WO2006097336A3 - A novel component of the wg/wnt signaling pathway - Google Patents

A novel component of the wg/wnt signaling pathway Download PDF

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Publication number
WO2006097336A3
WO2006097336A3 PCT/EP2006/002534 EP2006002534W WO2006097336A3 WO 2006097336 A3 WO2006097336 A3 WO 2006097336A3 EP 2006002534 W EP2006002534 W EP 2006002534W WO 2006097336 A3 WO2006097336 A3 WO 2006097336A3
Authority
WO
WIPO (PCT)
Prior art keywords
signaling pathway
wnt signaling
relates
novel component
well
Prior art date
Application number
PCT/EP2006/002534
Other languages
French (fr)
Other versions
WO2006097336A9 (en
WO2006097336A2 (en
Inventor
Carla Baenziger
Corina Schuett
Davide Soldini
Konrad Basler
Original Assignee
Genetics Co Inc
Carla Baenziger
Corina Schuett
Davide Soldini
Konrad Basler
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Co Inc, Carla Baenziger, Corina Schuett, Davide Soldini, Konrad Basler filed Critical Genetics Co Inc
Priority to EP06723552A priority Critical patent/EP1858922A2/en
Priority to JP2008501241A priority patent/JP2008537484A/en
Priority to CA002600540A priority patent/CA2600540A1/en
Publication of WO2006097336A2 publication Critical patent/WO2006097336A2/en
Publication of WO2006097336A9 publication Critical patent/WO2006097336A9/en
Publication of WO2006097336A3 publication Critical patent/WO2006097336A3/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value

Abstract

The present invention relates to a novel component of the Wg/Wnt signaling pathway. In particular, the invention relates to nucleic acid molecule being homologue to the sequence of the gene CG6210 (Drosophila melanogaster), of its encoded polypeptide named 3L3 or WLS, as well as derivatives, fragments and analogues thereof. The invention relates to methods for screening for a substance that inhibits or enhances the secretion of a protein of the Wnt- family as well as to antibodies binding to said (poly)peptides.
PCT/EP2006/002534 2005-03-18 2006-03-20 A novel component of the wg/wnt signaling pathway WO2006097336A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP06723552A EP1858922A2 (en) 2005-03-18 2006-03-20 A novel component of the wg/wnt signaling pathway
JP2008501241A JP2008537484A (en) 2005-03-18 2006-03-20 New component of WG / WNT signaling pathway
CA002600540A CA2600540A1 (en) 2005-03-18 2006-03-20 A novel component of the wg/wnt signaling pathway

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05006017.7 2005-03-18
EP05006017 2005-03-18

Publications (3)

Publication Number Publication Date
WO2006097336A2 WO2006097336A2 (en) 2006-09-21
WO2006097336A9 WO2006097336A9 (en) 2006-11-02
WO2006097336A3 true WO2006097336A3 (en) 2006-12-21

Family

ID=36572229

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2006/002534 WO2006097336A2 (en) 2005-03-18 2006-03-20 A novel component of the wg/wnt signaling pathway

Country Status (4)

Country Link
EP (1) EP1858922A2 (en)
JP (1) JP2008537484A (en)
CA (1) CA2600540A1 (en)
WO (1) WO2006097336A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2217223A2 (en) * 2007-11-05 2010-08-18 Novartis AG Methods and compositions for measuring wnt activation and for treating wnt-related cancers
EP2514765A1 (en) 2011-04-18 2012-10-24 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Gpr177 as target and marker in tumors
WO2013032905A1 (en) * 2011-08-26 2013-03-07 University Of Rochester Modulating wnt activity by targeting gpr177
KR101835939B1 (en) * 2014-08-26 2018-03-23 연세대학교 산학협력단 An antibody that recognizes a specific motif of WLS protein and a pharmaceutical composition comprising the same

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BÄNZIGER CARLA ET AL: "Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells.", CELL. 5 MAY 2006, vol. 125, no. 3, 5 May 2006 (2006-05-05), pages 509 - 522, XP002385895, ISSN: 0092-8674 *
BARTSCHERER KERSTIN ET AL: "Secretion of Wnt ligands requires Evi, a conserved transmembrane protein.", CELL. 5 MAY 2006, vol. 125, no. 3, 5 May 2006 (2006-05-05), pages 523 - 533, XP002385896, ISSN: 0092-8674 *
CHING WENDY ET AL: "A dedicated Wnt secretion factor.", CELL. 5 MAY 2006, vol. 125, no. 3, 5 May 2006 (2006-05-05), pages 432 - 433, XP002385897, ISSN: 0092-8674 *
DATABASE EMBL [online] 14 November 2001 (2001-11-14), "Drosophila melanogaster GH01813 full length cDNA.", XP002391697, retrieved from EBI accession no. EM_PRO:AY060600 Database accession no. AY060600 *
DATABASE UniProt [online] 1 October 2003 (2003-10-01), "Hypothetical protein DKFZp686K06169.", XP002391698, retrieved from EBI accession no. UNIPROT:Q7Z2Z9 Database accession no. Q7Z2Z9 *
VAN DEN HEUVEL MARCEL ET AL: "Mutations in the segment polarity genes wingless and porcupine impair secretion of the wingless protein", EMBO (EUROPEAN MOLECULAR BIOLOGY ORGANIZATION) JOURNAL, vol. 12, no. 13, 1993, pages 5293 - 5302, XP002385894, ISSN: 0261-4189 *

Also Published As

Publication number Publication date
WO2006097336A9 (en) 2006-11-02
WO2006097336A2 (en) 2006-09-21
JP2008537484A (en) 2008-09-18
CA2600540A1 (en) 2006-09-21
EP1858922A2 (en) 2007-11-28

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