WO2005077976A3 - Coiled-coil domains from c4b-binding protein - Google Patents

Coiled-coil domains from c4b-binding protein Download PDF

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Publication number
WO2005077976A3
WO2005077976A3 PCT/IB2005/000550 IB2005000550W WO2005077976A3 WO 2005077976 A3 WO2005077976 A3 WO 2005077976A3 IB 2005000550 W IB2005000550 W IB 2005000550W WO 2005077976 A3 WO2005077976 A3 WO 2005077976A3
Authority
WO
WIPO (PCT)
Prior art keywords
coiled
binding protein
coil domains
fragments
c4bp
Prior art date
Application number
PCT/IB2005/000550
Other languages
French (fr)
Other versions
WO2005077976A2 (en
Inventor
Fergal Hill
Jean-Baptiste Marchand
Original Assignee
Avidis Sa
Fergal Hill
Jean-Baptiste Marchand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avidis Sa, Fergal Hill, Jean-Baptiste Marchand filed Critical Avidis Sa
Publication of WO2005077976A2 publication Critical patent/WO2005077976A2/en
Publication of WO2005077976A3 publication Critical patent/WO2005077976A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

The present invention provides novel coiled coils including fragments of C4bp which are capable of forming oligomers. These fragments can be used to oligomerise other components, such as polypeptide and non-polypeptide antigens. Also provided are C4bp fragments which are modified by substitution of one or more amino acids or by conjugation to PEG.
PCT/IB2005/000550 2004-02-13 2005-02-14 Coiled-coil domains from c4b-binding protein WO2005077976A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04290397.1 2004-02-13
EP04290397 2004-02-13

Publications (2)

Publication Number Publication Date
WO2005077976A2 WO2005077976A2 (en) 2005-08-25
WO2005077976A3 true WO2005077976A3 (en) 2006-03-09

Family

ID=34854720

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000550 WO2005077976A2 (en) 2004-02-13 2005-02-14 Coiled-coil domains from c4b-binding protein

Country Status (1)

Country Link
WO (1) WO2005077976A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1790358A1 (en) 2005-11-23 2007-05-30 Université de Reims Champagne-Ardennes Protein constructs designed for targeting and lysis of cells
EP1795540A1 (en) 2005-11-30 2007-06-13 Imaxio Multimeric complexes of antigens and an adjuvant
EP2397547A4 (en) * 2009-02-10 2012-09-05 Univ Ryukyus Drug transporter, and adjuvant and vaccine each utilizing same
KR102237130B1 (en) 2012-12-11 2021-04-08 오시벡스 에스에이에스 Modified coiled coil type proteins having improved properties
IL309559A (en) * 2021-07-09 2024-02-01 Luxembourg Inst Of Health Lih Dimeric protein complexes and uses thereof

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011461A1 (en) * 1990-01-26 1991-08-08 Biogen, Inc. C4 binding protein fusion proteins
WO1997004109A1 (en) * 1995-07-21 1997-02-06 Universite Pierre Et Marie Curie (Paris Vi) α-β C4BP-TYPE RECOMBINANT HETEROMULTIMERIC PROTEINS
WO2003086444A1 (en) * 2002-04-04 2003-10-23 Amgen Inc. Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2004016283A2 (en) * 2002-08-14 2004-02-26 Avidis Sa Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use
WO2004020639A2 (en) * 2002-08-14 2004-03-11 Avidis Sa Production of multimeric fusion proteins using a c4bp scaffold
WO2005014654A2 (en) * 2003-08-12 2005-02-17 Avidis Sa Product comprising a c4bp core protein and a monomeric antigen, and its use

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991011461A1 (en) * 1990-01-26 1991-08-08 Biogen, Inc. C4 binding protein fusion proteins
WO1997004109A1 (en) * 1995-07-21 1997-02-06 Universite Pierre Et Marie Curie (Paris Vi) α-β C4BP-TYPE RECOMBINANT HETEROMULTIMERIC PROTEINS
WO2003086444A1 (en) * 2002-04-04 2003-10-23 Amgen Inc. Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2004016283A2 (en) * 2002-08-14 2004-02-26 Avidis Sa Heteropolymeric compound comprising a scaffold, an adjuvant and an antigen, and its use
WO2004020639A2 (en) * 2002-08-14 2004-03-11 Avidis Sa Production of multimeric fusion proteins using a c4bp scaffold
WO2005014654A2 (en) * 2003-08-12 2005-02-17 Avidis Sa Product comprising a c4bp core protein and a monomeric antigen, and its use

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HILLARP A ET AL: "Molecular cloning of rat C4b binding protein alpha- and beta-chains: structural and functional relationships among human, bovine, rabbit, mouse, and rat proteins.", JOURNAL OF IMMUNOLOGY (BALTIMORE, MD. : 1950) 1 FEB 1997, vol. 158, no. 3, 1 February 1997 (1997-02-01), pages 1315 - 1323, XP002335885, ISSN: 0022-1767 *
LUPAS A ET AL: "PREDICTING COILED COILS FROM PROTEIN SEQUENCES", SCIENCE (WASHINGTON D C), vol. 252, no. 5009, 1991, pages 1162 - 1164, XP001206937, ISSN: 0036-8075 *
SKERRA A: "ENGINEERED PROTEIN SCAFFOLDS FOR MOLECULAR RECOGNITION", JOURNAL OF MOLECULAR RECOGNITION, HEYDEN & SON LTD., LONDON, GB, vol. 13, no. 4, July 2000 (2000-07-01), pages 167 - 187, XP009019725, ISSN: 0952-3499 *
VILLOUTREIX BRUNO O ET AL: "Structural investigation of C4b-binding protein by molecular modeling: Localization of putative binding sites", PROTEINS, vol. 31, no. 4, 1 June 1998 (1998-06-01), pages 391 - 405, XP002335886, ISSN: 0887-3585 *

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Publication number Publication date
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