-03 |
California Institute Of Technology |
Artery- and vein-specific proteins and uses therefor
|
|
CA2331620A1
(en)
|
1998-05-11 |
1999-11-18 |
The Endowment For Research In Human Biology, Inc. |
Use of neomycin for treating angiogenesis-related diseases
|
|
US6413513B1
(en)
|
1998-05-22 |
2002-07-02 |
Entremed, Inc. |
Compositions and methods for inhibiting endothelial cell proliferation and regulating angiogenesis using cancer markers
|
|
US6395718B1
(en)
|
1998-07-06 |
2002-05-28 |
Guilford Pharmaceuticals Inc. |
Pharmaceutical compositions and methods of inhibiting angiogenesis using naaladase inhibitors
|
|
GB9814926D0
(en)
|
1998-07-09 |
1998-09-09 |
Smithkline Beecham Plc |
Novel compounds
|
|
US7341730B1
(en)
|
1998-07-13 |
2008-03-11 |
University Of Southern California |
Inhibitors of angiogenesis and tumor growth
|
|
JP2002520367A
(ja)
|
1998-07-14 |
2002-07-09 |
ブリストル−マイヤーズ スクイブ カンパニー |
アンギオスタチンのリジン結合フラグメント
|
|
WO2000010507A2
(en)
|
1998-08-21 |
2000-03-02 |
The Children's Medical Center Corporation |
Use of melanin for inhibition of angiogenesis and macular degeneration
|
|
AU8788998A
(en)
|
1998-10-02 |
2000-04-06 |
Universite Paris 7 |
Vascular specific regulatory elements contained in the desmin 5' flanking region
|
|
AUPP674898A0
(en)
|
1998-10-27 |
1998-11-19 |
Walter And Eliza Hall Institute Of Medical Research, The |
A method of treatment
|
|
ATE293989T1
(de)
*
|
1998-11-20 |
2005-05-15 |
Genentech Inc |
Verwendung von eph-rezeptor-antagonisten und agonisten zur behandlung von vaskulären krankheiten
|
|
CA2395191A1
(en)
|
1999-12-23 |
2001-06-28 |
Tedman Ehlers |
Chalcone and its analogs as agents for the inhibition of angiogenesis and related disease states
|
|
WO2001049743A2
(en)
|
2000-01-06 |
2001-07-12 |
The Hospital For Sick Children |
Methods of modulation of the immune system
|
|
AU4445601A
(en)
|
2000-03-31 |
2001-10-08 |
Centre National De La Recherche Scientifique-Cnrs |
Peptides blocking vascular endothelial growth factor (vegf)-mediated angiogenesis, polynucleotides encoding said peptides and methods of use thereof
|
|
EP1274720A4
(en)
|
2000-04-12 |
2004-08-18 |
Human Genome Sciences Inc |
FUSION PROTEINS CONTAINING ALBUMIN
|
|
JP2003530871A
(ja)
*
|
2000-04-21 |
2003-10-21 |
アムジエン・インコーポレーテツド |
インテグリン／接着因子アンタゴニスト
|
|
WO2002011785A2
(en)
|
2000-08-03 |
2002-02-14 |
The University Of Utah Research Foundation |
Manipulation of arterial-venous identity
|
|
ATE516820T1
(de)
|
2000-09-29 |
2011-08-15 |
Schering Corp |
Pegyliertes interleukin 10
|
|
WO2002026827A1
(en)
*
|
2000-09-29 |
2002-04-04 |
Novartis Ag |
Extracellular polypeptides of eph b receptors and ephrin b ligands and the corresponding nucleic acid molecules
|
|
US6548477B1
(en)
|
2000-11-01 |
2003-04-15 |
Praecis Pharmaceuticals Inc. |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
|
|
CA2429460A1
(en)
*
|
2000-11-20 |
2002-05-23 |
California Institute Of Technology |
Artery smooth muscle- and vein smooth muscle-specific proteins and uses therefor
|
|
US6958140B2
(en)
|
2001-01-26 |
2005-10-25 |
Regeneron Pharmaceuticals, Inc. |
Methods of imaging and targeting vasculature
|
|
EP1358211A2
(en)
|
2001-01-31 |
2003-11-05 |
Mount Sinai Hospital |
Methods for regulating the kinase domain of ephb2
|
|
WO2002079382A2
(en)
|
2001-03-30 |
2002-10-10 |
President And Fellows Of Harvard College |
B-ephrin regulation of g-protein coupled chemoattraction; compositions and methods of use
|
|
WO2002079415A2
(en)
|
2001-03-30 |
2002-10-10 |
Lexigen Pharmaceuticals Corp. |
Reducing the immunogenicity of fusion proteins
|
|
KR100576674B1
(ko)
|
2001-06-20 |
2006-05-10 |
제넨테크, 인크. |
종양의 진단 및 치료를 위한 방법 및 이를 위한 조성물
|
|
CA2450793A1
(en)
|
2001-06-20 |
2002-12-27 |
Prochon Biotech Ltd. |
Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
|
|
CA2452578A1
(en)
|
2001-07-03 |
2003-01-16 |
The Hospital For Sick Children |
Ephrin and eph receptor mediated immune modulation
|
|
US20060241027A1
(en)
*
|
2002-02-07 |
2006-10-26 |
Hans-Peter Hauser |
Hiv inhibiting proteins
|
|
EP1575509B1
(en)
|
2002-05-10 |
2011-10-26 |
Purdue Research Foundation |
Epha2 agonistic monoclonal antibodies and methods of use thereof
|
|
ATE525398T1
(de)
|
2002-05-10 |
2011-10-15 |
Medimmune Inc |
Epha2 monoklonale antikörper und deren anwendungsverfahren
|
|
US20040110150A1
(en)
*
|
2002-12-10 |
2004-06-10 |
Isis Pharmaceuticals Inc. |
Modulation of Ephrin-B2 expression
|
|
AU2003254641A1
(en)
*
|
2002-08-28 |
2004-03-19 |
Maxygen Aps |
Interferon beta-like molecules for treatment of cancer
|
|
AU2002951409A0
(en)
|
2002-09-16 |
2002-09-26 |
North Western Adelaide Health Services |
Methods for regulating cancer
|
|
EP1606305A4
(en)
*
|
2003-03-12 |
2009-06-24 |
Vasgene Therapeutics Inc |
NUCLEIC ACID COMPOUNDS FOR THE INHIBITION OF ANGIOGENESIS AND TUMOR GROWTH
|
|
NZ543122A
(en)
*
|
2003-03-24 |
2008-07-31 |
Sequoia Pharmaceuticals Inc |
An HIV fusion inhibitor peptide covalently linked to a blood protein
|
|
US20050049176A1
(en)
*
|
2003-04-11 |
2005-03-03 |
Kiener Peter A. |
EphA2, hypoproliferative cell disorders and epithelial and endothelial reconstitution
|
|
WO2004091375A2
(en)
|
2003-04-11 |
2004-10-28 |
Medimmune, Inc. |
Epha2 and non-neoplastic hyperproliferative cell disorders
|
|
WO2005048917A2
(en)
|
2003-06-06 |
2005-06-02 |
Medimmune, Inc. |
Use of epha4 and modulator or epha4 for diagnosis, treatment and prevention of cancer
|
|
EP2441474B1
(en)
*
|
2003-10-17 |
2015-08-05 |
Joslin Diabetes Center, Inc. |
Methods and compositions for modulating adipocyte function
|
|
CN1905899B
(zh)
|
2003-11-20 |
2011-09-28 |
医学免疫公司 |
EphA2激动性单克隆抗体及其使用方法
|
|
EP2275445A3
(en)
*
|
2004-03-12 |
2012-02-29 |
Vasgene Therapeutics, Inc. |
Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth
|
|
AU2005245896A1
(en)
*
|
2004-05-14 |
2005-12-01 |
Receptor Biologix, Inc. |
Cell surface receptor isoforms and methods of identifying and using the same
|
|
CA2581423A1
(en)
*
|
2004-09-23 |
2006-03-30 |
Vasgene Therapeutics, Inc. |
Polipeptide compounds for inhibiting angiogenesis and tumor growth
|